Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice - Dimitrov, Vassil; Bouttier, Manuella; Boukhaled, Giselle; Salehi-Tabar, Reyhaneh; Avramescu, Radu G.; Memari, Babak; Hasaj, Benedeta; Lukacs, Gergely L.; Krawczyk, Connie M.; White, John H. (The Journal of biological chemistry, 2017)
Keywords: Animals; anti-tumor immunity; B7-H1 Antigen - agonists; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Cell Line; Cells, Cultured; checkpoint inhibitors; Coculture Techniques; Female; gene expression; Gene Expression Regulation - drug effects; Humans; Immunology; inflammation; inflammatory T cell responses; Macrophages - cytology; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Male; Mice; Nasal Mucosa - cytology; Nasal Mucosa - drug effects; Nasal Mucosa - metabolism; Organ Specificity; Programmed Cell Death 1 Ligand 2 Protein - agonists; Programmed Cell Death 1 Ligand 2 Protein - genetics; Programmed Cell Death 1 Ligand 2 Protein - metabolism; Recombinant Proteins - chemistry; Recombinant Proteins - metabolism; Species Specificity; steroid hormone receptor; T-Lymphocytes - cytology; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Up-Regulation - drug effects; vitamin D; Vitamin D - analogs & derivatives; Vitamin D - pharmacology; Vitamin D Response Element - drug effects; vitamin D signaling; inflammation; vitamin D; inflammatory T cell responses; vitamin D signaling; steroid hormone receptor; anti-tumor immunity; immunology; gene expression; checkpoint inhibitors