Cranial growth in isolated sagittal craniosynostosis compared with normal growth in the first 6 months of age
Sagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing an...
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| Published in | Journal of anatomy Vol. 236; no. 1; pp. 105 - 116 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.01.2020
John Wiley and Sons Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-8782 1469-7580 1469-7580 |
| DOI | 10.1111/joa.13085 |
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| Abstract | Sagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing and technique on different SCS surgeries. The purpose of this study was to develop statistical models of infant (0–6 months old) skull growth in both normative and SCS subjects (prior to surgery). Our goal was to apply these models to the assessment of differences between these two groups in overall post‐natal growth patterns and sutural growth rates as a first step to develop methods for predictive models of surgical outcome. We identified 81 patients with isolated, non‐syndromic SCS from Seattle Children's Craniofacial Center patient database who had a preoperative CT exam before the age of 6 months. As a control group, we identified 117 CT exams without any craniofacial abnormalities or bone fractures in the same age group. We first created population‐level templates from the CT images of the SCS and normal groups. All CT images from both groups, as well as the canonical templates of both cohorts, were annotated with anatomical landmarks, which were used in a growth model that predicted the locations of these landmarks at a given age based on each population. Using the template images and the landmark positions predicted by the growth models, we created 3D meshes for each week of age up to 6 months for both populations. To analyze the growth patterns at the suture sites, we annotated both templates with additional semi‐landmarks equally spaced along the metopic, coronal, sagittal and lambdoidal cranial sutures. By transferring these semi‐landmarks to meshes produced from the growth model, we measured the displacement of the bone borders and suture closure rates. We found that the growth at the metopic and coronal sutures were more rapid in the SCS cohort than in the normal cohort. The antero‐posterior displacement of the semi‐landmarks also indicated a more rapid growth in the sagittal plane in the SCS model than in the normal model. Statistical templates and geometric morphometrics are promising tools for understanding the growth patterns in normal and synostotic populations and to produce objective and reproducible measurements of severity and outcome. Our study is the first of its kind to quantify the bone growth for the first 6 months of life in both normal and sagittal synostosis patients.
Normal growth vs. growth in sagittal craniosynostosis. (A) Mediolateral displacement: positive values indicate medial movement (can be interpreted as suture closure) and negative values indicate lateral movement (mostly associated with the overall growth of the skull). (B) Superoinferior displacement: positive values indicate a superior movement. (C) Anteroposterior displacement: positive values indicate anterior, and negative values indicate posterior movement with respect to basion. |
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| AbstractList | Sagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing and technique on different SCS surgeries. The purpose of this study was to develop statistical models of infant (0-6 months old) skull growth in both normative and SCS subjects (prior to surgery). Our goal was to apply these models to the assessment of differences between these two groups in overall post-natal growth patterns and sutural growth rates as a first step to develop methods for predictive models of surgical outcome. We identified 81 patients with isolated, non-syndromic SCS from Seattle Children's Craniofacial Center patient database who had a preoperative CT exam before the age of 6 months. As a control group, we identified 117 CT exams without any craniofacial abnormalities or bone fractures in the same age group. We first created population-level templates from the CT images of the SCS and normal groups. All CT images from both groups, as well as the canonical templates of both cohorts, were annotated with anatomical landmarks, which were used in a growth model that predicted the locations of these landmarks at a given age based on each population. Using the template images and the landmark positions predicted by the growth models, we created 3D meshes for each week of age up to 6 months for both populations. To analyze the growth patterns at the suture sites, we annotated both templates with additional semi-landmarks equally spaced along the metopic, coronal, sagittal and lambdoidal cranial sutures. By transferring these semi-landmarks to meshes produced from the growth model, we measured the displacement of the bone borders and suture closure rates. We found that the growth at the metopic and coronal sutures were more rapid in the SCS cohort than in the normal cohort. The antero-posterior displacement of the semi-landmarks also indicated a more rapid growth in the sagittal plane in the SCS model than in the normal model. Statistical templates and geometric morphometrics are promising tools for understanding the growth patterns in normal and synostotic populations and to produce objective and reproducible measurements of severity and outcome. Our study is the first of its kind to quantify the bone growth for the first 6 months of life in both normal and sagittal synostosis patients. Sagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing and technique on different SCS surgeries. The purpose of this study was to develop statistical models of infant (0–6 months old) skull growth in both normative and SCS subjects (prior to surgery). Our goal was to apply these models to the assessment of differences between these two groups in overall post‐natal growth patterns and sutural growth rates as a first step to develop methods for predictive models of surgical outcome. We identified 81 patients with isolated, non‐syndromic SCS from Seattle Children's Craniofacial Center patient database who had a preoperative CT exam before the age of 6 months. As a control group, we identified 117 CT exams without any craniofacial abnormalities or bone fractures in the same age group. We first created population‐level templates from the CT images of the SCS and normal groups. All CT images from both groups, as well as the canonical templates of both cohorts, were annotated with anatomical landmarks, which were used in a growth model that predicted the locations of these landmarks at a given age based on each population. Using the template images and the landmark positions predicted by the growth models, we created 3D meshes for each week of age up to 6 months for both populations. To analyze the growth patterns at the suture sites, we annotated both templates with additional semi‐landmarks equally spaced along the metopic, coronal, sagittal and lambdoidal cranial sutures. By transferring these semi‐landmarks to meshes produced from the growth model, we measured the displacement of the bone borders and suture closure rates. We found that the growth at the metopic and coronal sutures were more rapid in the SCS cohort than in the normal cohort. The antero‐posterior displacement of the semi‐landmarks also indicated a more rapid growth in the sagittal plane in the SCS model than in the normal model. Statistical templates and geometric morphometrics are promising tools for understanding the growth patterns in normal and synostotic populations and to produce objective and reproducible measurements of severity and outcome. Our study is the first of its kind to quantify the bone growth for the first 6 months of life in both normal and sagittal synostosis patients. Normal growth vs. growth in sagittal craniosynostosis. (A) Mediolateral displacement: positive values indicate medial movement (can be interpreted as suture closure) and negative values indicate lateral movement (mostly associated with the overall growth of the skull). (B) Superoinferior displacement: positive values indicate a superior movement. (C) Anteroposterior displacement: positive values indicate anterior, and negative values indicate posterior movement with respect to basion. Sagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing and technique on different SCS surgeries. The purpose of this study was to develop statistical models of infant (0–6 months old) skull growth in both normative and SCS subjects (prior to surgery). Our goal was to apply these models to the assessment of differences between these two groups in overall post‐natal growth patterns and sutural growth rates as a first step to develop methods for predictive models of surgical outcome. We identified 81 patients with isolated, non‐syndromic SCS from Seattle Children's Craniofacial Center patient database who had a preoperative CT exam before the age of 6 months. As a control group, we identified 117 CT exams without any craniofacial abnormalities or bone fractures in the same age group. We first created population‐level templates from the CT images of the SCS and normal groups. All CT images from both groups, as well as the canonical templates of both cohorts, were annotated with anatomical landmarks, which were used in a growth model that predicted the locations of these landmarks at a given age based on each population. Using the template images and the landmark positions predicted by the growth models, we created 3D meshes for each week of age up to 6 months for both populations. To analyze the growth patterns at the suture sites, we annotated both templates with additional semi‐landmarks equally spaced along the metopic, coronal, sagittal and lambdoidal cranial sutures. By transferring these semi‐landmarks to meshes produced from the growth model, we measured the displacement of the bone borders and suture closure rates. We found that the growth at the metopic and coronal sutures were more rapid in the SCS cohort than in the normal cohort. The antero‐posterior displacement of the semi‐landmarks also indicated a more rapid growth in the sagittal plane in the SCS model than in the normal model. Statistical templates and geometric morphometrics are promising tools for understanding the growth patterns in normal and synostotic populations and to produce objective and reproducible measurements of severity and outcome. Our study is the first of its kind to quantify the bone growth for the first 6 months of life in both normal and sagittal synostosis patients. Sagittal craniosynostosis ( SCS ), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing and technique on different SCS surgeries. The purpose of this study was to develop statistical models of infant (0–6 months old) skull growth in both normative and SCS subjects (prior to surgery). Our goal was to apply these models to the assessment of differences between these two groups in overall post‐natal growth patterns and sutural growth rates as a first step to develop methods for predictive models of surgical outcome. We identified 81 patients with isolated, non‐syndromic SCS from Seattle Children's Craniofacial Center patient database who had a preoperative CT exam before the age of 6 months. As a control group, we identified 117 CT exams without any craniofacial abnormalities or bone fractures in the same age group. We first created population‐level templates from the CT images of the SCS and normal groups. All CT images from both groups, as well as the canonical templates of both cohorts, were annotated with anatomical landmarks, which were used in a growth model that predicted the locations of these landmarks at a given age based on each population. Using the template images and the landmark positions predicted by the growth models, we created 3D meshes for each week of age up to 6 months for both populations. To analyze the growth patterns at the suture sites, we annotated both templates with additional semi‐landmarks equally spaced along the metopic, coronal, sagittal and lambdoidal cranial sutures. By transferring these semi‐landmarks to meshes produced from the growth model, we measured the displacement of the bone borders and suture closure rates. We found that the growth at the metopic and coronal sutures were more rapid in the SCS cohort than in the normal cohort. The antero‐posterior displacement of the semi‐landmarks also indicated a more rapid growth in the sagittal plane in the SCS model than in the normal model. Statistical templates and geometric morphometrics are promising tools for understanding the growth patterns in normal and synostotic populations and to produce objective and reproducible measurements of severity and outcome. Our study is the first of its kind to quantify the bone growth for the first 6 months of life in both normal and sagittal synostosis patients. Sagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing and technique on different SCS surgeries. The purpose of this study was to develop statistical models of infant (0–6 months old) skull growth in both normative and SCS subjects (prior to surgery). Our goal was to apply these models to the assessment of differences between these two groups in overall post‐natal growth patterns and sutural growth rates as a first step to develop methods for predictive models of surgical outcome. We identified 81 patients with isolated, non‐syndromic SCS from Seattle Children's Craniofacial Center patient database who had a preoperative CT exam before the age of 6 months. As a control group, we identified 117 CT exams without any craniofacial abnormalities or bone fractures in the same age group. We first created population‐level templates from the CT images of the SCS and normal groups. All CT images from both groups, as well as the canonical templates of both cohorts, were annotated with anatomical landmarks, which were used in a growth model that predicted the locations of these landmarks at a given age based on each population. Using the template images and the landmark positions predicted by the growth models, we created 3D meshes for each week of age up to 6 months for both populations. To analyze the growth patterns at the suture sites, we annotated both templates with additional semi‐landmarks equally spaced along the metopic, coronal, sagittal and lambdoidal cranial sutures. By transferring these semi‐landmarks to meshes produced from the growth model, we measured the displacement of the bone borders and suture closure rates. We found that the growth at the metopic and coronal sutures were more rapid in the SCS cohort than in the normal cohort. The antero‐posterior displacement of the semi‐landmarks also indicated a more rapid growth in the sagittal plane in the SCS model than in the normal model. Statistical templates and geometric morphometrics are promising tools for understanding the growth patterns in normal and synostotic populations and to produce objective and reproducible measurements of severity and outcome. Our study is the first of its kind to quantify the bone growth for the first 6 months of life in both normal and sagittal synostosis patients. Normal growth vs. growth in sagittal craniosynostosis. (A) Mediolateral displacement: positive values indicate medial movement (can be interpreted as suture closure) and negative values indicate lateral movement (mostly associated with the overall growth of the skull). (B) Superoinferior displacement: positive values indicate a superior movement. (C) Anteroposterior displacement: positive values indicate anterior, and negative values indicate posterior movement with respect to basion. Sagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing and technique on different SCS surgeries. The purpose of this study was to develop statistical models of infant (0-6 months old) skull growth in both normative and SCS subjects (prior to surgery). Our goal was to apply these models to the assessment of differences between these two groups in overall post-natal growth patterns and sutural growth rates as a first step to develop methods for predictive models of surgical outcome. We identified 81 patients with isolated, non-syndromic SCS from Seattle Children's Craniofacial Center patient database who had a preoperative CT exam before the age of 6 months. As a control group, we identified 117 CT exams without any craniofacial abnormalities or bone fractures in the same age group. We first created population-level templates from the CT images of the SCS and normal groups. All CT images from both groups, as well as the canonical templates of both cohorts, were annotated with anatomical landmarks, which were used in a growth model that predicted the locations of these landmarks at a given age based on each population. Using the template images and the landmark positions predicted by the growth models, we created 3D meshes for each week of age up to 6 months for both populations. To analyze the growth patterns at the suture sites, we annotated both templates with additional semi-landmarks equally spaced along the metopic, coronal, sagittal and lambdoidal cranial sutures. By transferring these semi-landmarks to meshes produced from the growth model, we measured the displacement of the bone borders and suture closure rates. We found that the growth at the metopic and coronal sutures were more rapid in the SCS cohort than in the normal cohort. The antero-posterior displacement of the semi-landmarks also indicated a more rapid growth in the sagittal plane in the SCS model than in the normal model. Statistical templates and geometric morphometrics are promising tools for understanding the growth patterns in normal and synostotic populations and to produce objective and reproducible measurements of severity and outcome. Our study is the first of its kind to quantify the bone growth for the first 6 months of life in both normal and sagittal synostosis patients.Sagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing and technique on different SCS surgeries. The purpose of this study was to develop statistical models of infant (0-6 months old) skull growth in both normative and SCS subjects (prior to surgery). Our goal was to apply these models to the assessment of differences between these two groups in overall post-natal growth patterns and sutural growth rates as a first step to develop methods for predictive models of surgical outcome. We identified 81 patients with isolated, non-syndromic SCS from Seattle Children's Craniofacial Center patient database who had a preoperative CT exam before the age of 6 months. As a control group, we identified 117 CT exams without any craniofacial abnormalities or bone fractures in the same age group. We first created population-level templates from the CT images of the SCS and normal groups. All CT images from both groups, as well as the canonical templates of both cohorts, were annotated with anatomical landmarks, which were used in a growth model that predicted the locations of these landmarks at a given age based on each population. Using the template images and the landmark positions predicted by the growth models, we created 3D meshes for each week of age up to 6 months for both populations. To analyze the growth patterns at the suture sites, we annotated both templates with additional semi-landmarks equally spaced along the metopic, coronal, sagittal and lambdoidal cranial sutures. By transferring these semi-landmarks to meshes produced from the growth model, we measured the displacement of the bone borders and suture closure rates. We found that the growth at the metopic and coronal sutures were more rapid in the SCS cohort than in the normal cohort. The antero-posterior displacement of the semi-landmarks also indicated a more rapid growth in the sagittal plane in the SCS model than in the normal model. Statistical templates and geometric morphometrics are promising tools for understanding the growth patterns in normal and synostotic populations and to produce objective and reproducible measurements of severity and outcome. Our study is the first of its kind to quantify the bone growth for the first 6 months of life in both normal and sagittal synostosis patients. |
| Author | Mercan, Ezgi Hopper, Richard A. Maga, A. Murat |
| AuthorAffiliation | 1 Craniofacial Center Seattle Children's Hospital Seattle WA USA 4 Seattle Children's Research Institute Center for Developmental Biology and Regenerative Medicine Seattle WA USA 2 Division of Plastic Surgery Department of Surgery University of Washington Seattle WA USA 3 Department of Pediatrics Division of Craniofacial Medicine University of Washington Seattle WA USA |
| AuthorAffiliation_xml | – name: 4 Seattle Children's Research Institute Center for Developmental Biology and Regenerative Medicine Seattle WA USA – name: 3 Department of Pediatrics Division of Craniofacial Medicine University of Washington Seattle WA USA – name: 1 Craniofacial Center Seattle Children's Hospital Seattle WA USA – name: 2 Division of Plastic Surgery Department of Surgery University of Washington Seattle WA USA |
| Author_xml | – sequence: 1 givenname: Ezgi surname: Mercan fullname: Mercan, Ezgi organization: Seattle Children's Hospital – sequence: 2 givenname: Richard A. surname: Hopper fullname: Hopper, Richard A. organization: University of Washington – sequence: 3 givenname: A. Murat orcidid: 0000-0002-7921-9018 surname: Maga fullname: Maga, A. Murat email: maga@uw.edu organization: University of Washington |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31691965$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1159/000028706 10.1097/GOX.0000000000000216 10.1016/j.anclin.2013.10.007 10.1097/PRS.0000000000003422 10.1055/s-0032-1320063 10.1097/SCS.0b013e3182a75102 10.1097/SCS.0b013e3182997885 10.1097/PRS.0000000000001505 10.3171/jns.1989.70.2.0159 10.1097/00006534-198904000-00025 10.1016/j.bjps.2016.08.006 10.1145/37402.37422 10.1016/j.neuroimage.2010.09.025 10.1097/00001665-200501000-00012 10.1016/j.jcms.2016.01.023 10.1097/SCS.0000000000004179 10.1097/PRS.0000000000002049 10.1016/j.mri.2012.05.001 10.1002/wdev.227 10.1097/01.prs.0000293762.71115.c5 10.1097/PRS.0000000000002125 10.3171/jns.1999.91.4.0617 10.1007/s40142-014-0042-x 10.1007/s00381-006-0251-z 10.1597/14-310 10.1093/jpepsy/jsh068 10.1016/j.pediatrneurol.2015.07.006 10.1542/peds.2014-1634 10.1227/01.NEU.0000371992.72539.8B 10.1371/journal.pone.0127322 10.1016/B978-0-12-810493-4.00011-0 10.1115/1.1287160 10.1002/ajmg.c.31383 10.1097/SCS.0000000000002519 10.1002/ana.410020607 10.1007/s00381-015-2900-6 10.1002/ajmg.a.38540 10.1098/rsif.2017.0202 10.1016/j.jocn.2006.07.001 10.1109/34.24792 10.3171/2013.4.PEDS12445 |
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| References | 1998; 29 1989; 83 2004; 29 2013; 24 2017; 28 2015; 53 2015; 10 2016; 32 2016; 53 2014; 25 2011; 54 2013; 163 2004 1991 2007; 14 2012; 30 2015; 24 2010; 67 2016; 5 2018; 176 1989; 11 1987; 21 2014; 2 2017; 14 2015; 135 2015; 136 2013; 12 2005; 103 1989; 70 1977; 2 2017 2017; 140 2008; 121(1 2016; 137 2000; 122 2009; 681 2012; 26 2005; 16 2016; 27 1999; 91 2007; 23 2016; 69 2014; 32 2016; 44 e_1_2_9_30_1 e_1_2_9_31_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_12_1 Sivakumar W (e_1_2_9_40_1) 2015; 24 Schroeder WJ (e_1_2_9_37_1) 2004 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_16_1 e_1_2_9_19_1 e_1_2_9_18_1 Netherway DJ (e_1_2_9_33_1) 2005; 103 e_1_2_9_41_1 e_1_2_9_42_1 e_1_2_9_20_1 Avants BB (e_1_2_9_3_1) 2009; 681 e_1_2_9_22_1 e_1_2_9_45_1 e_1_2_9_21_1 e_1_2_9_46_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_2_1 e_1_2_9_9_1 e_1_2_9_26_1 e_1_2_9_25_1 e_1_2_9_28_1 e_1_2_9_47_1 e_1_2_9_27_1 Bookstein FL (e_1_2_9_8_1) 1991 e_1_2_9_29_1 |
| References_xml | – volume: 54 start-page: 2033 year: 2011 end-page: 2044 article-title: A reproducible evaluation of ANTs similarity metric performance in brain image registration publication-title: NeuroImage – volume: 14 start-page: 20170202 year: 2017 article-title: Modelling human skull growth: a validated computational model publication-title: J R Soc Interface – volume: 24 start-page: 9 year: 2015 end-page: 64 article-title: Pancraniosynostosis following endoscopic‐assisted strip craniectomy for sagittal suture craniosynostosis in the setting of poor compliance with follow‐up: a case report publication-title: J Med Case Rep – volume: 11 start-page: 567 year: 1989 end-page: 585 article-title: Principal warps: thin‐plate splines and the decomposition of deformations publication-title: IEEE Trans Pattern Anal Mach Intell – volume: 10 start-page: e0127322 year: 2015 article-title: A statistical skull geometry model for children 0‐3 years old publication-title: PLoS One – volume: 21 start-page: 163 year: 1987 end-page: 169 article-title: Marching cubes: a high resolution 3D surface construction algorithm publication-title: Comput Graph – volume: 28 start-page: 2108 year: 2017 end-page: 2112 article-title: The directive growth approach for nonsyndromic, unicoronal craniosynostosis: patient and clinical outcomes publication-title: J Craniofac Surg – volume: 23 start-page: 269 year: 2007 end-page: 281 article-title: Neurodevelopment of children with single suture craniosynostosis: a review publication-title: Childs Nerv Syst – volume: 26 start-page: 53 year: 2012 end-page: 63 article-title: Nonsyndromic craniosynostosis publication-title: Semin Plast Surg – volume: 32 start-page: 143 year: 2016 end-page: 151 article-title: Minimizing blood transfusions in the surgical correction of craniosynostosis: a 10‐year single‐center experience publication-title: Childs Nerv Syst – volume: 2 start-page: 485 year: 1977 end-page: 491 article-title: Tables of cranial and orbital measurements, cranial volume, and derived indexes in males and females from 7 days to 20 years of age publication-title: Ann Neurol – volume: 29 start-page: 127 year: 1998 end-page: 132 article-title: Pancraniosynostosis after surgery for single sutural craniosynostosis publication-title: Pediatr Neurosurg – volume: 163 start-page: 213 year: 2013 end-page: 217 article-title: Perspectives and challenges in advancing research into craniofacial anomalies publication-title: Am J Med Genet C Semin Med Genet – volume: 29 start-page: 651 year: 2004 end-page: 668 article-title: Single‐suture craniosynostosis: a review of neurobehavioral research and theory publication-title: J Pediatr Psychol – volume: 2 start-page: 135 year: 2014 end-page: 145 article-title: Closing the gap: genetic and genomic continuum from syndromic to nonsyndromic craniosynostoses publication-title: Curr Genet Med Rep – volume: 2 start-page: e243 year: 2014 article-title: Intracranial volume in 15 children with bilateral coronal craniosynostosis publication-title: Plast Reconstr Surg Glob Open – volume: 103 start-page: 137 issue: 2 Suppl year: 2005 end-page: 141 article-title: Intracranial volume in patients with nonsyndromal craniosynostosis publication-title: J Neurosurg – volume: 135 start-page: e615 year: 2015 end-page: e623 article-title: Intellectual and academic functioning of school‐age children with single‐suture craniosynostosis publication-title: Pediatrics – volume: 67 start-page: 408 year: 2010 end-page: 415 article-title: Little evidence of association between severity of trigonocephaly and cognitive development in infants with single‐suture metopic synostosis publication-title: Neurosurgery – volume: 16 start-page: 59 year: 2005 end-page: 62 article-title: Blood loss and transfusion rates during repair of craniofacial deformities publication-title: J Craniofac Surg – volume: 681 year: 2009 article-title: Advanced Normalization Tools: V1.0 publication-title: Insight J – volume: 32 start-page: 215 year: 2014 end-page: 235 article-title: Anesthesia for craniofacial surgery in infancy publication-title: Anesthesiol Clin – volume: 176 start-page: 290 year: 2018 end-page: 300 article-title: Single suture craniosynostosis: identification of rare variants in genes associated with syndromic forms publication-title: Am J Med Genet A – volume: 27 start-page: 410 year: 2016 end-page: 413 article-title: Comparison of intracranial volume and cephalic index after correction of sagittal synostosis with spring‐assisted surgery or pi‐plasty publication-title: J Craniofac Surg – volume: 12 start-page: 77 year: 2013 end-page: 79 article-title: Pancraniosynostosis following endoscope‐assisted strip craniectomy and helmet orthosis for sagittal suture craniosynostosis in a nonsyndromic patient publication-title: J Neurosurg Pediatr – volume: 69 start-page: 1464 year: 2016 end-page: 1468 article-title: Review of quantitative outcome analysis of cranial morphology in craniosynostosis publication-title: J Plast Reconstr Aesthet Surg – volume: 44 start-page: 626 year: 2016 end-page: 631 article-title: Intracranial volume (ICV) in isolated sagittal craniosynostosis measured by 3D photocephalometry: a new perspective on a controversial issue publication-title: J Craniomaxillofac Surg – volume: 122 start-page: 364 year: 2000 end-page: 371 article-title: Infant skull and suture properties: measurements and implications for mechanisms of pediatric brain injury publication-title: J Biomech Eng – volume: 24 start-page: 1331 year: 2013 end-page: 1335 article-title: Laypersons’ ratings of appearance in children with and without single‐suture craniosynostosis publication-title: J Craniofac Surg – volume: 53 start-page: e95 year: 2016 end-page: e100 article-title: Evaluating children with metopic craniosynostosis: the cephalic width‐intercoronal distance ratio publication-title: Cleft Palate Craniofac J – volume: 70 start-page: 159 year: 1989 end-page: 165 article-title: Cranial vault growth in craniosynostosis publication-title: J Neurosurg – volume: 121(1 start-page: 187 year: 2008 end-page: 195 article-title: Intracranial volume and cephalic index outcomes for total calvarial reconstruction among nonsyndromic sagittal synostosis patients publication-title: Plast Reconstr Surg – volume: 137 start-page: 1557 year: 2016 end-page: 1565 article-title: Age at the time of surgery and maintenance of head size in nonsyndromic sagittal craniosynostosis publication-title: Plast Reconstr Surg – volume: 30 start-page: 1323 year: 2012 end-page: 1341 article-title: 3D Slicer as an image computing platform for the Quantitative Imaging Network publication-title: Magn Reson Imaging – volume: 83 start-page: 738 year: 1989 end-page: 742 article-title: Virchow and the pathogenesis of craniosynostosis: a translation of his original work publication-title: Plast Reconstr Surg – year: 2004 – volume: 140 start-page: 138 year: 2017 end-page: 145 article-title: An appraisal of the cephalic index in sagittal craniosynostosis, and the unseen third dimension publication-title: Plast Reconstr Surg – volume: 25 start-page: 119 issue: 1 year: 2014 end-page: 123 article-title: Delayed synostoses of uninvolved sutures after surgical treatment of nonsyndromic craniosynostosis publication-title: J Craniofac Surg – volume: 14 start-page: 455 year: 2007 end-page: 458 article-title: Intracranial volume measurement of sagittal craniosynostosis publication-title: J Clin Neurosci – volume: 53 start-page: 394 year: 2015 end-page: 401 article-title: Craniosynostosis publication-title: Pediatr Neurol – start-page: 217 year: 2017 end-page: 256 – year: 1991 – volume: 91 start-page: 617 year: 1999 end-page: 625 article-title: Intracranial volume change in craniosynostosis publication-title: J Neurosurg – volume: 5 start-page: 429 year: 2016 end-page: 459 article-title: Understanding craniosynostosis as a growth disorder publication-title: Wiley Interdiscip Rev Dev Biol – volume: 137 start-page: 1566 year: 2016 end-page: 1567 article-title: Discussion: age at the time of surgery and maintenance of head size in nonsyndromic sagittal craniosynostosis publication-title: Plast Reconstr Surg – volume: 136 start-page: 541 year: 2015 end-page: 548 article-title: Comparison of traditional versus normative cephalic index in patients with sagittal synostosis: measure of scaphocephaly and postoperative outcome publication-title: Plast Reconstr Surg – ident: e_1_2_9_21_1 doi: 10.1159/000028706 – ident: e_1_2_9_45_1 doi: 10.1097/GOX.0000000000000216 – ident: e_1_2_9_44_1 doi: 10.1016/j.anclin.2013.10.007 – ident: e_1_2_9_15_1 doi: 10.1097/PRS.0000000000003422 – ident: e_1_2_9_19_1 doi: 10.1055/s-0032-1320063 – volume-title: The Visualization Toolkit: An Object‐Oriented Approach to 3D Graphics year: 2004 ident: e_1_2_9_37_1 – ident: e_1_2_9_47_1 doi: 10.1097/SCS.0b013e3182a75102 – ident: e_1_2_9_10_1 doi: 10.1097/SCS.0b013e3182997885 – ident: e_1_2_9_14_1 doi: 10.1097/PRS.0000000000001505 – ident: e_1_2_9_13_1 doi: 10.3171/jns.1989.70.2.0159 – ident: e_1_2_9_35_1 doi: 10.1097/00006534-198904000-00025 – ident: e_1_2_9_28_1 doi: 10.1016/j.bjps.2016.08.006 – ident: e_1_2_9_29_1 doi: 10.1145/37402.37422 – ident: e_1_2_9_4_1 doi: 10.1016/j.neuroimage.2010.09.025 – ident: e_1_2_9_46_1 doi: 10.1097/00001665-200501000-00012 – ident: e_1_2_9_38_1 doi: 10.1016/j.jcms.2016.01.023 – ident: e_1_2_9_30_1 doi: 10.1097/SCS.0000000000004179 – ident: e_1_2_9_5_1 doi: 10.1097/PRS.0000000000002049 – ident: e_1_2_9_16_1 doi: 10.1016/j.mri.2012.05.001 – ident: e_1_2_9_18_1 doi: 10.1002/wdev.227 – ident: e_1_2_9_22_1 doi: 10.1097/01.prs.0000293762.71115.c5 – ident: e_1_2_9_34_1 doi: 10.1097/PRS.0000000000002125 – volume: 681 year: 2009 ident: e_1_2_9_3_1 article-title: Advanced Normalization Tools: V1.0 publication-title: Insight J – ident: e_1_2_9_39_1 doi: 10.3171/jns.1999.91.4.0617 – ident: e_1_2_9_23_1 doi: 10.1007/s40142-014-0042-x – ident: e_1_2_9_25_1 doi: 10.1007/s00381-006-0251-z – ident: e_1_2_9_32_1 doi: 10.1597/14-310 – ident: e_1_2_9_41_1 doi: 10.1093/jpepsy/jsh068 – ident: e_1_2_9_20_1 doi: 10.1016/j.pediatrneurol.2015.07.006 – ident: e_1_2_9_42_1 doi: 10.1542/peds.2014-1634 – volume: 103 start-page: 137 issue: 2 year: 2005 ident: e_1_2_9_33_1 article-title: Intracranial volume in patients with nonsyndromal craniosynostosis publication-title: J Neurosurg – ident: e_1_2_9_43_1 doi: 10.1227/01.NEU.0000371992.72539.8B – ident: e_1_2_9_26_1 doi: 10.1371/journal.pone.0127322 – ident: e_1_2_9_36_1 doi: 10.1016/B978-0-12-810493-4.00011-0 – ident: e_1_2_9_31_1 doi: 10.1115/1.1287160 – ident: e_1_2_9_11_1 doi: 10.1002/ajmg.c.31383 – ident: e_1_2_9_17_1 doi: 10.1097/SCS.0000000000002519 – ident: e_1_2_9_12_1 doi: 10.1002/ana.410020607 – volume-title: Morphometric Tools for Landmark Data: Geometry and Biology year: 1991 ident: e_1_2_9_8_1 – ident: e_1_2_9_6_1 doi: 10.1007/s00381-015-2900-6 – ident: e_1_2_9_9_1 doi: 10.1002/ajmg.a.38540 – ident: e_1_2_9_27_1 doi: 10.1098/rsif.2017.0202 – ident: e_1_2_9_2_1 doi: 10.1016/j.jocn.2006.07.001 – ident: e_1_2_9_7_1 doi: 10.1109/34.24792 – volume: 24 start-page: 9 year: 2015 ident: e_1_2_9_40_1 article-title: Pancraniosynostosis following endoscopic‐assisted strip craniectomy for sagittal suture craniosynostosis in the setting of poor compliance with follow‐up: a case report publication-title: J Med Case Rep – ident: e_1_2_9_24_1 doi: 10.3171/2013.4.PEDS12445 |
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| SubjectTerms | Age Bone growth Cranial sutures Cranial Sutures - diagnostic imaging Cranial Sutures - growth & development Craniosynostoses - diagnostic imaging Craniosynostosis Dysostosis Female Fractures geometric morphometrics Growth models Growth patterns Growth rate Humans Imaging, Three-Dimensional Infant Infant, Newborn Male Mathematical models Methods morphometrics Morphometry Original Prediction models shape modeling Skull Skull - diagnostic imaging Skull - growth & development Statistical analysis Surgery Surgical mesh Surgical outcomes Tomography, X-Ray Computed |
| Title | Cranial growth in isolated sagittal craniosynostosis compared with normal growth in the first 6 months of age |
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