Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma
In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33...
Saved in:
| Published in | International journal of cancer Vol. 145; no. 10; pp. 2781 - 2791 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken, USA
John Wiley & Sons, Inc
15.11.2019
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0020-7136 1097-0215 1097-0215 |
| DOI | 10.1002/ijc.32361 |
Cover
| Abstract | In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. The frequency of CRG/EMG variations in NB cases was then compared to the Genome Aggregation Database (gnomAD). The sequencing revealed SNVs/small InDels or focal CNAs of CRGs/EMGs in 20% (56/283) of all cases, occurring at a somatic level in 4 (7.2%), at a germline level in 12 (22%) cases, whereas for the remaining cases, only tumor material could be analyzed. The most frequently altered genes were ATRX (5%), SMARCA4 (2.5%), MLL3 (2.5%) and ARID1B (2.5%). Double events (SNVs/small InDels/CNAs associated with LOH) were observed in SMARCA4 (n = 3), ATRX (n = 1) and PBRM1 (n = 1). Among the 60 variations, 24 (8.4%) targeted domains of functional importance for chromatin remodeling or highly conserved domains but of unknown function. Variations in SMARCA4 and ATRX occurred more frequently in the NB as compared to the gnomAD control cohort (OR = 4.49, 95%CI: 1.63–9.97, p = 0.038; OR 3.44, 95%CI: 1.46–6.91, p = 0.043, respectively). Cases with CRG/EMG variations showed a poorer overall survival compared to cases without variations. Genetic variations of CRGs/EMGs with likely functional impact were observed in 8.4% (24/283) of NB. Our case–control approach suggests a role of SMARCA4 as a player of NB oncogenesis.
What's new?
Mutations that affect chromatin remodeling can lead to cancer. In this paper, the authors investigated the impact of variations in chromatin remodeling genes and epigenetic modifier genes on neuroblastoma patients. They compared the frequency of these variations in NB cases with data from the Genome Aggregation Database (gnomAD). Neuroblastoma cases had a higher frequency of SMARCA4 and ATRX gene variations than the general population. Furthermore, NB patients with CRG/EMG mutations had poorer overall survival than NB cases without such mutations. These findings highlight the importance of chromatin remodeling in neuroblastoma as an avenue for new therapeutics. |
|---|---|
| AbstractList | In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. The frequency of CRG/EMG variations in NB cases was then compared to the Genome Aggregation Database (gnomAD). The sequencing revealed SNVs/small InDels or focal CNAs of CRGs/EMGs in 20% (56/283) of all cases, occurring at a somatic level in 4 (7.2%), at a germline level in 12 (22%) cases, whereas for the remaining cases, only tumor material could be analyzed. The most frequently altered genes were ATRX (5%), SMARCA4 (2.5%), MLL3 (2.5%) and ARID1B (2.5%). Double events (SNVs/small InDels/CNAs associated with LOH) were observed in SMARCA4 (n = 3), ATRX (n = 1) and PBRM1 (n = 1). Among the 60 variations, 24 (8.4%) targeted domains of functional importance for chromatin remodeling or highly conserved domains but of unknown function. Variations in SMARCA4 and ATRX occurred more frequently in the NB as compared to the gnomAD control cohort (OR = 4.49, 95%CI: 1.63–9.97, p = 0.038; OR 3.44, 95%CI: 1.46–6.91, p = 0.043, respectively). Cases with CRG/EMG variations showed a poorer overall survival compared to cases without variations. Genetic variations of CRGs/EMGs with likely functional impact were observed in 8.4% (24/283) of NB. Our case–control approach suggests a role of SMARCA4 as a player of NB oncogenesis. In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. The frequency of CRG/EMG variations in NB cases was then compared to the Genome Aggregation Database (gnomAD). The sequencing revealed SNVs/small InDels or focal CNAs of CRGs/EMGs in 20% (56/283) of all cases, occurring at a somatic level in 4 (7.2%), at a germline level in 12 (22%) cases, whereas for the remaining cases, only tumor material could be analyzed. The most frequently altered genes were ATRX (5%), SMARCA4 (2.5%), MLL3 (2.5%) and ARID1B (2.5%). Double events (SNVs/small InDels/CNAs associated with LOH) were observed in SMARCA4 ( n = 3), ATRX ( n = 1) and PBRM1 ( n = 1). Among the 60 variations, 24 (8.4%) targeted domains of functional importance for chromatin remodeling or highly conserved domains but of unknown function. Variations in SMARCA4 and ATRX occurred more frequently in the NB as compared to the gnomAD control cohort (OR = 4.49, 95%CI: 1.63–9.97, p = 0.038; OR 3.44, 95%CI: 1.46–6.91, p = 0.043, respectively). Cases with CRG/EMG variations showed a poorer overall survival compared to cases without variations. Genetic variations of CRGs/EMGs with likely functional impact were observed in 8.4% (24/283) of NB. Our case–control approach suggests a role of SMARCA4 as a player of NB oncogenesis. What's new? Mutations that affect chromatin remodeling can lead to cancer. In this paper, the authors investigated the impact of variations in chromatin remodeling genes and epigenetic modifier genes on neuroblastoma patients. They compared the frequency of these variations in NB cases with data from the Genome Aggregation Database (gnomAD). Neuroblastoma cases had a higher frequency of SMARCA4 and ATRX gene variations than the general population. Furthermore, NB patients with CRG/EMG mutations had poorer overall survival than NB cases without such mutations. These findings highlight the importance of chromatin remodeling in neuroblastoma as an avenue for new therapeutics. In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. The frequency of CRG/EMG variations in NB cases was then compared to the Genome Aggregation Database (gnomAD). The sequencing revealed SNVs/small InDels or focal CNAs of CRGs/EMGs in 20% (56/283) of all cases, occurring at a somatic level in 4 (7.2%), at a germline level in 12 (22%) cases, whereas for the remaining cases, only tumor material could be analyzed. The most frequently altered genes were ATRX (5%), SMARCA4 (2.5%), MLL3 (2.5%) and ARID1B (2.5%). Double events (SNVs/small InDels/CNAs associated with LOH) were observed in SMARCA4 (n = 3), ATRX (n = 1) and PBRM1 (n = 1). Among the 60 variations, 24 (8.4%) targeted domains of functional importance for chromatin remodeling or highly conserved domains but of unknown function. Variations in SMARCA4 and ATRX occurred more frequently in the NB as compared to the gnomAD control cohort (OR = 4.49, 95%CI: 1.63-9.97, p = 0.038; OR 3.44, 95%CI: 1.46-6.91, p = 0.043, respectively). Cases with CRG/EMG variations showed a poorer overall survival compared to cases without variations. Genetic variations of CRGs/EMGs with likely functional impact were observed in 8.4% (24/283) of NB. Our case-control approach suggests a role of SMARCA4 as a player of NB oncogenesis.In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. The frequency of CRG/EMG variations in NB cases was then compared to the Genome Aggregation Database (gnomAD). The sequencing revealed SNVs/small InDels or focal CNAs of CRGs/EMGs in 20% (56/283) of all cases, occurring at a somatic level in 4 (7.2%), at a germline level in 12 (22%) cases, whereas for the remaining cases, only tumor material could be analyzed. The most frequently altered genes were ATRX (5%), SMARCA4 (2.5%), MLL3 (2.5%) and ARID1B (2.5%). Double events (SNVs/small InDels/CNAs associated with LOH) were observed in SMARCA4 (n = 3), ATRX (n = 1) and PBRM1 (n = 1). Among the 60 variations, 24 (8.4%) targeted domains of functional importance for chromatin remodeling or highly conserved domains but of unknown function. Variations in SMARCA4 and ATRX occurred more frequently in the NB as compared to the gnomAD control cohort (OR = 4.49, 95%CI: 1.63-9.97, p = 0.038; OR 3.44, 95%CI: 1.46-6.91, p = 0.043, respectively). Cases with CRG/EMG variations showed a poorer overall survival compared to cases without variations. Genetic variations of CRGs/EMGs with likely functional impact were observed in 8.4% (24/283) of NB. Our case-control approach suggests a role of SMARCA4 as a player of NB oncogenesis. In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. The frequency of CRG/EMG variations in NB cases was then compared to the Genome Aggregation Database (gnomAD). The sequencing revealed SNVs/small InDels or focal CNAs of CRGs/EMGs in 20% (56/283) of all cases, occurring at a somatic level in 4 (7.2%), at a germline level in 12 (22%) cases, whereas for the remaining cases, only tumor material could be analyzed. The most frequently altered genes were ATRX (5%), SMARCA4 (2.5%), MLL3 (2.5%) and ARID1B (2.5%). Double events (SNVs/small InDels/CNAs associated with LOH) were observed in SMARCA4 (n = 3), ATRX (n = 1) and PBRM1 (n = 1). Among the 60 variations, 24 (8.4%) targeted domains of functional importance for chromatin remodeling or highly conserved domains but of unknown function. Variations in SMARCA4 and ATRX occurred more frequently in the NB as compared to the gnomAD control cohort (OR = 4.49, 95%CI: 1.63–9.97, p = 0.038; OR 3.44, 95%CI: 1.46–6.91, p = 0.043, respectively). Cases with CRG/EMG variations showed a poorer overall survival compared to cases without variations. Genetic variations of CRGs/EMGs with likely functional impact were observed in 8.4% (24/283) of NB. Our case–control approach suggests a role of SMARCA4 as a player of NB oncogenesis. What's new? Mutations that affect chromatin remodeling can lead to cancer. In this paper, the authors investigated the impact of variations in chromatin remodeling genes and epigenetic modifier genes on neuroblastoma patients. They compared the frequency of these variations in NB cases with data from the Genome Aggregation Database (gnomAD). Neuroblastoma cases had a higher frequency of SMARCA4 and ATRX gene variations than the general population. Furthermore, NB patients with CRG/EMG mutations had poorer overall survival than NB cases without such mutations. These findings highlight the importance of chromatin remodeling in neuroblastoma as an avenue for new therapeutics. |
| Author | Le Roux, Laura Louis‐Brennetot, Caroline Bhalshankar, Jaydutt Bernard, Virginie Michon, Jean Gambart, Marion Pierron, Gaelle Valteau‐Couanet, Dominique Schleiermacher, Gudrun Colmet‐Daage, Léo Bessoltane‐Bentahar, Nadia Clement, Nathalie Combaret, Valérie Raynal, Virginie Danzon, Adrien Planchon, Julien M. Janoueix‐Lerosey, Isabelle Chicard, Mathieu Thebaud, Estelle Defachelles, Anne‐Sophie Bellini, Angela Lapouble, Eve Baulande, Sylvain Delattre, Olivier Bourdeaut, Franck Corradini, Nadège |
| AuthorAffiliation | 2 INSERM U830, Laboratoire de Génétique et Biologie des Cancers Institut Curie Paris France 1 Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique Institut Curie Paris France 6 Institut Curie, PSL Research University, NGS Platform Paris France 14 Pediatric Oncology Unit AntiCancer Center Oscar Lambret Lille France 4 Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer Paris France 11 Service d'Oncologie Pédiatrique Hôpital de la Mère et l'enfant Nantes France 9 Laboratoire de Recherche Translationnelle Centre Léon‐Bérard Lyon France 7 Department of Biopathology Institut Curie, PSL Research University Paris France 12 Unite d'Hemato‐Oncologie Hôpital des Enfants Toulouse France 5 Plateforme de Séquençage ICGex, Institut Curie Paris France 13 Service d'Oncologie Pédiatrique Institut Gustave Roussy Paris France 8 Unité de Génétique Somatique Institut Curie Paris France 3 SIREDO: Care, Innovation and Research for Children Adolescents and Young A |
| AuthorAffiliation_xml | – name: 14 Pediatric Oncology Unit AntiCancer Center Oscar Lambret Lille France – name: 12 Unite d'Hemato‐Oncologie Hôpital des Enfants Toulouse France – name: 13 Service d'Oncologie Pédiatrique Institut Gustave Roussy Paris France – name: 5 Plateforme de Séquençage ICGex, Institut Curie Paris France – name: 2 INSERM U830, Laboratoire de Génétique et Biologie des Cancers Institut Curie Paris France – name: 9 Laboratoire de Recherche Translationnelle Centre Léon‐Bérard Lyon France – name: 11 Service d'Oncologie Pédiatrique Hôpital de la Mère et l'enfant Nantes France – name: 3 SIREDO: Care, Innovation and Research for Children Adolescents and Young Adults with Cancer, Institut Curie Paris France – name: 4 Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer Paris France – name: 1 Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique Institut Curie Paris France – name: 7 Department of Biopathology Institut Curie, PSL Research University Paris France – name: 6 Institut Curie, PSL Research University, NGS Platform Paris France – name: 8 Unité de Génétique Somatique Institut Curie Paris France – name: 10 Institut d'Hématologie et Oncologie Pédiatrique Lyon France |
| Author_xml | – sequence: 1 givenname: Angela surname: Bellini fullname: Bellini, Angela organization: Adolescents and Young Adults with Cancer, Institut Curie – sequence: 2 givenname: Nadia surname: Bessoltane‐Bentahar fullname: Bessoltane‐Bentahar, Nadia organization: Adolescents and Young Adults with Cancer, Institut Curie – sequence: 3 givenname: Jaydutt surname: Bhalshankar fullname: Bhalshankar, Jaydutt organization: Adolescents and Young Adults with Cancer, Institut Curie – sequence: 4 givenname: Nathalie surname: Clement fullname: Clement, Nathalie organization: Adolescents and Young Adults with Cancer, Institut Curie – sequence: 5 givenname: Virginie surname: Raynal fullname: Raynal, Virginie organization: Plateforme de Séquençage ICGex, Institut Curie – sequence: 6 givenname: Sylvain surname: Baulande fullname: Baulande, Sylvain organization: Institut Curie, PSL Research University, NGS Platform – sequence: 7 givenname: Virginie surname: Bernard fullname: Bernard, Virginie organization: Institut Curie, PSL Research University – sequence: 8 givenname: Adrien surname: Danzon fullname: Danzon, Adrien organization: Adolescents and Young Adults with Cancer, Institut Curie – sequence: 9 givenname: Mathieu surname: Chicard fullname: Chicard, Mathieu organization: Adolescents and Young Adults with Cancer, Institut Curie – sequence: 10 givenname: Léo surname: Colmet‐Daage fullname: Colmet‐Daage, Léo organization: Adolescents and Young Adults with Cancer, Institut Curie – sequence: 11 givenname: Gaelle surname: Pierron fullname: Pierron, Gaelle organization: Institut Curie – sequence: 12 givenname: Laura surname: Le Roux fullname: Le Roux, Laura organization: Institut Curie – sequence: 13 givenname: Julien M. surname: Planchon fullname: Planchon, Julien M. organization: Institut Curie, PSL Research University – sequence: 14 givenname: Valérie surname: Combaret fullname: Combaret, Valérie organization: Centre Léon‐Bérard – sequence: 15 givenname: Eve surname: Lapouble fullname: Lapouble, Eve organization: Institut Curie – sequence: 16 givenname: Nadège surname: Corradini fullname: Corradini, Nadège organization: Institut d'Hématologie et Oncologie Pédiatrique – sequence: 17 givenname: Estelle surname: Thebaud fullname: Thebaud, Estelle organization: Hôpital de la Mère et l'enfant – sequence: 18 givenname: Marion surname: Gambart fullname: Gambart, Marion organization: Hôpital des Enfants – sequence: 19 givenname: Dominique surname: Valteau‐Couanet fullname: Valteau‐Couanet, Dominique organization: Institut Gustave Roussy – sequence: 20 givenname: Jean surname: Michon fullname: Michon, Jean organization: Adolescents and Young Adults with Cancer, Institut Curie – sequence: 21 givenname: Caroline surname: Louis‐Brennetot fullname: Louis‐Brennetot, Caroline organization: Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer – sequence: 22 givenname: Isabelle orcidid: 0000-0003-0434-3003 surname: Janoueix‐Lerosey fullname: Janoueix‐Lerosey, Isabelle organization: Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer – sequence: 23 givenname: Anne‐Sophie surname: Defachelles fullname: Defachelles, Anne‐Sophie organization: AntiCancer Center Oscar Lambret – sequence: 24 givenname: Franck surname: Bourdeaut fullname: Bourdeaut, Franck organization: Adolescents and Young Adults with Cancer, Institut Curie – sequence: 25 givenname: Olivier surname: Delattre fullname: Delattre, Olivier organization: Institut Curie – sequence: 26 givenname: Gudrun orcidid: 0000-0002-0133-5879 surname: Schleiermacher fullname: Schleiermacher, Gudrun email: gudrun.schleiermacher@curie.fr organization: Adolescents and Young Adults with Cancer, Institut Curie |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31018240$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1u1DAUhS1URKctC14AWWIDSGn9k8TxBmk0olBUhERhbTmOM_Xg2KmdtMrb15kppa1EV7Z1v3N877kHYM95pwF4g9ExRoicmI06poSW-AVYYMRZhggu9sAi1VDGMC33wUGMG4QwLlD-CuxTjHBFcrQAfy6GsZmgb6G6DL6Tg3Ew6M432hq3hmvtdISm661RckjXi-_Ln6tlDmWEEvbjkATXGvZWTjrApPVO-a3IxPnp9Bh8bWUckvcReNlKG_Xru_MQ_D79_Gv1NTv_8eVstTzPVJ5TnHHesFZpVta4ZiXiVV02qKoI4zwva1Up1dC6kGkahJqCt5S2iGlZtqoinKCCHoKPO9_R9XK6kdaKPphOhklgJObEREpMbBNL8Kcd3I91pxul3RDkP4GXRjyuOHMp1v5alIzhavvb-zuD4K9GHQfRmai0tdJpP0ZB0i5S2jkuE_ruCbrxY3Api0RxTChnZKbePuzovpW_S0vAhx2ggo8x6PbZ8U6esMrMS_PzMMY-p7gxVk__txZn31Y7xS1-08Xc |
| CitedBy_id | crossref_primary_10_1002_ajmg_a_61732 crossref_primary_10_1089_jayao_2022_0059 crossref_primary_10_12998_wjcc_v10_i29_10501 crossref_primary_10_1038_s44318_024_00206_1 crossref_primary_10_1056_NEJMoa2000962 crossref_primary_10_1200_JCO_21_00086 crossref_primary_10_1038_s41525_020_0125_4 crossref_primary_10_1371_journal_pone_0273280 crossref_primary_10_1111_cas_15363 crossref_primary_10_1101_mcs_a006286 crossref_primary_10_1007_s10689_022_00306_z crossref_primary_10_1158_2159_8290_CD_20_1631 crossref_primary_10_1016_j_gene_2023_147233 crossref_primary_10_1136_jmg_2022_108854 crossref_primary_10_1007_s00401_023_02546_4 crossref_primary_10_3389_fonc_2023_1209150 |
| Cites_doi | 10.1038/nature12113 10.1038/ng.2628 10.1038/nbt.1754 10.1158/0008-5472.CAN-16-1106 10.1093/bioinformatics/btr509 10.1038/ng.3333 10.1126/science.aat6768 10.1016/j.jmoldx.2015.06.005 10.1093/hmg/ddu733 10.1038/nature11329 10.1038/ng.2892 10.1158/1078-0432.CCR-15-0423 10.1038/ng.3703 10.1038/nature25480 10.1093/bioinformatics/btr670 10.1038/ng.806 10.1016/j.ajhg.2016.08.016 10.1101/gr.107524.110 10.1002/ajmg.c.31410 10.1038/nmeth.2890 10.1186/1471-2164-14-S3-S3 10.1126/sciadv.1500447 10.1038/nmeth.1923 10.1038/ng.3735 10.1038/onc.2016.50 10.1093/nar/gkw1121 10.1093/nar/29.1.308 10.1093/nar/gkv1222 10.1038/ng.2529 10.1038/28212 10.1093/bioinformatics/btp324 10.1158/2159-8290.CD-17-0321 10.1093/bioinformatics/btv710 10.1038/ng.2931 10.4161/fly.19695 10.1002/humu.22932 10.1038/s41431-018-0143-1 10.4155/fmc.12.3 10.1038/nature10910 10.1146/annurev-pathol-012414-040445 10.1038/nature14980 10.1038/nrdp.2016.78 10.1016/j.path.2016.01.005 10.1038/nature11213 10.1016/j.jpedsurg.2014.09.029 10.1101/gr.129684.111 10.1093/bioinformatics/btu436 10.1038/nature19057 10.1038/nrc3526 10.1038/ng.2493 |
| ContentType | Journal Article |
| Copyright | 2019 The Authors. published by John Wiley & Sons Ltd on behalf of UICC 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. 2019 UICC |
| Copyright_xml | – notice: 2019 The Authors. published by John Wiley & Sons Ltd on behalf of UICC – notice: 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. – notice: 2019 UICC |
| DBID | 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 7TO 7U9 H94 K9. 7X8 5PM ADTOC UNPAY |
| DOI | 10.1002/ijc.32361 |
| DatabaseName | Wiley Online Library Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts CrossRef MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Genetic study of chromatin remodeling genes in neuroblastoma |
| EISSN | 1097-0215 |
| EndPage | 2791 |
| ExternalDocumentID | 10.1002/ijc.32361 PMC6771805 31018240 10_1002_ijc_32361 IJC32361 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Equipex funderid: ANR‐10‐EQPX‐03 – fundername: Association Les amis de Claire – fundername: Programme Hospitalier de recherche en Cancérologie (PHRC) funderid: IC2007‐09 – fundername: France Génomique Consortium funderid: ANR‐10‐INBS‐09‐08 – fundername: Agence Nationale pour la Recherche funderid: ANR‐10‐INBS‐518 09 – fundername: Associations Enfants et Santé – fundername: Annenberg Foundation – fundername: Fondation Nelia et Amadeo Barletta – fundername: SiRIC‐Curie Program‐SiRIC – fundername: CEST of Institute Curie – fundername: Agence Nationale pour la Recherche grantid: ANR‐10‐INBS‐518 09 – fundername: France Génomique Consortium grantid: ANR‐10‐INBS‐09‐08 – fundername: Associations Les Bagouz à Manon – fundername: Canceropole Ile‐de‐France |
| GroupedDBID | --- -~X .3N .GA 05W 0R~ 10A 1L6 1OB 1OC 1ZS 24P 33P 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 5GY 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAHQN AAIPD AAMNL AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABIJN ABJNI ABLJU ABOCM ABPVW ABQWH ABXGK ACAHQ ACCFJ ACCZN ACFBH ACGFO ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFWVQ AFZJQ AHBTC AHMBA AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AZBYB AZVAB BAFTC BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBS EJD EMOBN F00 F01 F04 F5P FUBAC G-S G.N GNP GODZA H.X HBH HGLYW HHY HHZ HZ~ IH2 IX1 J0M JPC KBYEO KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 QRW R.K RIWAO ROL RWI RX1 RYL SUPJJ TEORI UB1 UDS V2E V8K V9Y W2D W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WIN WJL WOHZO WQJ WRC WUP WVDHM WWO WXI WXSBR XG1 XPP XV2 ZZTAW ~IA ~WT AAMMB AAYXX AEFGJ AEYWJ AGHNM AGXDD AGYGG AIDQK AIDYY CITATION CGR CUY CVF ECM EIF NPM 7T5 7TO 7U9 H94 K9. 7X8 5PM .55 .GJ .Y3 31~ 3O- 53G 8WZ A6W AANHP ABEFU ABEML ACBWZ ACRPL ACSCC ACYXJ ADNMO ADTOC AGQPQ AHEFC AI. AIQQE ASPBG AVWKF AZFZN BDRZF EX3 FEDTE GLUZI HF~ HVGLF LW6 M6P PALCI RJQFR SAMSI UNPAY VH1 WOW X7M Y6R ZGI ZXP |
| ID | FETCH-LOGICAL-c4431-99d7fce76b1b76098b6d088279946bc8ccd3b5a00100d59f33f07ea6fc8292053 |
| IEDL.DBID | 24P |
| ISSN | 0020-7136 1097-0215 |
| IngestDate | Sun Oct 26 02:47:33 EDT 2025 Tue Sep 30 17:05:52 EDT 2025 Tue Oct 28 16:48:44 EDT 2025 Tue Oct 07 05:39:09 EDT 2025 Thu Apr 03 07:03:11 EDT 2025 Wed Oct 01 03:10:17 EDT 2025 Thu Apr 24 22:52:42 EDT 2025 Wed Jan 22 16:38:27 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | neuroblastoma epigenetic modifier chromatin remodeling complex SWI/SNF SMARCA4 |
| Language | English |
| License | Attribution-NonCommercial 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4431-99d7fce76b1b76098b6d088279946bc8ccd3b5a00100d59f33f07ea6fc8292053 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 A.B. and N.B.‐B. contributed equally to this work Conflict of interest: The authors declare no conflict of interest. |
| ORCID | 0000-0003-0434-3003 0000-0002-0133-5879 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fijc.32361 |
| PMID | 31018240 |
| PQID | 2291239726 |
| PQPubID | 105430 |
| PageCount | 11 |
| ParticipantIDs | unpaywall_primary_10_1002_ijc_32361 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6771805 proquest_miscellaneous_2215018416 proquest_journals_2291239726 pubmed_primary_31018240 crossref_primary_10_1002_ijc_32361 crossref_citationtrail_10_1002_ijc_32361 wiley_primary_10_1002_ijc_32361_IJC32361 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 15 November 2019 |
| PublicationDateYYYYMMDD | 2019-11-15 |
| PublicationDate_xml | – month: 11 year: 2019 text: 15 November 2019 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | Hoboken, USA |
| PublicationPlace_xml | – name: Hoboken, USA – name: United States – name: Hoboken |
| PublicationTitle | International journal of cancer |
| PublicationTitleAlternate | Int J Cancer |
| PublicationYear | 2019 |
| Publisher | John Wiley & Sons, Inc Wiley Subscription Services, Inc |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: Wiley Subscription Services, Inc |
| References | 2018; 362 2015; 1 2009; 25 2012; 483 2015; 17 2014; 166C 2013; 45 2017; 49 2015; 10 2017; 45 2014; 49 2016; 32 2014; 46 2015; 526 2001; 29 2012; 488 2016; 37 2018; 26 2016; 35 1998; 394 2016; 99 2015; 24 2015; 47 2010; 20 2018; 8 2013; 14 2016; 2 2013; 13 2016; 536 2017; 77 2018; 555 2015; 21 2013; 497 2018 2011; 43 2016 2012; 28 2014; 30 2012; 6 2011; 27 2012; 4 2012; 22 2011; 29 2016; 48 2014; 11 2016; 9 2012; 9 2016; 44 e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_17_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_28_1 Seshan V (e_1_2_7_18_1) 2016 R Core Team (e_1_2_7_38_1) 2018 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_52_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_37_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_48_1 e_1_2_7_27_1 e_1_2_7_29_1 e_1_2_7_51_1 e_1_2_7_30_1 e_1_2_7_53_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_20_1 e_1_2_7_36_1 |
| References_xml | – volume: 21 start-page: 4913 year: 2015 end-page: 21 article-title: Deep sequencing reveals occurrence of subclonal ALK mutations in neuroblastoma at diagnosis publication-title: Clin Cancer Res – volume: 2 start-page: 16078 year: 2016 article-title: Neuroblastoma publication-title: Nat Rev Dis Primer – volume: 32 start-page: 1220 year: 2016 end-page: 2 article-title: Manta: rapid detection of structural variants and indels for germline and cancer sequencing applications publication-title: Bioinformatics – volume: 166C start-page: 350 year: 2014 end-page: 66 article-title: SWI/SNF chromatin remodeling complexes and cancer publication-title: Am J Med Genet C Semin Med Genet – volume: 22 start-page: 568 year: 2012 end-page: 76 article-title: VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing publication-title: Genome Res – volume: 48 start-page: 1581 year: 2016 end-page: 6 article-title: M‐CAP eliminates a majority of variants of uncertain significance in clinical exomes at high sensitivity publication-title: Nat Genet – volume: 37 start-page: 235 year: 2016 end-page: 41 article-title: dbNSFP v3.0: a one‐stop database of functional predictions and annotations for human nonsynonymous and splice‐site SNVs publication-title: Hum Mutat – volume: 99 start-page: 877 year: 2016 end-page: 85 article-title: REVEL: an ensemble method for predicting the pathogenicity of rare missense variants publication-title: Am J Hum Genet – volume: 394 start-page: 203 year: 1998 end-page: 6 article-title: Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer publication-title: Nature – volume: 45 start-page: 12 year: 2013 end-page: 7 article-title: Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma publication-title: Nat Genet – volume: 1 year: 2015 article-title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: mechanistic insights gained from human genomics publication-title: Sci Adv – volume: 45 start-page: 279 year: 2013 end-page: 84 article-title: The genetic landscape of high‐risk neuroblastoma publication-title: Nat Genet – volume: 536 start-page: 285 year: 2016 end-page: 91 article-title: Analysis of protein‐coding genetic variation in 60,706 humans publication-title: Nature – volume: 8 start-page: 174 year: 2018 end-page: 83 article-title: Accelerating discovery of functional mutant alleles in cancer publication-title: Cancer Discov – year: 2018 – volume: 488 start-page: 106 year: 2012 end-page: 10 article-title: Medulloblastoma exome sequencing uncovers subtype‐specific somatic mutations publication-title: Nature – volume: 45 start-page: D777 year: 2017 end-page: 83 article-title: COSMIC: somatic cancer genetics at high‐resolution publication-title: Nucleic Acids Res – volume: 26 start-page: 1083 year: 2018 end-page: 93 article-title: Germline variants in SMARCB1 and other members of the BAF chromatin‐remodeling complex across human disease entities: a meta‐analysis publication-title: Eur J Hum Genet – volume: 526 start-page: 700 year: 2015 end-page: 4 article-title: Telomerase activation by genomic rearrangements in high‐risk neuroblastoma publication-title: Nature – volume: 24 start-page: 2125 year: 2015 end-page: 37 article-title: Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies publication-title: Hum Mol Genet – volume: 43 start-page: 491 year: 2011 end-page: 8 article-title: A framework for variation discovery and genotyping using next‐generation DNA sequencing data publication-title: Nat Genet – volume: 10 start-page: 145 year: 2015 end-page: 71 article-title: SWI/SNF chromatin remodeling and human malignancies publication-title: Annu Rev Pathol Mech Dis – volume: 11 start-page: 361 year: 2014 end-page: 2 article-title: MutationTaster2: mutation prediction for the deep‐sequencing age publication-title: Nat Methods – volume: 6 start-page: 80 year: 2012 end-page: 92 article-title: A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of strain w1118; iso‐2; iso‐3 publication-title: Fly (Austin) – volume: 29 start-page: 308 year: 2001 end-page: 11 article-title: dbSNP: the NCBI database of genetic variation publication-title: Nucleic Acids Res – volume: 4 start-page: 505 year: 2012 end-page: 24 article-title: Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed publication-title: Future Med Chem – volume: 27 start-page: 2987 year: 2011 end-page: 93 article-title: A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data publication-title: Bioinformatics – volume: 17 start-page: 635 year: 2015 end-page: 43 article-title: Amplicon Indel hunter is a novel bioinformatics tool to detect large somatic insertion/deletion mutations in amplicon‐based next‐generation sequencing data publication-title: J Mol Diagn – volume: 44 start-page: D862 year: 2016 end-page: 8 article-title: ClinVar: public archive of interpretations of clinically relevant variants publication-title: Nucleic Acids Res – volume: 77 start-page: 509 year: 2017 end-page: 19 article-title: Genomic profiling of a large set of diverse pediatric cancers identifies known and novel mutations across tumor spectra publication-title: Cancer Res – volume: 483 start-page: 589 year: 2012 end-page: 93 article-title: Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes publication-title: Nature – volume: 28 start-page: 423 year: 2012 end-page: 5 article-title: Control‐FREEC: a tool for assessing copy number and allelic content using next‐generation sequencing data publication-title: Bioinformatics – volume: 20 start-page: 1297 year: 2010 end-page: 303 article-title: The genome analysis toolkit: a MapReduce framework for analyzing next‐generation DNA sequencing data publication-title: Genome Res – year: 2016 – volume: 35 start-page: 5179 year: 2016 end-page: 90 article-title: BRG1/SMARCA4 is essential for neuroblastoma cell viability through modulation of cell death and survival pathways publication-title: Oncogene – volume: 362 start-page: 1165 year: 2018 end-page: 70 article-title: A mechanistic classification of clinical phenotypes in neuroblastoma publication-title: Science – volume: 46 start-page: 438 year: 2014 end-page: 43 article-title: Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type publication-title: Nat Genet – volume: 488 start-page: 43 year: 2012 end-page: 8 article-title: Novel mutations target distinct subgroups of medulloblastoma publication-title: Nature – volume: 9 start-page: 357 year: 2012 end-page: 9 article-title: Fast gapped‐read alignment with bowtie 2 publication-title: Nat Methods – volume: 29 start-page: 24 year: 2011 end-page: 6 article-title: Integrative genomics viewer publication-title: Nat Biotechnol – volume: 25 start-page: 1754 year: 2009 end-page: 60 article-title: Fast and accurate short read alignment with Burrows–Wheeler transform publication-title: Bioinformatics – volume: 13 start-page: 397 year: 2013 end-page: 411 article-title: Neuroblastoma: developmental biology, cancer genomics and immunotherapy publication-title: Nat Rev Cancer – volume: 45 start-page: 592 year: 2013 end-page: 601 article-title: Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy publication-title: Nat Genet – volume: 46 start-page: 310 year: 2014 end-page: 5 article-title: A general framework for estimating the relative pathogenicity of human genetic variants publication-title: Nat Genet – volume: 30 start-page: 3443 year: 2014 end-page: 50 article-title: Multi‐factor data normalization enables the detection of copy number aberrations in amplicon sequencing data publication-title: Bioinformatics – volume: 497 start-page: 67 year: 2013 end-page: 73 article-title: Integrated genomic characterization of endometrial carcinoma publication-title: Nature – volume: 47 start-page: 864 year: 2015 end-page: 71 article-title: Relapsed neuroblastomas show frequent RAS‐MAPK pathway mutations publication-title: Nat Genet – volume: 9 start-page: 215 year: 2016 end-page: 26 article-title: Small‐cell carcinoma of the ovary of hypercalcemic type (malignant Rhabdoid tumor of the ovary): a review with recent developments on pathogenesis publication-title: Surg Pathol Clin – volume: 49 start-page: 1835 year: 2014 end-page: 8 article-title: Clinical features of ATRX or DAXX mutated neuroblastoma publication-title: J Pediatr Surg – volume: 49 start-page: 282 year: 2017 end-page: 8 article-title: Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin publication-title: Nat Genet – volume: 14 start-page: S3 issue: Suppl 3 year: 2013 article-title: Identifying Mendelian disease genes with the variant effect scoring tool publication-title: BMC Genomics – volume: 555 start-page: 321 year: 2018 end-page: 7 article-title: The landscape of genomic alterations across childhood cancers publication-title: Nature – ident: e_1_2_7_42_1 doi: 10.1038/nature12113 – ident: e_1_2_7_4_1 doi: 10.1038/ng.2628 – ident: e_1_2_7_24_1 doi: 10.1038/nbt.1754 – ident: e_1_2_7_44_1 doi: 10.1158/0008-5472.CAN-16-1106 – ident: e_1_2_7_21_1 doi: 10.1093/bioinformatics/btr509 – ident: e_1_2_7_11_1 doi: 10.1038/ng.3333 – ident: e_1_2_7_52_1 doi: 10.1126/science.aat6768 – volume-title: DNAcopy: DNA copy number data analysis. R package version 1.46.0 year: 2016 ident: e_1_2_7_18_1 – ident: e_1_2_7_22_1 doi: 10.1016/j.jmoldx.2015.06.005 – ident: e_1_2_7_32_1 doi: 10.1093/hmg/ddu733 – ident: e_1_2_7_49_1 doi: 10.1038/nature11329 – ident: e_1_2_7_36_1 doi: 10.1038/ng.2892 – ident: e_1_2_7_37_1 doi: 10.1158/1078-0432.CCR-15-0423 – ident: e_1_2_7_35_1 doi: 10.1038/ng.3703 – ident: e_1_2_7_51_1 doi: 10.1038/nature25480 – ident: e_1_2_7_16_1 doi: 10.1093/bioinformatics/btr670 – ident: e_1_2_7_14_1 doi: 10.1038/ng.806 – ident: e_1_2_7_33_1 doi: 10.1016/j.ajhg.2016.08.016 – ident: e_1_2_7_13_1 doi: 10.1101/gr.107524.110 – ident: e_1_2_7_39_1 doi: 10.1002/ajmg.c.31410 – ident: e_1_2_7_34_1 doi: 10.1038/nmeth.2890 – ident: e_1_2_7_31_1 doi: 10.1186/1471-2164-14-S3-S3 – ident: e_1_2_7_43_1 doi: 10.1126/sciadv.1500447 – ident: e_1_2_7_20_1 doi: 10.1038/nmeth.1923 – ident: e_1_2_7_47_1 doi: 10.1038/ng.3735 – ident: e_1_2_7_50_1 doi: 10.1038/onc.2016.50 – ident: e_1_2_7_28_1 doi: 10.1093/nar/gkw1121 – ident: e_1_2_7_26_1 doi: 10.1093/nar/29.1.308 – ident: e_1_2_7_29_1 doi: 10.1093/nar/gkv1222 – ident: e_1_2_7_8_1 doi: 10.1038/ng.2529 – ident: e_1_2_7_3_1 doi: 10.1038/28212 – ident: e_1_2_7_12_1 doi: 10.1093/bioinformatics/btp324 – ident: e_1_2_7_30_1 doi: 10.1158/2159-8290.CD-17-0321 – volume-title: R: a language and environment for statistical computing year: 2018 ident: e_1_2_7_38_1 – ident: e_1_2_7_15_1 doi: 10.1093/bioinformatics/btv710 – ident: e_1_2_7_46_1 doi: 10.1038/ng.2931 – ident: e_1_2_7_25_1 doi: 10.4161/fly.19695 – ident: e_1_2_7_19_1 doi: 10.1002/humu.22932 – ident: e_1_2_7_40_1 doi: 10.1038/s41431-018-0143-1 – ident: e_1_2_7_53_1 doi: 10.4155/fmc.12.3 – ident: e_1_2_7_6_1 doi: 10.1038/nature10910 – ident: e_1_2_7_2_1 doi: 10.1146/annurev-pathol-012414-040445 – ident: e_1_2_7_41_1 doi: 10.1038/nature14980 – ident: e_1_2_7_5_1 doi: 10.1038/nrdp.2016.78 – ident: e_1_2_7_45_1 doi: 10.1016/j.path.2016.01.005 – ident: e_1_2_7_48_1 doi: 10.1038/nature11213 – ident: e_1_2_7_9_1 doi: 10.1016/j.jpedsurg.2014.09.029 – ident: e_1_2_7_17_1 doi: 10.1101/gr.129684.111 – ident: e_1_2_7_23_1 doi: 10.1093/bioinformatics/btu436 – ident: e_1_2_7_27_1 doi: 10.1038/nature19057 – ident: e_1_2_7_7_1 doi: 10.1038/nrc3526 – ident: e_1_2_7_10_1 doi: 10.1038/ng.2493 |
| SSID | ssj0011504 |
| Score | 2.4066596 |
| Snippet | In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine... |
| SourceID | unpaywall pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2781 |
| SubjectTerms | Adolescent Cancer Carcinogenesis - genetics Case-Control Studies Child Child, Preschool Chromatin Assembly and Disassembly - genetics Chromatin remodeling chromatin remodeling complex DNA Copy Number Variations DNA Helicases - genetics Electromyography epigenetic modifier Exons - genetics Female Genetic diversity Genomes Germ-Line Mutation Humans INDEL Mutation Infant Infant, Newborn Kaplan-Meier Estimate Male Medical research Molecular Cancer Biology Neuroblastoma Neuroblastoma - genetics Neuroblastoma - mortality Neuroblastoma - pathology Nuclear Proteins - genetics Polymorphism, Single Nucleotide Progression-Free Survival SMARCA4 SWI/SNF Transcription Factors - genetics Tumorigenesis Whole Exome Sequencing Whole genome sequencing X-linked Nuclear Protein - genetics |
| SummonAdditionalLinks | – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7BVgIulDehBZnHoZcsedrJcbVqVSpthYCVyinYjkOXrpJoNxEqv54ZJxuxLSAkbo48k-eM53M8_gbgTWIwpoRGuiKJCjcyvnFlEOYuV4WRSsZaa_qhPzvlx_Po5Cw-6-uc0l6Yjh9i-OFGnmHHa3LwOi-6cb5f3Q_eLr7pcUj0ITdhh8cIxkewMz99P_ncJXZ4Lk7B7P4ijzhHMbptuIV-1d2OSNdg5vVsydttWcvL73K53Ea0NiQd7cKXzcN0mSgX47ZRY_3jCs_jfzztPbjbw1U26ezrPtww5QO4NesX5B_CBeUhXrKqYPp8VRH6LdnK2PI6GBPZVxpJ2aLPWsfmx9nkw3QSMblmktVtY2nHWb2UiPwZ6lalrqzSYk2Hlm1TIcBv8NyPYH50-Gl67Pb1G1wdIS5x0zQXhTaCK18J7qWJ4jkhepGmEVc60ToPVSxpWurlcVqEYeEJI3mhE6qhFYePYVRWpXkKTEnDjRAUTUWkvASVlCfjXCtj_MALHDjYfMNM9-TmVGNjmXW0zEGGLy-zL8-BV4No3TF6_E5of2MIWe_U6ywIUozzqQi4Ay-HbnRHWmORpalakvGJIhFhrgNPOrsZrhISOxoiKAfElkUNAkT1vd1TLs4t5TcXiCG82IHXg-397eYPrCn9WSJ7dzK1jWf_dMI9uIM4MaUtmH68D6Nm1ZrniMUa9aL3t5-3QjO0 priority: 102 providerName: Unpaywall |
| Title | Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fijc.32361 https://www.ncbi.nlm.nih.gov/pubmed/31018240 https://www.proquest.com/docview/2291239726 https://www.proquest.com/docview/2215018416 https://pubmed.ncbi.nlm.nih.gov/PMC6771805 https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32361 |
| UnpaywallVersion | publishedVersion |
| Volume | 145 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library - Core collection (SURFmarket) issn: 1097-0215 databaseCode: DR2 dateStart: 19960101 customDbUrl: isFulltext: true eissn: 1097-0215 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0011504 providerName: Wiley-Blackwell |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwEB6VVgIuqDwbKJV5HHoJTZzEjsVptVCVSltVhZXKKbIdh25ZJat9CPXfM-NkU60KiEvkyDNJlPF4Pr--AXifO4wpidOhzNMqTF3sQs2TMhSmctrozFpLE_qjM3EyTk8vs8st-Lg-C9PyQ_QTbuQZvr8mB9dmcXRLGjq5th8Sog65Bzsx4hhq3jw975cQEOl0FMxRiCMxsaYVivhRr7oZjO4gzLsbJR-s6pm--aWn000w66PR8S486mAkG7R2fwxbrn4C90fdQvlT-En7A29YUzF7NW8IldZs7nzaG4xV7Af1cGzS7SbH4tfR4GI4SJleMM1mq6WnA2ezqUZEzlC3qW3jlSYLuvUsmAaB9xKf_QzGx5-_DU_CLq9CaFPEC6FSpaysk8LERopI5UaUhLSlUqkwNre2TEymabgYlZmqkqSKpNOisjnltsqS57BdN7XbA2a0E05KinIyNVGOSibSWWmNczGPeACH6x9c2I50nHJfTIuWLpkXaIvC2yKAt73orGXa-JPQ_tpKRedsi4JzhfFXSS4CeNNXo5vQ2oeuXbMimZioCxF-BvCiNWr_loRYyxDZBCA3zN0LEAX3Zk09ufJU3EJibI-yAN71DeNfH3_om8zfJYovp0NfePn_oq_gIYI4Recj42wftpfzlXuNQGlpDrxD4PXTBT-AnfHZ-eD7b8m6Ec4 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwEB6VIlEuiDeBAuZx6CWtkzh2InFZrai2pVshaKXeIttx6LarZLUPof57Zpxs0KqAuDnyTGJlPJ7Pr28APmYOY0ridKgyUYXCRS7UcVKG0lROG51aa2lBf3wqR-fi-CK92IJP67swLT9Ev-BGnuHHa3JwWpA--M0aOrmy-wlxh9yBu0JGkqZesfja7yEg1Ok4mHmIUzG55hXi8UGvuhmNbkHM2ycld1b1TN_81NPpJpr14ejwITzocCQbtIZ_BFuufgz3xt1O-RO4pgOCN6ypmL2cNwRLazZ3Pu8NBiv2g4Y4NumOk2Px-3jwbTgQTC-YZrPV0vOBs9lUIyRnqNvUtvFKkwU9ehpMg8h7ie9-CueHn8-Go7BLrBBagYAhzPNSVdYpaSKjJM8zI0uC2irPhTQ2s7ZMTKppvsjLNK-SpOLKaVnZjJJbpckz2K6b2r0AZrSTTikKc0oYnqGS4TotrXEuinkcwN76Bxe2Yx2n5BfTouVLjgu0ReFtEcD7XnTWUm38SWh3baWi87ZFEcc5BuBcxTKAd301-gltfujaNSuSiYi7EPFnAM9bo_ZfSYi2DKFNAGrD3L0AcXBv1tSTS8_FLRUGd54G8KHvGP9q_J7vMn-XKI6Oh77w8v9F38LO6Gx8UpwcnX55BfcR0eV0WTJKd2F7OV-514ialuaNd45fgVsSoQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIhUuvB-BAuZx6CXbPO1Y4rLasmoLW6FCpV6qyHYcunSVRLuJUPn1eJwHWgoIcXOUmSR2Zjyf7fFngDeJNjEl1MJlSZS7kfa1K4Iwc6nMtZAiVkrhhP7siO6fRIen8ekGvO33wrT8EMOEG3qG7a_RwXWV5bs_WUPnX9UoRO6Qa3A9inmCCX17xwN5FEKdjoPZc81QjPa8Ql6wO6iuR6MrEPNqpuSNpqjE5TexWKyjWRuOprfhrK9Im4VyMWpqOVLff-F4_N-a3oFbHU4l49aw7sKGLu7B1qxbib8PF5iAeEnKnKjzZYmwtyBLbc_VMcGQfMEulMy7dHVT_DQbH0_GERErIkjV1JZvnFQLYSA_MbploUqrNF_hpaXZlAbZ1-bZD-Bk-u7zZN_tDm5wVWQAict5xnKlGZW-ZNTjiaQZQnnGeUSlSpTKQhkLHI96WczzMMw9pgXNVYKHZ8XhQ9gsykI_BiKFppoxDKMskl5ilKQn4kxJrf3ACxzY6X9gqjpWczxcY5G2fMxBahovtY3nwKtBtGqpPH4ntN1bQdp58yoNAm4CPGcBdeDlcNv4IS6uiEKXDcr4yI1o8K0Dj1qjGd4SIi2agU4OsDVzGgSQ43v9TjE_t1zflBnw4MUOvB4M728fv2Pt6M8S6cHhxBae_LvoC9j6uDdNPxwcvX8KNw1g5LgX04-3YbNeNvqZAWW1fG597wfOMDLO |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7BVgIulDehBZnHoZcsedrJcbVqVSpthYCVyinYjkOXrpJoNxEqv54ZJxuxLSAkbo48k-eM53M8_gbgTWIwpoRGuiKJCjcyvnFlEOYuV4WRSsZaa_qhPzvlx_Po5Cw-6-uc0l6Yjh9i-OFGnmHHa3LwOi-6cb5f3Q_eLr7pcUj0ITdhh8cIxkewMz99P_ncJXZ4Lk7B7P4ijzhHMbptuIV-1d2OSNdg5vVsydttWcvL73K53Ea0NiQd7cKXzcN0mSgX47ZRY_3jCs_jfzztPbjbw1U26ezrPtww5QO4NesX5B_CBeUhXrKqYPp8VRH6LdnK2PI6GBPZVxpJ2aLPWsfmx9nkw3QSMblmktVtY2nHWb2UiPwZ6lalrqzSYk2Hlm1TIcBv8NyPYH50-Gl67Pb1G1wdIS5x0zQXhTaCK18J7qWJ4jkhepGmEVc60ToPVSxpWurlcVqEYeEJI3mhE6qhFYePYVRWpXkKTEnDjRAUTUWkvASVlCfjXCtj_MALHDjYfMNM9-TmVGNjmXW0zEGGLy-zL8-BV4No3TF6_E5of2MIWe_U6ywIUozzqQi4Ay-HbnRHWmORpalakvGJIhFhrgNPOrsZrhISOxoiKAfElkUNAkT1vd1TLs4t5TcXiCG82IHXg-397eYPrCn9WSJ7dzK1jWf_dMI9uIM4MaUtmH68D6Nm1ZrniMUa9aL3t5-3QjO0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Study+of+chromatin+remodeling+genes+implicates+SMARCA4+as+a+putative+player+in+oncogenesis+in+neuroblastoma&rft.jtitle=International+journal+of+cancer&rft.au=Bellini%2C+Angela&rft.au=Nadia+Bessoltane%E2%80%90Bentahar&rft.au=Bhalshankar%2C+Jaydutt&rft.au=Clement%2C+Nathalie&rft.date=2019-11-15&rft.pub=Wiley+Subscription+Services%2C+Inc&rft.issn=0020-7136&rft.eissn=1097-0215&rft.volume=145&rft.issue=10&rft.spage=2781&rft.epage=2791&rft_id=info:doi/10.1002%2Fijc.32361&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0020-7136&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0020-7136&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0020-7136&client=summon |