Targeting pulmonary vascular endothelial cells for the treatment of respiratory diseases

Pulmonary vascular endothelial cells (VECs) are the main damaged cells in the pathogenesis of various respiratory diseases and they mediate the development and regulation of the diseases. Effective intervention targeting pulmonary VECs is of great significance for the treatment of respiratory diseas...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in pharmacology Vol. 13; p. 983816
Main Authors Li, Yi-Xuan, Wang, Hong-Bo, Li, Jing, Jin, Jian-Bo, Hu, Jing-Bo, Yang, Chun-Lin
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 30.08.2022
Subjects
acute lung injury
drug delivery systems
Pharmacology
pneumonia
respiratory diseases
vascular endothelial cells
Online AccessGet full text
ISSN1663-9812
1663-9812
DOI10.3389/fphar.2022.983816

Cover

Abstract Pulmonary vascular endothelial cells (VECs) are the main damaged cells in the pathogenesis of various respiratory diseases and they mediate the development and regulation of the diseases. Effective intervention targeting pulmonary VECs is of great significance for the treatment of respiratory diseases. A variety of cell markers are expressed on the surface of VECs, some of which can be specifically combined with the drugs or carriers modified by corresponding ligands such as ICAM-1, PECAM-1, and P-selectin, to achieve effective delivery of drugs in lung tissues. In addition, the great endothelial surface area of the pulmonary vessels, the “first pass effect” of venous blood in lung tissues, and the high volume and relatively slow blood perfusion rate of pulmonary capillaries further promote the drug distribution in lung tissues. This review summarizes the representative markers at the onset of respiratory diseases, drug delivery systems designed to target these markers and their therapeutic effects.
AbstractList Pulmonary vascular endothelial cells (VECs) are the main damaged cells in the pathogenesis of various respiratory diseases and they mediate the development and regulation of the diseases. Effective intervention targeting pulmonary VECs is of great significance for the treatment of respiratory diseases. A variety of cell markers are expressed on the surface of VECs, some of which can be specifically combined with the drugs or carriers modified by corresponding ligands such as ICAM-1, PECAM-1, and P-selectin, to achieve effective delivery of drugs in lung tissues. In addition, the great endothelial surface area of the pulmonary vessels, the “first pass effect” of venous blood in lung tissues, and the high volume and relatively slow blood perfusion rate of pulmonary capillaries further promote the drug distribution in lung tissues. This review summarizes the representative markers at the onset of respiratory diseases, drug delivery systems designed to target these markers and their therapeutic effects.
Pulmonary vascular endothelial cells (VECs) are the main damaged cells in the pathogenesis of various respiratory diseases and they mediate the development and regulation of the diseases. Effective intervention targeting pulmonary VECs is of great significance for the treatment of respiratory diseases. A variety of cell markers are expressed on the surface of VECs, some of which can be specifically combined with the drugs or carriers modified by corresponding ligands such as ICAM-1, PECAM-1, and P-selectin, to achieve effective delivery of drugs in lung tissues. In addition, the great endothelial surface area of the pulmonary vessels, the "first pass effect" of venous blood in lung tissues, and the high volume and relatively slow blood perfusion rate of pulmonary capillaries further promote the drug distribution in lung tissues. This review summarizes the representative markers at the onset of respiratory diseases, drug delivery systems designed to target these markers and their therapeutic effects.Pulmonary vascular endothelial cells (VECs) are the main damaged cells in the pathogenesis of various respiratory diseases and they mediate the development and regulation of the diseases. Effective intervention targeting pulmonary VECs is of great significance for the treatment of respiratory diseases. A variety of cell markers are expressed on the surface of VECs, some of which can be specifically combined with the drugs or carriers modified by corresponding ligands such as ICAM-1, PECAM-1, and P-selectin, to achieve effective delivery of drugs in lung tissues. In addition, the great endothelial surface area of the pulmonary vessels, the "first pass effect" of venous blood in lung tissues, and the high volume and relatively slow blood perfusion rate of pulmonary capillaries further promote the drug distribution in lung tissues. This review summarizes the representative markers at the onset of respiratory diseases, drug delivery systems designed to target these markers and their therapeutic effects.
Author Hu, Jing-Bo
Wang, Hong-Bo
Li, Jing
Jin, Jian-Bo
Li, Yi-Xuan
Yang, Chun-Lin
AuthorAffiliation 2 Department of Pharmacy , Yuyao People’s Hospital , Yuyao , China
1 School of Materials Science and Chemical Engineering , Ningbo University , Ningbo , China
AuthorAffiliation_xml – name: 1 School of Materials Science and Chemical Engineering , Ningbo University , Ningbo , China
– name: 2 Department of Pharmacy , Yuyao People’s Hospital , Yuyao , China
Author_xml – sequence: 1
  givenname: Yi-Xuan
  surname: Li
  fullname: Li, Yi-Xuan
– sequence: 2
  givenname: Hong-Bo
  surname: Wang
  fullname: Wang, Hong-Bo
– sequence: 3
  givenname: Jing
  surname: Li
  fullname: Li, Jing
– sequence: 4
  givenname: Jian-Bo
  surname: Jin
  fullname: Jin, Jian-Bo
– sequence: 5
  givenname: Jing-Bo
  surname: Hu
  fullname: Hu, Jing-Bo
– sequence: 6
  givenname: Chun-Lin
  surname: Yang
  fullname: Yang, Chun-Lin
BookMark eNp1kctqHDEQRUVwiB3HH5BdL7OZiV6tbm0CweRhMGTjQHaiRirNyKhbHUltyN9H43EgDkQbidK9h6q6r8nZnGYk5C2jWyFG_d4vB8hbTjnf6lGMTL0gF0wpsdEj42d_vc_JVSn3tB2htVDyFTkXijHa8_6C_LiDvMca5n23rHFKM-Rf3QMUu0bIHc4u1QPGALGzGGPpfMpdq3Q1I9QJ59ol32UsS8hQU_O6UBAKljfkpYdY8OrpviTfP3-6u_66uf325eb64-3GSsnrBhT0rRs3UImaCc81V4NVbrCMMuDWWdaEY8-Y9Z4JbUELcNyPKLR0OyEuyc2J6xLcmyWHqU1gEgTzWEh5byDXYCMaoanlXAATqKR0qHu5Y3bwo3O4Q-4b68OJtay7CZ1t42WIz6DPf-ZwMPv0YLRUo6K6Ad49AXL6uWKpZgrluDiYMa3F8IH1UopBsCYdTlKbUykZvbGhQg3pSA7RMGqOMZvHmM0xZnOKuTnZP84_Df7f8xuSba9d
CitedBy_id crossref_primary_10_1038_s42003_024_06925_9
crossref_primary_10_1021_acsnano_3c13039
crossref_primary_10_3390_biomedicines12030632
crossref_primary_10_1039_D3BM00802A
crossref_primary_10_3389_fmolb_2022_1093369
crossref_primary_10_1021_acs_nanolett_4c01854
Cites_doi 10.1021/nl404816m
10.1016/j.addr.2012.07.005
10.1152/ajplung.2001.280.6.L1335
10.1016/j.jconrel.2011.09.067
10.1371/journal.pone.0102329
10.1080/1061186X.2017.1349771
10.1016/j.biomaterials.2011.08.093
10.1517/17425247.2015.961418
10.1021/nn2015453
10.1021/bc00016a011
10.1016/j.jconrel.2015.05.006
10.1016/j.nano.2011.08.014
10.1182/blood-2002-09-2853
10.1016/j.biomaterials.2013.01.069
10.1152/ajplung.00037.2015
10.1021/bc200629f
10.1016/j.biomaterials.2017.11.047
10.1164/rccm.201003-0423OC
10.1021/acs.molpharmaceut.8b00861
10.1016/j.jconrel.2006.12.025
10.1016/j.addr.2003.10.043
10.1242/jcs.01325
10.1016/j.ymthe.2005.02.025
10.1016/j.jconrel.2014.06.008
10.1016/j.ejps.2013.03.007
10.3390/molecules26010039
10.1016/j.ccr.2011.08.025
10.1016/j.mvr.2003.11.006
10.7150/thno.19571
10.1016/j.jconrel.2019.02.033
10.1208/s12249-019-1403-2
10.1002/btm2.10050
10.1517/17425247.2.5.909
10.1093/glycob/cwm014
10.1111/micc.12654
10.1371/journal.pone.0080110
10.1164/ajrccm/139.6.1464
10.3390/pharmaceutics12111066
10.1186/s13054-019-2552-0
10.1111/j.1399-0039.2005.00516.x
10.1002/smll.202001647
10.1016/j.carbpol.2021.119035
10.1007/s12975-021-00931-3
10.3390/cancers13020335
10.1007/s10545-012-9534-6
10.1016/j.jconrel.2010.10.025
10.1016/j.nano.2018.08.009
10.1161/ATVBAHA.111.241844
10.1002/wnan.1763
10.1155/2018/1619293
10.1016/j.jconrel.2018.10.015
10.1021/acs.nanolett.8b02229
10.1021/nn505672x
10.1016/j.jconrel.2011.09.084
10.3390/ijms19041057
10.1016/j.jconrel.2015.01.015
10.1016/j.ymthe.2017.05.014
10.1016/j.jconrel.2009.08.001
10.1016/j.carbpol.2018.05.035
10.1016/j.biomaterials.2015.07.043
10.1016/j.nano.2020.102342
10.1021/acs.biomac.7b00572
10.7554/eLife.57278
10.1128/CMR.00051-05
10.2147/IJN.S44997
10.1016/S0002-9440(10)64935-8
10.1016/j.ijbiomac.2021.04.045
10.1080/10717544.2016.1259369
10.1007/s11095-013-1027-2
10.3389/fimmu.2020.542818
10.1016/j.carbpol.2019.01.010
10.1146/annurev-pathol-011110-130158
10.1007/978-94-007-4549-0_26
10.1016/j.ymthe.2005.07.687
10.1016/j.biomaterials.2019.119326
10.1016/j.mvr.2010.12.003
10.1016/j.ejps.2009.02.008
10.1182/blood-2004-05-1714
10.1016/j.jconrel.2020.04.047
10.1016/j.jconrel.2013.12.035
10.1186/s13195-020-00744-w
10.1016/j.ijpharm.2017.10.027
10.1126/science.2466335
10.1124/jpet.113.205104
10.1182/blood-2007-06-098657
10.1021/nn500136z
10.1097/MOH.0000000000000239
ContentType Journal Article
Copyright Copyright © 2022 Li, Wang, Li, Jin, Hu and Yang.
Copyright © 2022 Li, Wang, Li, Jin, Hu and Yang. 2022 Li, Wang, Li, Jin, Hu and Yang
Copyright_xml – notice: Copyright © 2022 Li, Wang, Li, Jin, Hu and Yang.
– notice: Copyright © 2022 Li, Wang, Li, Jin, Hu and Yang. 2022 Li, Wang, Li, Jin, Hu and Yang
DBID AAYXX
CITATION
7X8
5PM
DOA
DOI 10.3389/fphar.2022.983816
DatabaseName CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE - Academic
DatabaseTitleList CrossRef


MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
DocumentTitleAlternate Li et al
EISSN 1663-9812
ExternalDocumentID oai_doaj_org_article_390c223a13e644de954b1c7f8ddebe2f
PMC9468609
10_3389_fphar_2022_983816
GrantInformation_xml – fundername: ;
– fundername: ;
  grantid: 2019A610207 2019A610231 202003N4303
GroupedDBID 53G
5VS
9T4
AAFWJ
AAKDD
AAYXX
ACGFO
ACGFS
ACXDI
ADBBV
ADRAZ
AENEX
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
EMOBN
GROUPED_DOAJ
GX1
HYE
KQ8
M48
M~E
O5R
O5S
OK1
P2P
PGMZT
RNS
RPM
7X8
5PM
ID FETCH-LOGICAL-c442t-a6a5361d704e913f29267c6d7c101a2cdc1c448511cff139ca93ad2f8e394db33
IEDL.DBID M48
ISSN 1663-9812
IngestDate Wed Aug 27 01:29:26 EDT 2025
Thu Aug 21 14:24:00 EDT 2025
Fri Sep 05 13:48:23 EDT 2025
Tue Jul 01 02:33:41 EDT 2025
Thu Apr 24 23:02:44 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c442t-a6a5361d704e913f29267c6d7c101a2cdc1c448511cff139ca93ad2f8e394db33
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Yuan Tang, University of Toledo, United States
Edited by: Richard D. Minshall, University of Illinois at Chicago, United States
This article was submitted to Inflammation Pharmacology, a section of the journal Frontiers in Pharmacology
Reviewed by: Alexander Verin, Medical College of Georgia, Augusta University, United States
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fphar.2022.983816
PMID 36110525
PQID 2715443731
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_390c223a13e644de954b1c7f8ddebe2f
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9468609
proquest_miscellaneous_2715443731
crossref_citationtrail_10_3389_fphar_2022_983816
crossref_primary_10_3389_fphar_2022_983816
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-08-30
PublicationDateYYYYMMDD 2022-08-30
PublicationDate_xml – month: 08
  year: 2022
  text: 2022-08-30
  day: 30
PublicationDecade 2020
PublicationTitle Frontiers in pharmacology
PublicationYear 2022
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References Muro (B66) 2006; 13
Ferrante (B22) 2009; 140
Hurrell (B40) 2020; 11
Okada (B72) 2021; 28
Anselmo (B1) 2015; 68
Jin (B43) 2019; 16
Juenet (B45) 2018; 156
Chittasupho (B14) 2009; 37
Tong (B84) 2018; 196
Koenig (B49) 2006; 19
Trubetskoy (B85) 1992; 3
Howard (B36) 2014; 8
Nowak (B71) 2013; 756
Metzger (B60) 2011; 81
Muz (B67) 2021; 13
Bruckman (B7) 2014; 14
Chacko (B11) 2015; 9
Manthe (B57) 2017; 2
Muhammad (B63) 2021; 14
Shuvaev (B80) 2007; 118
Hsu (B37) 2012; 8
Jubeli (B44) 2012; 158
Muzykantov (B68) 1996; 279
Carnemolla (B10) 2013; 347
Shrestha (B78) 2012; 23
Drożdż (B21) 2018; 2018
Ferrer (B23) 2014; 9
Liu (B53) 2015; 309
Gibbins (B29) 2004; 117
Han (B32) 2015; 210
Garnacho (B25) 2017; 25
Xu (B88) 2020; 323
Rossi (B77) 2020; 9
Greineder (B30) 2013; 8
Yang (B89) 2013; 8
Lertkiatmongkol (B51) 2016; 23
Chan (B12) 2022; 13
van den Hoven (B86) 2013; 49
Chen (B13) 2011; 20
Craig (B16) 2011; 183
Papademetriou (B75) 2013; 36
Shuvaev (B81) 2011; 5
Tang (B83) 2018; 18
Bevilacqua (B3) 1989; 243
Kong (B50) 2018; 19
Brenner (B6) 2015; 12
Fuior (B24) 2020; 12
Gholizadeh (B28) 2018; 548
Wang (B87) 2019; 217
Kardara (B46) 2013; 30
Christofidou-Solomidou (B15) 2002; 160
Papademetriou (B73) 2013; 34
Bohr (B5) 2017; 18
Garnacho (B26) 2017; 25
Hu (B38) 2017; 7
Bhowmick (B4) 2012; 157
Gunawan (B31) 2011; 32
Calderon (B8) 2011; 150
Hassanpour (B33) 2020; 16
Hopkins (B34) 2004; 56
Manivasagan (B56) 2019; 211
Muzykantov (B69) 2005; 2
Balyasnikova (B2) 2006; 67
Li (B52) 2017; 24
McAteer (B59) 2012; 32
Papademetriou (B74) 2014; 188
Parhiz (B76) 2018; 291
Miners (B62) 2020; 12
Muzykantov (B70) 1989; 139
Murciano (B64) 2003; 101
Cao (B9) 2015; 205
Howard (B35) 2014; 177
Cumashi (B17) 2007; 17
Matthay (B58) 2011; 6
Miller (B61) 2005; 12
Huang (B39) 2019; 300
Lu (B55) 2022; 281
Danilov (B18) 2001; 280
Ito (B41) 2019; 23
Garnacho (B27) 2008; 111
Jiang (B42) 2019; 15
Liu (B54) 2019; 20
Danilov (B19) 1989; 30
Muro (B65) 2005; 105
Shu (B79) 2021; 32
Szebeni (B82) 2012; 64
King (B48) 2004; 67
Khan (B47) 2020; 26
Don (B20) 2021; 181
References_xml – volume: 14
  start-page: 1551
  year: 2014
  ident: B7
  article-title: Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus
  publication-title: Nano Lett.
  doi: 10.1021/nl404816m
– volume: 64
  start-page: 1706
  year: 2012
  ident: B82
  article-title: A porcine model of complement-mediated infusion reactions to drug carrier nanosystems and other medicines
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2012.07.005
– volume: 280
  start-page: L1335
  year: 2001
  ident: B18
  article-title: Lung uptake of antibodies to endothelial antigens: Key determinants of vascular immunotargeting
  publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.2001.280.6.L1335
– volume: 157
  start-page: 485
  year: 2012
  ident: B4
  article-title: Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2011.09.067
– volume: 9
  start-page: e102329
  year: 2014
  ident: B23
  article-title: Icam-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0102329
– volume: 25
  start-page: 786
  year: 2017
  ident: B26
  article-title: ICAM-1 targeting, intracellular trafficking, and functional activity of polymer nanocarriers coated with a fibrinogen-derived peptide for lysosomal enzyme replacement
  publication-title: J. Drug Target.
  doi: 10.1080/1061186X.2017.1349771
– volume: 32
  start-page: 9848
  year: 2011
  ident: B31
  article-title: Complementary targeting of liposomes to IL-1α and TNF-α activated endothelial cells via the transient expression of VCAM1 and E-selectin
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2011.08.093
– volume: 12
  start-page: 239
  year: 2015
  ident: B6
  article-title: Endothelial nanomedicine for the treatment of pulmonary disease
  publication-title: Expert Opin. Drug Deliv.
  doi: 10.1517/17425247.2015.961418
– volume: 5
  start-page: 6991
  year: 2011
  ident: B81
  article-title: Endothelial targeting of antibody-decorated polymeric filomicelles
  publication-title: ACS Nano
  doi: 10.1021/nn2015453
– volume: 3
  start-page: 323
  year: 1992
  ident: B85
  article-title: Use of N-terminal modified poly(L-lysine)-antibody conjugate as a carrier for targeted gene delivery in mouse lung endothelial cells
  publication-title: Bioconjug. Chem.
  doi: 10.1021/bc00016a011
– volume: 210
  start-page: 39
  year: 2015
  ident: B32
  article-title: Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.05.006
– volume: 8
  start-page: 731
  year: 2012
  ident: B37
  article-title: Enhanced delivery of α-glucosidase for pompe disease by ICAM-1-targeted nanocarriers: Comparative performance of a strategy for three distinct lysosomal storage disorders
  publication-title: Nanomedicine.
  doi: 10.1016/j.nano.2011.08.014
– volume: 101
  start-page: 3977
  year: 2003
  ident: B64
  article-title: ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface
  publication-title: Blood
  doi: 10.1182/blood-2002-09-2853
– volume: 34
  start-page: 3459
  year: 2013
  ident: B73
  article-title: In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.01.069
– volume: 309
  start-page: L226
  year: 2015
  ident: B53
  article-title: ICAM-1-dependent and ICAM-1-independent neutrophil lung infiltration by porcine reproductive and respiratory syndrome virus infection
  publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00037.2015
– volume: 23
  start-page: 574
  year: 2012
  ident: B78
  article-title: Dual peptide nucleic acid- and peptide-functionalized shell cross-linked nanoparticles designed to target mRNA toward the diagnosis and treatment of acute lung injury
  publication-title: Bioconjug. Chem.
  doi: 10.1021/bc200629f
– volume: 156
  start-page: 204
  year: 2018
  ident: B45
  article-title: Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2017.11.047
– volume: 183
  start-page: 620
  year: 2011
  ident: B16
  article-title: A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study)
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201003-0423OC
– volume: 16
  start-page: 71
  year: 2019
  ident: B43
  article-title: Sialic acid-functionalized PEG-PLGA microspheres loading mitochondrial-targeting-modified curcumin for acute lung injury therapy
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.8b00861
– volume: 118
  start-page: 235
  year: 2007
  ident: B80
  article-title: Factors modulating the delivery and effect of enzymatic cargo conjugated with antibodies targeted to the pulmonary endothelium
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2006.12.025
– volume: 56
  start-page: 763
  year: 2004
  ident: B34
  article-title: ICAM-1: Targeted docking for exogenous as well as endogenous ligands
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2003.10.043
– volume: 117
  start-page: 3415
  year: 2004
  ident: B29
  article-title: Platelet adhesion signalling and the regulation of thrombus formation
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.01325
– volume: 12
  start-page: 321
  year: 2005
  ident: B61
  article-title: Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2005.02.025
– volume: 188
  start-page: 87
  year: 2014
  ident: B74
  article-title: Combination-targeting to multiple endothelial cell adhesion molecules modulates binding, endocytosis, and in vivo biodistribution of drug nanocarriers and their therapeutic cargoes
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2014.06.008
– volume: 49
  start-page: 265
  year: 2013
  ident: B86
  article-title: Complement activation by PEGylated liposomes containing prednisolone
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2013.03.007
– volume: 26
  start-page: E39
  year: 2020
  ident: B47
  article-title: COVID-19: A global challenge with old history, epidemiology and progress so far
  publication-title: Molecules
  doi: 10.3390/molecules26010039
– volume: 20
  start-page: 538
  year: 2011
  ident: B13
  article-title: Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.08.025
– volume: 67
  start-page: 139
  year: 2004
  ident: B48
  article-title: Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes
  publication-title: Microvasc. Res.
  doi: 10.1016/j.mvr.2003.11.006
– volume: 7
  start-page: 2204
  year: 2017
  ident: B38
  article-title: E-selectin-targeted sialic acid-PEG-dexamethasone micelles for enhanced anti-inflammatory efficacy for acute kidney injury
  publication-title: Theranostics
  doi: 10.7150/thno.19571
– volume: 300
  start-page: 1
  year: 2019
  ident: B39
  article-title: An activated-platelet-sensitive nanocarrier enables targeted delivery of tissue plasminogen activator for effective thrombolytic therapy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2019.02.033
– volume: 20
  start-page: 270
  year: 2019
  ident: B54
  article-title: E-Selectin-Binding peptide-modified bovine serum albumin nanoparticles for the treatment of acute lung injury
  publication-title: AAPS PharmSciTech
  doi: 10.1208/s12249-019-1403-2
– volume: 2
  start-page: 109
  year: 2017
  ident: B57
  article-title: ICAM-1-Targeted nanocarriers attenuate endothelial release of soluble ICAM-1, an inflammatory regulator
  publication-title: Bioeng. Transl. Med.
  doi: 10.1002/btm2.10050
– volume: 2
  start-page: 909
  year: 2005
  ident: B69
  article-title: Biomedical aspects of targeted delivery of drugs to pulmonary endothelium
  publication-title: Expert Opin. Drug Deliv.
  doi: 10.1517/17425247.2.5.909
– volume: 17
  start-page: 541
  year: 2007
  ident: B17
  article-title: A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwm014
– volume: 28
  start-page: e12654
  year: 2021
  ident: B72
  article-title: Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection
  publication-title: Microcirculation
  doi: 10.1111/micc.12654
– volume: 8
  start-page: e80110
  year: 2013
  ident: B30
  article-title: Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0080110
– volume: 139
  start-page: 1464
  year: 1989
  ident: B70
  article-title: In vivo administration of glucose oxidase conjugated with monoclonal antibodies to angiotensin-converting enzyme. The tissue distribution, blood clearance, and targeting into rat lungs
  publication-title: Am. Rev. Respir. Dis.
  doi: 10.1164/ajrccm/139.6.1464
– volume: 12
  start-page: E1066
  year: 2020
  ident: B24
  article-title: Evaluation of VCAM-1 targeted naringenin/indocyanine green-loaded lipid nanoemulsions as theranostic nanoplatforms in inflammation
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics12111066
– volume: 23
  start-page: 280
  year: 2019
  ident: B41
  article-title: Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential
  publication-title: Crit. Care
  doi: 10.1186/s13054-019-2552-0
– volume: 67
  start-page: 10
  year: 2006
  ident: B2
  article-title: Monoclonal antibodies to native mouse angiotensin-converting enzyme (CD143): ACE expression quantification, lung endothelial cell targeting and gene delivery
  publication-title: Tissue Antigens
  doi: 10.1111/j.1399-0039.2005.00516.x
– volume: 16
  start-page: e2001647
  year: 2020
  ident: B33
  article-title: Thrombolytic agents: Nanocarriers in controlled release
  publication-title: Small
  doi: 10.1002/smll.202001647
– volume: 281
  start-page: 119035
  year: 2022
  ident: B55
  article-title: Modification of chitosan nanofibers with CuS and fucoidan for antibacterial and bone tissue engineering applications
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2021.119035
– volume: 13
  start-page: 245
  year: 2022
  ident: B12
  article-title: Development of molecular magnetic resonance imaging tools for risk stratification of carotid atherosclerotic disease using dual-targeted microparticles of iron oxide
  publication-title: Transl. Stroke Res.
  doi: 10.1007/s12975-021-00931-3
– volume: 13
  start-page: 335
  year: 2021
  ident: B67
  article-title: Targeting E-selectin to tackle cancer using uproleselan
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers13020335
– volume: 36
  start-page: 467
  year: 2013
  ident: B75
  article-title: Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor
  publication-title: J. Inherit. Metab. Dis.
  doi: 10.1007/s10545-012-9534-6
– volume: 150
  start-page: 37
  year: 2011
  ident: B8
  article-title: Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2010.10.025
– volume: 15
  start-page: 25
  year: 2019
  ident: B42
  article-title: Combined delivery of angiopoietin-1 gene and simvastatin mediated by anti-intercellular adhesion molecule-1 antibody-conjugated ternary nanoparticles for acute lung injury therapy
  publication-title: Nanomedicine.
  doi: 10.1016/j.nano.2018.08.009
– volume: 32
  start-page: 1427
  year: 2012
  ident: B59
  article-title: A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.111.241844
– volume: 14
  start-page: e1763
  year: 2021
  ident: B63
  article-title: Inflammation-modulating nanoparticles for pneumonia therapy
  publication-title: Wiley Interdiscip. Rev. Nanomed Nanobiotechnol
  doi: 10.1002/wnan.1763
– volume: 2018
  start-page: 1619293
  year: 2018
  ident: B21
  article-title: Thrombomodulin as a new marker of endothelial dysfunction in chronic kidney disease in children
  publication-title: Oxid. Med. Cell. Longev.
  doi: 10.1155/2018/1619293
– volume: 291
  start-page: 106
  year: 2018
  ident: B76
  article-title: PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.10.015
– volume: 18
  start-page: 6207
  year: 2018
  ident: B83
  article-title: Nanoparticles targeted against cryptococcal pneumonia by interactions between chitosan and its peptide ligand
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.8b02229
– volume: 9
  start-page: 6785
  year: 2015
  ident: B11
  article-title: Collaborative enhancement of endothelial targeting of nanocarriers by modulating platelet-endothelial cell adhesion molecule-1/CD31 epitope engagement
  publication-title: ACS Nano
  doi: 10.1021/nn505672x
– volume: 158
  start-page: 194
  year: 2012
  ident: B44
  article-title: E-selectin as a target for drug delivery and molecular imaging
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2011.09.084
– volume: 30
  start-page: 1686
  year: 1989
  ident: B19
  article-title: Radioimmunoimaging of lung vessels: An approach using indium-111-labeled monoclonal antibody to angiotensin-converting enzyme
  publication-title: J. Nucl. Med.
– volume: 19
  start-page: E1057
  year: 2018
  ident: B50
  article-title: Emerging roles of vascular cell adhesion molecule-1 (VCAM-1) in immunological disorders and cancer
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms19041057
– volume: 205
  start-page: 162
  year: 2015
  ident: B9
  article-title: Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.01.015
– volume: 25
  start-page: 1686
  year: 2017
  ident: B25
  article-title: Enhanced delivery and effects of acid sphingomyelinase by ICAM-1-targeted nanocarriers in type B niemann-pick disease mice
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2017.05.014
– volume: 140
  start-page: 100
  year: 2009
  ident: B22
  article-title: Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2009.08.001
– volume: 196
  start-page: 110
  year: 2018
  ident: B84
  article-title: Characterization of a P-selectin-binding moiety from Bupleurum chinense polysaccharide and its antagonistic effect against P-selectin-mediated function
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2018.05.035
– volume: 68
  start-page: 1
  year: 2015
  ident: B1
  article-title: Exploiting shape, cellular-hitchhiking and antibodies to target nanoparticles to lung endothelium: Synergy between physical, chemical and biological approaches
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2015.07.043
– volume: 32
  start-page: 102342
  year: 2021
  ident: B79
  article-title: Fucoidan-based micelles as P-selectin targeted carriers for synergistic treatment of acute kidney injury
  publication-title: Nanomedicine.
  doi: 10.1016/j.nano.2020.102342
– volume: 18
  start-page: 2379
  year: 2017
  ident: B5
  article-title: Anti-inflammatory effect of anti-TNF-α SiRNA cationic phosphorus dendrimer nanocomplexes administered intranasally in a murine acute lung injury model
  publication-title: Biomacromolecules
  doi: 10.1021/acs.biomac.7b00572
– volume: 9
  start-page: e57278
  year: 2020
  ident: B77
  article-title: Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients
  publication-title: Elife
  doi: 10.7554/eLife.57278
– volume: 19
  start-page: 637
  year: 2006
  ident: B49
  article-title: Ventilator-associated pneumonia: Diagnosis, treatment, and prevention
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00051-05
– volume: 8
  start-page: 1897
  year: 2013
  ident: B89
  article-title: VCAM-1-targeted core/shell nanoparticles for selective adhesion and delivery to endothelial cells with lipopolysaccharide-induced inflammation under shear flow and cellular magnetic resonance imaging in vitro
  publication-title: Int. J. Nanomedicine
  doi: 10.2147/IJN.S44997
– volume: 160
  start-page: 1155
  year: 2002
  ident: B15
  article-title: Vascular immunotargeting of glucose oxidase to the endothelial antigens induces distinct forms of oxidant acute lung injury: Targeting to thrombomodulin, but not to PECAM-1, causes pulmonary thrombosis and neutrophil transmigration
  publication-title: Am. J. Pathol.
  doi: 10.1016/S0002-9440(10)64935-8
– volume: 181
  start-page: 835
  year: 2021
  ident: B20
  article-title: Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2021.04.045
– volume: 24
  start-page: 402
  year: 2017
  ident: B52
  article-title: Targeting delivery of simvastatin using ICAM-1 antibody-conjugated nanostructured lipid carriers for acute lung injury therapy
  publication-title: Drug Deliv.
  doi: 10.1080/10717544.2016.1259369
– volume: 30
  start-page: 1836
  year: 2013
  ident: B46
  article-title: Caveolar uptake and endothelial-protective effects of nanostructured lipid carriers in acid aspiration murine acute lung injury
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-013-1027-2
– volume: 11
  start-page: 542818
  year: 2020
  ident: B40
  article-title: Distinct roles of LFA-1 and ICAM-1 on ILC2s control lung infiltration, effector functions, and development of airway hyperreactivity
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.542818
– volume: 211
  start-page: 360
  year: 2019
  ident: B56
  article-title: Chitosan/fucoidan multilayer coating of gold nanorods as highly efficient near-infrared photothermal agents for cancer therapy
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2019.01.010
– volume: 6
  start-page: 147
  year: 2011
  ident: B58
  article-title: The acute respiratory distress syndrome: Pathogenesis and treatment
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev-pathol-011110-130158
– volume: 756
  start-page: 203
  year: 2013
  ident: B71
  article-title: Immunotargeting of the pulmonary endothelium via angiotensin-converting-enzyme in isolated ventilated and perfused human lung
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-94-007-4549-0_26
– volume: 13
  start-page: 135
  year: 2006
  ident: B66
  article-title: Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation- and clathrin-dependent endocytosis
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2005.07.687
– volume: 217
  start-page: 119326
  year: 2019
  ident: B87
  article-title: Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2019.119326
– volume: 81
  start-page: 206
  year: 2011
  ident: B60
  article-title: Heterogeneous distribution of angiotensin I-converting enzyme (CD143) in the human and rat vascular systems: Vessel, organ and species specificity
  publication-title: Microvasc. Res.
  doi: 10.1016/j.mvr.2010.12.003
– volume: 37
  start-page: 141
  year: 2009
  ident: B14
  article-title: ICAM-1 targeting of doxorubicin-loaded PLGA nanoparticles to lung epithelial cells
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2009.02.008
– volume: 105
  start-page: 650
  year: 2005
  ident: B65
  article-title: ICAM-1 recycling in endothelial cells: A novel pathway for sustained intracellular delivery and prolonged effects of drugs
  publication-title: Blood
  doi: 10.1182/blood-2004-05-1714
– volume: 323
  start-page: 578
  year: 2020
  ident: B88
  article-title: Sialic acid-modified chitosan oligosaccharide-based biphasic calcium phosphate promote synergetic bone formation in rheumatoid arthritis therapy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2020.04.047
– volume: 177
  start-page: 34
  year: 2014
  ident: B35
  article-title: Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2013.12.035
– volume: 12
  start-page: 170
  year: 2020
  ident: B62
  article-title: Cognitive impact of COVID-19: Looking beyond the short term
  publication-title: Alzheimers Res. Ther.
  doi: 10.1186/s13195-020-00744-w
– volume: 548
  start-page: 759
  year: 2018
  ident: B28
  article-title: E-selectin targeted immunoliposomes for rapamycin delivery to activated endothelial cells
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2017.10.027
– volume: 279
  start-page: 1026
  year: 1996
  ident: B68
  article-title: Targeting of antibody-conjugated plasminogen activators to the pulmonary vasculature
  publication-title: J. Pharmacol. Exp. Ther.
– volume: 243
  start-page: 1160
  year: 1989
  ident: B3
  article-title: Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins
  publication-title: Science
  doi: 10.1126/science.2466335
– volume: 347
  start-page: 339
  year: 2013
  ident: B10
  article-title: Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.113.205104
– volume: 111
  start-page: 3024
  year: 2008
  ident: B27
  article-title: RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: Critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1
  publication-title: Blood
  doi: 10.1182/blood-2007-06-098657
– volume: 8
  start-page: 4100
  year: 2014
  ident: B36
  article-title: Vascular targeting of nanocarriers: Perplexing aspects of the seemingly straightforward paradigm
  publication-title: ACS Nano
  doi: 10.1021/nn500136z
– volume: 23
  start-page: 253
  year: 2016
  ident: B51
  article-title: Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31)
  publication-title: Curr. Opin. Hematol.
  doi: 10.1097/MOH.0000000000000239
SSID ssj0000399364
Score 2.3806307
SecondaryResourceType review_article
Snippet Pulmonary vascular endothelial cells (VECs) are the main damaged cells in the pathogenesis of various respiratory diseases and they mediate the development and...
SourceID doaj
pubmedcentral
proquest
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 983816
SubjectTerms acute lung injury
drug delivery systems
Pharmacology
pneumonia
respiratory diseases
vascular endothelial cells
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA7iyYv4xPVFBPEgW23zaJqjiiKC4mEX9hbSNEFh6S77OOy_d6btPnrRi9c0pel8k8xMZvKFkGvrskJYpSLlRByJXMook15GTIYs91pJ5vGA8_tH-toXbwM52LjqC2vCanrgWnD3EJM7MGE24R5Md-G1FHniVMhgXuaeBVx9Yx1vBFPVGox2NxV1GhOiMH0fxl8W-T8Zu9MZZstahqji6285me0SyQ2b87JHdhtnkT7Ug9wnW748IDefNdv0okt768NT0y69oZ9rHurFIRn0qipvsE10PB-CutnJgi4rT6kvCzx8NQT9o7h7P6XgvlJooavaczoKdLJOxdMmmTM9Iv2X597Ta9RcpBA5IdgssqmVPE0KFQuvEx6YZqlyaaEcTEjLXOES6Ii-lwsBXEJnNbcFC5nnWhQ558dkuxyV_oRQLjMI4QLE40h9BrPZhURmgHPqJaATd0i8lKpxDcs4XnYxNBBtIBCmAsIgEKYGokNuV6-Ma4qN3zo_IlSrjsiOXTWAzphGZ8xfOtMhV0ugDcwmFLIt_Wg-NUwhOxFXPOkQ1dKA1hfbT8rvr4qXW4sUhKNP_2OIZ2QH_7ravY7PyfZsMvcX4P7M8stK038ANJcH5Q
  priority: 102
  providerName: Directory of Open Access Journals
Title Targeting pulmonary vascular endothelial cells for the treatment of respiratory diseases
URI https://www.proquest.com/docview/2715443731
https://pubmed.ncbi.nlm.nih.gov/PMC9468609
https://doaj.org/article/390c223a13e644de954b1c7f8ddebe2f
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBddB6Mvpd0Hy9YVDUYfRt3Z-rCshzHWsVIGG31IIG9ClqW1EJzMTqD573cnO0kNZQ97tSWMdXe63-lOvyPkg3VFJaxSiXIiTUQpZVJILxMmQ1F6rSTzeMH556_8eiJ-TOV0j2zaW_UL2D4a2mE_qUkzu7j_s_4CBv8ZI07wt5_C4tYitSdjF7rARNgT8jSmi7CSr0f7cWNGZ5yLLrf5-MwD8ozn4BElts5-4Kgin_8AhA5LKB_4pKsjctiDSfq1k_4x2fP1c3J207FRr8_peHe5qj2nZ_Rmx1O9fkGm41gFDr6LLlYzUEfbrOmmMpX6usLLWTPQT4qn-y0FeEvhCd3WptN5oM0uVU_7ZE_7kkyuvo-_XSd9o4XECcGWic2thN-uVCq8znhgmuXK5ZVyYLCWucplMBCxmQsBIKOzmtuKhcJzLaqS81dkv57X_jWhXBYQ4gWI15EaDazdhUwWoAe5l6Ly6Yikm1U1rmchx2YYMwPRCMrERJkYlInpZDIiH7dTFh0Fx78GX6KotgORPTs-mDe_TW-MhuvUASyyGfcAByuvpSgzp0IBe33pWRiR9xtBG7A2XGRb-_mqNUwhexFXPBsRNdCAwReHb-q728jbrUUOi6Pf_PfMt-QAfzUeaacnZH_ZrPw7wETL8jSeJZxGff8LH_EQtA
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Targeting+pulmonary+vascular+endothelial+cells+for+the+treatment+of+respiratory+diseases&rft.jtitle=Frontiers+in+pharmacology&rft.au=Li%2C+Yi-Xuan&rft.au=Wang%2C+Hong-Bo&rft.au=Li%2C+Jing&rft.au=Jin%2C+Jian-Bo&rft.date=2022-08-30&rft.pub=Frontiers+Media+S.A&rft.eissn=1663-9812&rft.volume=13&rft_id=info:doi/10.3389%2Ffphar.2022.983816&rft_id=info%3Apmid%2F36110525&rft.externalDocID=PMC9468609
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1663-9812&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1663-9812&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1663-9812&client=summon