Impact of Young Age at Diagnosis on Survival in Patients with Surgically Treated Renal Cell Carcinoma: a Multicenter Study

The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent sur...

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Published in	Journal of Korean medical science Vol. 31; no. 12; pp. 1976 - 1982
Main Authors	Kang, Ho Won, Seo, Sung Pil, Kim, Won Tae, Yun, Seok Joong, Lee, Sang-Cheol, Kim, Wun-Jae, Hwang, Eu Chang, Kang, Seok Ho, Hong, Sung-Hoo, Chung, Jinsoo, Kwon, Tae Gyun, Kim, Hyeon Hoe, Kwak, Cheol, Byun, Seok-Soo, Kim, Yong-June
Format	Journal Article
Language	English
Published	Korea (South) The Korean Academy of Medical Sciences 01.12.2016 대한의학회
Subjects	Adult Age Factors Aged Carcinoma, Renal Cell - diagnosis Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - surgery Databases, Factual Female Humans Kaplan-Meier Estimate Kidney Neoplasms - diagnosis Kidney Neoplasms - mortality Kidney Neoplasms - surgery Male Middle Aged Multivariate Analysis Neoplasm Metastasis Neoplasm Recurrence, Local Neoplasm Staging Nephrectomy Original Prognosis Proportional Hazards Models Retrospective Studies 의학일반 Recurrence Nephrectomy Renal Cell Carcinoma Survival Age
Online Access	Get full text
ISSN	1011-8934 1598-6357 1598-6357
DOI	10.3346/jkms.2016.31.12.1976

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Abstract	The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n = 541), middle-age (≥ 40 and < 60 years, n = 2,551), and old age (≥ 60 years, n = 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC.
AbstractList	The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n = 541), middle-age (≥ 40 and < 60 years, n = 2,551), and old age (≥ 60 years, n = 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC. The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n = 541), middle-age (≥ 40 and < 60 years, n = 2,551), and old age (≥ 60 years, n = 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC.The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n = 541), middle-age (≥ 40 and < 60 years, n = 2,551), and old age (≥ 60 years, n = 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC. The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n = 541), middle-age (≥ 40 and < 60 years, n = 2,551), and old age (≥ 60 years, n = 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC. KCI Citation Count: 0
Author	Kim, Wun-Jae Byun, Seok-Soo Hwang, Eu Chang Kim, Won Tae Yun, Seok Joong Kwon, Tae Gyun Seo, Sung Pil Kim, Hyeon Hoe Hong, Sung-Hoo Kang, Ho Won Kang, Seok Ho Chung, Jinsoo Kwak, Cheol Kim, Yong-June Lee, Sang-Cheol
AuthorAffiliation	1 Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea 3 Department of Urology, Korea University School of Medicine, Seoul, Korea 5 Department of Urology, National Cancer Center, Goyang, Korea 8 Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea 6 Department of Urology, Kyungpook National University College of Medicine, Daegu, Korea 4 Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea 7 Department of Urology, Seoul National University College of Medicine, Seoul, Korea 2 Department of Urology, Chonnam National University Hwasun Hospital, Hwasun, Korea
AuthorAffiliation_xml	– name: 2 Department of Urology, Chonnam National University Hwasun Hospital, Hwasun, Korea – name: 4 Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea – name: 7 Department of Urology, Seoul National University College of Medicine, Seoul, Korea – name: 8 Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea – name: 1 Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea – name: 3 Department of Urology, Korea University School of Medicine, Seoul, Korea – name: 5 Department of Urology, National Cancer Center, Goyang, Korea – name: 6 Department of Urology, Kyungpook National University College of Medicine, Daegu, Korea
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Snippet	The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the...
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SubjectTerms	Adult Age Factors Aged Carcinoma, Renal Cell - diagnosis Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - surgery Databases, Factual Female Humans Kaplan-Meier Estimate Kidney Neoplasms - diagnosis Kidney Neoplasms - mortality Kidney Neoplasms - surgery Male Middle Aged Multivariate Analysis Neoplasm Metastasis Neoplasm Recurrence, Local Neoplasm Staging Nephrectomy Original Prognosis Proportional Hazards Models Retrospective Studies 의학일반
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Title	Impact of Young Age at Diagnosis on Survival in Patients with Surgically Treated Renal Cell Carcinoma: a Multicenter Study
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