Physicochemical modifications in microwave-irradiated chitosan: biopharmaceutical and medical applications

Biopharmaceutical and biomedical applications of chitosan has evolved exponentially in the past decade, owing to its unique physicochemical properties. However, further applications can be garnered from modified chitosan, specifically, depolymerized chitosan, with potentially useful applications in...

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Published inJournal of biomaterials science. Polymer ed. Vol. 35; no. 6; pp. 898 - 915
Main Authors Elsayed Mahmoud, Doaa, Billa, Nashiru
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 12.04.2024
Taylor & Francis Ltd
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ISSN0920-5063
1568-5624
DOI10.1080/09205063.2024.2306695

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Abstract Biopharmaceutical and biomedical applications of chitosan has evolved exponentially in the past decade, owing to its unique physicochemical properties. However, further applications can be garnered from modified chitosan, specifically, depolymerized chitosan, with potentially useful applications in drug delivery or biomedicine. The use of microwave irradiation in depolymerization of chitosan appears to be more consequential than other methods, and results in modification of key physicochemical properties of chitosan, including molecular weight, viscosity and degree of deacetylation. In-depth review of such microwave-depolymerized chitosan and subsequent potential biopharmaceutical or biomedical applications has not been presented before. Herein, we present a detailed review of key physicochemical changes in chitosan following various depolymerization approaches, with focus on microwave irradiation and how these changes impact relevant biopharmaceutical or biomedical applications.
AbstractList Biopharmaceutical and biomedical applications of chitosan has evolved exponentially in the past decade, owing to its unique physicochemical properties. However, further applications can be garnered from modified chitosan, specifically, depolymerized chitosan, with potentially useful applications in drug delivery or biomedicine. The use of microwave irradiation in depolymerization of chitosan appears to be more consequential than other methods, and results in modification of key physicochemical properties of chitosan, including molecular weight, viscosity and degree of deacetylation. In-depth review of such microwave-depolymerized chitosan and subsequent potential biopharmaceutical or biomedical applications has not been presented before. Herein, we present a detailed review of key physicochemical changes in chitosan following various depolymerization approaches, with focus on microwave irradiation and how these changes impact relevant biopharmaceutical or biomedical applications.
Author Billa, Nashiru
Elsayed Mahmoud, Doaa
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Keywords microwave irradiation
molecular weight
Chitosan
biopharmaceutical, biomedical, applications
physicochemical
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Snippet Biopharmaceutical and biomedical applications of chitosan has evolved exponentially in the past decade, owing to its unique physicochemical properties....
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SubjectTerms biopharmaceutical, biomedical, applications
Chitosan
microwave irradiation
molecular weight
physicochemical
Physicochemical properties
Title Physicochemical modifications in microwave-irradiated chitosan: biopharmaceutical and medical applications
URI https://www.tandfonline.com/doi/abs/10.1080/09205063.2024.2306695
https://www.ncbi.nlm.nih.gov/pubmed/38284331
https://www.proquest.com/docview/3037745823
Volume 35
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