Remote Control: Impacts of Peripheral Tumor Necrosis Factor-Alpha on Alzheimer Disease-Related Pathology

• Published in: The Journal of neuroscience Vol. 37; no. 34; pp. 8045 - 8047
• Main Author: Süß, Patrick
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 23.08.2017
• Subjects: 3' Untranslated regions; Alzheimer Disease; Alzheimer's disease; Amyloid; Amyloidogenic Proteins; Animals; Arthritis; Brain; Deposition; Disease control; Infliximab; Journal Club; Mice; Mice, Transgenic; Monoclonal antibodies; Neurodegenerative diseases; Pathology; Remote control; Rheumatoid arthritis; Tumor Necrosis Factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumors; β-Amyloid
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.1480-17.2017

Sub examines the impacts of peripheral tumor necrosis factor-alpha on Alzheimer's disease-related pathology. She cites a study which demonstrated differing effects of peripheral human TNF-a expression on amyloid plaque load, glial activation, and synaptic integrity in the brain of 5XFAD mice. Researchers crossed 5XFAD mice with Tg197 mice, which express human TNF-a modified in its 3'-untranslated region to yield constitutive overexpression and serve as a model of rheumatoid arthritis. The authors found that 5XFAD/Tg197 (5XTg197) mice had reduced amyloid deposition in the hippocampus and cortex compared with 5XFAD controls at the ages of 2.5 and 4 months. Inhibition of human TNF-a with the monoclonal antibody infliximab had no effect on plaque load in 5XFAD mice, but partially restored Ab deposition in 5XTg197 mice.