Selective Regulation of Human Immunodeficiency Virus-Infected CD4+ Lymphocytes by a Synthetic Immunomodulator Leads to Potent Virus Suppression In Vitro and in hu-PBL-SCID Mice

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Published inJournal of Virology Vol. 75; no. 15; pp. 6941 - 6952
Main Authors Bahr, George M., Darcissac, Edith C. A., Castéran, Nathalie, Amiel, Corinne, Cocude, Cécile, Truong, Marie-José, Dewulf, Joëlle, Capron, André, Mouton, Yves
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.08.2001
Subjects
Acetylmuramyl-Alanyl-Isoglutamine - analogs & derivatives
Acetylmuramyl-Alanyl-Isoglutamine - pharmacology
Adjuvants, Immunologic
Adult
Animals
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - virology
Cell Division
Cell Survival
Cells, Cultured
Cytokines - metabolism
DNA, Viral - blood
Down-Regulation
Gene Expression Regulation, Viral
HIV Infections - blood
HIV Infections - virology
HIV-1 - drug effects
HIV-1 - genetics
HIV-1 - physiology
Humans
Leukocytes, Mononuclear - cytology
Mice
Mice, SCID
Pathogenesis and Immunity
Proto-Oncogene Proteins c-myc - genetics
Receptors, CCR5 - biosynthesis
Receptors, CXCR4 - biosynthesis
Receptors, Interleukin-2 - biosynthesis
RNA, Messenger
RNA, Viral - blood
Viral Load
Virus Replication - drug effects
Online AccessGet full text
ISSN0022-538X
1070-6321
1098-5514
1098-5514
DOI10.1128/JVI.75.15.6941-6952.2001

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Corresponding author. Mailing address: Laboratoire d'Immunologie Moléculaire de l'Infection et de l'Inflammation, Institut Pasteur de Lille, 1 rue du Professeur Calmette, B.P. 245, 59019 Lille Cedex, France. Phone: (33) 3-20-87-72-91. Fax: (33) 3-20-87-72-92. E-mail: georges.bahr@pasteur-lille.fr.
ISSN:0022-538X
1070-6321
1098-5514
1098-5514
DOI:10.1128/JVI.75.15.6941-6952.2001