First-in-class humanized FSH blocking antibody targets bone and fat - Gera, Sakshi; Sant, Damini; Haider, Shozeb; Korkmaz, Funda; Kuo, Tan-Chun; Mathew, Mehr; Perez-Pena, Helena; Xie, Honglin; Chend, Hao; Batista, Rogerio; Ma, Kejun; Cheng, Zhen; et al. (Proceedings of the National Academy of Sciences - PNAS, 2020)
Keywords: Adipose Tissue - metabolism; Animals; Antibodies; Antibodies, Blocking - chemistry; Antibodies, Blocking - immunology; Antibodies, Monoclonal; Biological Sciences; Biomedical materials; Blocking; Blocking antibodies; Body fat; Bone and Bones - metabolism; Bone Density; Bone mass; Chemical compounds; Cholesterol; Epitopes; Female; Follicle Stimulating Hormone - chemistry; Follicle Stimulating Hormone - immunology; Follicle Stimulating Hormone, beta Subunit - immunology; Follicle-stimulating hormone; Humans; Hypercholesterolemia; Mice; Mice, Inbred C57BL; Molecular dynamics; Molecular Dynamics Simulation; Obesity; Osteoporosis; Peptide mapping; Pharmacology; Receptors; Receptors, FSH - metabolism; Structure-function relationships; adipose; follicle-stimulating hormone; monoclonal antibody; humanization