Primary cilia control glucose homeostasis via islet paracrine interactions - Hughes, Jing W.; Cho, Jung Hoon; Conway, Hannah E.; DiGruccio, Michael R.; Ng, Xue Wen; Roseman, Henry F.; Abreu, Damien; Urano, Fumihiko; Piston, David W. (Proceedings of the National Academy of Sciences - PNAS, 2020)
Keywords: Animals; Beta cells; Biological Sciences; Calcium - metabolism; Calcium influx; Cell Communication - physiology; Cellular structure; Chemoreception; Cilia; Cilia - genetics; Cilia - metabolism; Cilia - pathology; Clonal deletion; Crosstalk; Diabetes; Diabetes mellitus; Diabetes Mellitus - genetics; Diabetes Mellitus - pathology; Disease Models, Animal; Energy Metabolism - physiology; Female; Glucagon-Secreting Cells - metabolism; Glucose; Glucose - metabolism; Homeostasis; Humans; Insulin; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - cytology; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Male; Mice; Mice, Knockout; Pancreas; Paracrine signalling; Perturbation; Secretion; Signal Transduction - physiology