Selective Regulation of Human Immunodeficiency Virus-Infected CD4+ Lymphocytes by a Synthetic Immunomodulator Leads to Potent Virus Suppression In Vitro and in hu-PBL-SCID Mice - Bahr, George M.; Darcissac, Edith C. A.; Castéran, Nathalie; Amiel, Corinne; Cocude, Cécile; Truong, Marie-José; Dewulf, Joëlle; Capron, André; Mouton, Yves (Journal of Virology, 2001)
Keywords: Acetylmuramyl-Alanyl-Isoglutamine - analogs & derivatives; Acetylmuramyl-Alanyl-Isoglutamine - pharmacology; Adjuvants, Immunologic; Adult; Animals; CD4-Positive T-Lymphocytes - cytology; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - virology; Cell Division; Cell Survival; Cells, Cultured; Cytokines - metabolism; DNA, Viral - blood; Down-Regulation; Gene Expression Regulation, Viral; HIV Infections - blood; HIV Infections - virology; HIV-1 - drug effects; HIV-1 - genetics; HIV-1 - physiology; Humans; Leukocytes, Mononuclear - cytology; Mice; Mice, SCID; Pathogenesis and Immunity; Proto-Oncogene Proteins c-myc - genetics; Receptors, CCR5 - biosynthesis; Receptors, CXCR4 - biosynthesis; Receptors, Interleukin-2 - biosynthesis; RNA, Messenger; RNA, Viral - blood; Viral Load; Virus Replication - drug effects