IL-18 and IL-35 in the serum of patients with sepsis thrombocytopenia and the clinical significance
Expression levels of interleukin-18 (IL-18) and IL-35 in the serum of patients with sepsis and without thrombocytopenia and patients with sepsis thrombocytopenia (TCP) were detected to preliminarily investigate their clinical significance. One hundred and sixty-six patients admitted to Jinan Central...
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| Published in | Experimental and therapeutic medicine Vol. 19; no. 2; pp. 1251 - 1258 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Greece
D.A. Spandidos
01.02.2020
Spandidos Publications Spandidos Publications UK Ltd |
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| Online Access | Get full text |
| ISSN | 1792-0981 1792-1015 1792-1015 |
| DOI | 10.3892/etm.2019.8347 |
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| Abstract | Expression levels of interleukin-18 (IL-18) and IL-35 in the serum of patients with sepsis and without thrombocytopenia and patients with sepsis thrombocytopenia (TCP) were detected to preliminarily investigate their clinical significance. One hundred and sixty-six patients admitted to Jinan Central Hospital Affiliated to Shandong University from July 2013 to September 2015 were retrospectively analysed. There were 96 patients with sepsis without thrombocytopenia in the sepsis group, and 70 patients with sepsis TCP in the sepsis TCP group. In the same period, 80 healthy subjects were selected as the control group. Fluorescent quantitative PCR was used for the detection the expression of mRNA levels of IL-18 and IL-35, and Enzyme-linked immunosorbent assay for the detection of the protein concentrations of IL-18 and IL-35 in the serum of peripheral blood. The correlation between IL-18, IL-35 and platelets was analyzed. There were significant differences in albumin, creatinine, total bilirubin and platelet count between the sepsis group and the sepsis TCP group (P<0.05); the expression levels of mRNA of IL-18 and IL-35 in a karyocyte in peripheral blood in the sepsis group and the sepsis TCP group were higher than those in the control group (P<0.05); the expression of mRNA of IL-18 and IL-35 in the sepsis TCP group was higher than those in the sepsis group (P<0.05). The concentration of IL-18 and IL-35 in the sepsis TCP group was higher than in the sepsis group (P<0.05); IL-18 and IL-35 were negatively correlated with platelets (r=−0.8749, −0.6228, P<0.001). There was a significant positive correlation between serum IL-18 and IL-35 in the control group, sepsis group, and sepsis TCP group (r=0.5124, 0.5718, 0.5511, P<0.001). IL-18 and IL-35 were negatively correlated with the reduced degree of platelets in patients with sepsis and are likely to play an important role in the pathogenetic process of sepsis TCP. |
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| AbstractList | Expression levels of interleukin-18 (IL-18) and IL-35 in the serum of patients with sepsis and without thrombocytopenia and patients with sepsis thrombocytopenia (TCP) were detected to preliminarily investigate their clinical significance. One hundred and sixty-six patients admitted to Jinan Central Hospital Affiliated to Shandong University from July 2013 to September 2015 were retrospectively analysed. There were 96 patients with sepsis without thrombocytopenia in the sepsis group, and 70 patients with sepsis TCP in the sepsis TCP group. In the same period, 80 healthy subjects were selected as the control group. Fluorescent quantitative PCR was used for the detection the expression of mRNA levels of IL-18 and IL-35, and Enzyme-linked immunosorbent assay for the detection of the protein concentrations of IL-18 and IL-35 in the serum of peripheral blood. The correlation between IL-18, IL-35 and platelets was analyzed. There were significant differences in albumin, creatinine, total bilirubin and platelet count between the sepsis group and the sepsis TCP group (P<0.05); the expression levels of mRNA of IL-18 and IL-35 in a karyocyte in peripheral blood in the sepsis group and the sepsis TCP group were higher than those in the control group (P<0.05); the expression of mRNA of IL-18 and IL-35 in the sepsis TCP group was higher than those in the sepsis group (P<0.05). The concentration of IL-18 and IL-35 in the sepsis TCP group was higher than in the sepsis group (P<0.05); IL-18 and IL-35 were negatively correlated with platelets (r=-0.8749, -0.6228, P<0.001). There was a significant positive correlation between serum IL-18 and IL-35 in the control group, sepsis group, and sepsis TCP group (r=0.5124, 0.5718, 0.5511, P<0.001). IL-18 and IL-35 were negatively correlated with the reduced degree of platelets in patients with sepsis Key words: IL-18, IL-35, sepsis, sepsis thrombocytopenia, platelet and are likely to play an important role in the pathogenetic process of sepsis TCP. Expression levels of interleukin-18 (IL-18) and IL-35 in the serum of patients with sepsis and without thrombocytopenia and patients with sepsis thrombocytopenia (TCP) were detected to preliminarily investigate their clinical significance. One hundred and sixty-six patients admitted to Jinan Central Hospital Affiliated to Shandong University from July 2013 to September 2015 were retrospectively analysed. There were 96 patients with sepsis without thrombocytopenia in the sepsis group, and 70 patients with sepsis TCP in the sepsis TCP group. In the same period, 80 healthy subjects were selected as the control group. Fluorescent quantitative PCR was used for the detection the expression of mRNA levels of IL-18 and IL-35, and Enzyme-linked immunosorbent assay for the detection of the protein concentrations of IL-18 and IL-35 in the serum of peripheral blood. The correlation between IL-18, IL-35 and platelets was analyzed. There were significant differences in albumin, creatinine, total bilirubin and platelet count between the sepsis group and the sepsis TCP group (P<0.05); the expression levels of mRNA of IL-18 and IL-35 in a karyocyte in peripheral blood in the sepsis group and the sepsis TCP group were higher than those in the control group (P<0.05); the expression of mRNA of IL-18 and IL-35 in the sepsis TCP group was higher than those in the sepsis group (P<0.05). The concentration of IL-18 and IL-35 in the sepsis TCP group was higher than in the sepsis group (P<0.05); IL-18 and IL-35 were negatively correlated with platelets (r=-0.8749, -0.6228, P<0.001). There was a significant positive correlation between serum IL-18 and IL-35 in the control group, sepsis group, and sepsis TCP group (r=0.5124, 0.5718, 0.5511, P<0.001). IL-18 and IL-35 were negatively correlated with the reduced degree of platelets in patients with sepsis and are likely to play an important role in the pathogenetic process of sepsis TCP.Expression levels of interleukin-18 (IL-18) and IL-35 in the serum of patients with sepsis and without thrombocytopenia and patients with sepsis thrombocytopenia (TCP) were detected to preliminarily investigate their clinical significance. One hundred and sixty-six patients admitted to Jinan Central Hospital Affiliated to Shandong University from July 2013 to September 2015 were retrospectively analysed. There were 96 patients with sepsis without thrombocytopenia in the sepsis group, and 70 patients with sepsis TCP in the sepsis TCP group. In the same period, 80 healthy subjects were selected as the control group. Fluorescent quantitative PCR was used for the detection the expression of mRNA levels of IL-18 and IL-35, and Enzyme-linked immunosorbent assay for the detection of the protein concentrations of IL-18 and IL-35 in the serum of peripheral blood. The correlation between IL-18, IL-35 and platelets was analyzed. There were significant differences in albumin, creatinine, total bilirubin and platelet count between the sepsis group and the sepsis TCP group (P<0.05); the expression levels of mRNA of IL-18 and IL-35 in a karyocyte in peripheral blood in the sepsis group and the sepsis TCP group were higher than those in the control group (P<0.05); the expression of mRNA of IL-18 and IL-35 in the sepsis TCP group was higher than those in the sepsis group (P<0.05). The concentration of IL-18 and IL-35 in the sepsis TCP group was higher than in the sepsis group (P<0.05); IL-18 and IL-35 were negatively correlated with platelets (r=-0.8749, -0.6228, P<0.001). There was a significant positive correlation between serum IL-18 and IL-35 in the control group, sepsis group, and sepsis TCP group (r=0.5124, 0.5718, 0.5511, P<0.001). IL-18 and IL-35 were negatively correlated with the reduced degree of platelets in patients with sepsis and are likely to play an important role in the pathogenetic process of sepsis TCP. Expression levels of interleukin-18 (IL-18) and IL-35 in the serum of patients with sepsis and without thrombocytopenia and patients with sepsis thrombocytopenia (TCP) were detected to preliminarily investigate their clinical significance. One hundred and sixty-six patients admitted to Jinan Central Hospital Affiliated to Shandong University from July 2013 to September 2015 were retrospectively analysed. There were 96 patients with sepsis without thrombocytopenia in the sepsis group, and 70 patients with sepsis TCP in the sepsis TCP group. In the same period, 80 healthy subjects were selected as the control group. Fluorescent quantitative PCR was used for the detection the expression of mRNA levels of IL-18 and IL-35, and Enzyme-linked immunosorbent assay for the detection of the protein concentrations of IL-18 and IL-35 in the serum of peripheral blood. The correlation between IL-18, IL-35 and platelets was analyzed. There were significant differences in albumin, creatinine, total bilirubin and platelet count between the sepsis group and the sepsis TCP group (P<0.05); the expression levels of mRNA of IL-18 and IL-35 in a karyocyte in peripheral blood in the sepsis group and the sepsis TCP group were higher than those in the control group (P<0.05); the expression of mRNA of IL-18 and IL-35 in the sepsis TCP group was higher than those in the sepsis group (P<0.05). The concentration of IL-18 and IL-35 in the sepsis TCP group was higher than in the sepsis group (P<0.05); IL-18 and IL-35 were negatively correlated with platelets (r=-0.8749, -0.6228, P<0.001). There was a significant positive correlation between serum IL-18 and IL-35 in the control group, sepsis group, and sepsis TCP group (r=0.5124, 0.5718, 0.5511, P<0.001). IL-18 and IL-35 were negatively correlated with the reduced degree of platelets in patients with sepsis Expression levels of interleukin-18 (IL-18) and IL-35 in the serum of patients with sepsis and without thrombocytopenia and patients with sepsis thrombocytopenia (TCP) were detected to preliminarily investigate their clinical significance. One hundred and sixty-six patients admitted to Jinan Central Hospital Affiliated to Shandong University from July 2013 to September 2015 were retrospectively analysed. There were 96 patients with sepsis without thrombocytopenia in the sepsis group, and 70 patients with sepsis TCP in the sepsis TCP group. In the same period, 80 healthy subjects were selected as the control group. Fluorescent quantitative PCR was used for the detection the expression of mRNA levels of IL-18 and IL-35, and Enzyme-linked immunosorbent assay for the detection of the protein concentrations of IL-18 and IL-35 in the serum of peripheral blood. The correlation between IL-18, IL-35 and platelets was analyzed. There were significant differences in albumin, creatinine, total bilirubin and platelet count between the sepsis group and the sepsis TCP group (P<0.05); the expression levels of mRNA of IL-18 and IL-35 in a karyocyte in peripheral blood in the sepsis group and the sepsis TCP group were higher than those in the control group (P<0.05); the expression of mRNA of IL-18 and IL-35 in the sepsis TCP group was higher than those in the sepsis group (P<0.05). The concentration of IL-18 and IL-35 in the sepsis TCP group was higher than in the sepsis group (P<0.05); IL-18 and IL-35 were negatively correlated with platelets (r=−0.8749, −0.6228, P<0.001). There was a significant positive correlation between serum IL-18 and IL-35 in the control group, sepsis group, and sepsis TCP group (r=0.5124, 0.5718, 0.5511, P<0.001). IL-18 and IL-35 were negatively correlated with the reduced degree of platelets in patients with sepsis and are likely to play an important role in the pathogenetic process of sepsis TCP. Expression levels of interleukin-18 (IL-18) and IL-35 in the serum of patients with sepsis and without thrombocytopenia and patients with sepsis thrombocytopenia (TCP) were detected to preliminarily investigate their clinical significance. One hundred and sixty-six patients admitted to Jinan Central Hospital Affiliated to Shandong University from July 2013 to September 2015 were retrospectively analysed. There were 96 patients with sepsis without thrombocytopenia in the sepsis group, and 70 patients with sepsis TCP in the sepsis TCP group. In the same period, 80 healthy subjects were selected as the control group. Fluorescent quantitative PCR was used for the detection the expression of mRNA levels of IL-18 and IL-35, and Enzyme-linked immunosorbent assay for the detection of the protein concentrations of IL-18 and IL-35 in the serum of peripheral blood. The correlation between IL-18, IL-35 and platelets was analyzed. There were significant differences in albumin, creatinine, total bilirubin and platelet count between the sepsis group and the sepsis TCP group (P<0.05); the expression levels of mRNA of IL-18 and IL-35 in a karyocyte in peripheral blood in the sepsis group and the sepsis TCP group were higher than those in the control group (P<0.05); the expression of mRNA of IL-18 and IL-35 in the sepsis TCP group was higher than those in the sepsis group (P<0.05). The concentration of IL-18 and IL-35 in the sepsis TCP group was higher than in the sepsis group (P<0.05); IL-18 and IL-35 were negatively correlated with platelets (r=-0.8749, -0.6228, P<0.001). There was a significant positive correlation between serum IL-18 and IL-35 in the control group, sepsis group, and sepsis TCP group (r=0.5124, 0.5718, 0.5511, P<0.001). IL-18 and IL-35 were negatively correlated with the reduced degree of platelets in patients with sepsis and are likely to play an important role in the pathogenetic process of sepsis TCP. |
| Audience | Academic |
| Author | Zhu, Meirong Rong, Xiaoqian Li, Min Wang, Shaoqin |
| AuthorAffiliation | Department of Critical Care Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China |
| AuthorAffiliation_xml | – name: Department of Critical Care Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China |
| Author_xml | – sequence: 1 givenname: Meirong surname: Zhu fullname: Zhu, Meirong organization: Department of Critical Care Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China – sequence: 2 givenname: Xiaoqian surname: Rong fullname: Rong, Xiaoqian organization: Department of Critical Care Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China – sequence: 3 givenname: Min surname: Li fullname: Li, Min organization: Department of Critical Care Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China – sequence: 4 givenname: Shaoqin surname: Wang fullname: Wang, Shaoqin organization: Department of Critical Care Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32010296$$D View this record in MEDLINE/PubMed |
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| Keywords | platelet sepsis thrombocytopenia IL-35 IL-18 sepsis |
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Current estimates and limitations publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201504-0781OC – volume: 25 start-page: 193 year: 2014 ident: key20200713005637_b31-etm-0-0-8347 article-title: Detection of expression of IL-18 and its binding protein in Egyptian pediatric immune thrombocytopenic purpura publication-title: Platelets doi: 10.3109/09537104.2013.784734 – volume: 160 start-page: 62 year: 2015 ident: key20200713005637_b21-etm-0-0-8347 article-title: Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome publication-title: Cell doi: 10.1016/j.cell.2014.11.047 – volume: 141 start-page: 11 year: 2016 ident: key20200713005637_b3-etm-0-0-8347 article-title: Sepsis-associated thrombocytopenia publication-title: Thromb Res doi: 10.1016/j.thromres.2016.02.022 – volume: 243 start-page: 396 year: 2017 ident: key20200713005637_b12-etm-0-0-8347 article-title: Interleukin-18 gene deletion protects against sepsis-induced cardiac dysfunction by inhibiting PP2A activity publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2017.04.082 – volume: 67 start-page: 499 year: 2010 ident: key20200713005637_b19-etm-0-0-8347 article-title: Platelets and innate immunity publication-title: Cell Mol Life Sci doi: 10.1007/s00018-009-0205-1 – volume: 453 start-page: 100 year: 2016 ident: key20200713005637_b11-etm-0-0-8347 article-title: Biochemical and inflammatory aspects in patients with severe sepsis and septic shock: The predictive role of IL-18 in mortality publication-title: Clin Chim Acta doi: 10.1016/j.cca.2015.12.009 – volume: 2014 start-page: 803561 year: 2014 ident: key20200713005637_b17-etm-0-0-8347 article-title: Early response roles for prolactin cortisol and circulating and cellular levels of heat shock proteins 72 and 90α in severe sepsis and SIRS publication-title: BioMed Res Int doi: 10.1155/2014/803561 – volume: 23 start-page: 299 year: 2011 ident: key20200713005637_b27-etm-0-0-8347 article-title: The value of serum interleukin-18 and 10 in the evaluation of severity and prognosis in the early stage of sepsis publication-title: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue – volume: 18 start-page: 301 year: 2002 ident: key20200713005637_b28-etm-0-0-8347 article-title: Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: High serum IL-18 as an early predictive indicator of lethal outcome publication-title: Shock doi: 10.1097/00024382-200210000-00002 – volume: 13 start-page: 103 year: 2016 ident: key20200713005637_b6-etm-0-0-8347 article-title: Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis publication-title: Cell Mol Immunol doi: 10.1038/cmi.2014.136 – volume: 39 start-page: 21 year: 2010 ident: key20200713005637_b5-etm-0-0-8347 article-title: Thrombocytopenia and outcome in critically ill patients with bloodstream infection publication-title: Heart Lung doi: 10.1016/j.hrtlng.2009.07.005 – volume: 35 start-page: 242 year: 2015 ident: key20200713005637_b30-etm-0-0-8347 article-title: The growing spectrum of anti-inflammatory interleukins and their potential roles in the development of sepsis publication-title: J Interferon Cytokine Res doi: 10.1089/jir.2014.0119 – volume: 462 start-page: 90 year: 2016 ident: key20200713005637_b25-etm-0-0-8347 article-title: Interleukin 35: A novel candidate biomarker to diagnose early onset sepsis in neonates publication-title: Clin Chim Acta doi: 10.1016/j.cca.2016.09.005 – volume: 13 start-page: 722 year: 2012 ident: key20200713005637_b23-etm-0-0-8347 article-title: IL-12 family cytokines: Immunological playmakers publication-title: Nat Immunol doi: 10.1038/ni.2366 – volume: 7 start-page: 115 year: 2017 ident: key20200713005637_b1-etm-0-0-8347 article-title: Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critically [corrected] ill patients? publication-title: Ann Intensive Care doi: 10.1186/s13613-017-0337-7 – volume: 290 start-page: 19307 year: 2015 ident: key20200713005637_b15-etm-0-0-8347 article-title: Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 pathway publication-title: J Biol Chem doi: 10.1074/jbc.M115.663286 |
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| SubjectTerms | Albumin Bacteria Bilirubin Blood platelets Clinical significance Enzyme-linked immunosorbent assay Enzymes Experiments IL-18 IL-35 Infection Infections Interleukins Messenger RNA Mortality platelet Polymerase chain reaction RNA Sepsis sepsis thrombocytopenia Software TCP/IP (Network protocols) Thrombocytopenia |
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| Title | IL-18 and IL-35 in the serum of patients with sepsis thrombocytopenia and the clinical significance |
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