MLN2238 synergizes BH3 mimetic ABT-263 in castration-resistant prostate cancer cells by induction of NOXA - Wei, Xinghua; Zhou, Ping; Lin, Xuanting; Lin, Yurong; Wu, Sifeng; Diao, Pengfei; Xie, Haiqing; Xie, Keji; Tang, Ping (Tumor biology, 2014)
Keywords: Aniline Compounds - pharmacology; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Apoptosis - drug effects; BH3 Interacting Domain Death Agonist Protein - agonists; Biomedical and Life Sciences; Biomedicine; Boron Compounds - pharmacology; Cancer Research; Cell Line, Tumor; Cell Survival - drug effects; Cells; Cytotoxicity; Drug resistance; Drug Synergism; Glycine - analogs & derivatives; Glycine - pharmacology; Humans; Immunoblotting; Immunoprecipitation; Male; Prostate cancer; Prostatic Neoplasms, Castration-Resistant - metabolism; Proto-Oncogene Proteins c-bcl-2 - biosynthesis; Research Article; RNA, Small Interfering; Sulfonamides - pharmacology; Transfection; Castration-resistant prostate cancer; Mcl-1; ABT-263; MLN2238; NOXA