Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality - Metzger, Michael W.; Walser, Sandra M.; Dedic, Nina; Aprile-Garcia, Fernando; Jakubcakova, Vladimira; Adamczyk, Marek; Webb, Katharine J.; Uhr, Manfred; Refojo, Damian; Schmidt, Mathias V.; Friess, Elisabeth; Steiger, Axel; et al. (The Journal of neuroscience, 2017)
Keywords: Animals; Arginine; Arginine - genetics; Bipolar disorder; Calcium; Calcium influx; Cells, Cultured; Disorders; Emotional disorders; Gene polymorphism; Genetic engineering; Genetic Variation - genetics; Glutamine; Glutamine - genetics; Heterozygosity; Heterozygote; Hippocampus; Hippocampus - physiology; Housing; Humans; Male; Mental depression; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Mood; Mood Disorders - genetics; Polymorphism; Receptors, Purinergic P2X7 - genetics; Risk analysis; Risk factors; Single-nucleotide polymorphism; Sleep; Sleep - genetics; sleep; stress; purinergic signaling; mood disorder; P2X7 receptor; humanized mouse model