Blockade of the High-Affinity Interleukin-2 Receptors with Daclizumab High-Yield Process: Pharmacokinetic/Pharmacodynamic Analysis of Single- and Multiple-Dose Phase I Trials - Minocha, Mukul; Tran, Jonathan Q.; Sheridan, James P.; Othman, Ahmed A. (Clinical pharmacokinetics, 2016)
Keywords: Administration, Intravenous; Antibodies, Monoclonal, Humanized - administration & dosage; Antibodies, Monoclonal, Humanized - pharmacokinetics; Double-Blind Method; Drug Administration Schedule; Humans; Immunoglobulin G - administration & dosage; Interleukin-2 Receptor alpha Subunit - blood; Internal Medicine; Medicine; Medicine & Public Health; Models, Biological; Nonlinear Dynamics; Original Research Article; Pharmacology/Toxicology; Pharmacotherapy; Receptors, Interleukin-2 - antagonists & inhibitors; Multiple Sclerosis; Daclizumab; CD56bright Natural Killer Cell; Visual Predictive Check; Hill Coefficient