Human wildtype tau expression in cholinergic pedunculopontine tegmental neurons is sufficient to produce PSP‐like behavioural deficits and neuropathology - King, Gabriella; Veros, Kaliana M.; MacLaren, Duncan Archibald Allan; Leigh, Martin Peter Konrad; Spernyak, Joseph A.; Clark, Stewart D. (The European journal of neuroscience, 2021)
Keywords: AAV; acoustic startle; Alzheimer's disease; Animal models; Animals; Autopsy; Basal ganglia; Central nervous system diseases; Cholinergic Agents; Cholinergic Neurons - metabolism; Dementia disorders; Dopamine receptors; Drug therapy; Executive function; Hindbrain; Humans; motor deficit; Movement disorders; MRI; Nervous System Diseases; Neurodegenerative diseases; Neurons; Paralysis; Parkinson's disease; Pathology; Pedunculopontine tegmental nucleus; Progressive supranuclear palsy; Rats; Startle response; Substantia nigra; Supranuclear Palsy, Progressive - genetics; Tau protein; tau Proteins - genetics; tau Proteins - metabolism; tauopathy; Tegmentum; Tegmentum Mesencephali - metabolism; motor deficit; tauopathy; MRI; AAV; acoustic startle