Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
Hypoxia-inducible factor (HIF)-1α is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1α regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atrac...
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| Published in | BMB reports Vol. 49; no. 9; pp. 508 - 513 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Society for Biochemistry and Molecular Biology
30.09.2016
생화학분자생물학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1976-6696 1976-670X |
| DOI | 10.5483/BMBRep.2016.49.9.069 |
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| Abstract | Hypoxia-inducible factor (HIF)-1α is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1α regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1α inhibitor that inhibits the Akt signaling pathway. DAA dose-dependently inhibited hypoxia-induced HIF-1α and downregulated Akt signaling without affecting the stability of HIF-1α protein. Furthermore, DAA prevented hypoxia-mediated angiogenesis based on in vitro tube formation and in vivo chorioallantoic membrane (CAM) assays. Therefore, DAA might be useful for treatment of hypoxia-related tumorigenesis, including angiogenesis. [BMB Reports 2016; 49(9): 508-513]. |
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| AbstractList | Hypoxia-inducible factor (HIF)-1α is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1α regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1α inhibitor that inhibits the Akt signaling pathway. DAA dose-dependently inhibited hypoxia-induced HIF-1α and downregulated Akt signaling without affecting the stability of HIF-1α protein. Furthermore, DAA prevented hypoxia-mediated angiogenesis based on in vitro tube formation and in vivo chorioallantoic membrane (CAM) assays. Therefore, DAA might be useful for treatment of hypoxia-related tumorigenesis, including angiogenesis. [BMB Reports 2016; 49(9): 508-513] Hypoxia-inducible factor (HIF)-1α is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1α regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1α inhibitor that inhibits the Akt signaling pathway. DAA dose-dependently inhibited hypoxia-induced HIF-1α and downregulated Akt signaling without affecting the stability of HIF-1α protein. Furthermore, DAA prevented hypoxia-mediated angiogenesis based on in vitro tube formation and in vivo chorioallantoic membrane (CAM) assays. Therefore, DAA might be useful for treatment of hypoxia-related tumorigenesis, including angiogenesis. KCI Citation Count: 7 |
| Author | Kim, Hyun Young Lee, Kwang-Sik Lee, Mi Ja Choi, Sik-Won Kim, Sun-Lim Kang, Hyeon Jung Seo, Woo Duck Lee, Jin Hwan Park, Kie-In Shin, Hye Kyoung |
| AuthorAffiliation | 5 Department of surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea 1 Division of Crop Foundation, National Institute of Crop Science (NICS), Rural Development Administration (RDA), Wanju 55365 3 Division of Research Development and Education, National Institute of Chemical Safety, Ministry of Environment, Daejeon 34111 4 Division of Biological Sciences, College of Natural Science, Chonbuk National University, Jeonju 54896 2 College of Crop Science and Biotechnology, Dankook University, Cheonan 31116 |
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| SubjectTerms | Atractylodes - chemistry Atractylodes - metabolism Blotting, Western Chorioallantoic Membrane - drug effects Chorioallantoic Membrane - physiology Cobalt - toxicity Down-Regulation - drug effects Enediynes - pharmacology HeLa Cells Human Umbilical Vein Endothelial Cells Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Neovascularization, Physiologic - drug effects Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Real-Time Polymerase Chain Reaction Signal Transduction - drug effects Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism 화학 |
| Title | Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis |
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