Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages: Free Cholesterol Accumulation, Increased Signaling via Toll-Like Receptors, and Neutrophil Infiltration of Atherosclerotic Lesions - Yvan-Charvet, Laurent; Welch, Carrie; Pagler, Tamara A.; Ranalletta, Mollie; Lamkanfi, Mohamed; Han, Seongah; Ishibashi, Minako; Li, Rong; Wang, Nan; Tall, Alan R. (Circulation (New York, N.Y.), 2008)
Keywords: Animals; Atherosclerosis - immunology; Atherosclerosis - metabolism; Atherosclerosis - physiopathology; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - immunology; ATP-Binding Cassette Transporters - metabolism; Biological and medical sciences; Blood and lymphatic vessels; Blood coagulation. Blood cells; Cardiology. Vascular system; Cholesterol - metabolism; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - immunology; Ligands; Lipopolysaccharides - pharmacology; Lipoproteins - genetics; Lipoproteins - immunology; Lipoproteins - metabolism; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Medical sciences; Membrane Microdomains - immunology; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Molecular and cellular biology; Neutrophils - immunology; Platelet; Receptors, LDL - genetics; Receptors, LDL - metabolism; Signal Transduction - immunology; Toll-Like Receptor 2 - metabolism; Toll-Like Receptor 3 - metabolism; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - immunology; Toll-Like Receptor 4 - metabolism; Lipids; Cardiovascular disease; Inflammation; Lipoprotein; Gene expression; Cholesterol; Vascular disease; Atherosclerosis; Infiltration; ABC transporters; Neutrophil; lipoproteins; Macrophage