Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor - Ferreira, Amanda Petrina Scotá; Cassago, Alexandre; Gonçalves, Kaliandra de Almeida; Dias, Marília Meira; Adamoski, Douglas; Ascenção, Carolline Fernanda Rodrigues; Honorato, Rodrigo Vargas; de Oliveira, Juliana Ferreira; Ferreira, Igor Monteze; Fornezari, Camila; Bettini, Jefferson; Oliveira, Paulo Sérgio Lopes; et al. (The Journal of biological chemistry, 2013)
Keywords: Algorithms; Allosteric Site; Cancer; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Cross-Linking Reagents; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Inhibitors - chemistry; Enzyme Mechanisms; Gene Expression Regulation, Neoplastic; Glutaminase; Glutaminase - chemistry; Glutaminase - metabolism; Humans; Isoenzymes - chemistry; Metabolism; Microscopy, Electron, Transmission; Mutagenesis; Mutation; Phosphates - metabolism; Polymers - chemistry; Protein Conformation; Protein Multimerization; Protein Structure and Folding; Recombinant Proteins - metabolism; Warburg Effect; Enzyme Mechanisms; Enzyme Inhibitors; Warburg Effect; Metabolism; Glutaminase; Cancer