The contributions of insulin to science in medicine
The discovery of insulin in Toronto in 1921, now 100 years ago, was nothing less than a miracle. It quite rightly stands out as one of the most significant accomplishments of modern medicine and has undoubtedly saved the lives of millions of people now able to live with diabetes. It would, however,...
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| Published in | Diabetic medicine Vol. 38; no. 12; pp. e14623 - n/a |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.12.2021
John Wiley and Sons Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0742-3071 1464-5491 1464-5491 |
| DOI | 10.1111/dme.14623 |
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| Abstract | The discovery of insulin in Toronto in 1921, now 100 years ago, was nothing less than a miracle. It quite rightly stands out as one of the most significant accomplishments of modern medicine and has undoubtedly saved the lives of millions of people now able to live with diabetes. It would, however, be neglectful to imagine a world without insulin without considering the true impact of its discovery on so many other aspects in medicine and science. |
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| AbstractList | The discovery of insulin in Toronto in 1921, now 100 years ago, was nothing less than a miracle. It quite rightly stands out as one of the most significant accomplishments of modern medicine and has undoubtedly saved the lives of millions of people now able to live with diabetes. It would, however, be neglectful to imagine a world without insulin without considering the true impact of its discovery on so many other aspects in medicine and science. |
| Author | Gough, Stephen C. L. Kurtzhals, Peter |
| AuthorAffiliation | 1 Global Chief Medical Office Novo Nordisk A/S Søborg Denmark |
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| Cites_doi | 10.1056/NEJMoa2022474 10.1089/dia.2016.0421 10.1056/NEJMoa0806470 10.1073/pnas.83.18.6766 10.1073/pnas.75.8.3727 10.1001/jama.2014.16425 10.1126/science.157.3789.697 10.1016/j.molmet.2018.09.009 10.1016/S2213‐8587(20)30337‐5 10.3138/9781442621480 10.1073/pnas.76.1.106 10.7326/0003‐4819‐62‐5‐1079_2 10.1042/bj3120725 10.1016/s2213‐8587(18)30372‐3 10.1042/bj0600541 10.2337/diabetes.48.2.383 10.1016/s0140‐6736(12)60204‐9 10.1126/scitranslmed.aar7047 10.1111/j.1464‐5491.2008.02501.x 10.2337/dc13‐2112 10.1016/s0140‐6736(20)32514‐9 10.1038/224491a0 10.1016/j.molmet.2020.101102 10.2165/11584360‐000000000‐00000 10.2337/dc16‐1647 10.1073/pnas.1323264111 10.1021/ja00973a068 10.1080/00325481.1948.11693701 |
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| References | 2021; 46 2019; 7 2020; 383 1978; 75 1999; 48 1967; 157 1955; 60 1995; 312 2016; 39 2014; 111 1969; 224 1979; 76 2020; 8 1965; 62 2018; 18 1986; 83 2000 2015; 313 1948; 4 2008; 25 2014; 37 2008; 359 2017; 19 2021; 397 2012; 379 2018; 10 1966; 88 2010; 30 e_1_2_4_21_1 e_1_2_4_20_1 e_1_2_4_23_1 e_1_2_4_22_1 e_1_2_4_25_1 e_1_2_4_24_1 e_1_2_4_27_1 e_1_2_4_26_1 e_1_2_4_29_1 e_1_2_4_28_1 e_1_2_4_3_1 e_1_2_4_2_1 e_1_2_4_5_1 e_1_2_4_4_1 e_1_2_4_7_1 e_1_2_4_6_1 e_1_2_4_9_1 e_1_2_4_8_1 e_1_2_4_10_1 e_1_2_4_11_1 e_1_2_4_12_1 e_1_2_4_13_1 e_1_2_4_14_1 e_1_2_4_15_1 e_1_2_4_16_1 e_1_2_4_18_1 e_1_2_4_17_1 e_1_2_4_19_1 |
| References_xml | – volume: 312 start-page: 725 issue: 3 year: 1995 end-page: 731 article-title: Albumin binding of insulins acylated with fatty acids: characterization of the ligand‐protein interaction and correlation between binding affinity and timing of the insulin effect in vivo publication-title: Biochem J – volume: 39 start-page: 2111 issue: 12 year: 2016 end-page: 2117 article-title: Pregnancy outcomes in women with diabetes‐lessons learned from clinical research: the 2015 Norbert Freinkel Award lecture publication-title: Diabetes Care – volume: 313 start-page: 37 issue: 1 year: 2015 end-page: 44 article-title: Estimated life expectancy in a Scottish cohort with type 1 diabetes, 2008–2010 publication-title: JAMA – volume: 383 start-page: 2107 issue: 22 year: 2020 end-page: 2116 article-title: Once‐weekly insulin for type 2 diabetes without previous insulin treatment publication-title: N Engl J Med – volume: 25 start-page: 2 issue: Suppl 2 year: 2008 end-page: 8 article-title: Impact of the UKPDS–an overview publication-title: Diabet Med – volume: 379 start-page: 1489 issue: 9825 year: 2012 end-page: 1497 article-title: Insulin degludec, an ultra‐longacting basal insulin, versus insulin glargine in basal‐bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal‐Bolus Type 1): a phase 3, randomised, open‐label, treat‐to‐target non‐inferiority trial publication-title: Lancet – volume: 8 start-page: 971 issue: 12 year: 2020 end-page: 977 article-title: Insulin's centenary: the birth of an idea publication-title: Lancet Diabetes Endocrinol – volume: 76 start-page: 106 issue: 1 year: 1979 end-page: 110 article-title: Expression in of chemically synthesized genes for human insulin publication-title: Proc Natl Acad Sci USA – year: 2000 – volume: 157 start-page: 697 issue: 3789 year: 1967 end-page: 700 article-title: Insulin biosynthesis: evidence for a precursor publication-title: Science (New York, NY) – volume: 30 start-page: 643 issue: 10 year: 2010 end-page: 674 article-title: A review of 25 years' experience with the NovoPen family of insulin pens in the management of diabetes mellitus publication-title: Clin Drug Invest – volume: 7 start-page: 179 issue: 3 year: 2019 end-page: 188 article-title: Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double‐blind, phase 2 trial publication-title: Lancet Diabetes Endocrinol – volume: 37 start-page: 9 issue: 1 year: 2014 end-page: 16 article-title: The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview publication-title: Diabetes Care – volume: 60 start-page: 541 issue: 4 year: 1955 end-page: 556 article-title: The disulphide bonds of insulin publication-title: Biochem J – volume: 359 start-page: 1577 issue: 15 year: 2008 end-page: 1589 article-title: 10‐year follow‐up of intensive glucose control in type 2 diabetes publication-title: N Engl J Med – volume: 46 start-page: 101102 year: 2021 article-title: GLP‐1 receptor agonists in the treatment of type 2 diabetes—state‐of‐the‐art publication-title: Mol Metabol – volume: 83 start-page: 6766 issue: 18 year: 1986 end-page: 6770 article-title: Secretion and processing of insulin precursors in yeast publication-title: Proc Natl Acad Sci USA – volume: 10 start-page: eaar7047 issue: 467 year: 2018 article-title: Transcellular stomach absorption of a derivatized glucagon‐like peptide‐1 receptor agonist publication-title: Sci Transl Med – volume: 19 start-page: 155 issue: 3 year: 2017 end-page: 163 article-title: Glucose outcomes with the in‐home use of a hybrid closed‐loop insulin delivery system in adolescents and adults with type 1 diabetes publication-title: Diabetes Technol Ther – volume: 397 start-page: 208 issue: 10270 year: 2021 end-page: 219 article-title: A comparison of two hybrid closed‐loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial publication-title: Lancet – volume: 88 start-page: 5051 issue: 21 year: 1966 end-page: 5052 article-title: The synthesis of bovine insulin by the solid phase method publication-title: J Am Chem Soc – volume: 18 start-page: 3 year: 2018 end-page: 14 article-title: LY3298176, a novel dual GIP and GLP‐1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept publication-title: Mol Metabol – volume: 48 start-page: 383 issue: 2 year: 1999 end-page: 390 article-title: Effect of intensive diabetes treatment on carotid artery wall thickness in the epidemiology of diabetes interventions and complications publication-title: Diabetes – volume: 111 start-page: 883 issue: 3 year: 2014 end-page: 884 article-title: Fred Sanger: a memorial tribute publication-title: Proc Natl Acad Sci USA – volume: 75 start-page: 3727 issue: 8 year: 1978 end-page: 3731 article-title: A bacterial clone synthesizing proinsulin publication-title: Proc Natl Acad Sci USA – volume: 62 start-page: 1079 issue: 5 year: 1965 article-title: Total synthesis of insulin publication-title: Ann Intern Med – volume: 4 start-page: 302 issue: 4 year: 1948 end-page: 306 article-title: The unknown diabetic publication-title: Postgrad Med – volume: 224 start-page: 491 issue: 5218 year: 1969 end-page: 495 article-title: Structure of rhombohedral 2 zinc insulin crystals publication-title: Nature – ident: e_1_2_4_22_1 doi: 10.1056/NEJMoa2022474 – ident: e_1_2_4_29_1 doi: 10.1089/dia.2016.0421 – ident: e_1_2_4_9_1 doi: 10.1056/NEJMoa0806470 – ident: e_1_2_4_19_1 doi: 10.1073/pnas.83.18.6766 – ident: e_1_2_4_17_1 doi: 10.1073/pnas.75.8.3727 – ident: e_1_2_4_5_1 doi: 10.1001/jama.2014.16425 – ident: e_1_2_4_16_1 doi: 10.1126/science.157.3789.697 – ident: e_1_2_4_24_1 doi: 10.1016/j.molmet.2018.09.009 – ident: e_1_2_4_2_1 doi: 10.1016/S2213‐8587(20)30337‐5 – ident: e_1_2_4_3_1 doi: 10.3138/9781442621480 – ident: e_1_2_4_18_1 doi: 10.1073/pnas.76.1.106 – ident: e_1_2_4_14_1 doi: 10.7326/0003‐4819‐62‐5‐1079_2 – ident: e_1_2_4_20_1 doi: 10.1042/bj3120725 – ident: e_1_2_4_26_1 doi: 10.1016/s2213‐8587(18)30372‐3 – ident: e_1_2_4_11_1 doi: 10.1042/bj0600541 – ident: e_1_2_4_8_1 doi: 10.2337/diabetes.48.2.383 – ident: e_1_2_4_21_1 doi: 10.1016/s0140‐6736(12)60204‐9 – ident: e_1_2_4_25_1 doi: 10.1126/scitranslmed.aar7047 – ident: e_1_2_4_7_1 doi: 10.1111/j.1464‐5491.2008.02501.x – ident: e_1_2_4_6_1 doi: 10.2337/dc13‐2112 – ident: e_1_2_4_28_1 doi: 10.1016/s0140‐6736(20)32514‐9 – ident: e_1_2_4_13_1 doi: 10.1038/224491a0 – ident: e_1_2_4_23_1 doi: 10.1016/j.molmet.2020.101102 – ident: e_1_2_4_27_1 doi: 10.2165/11584360‐000000000‐00000 – ident: e_1_2_4_10_1 doi: 10.2337/dc16‐1647 – ident: e_1_2_4_12_1 doi: 10.1073/pnas.1323264111 – ident: e_1_2_4_15_1 doi: 10.1021/ja00973a068 – ident: e_1_2_4_4_1 doi: 10.1080/00325481.1948.11693701 |
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| SubjectTerms | Chemical synthesis COMMENTARY Diabetes Diabetes Mellitus - drug therapy Diabetes Mellitus - history History of medicine History, 20th Century History, 21st Century Humans Hypoglycemic Agents - history Hypoglycemic Agents - pharmacology Insulin Insulin - history Insulin - pharmacology insulin discovery Internal Medicine - history Medical research medicine Ontario research and development science |
| Title | The contributions of insulin to science in medicine |
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