Performance and Robustness of the Monte Carlo Importance Sampling Algorithm Using Parallelized S-ADAPT for Basic and Complex Mechanistic Models - Bulitta, Jurgen B.; Landersdorfer, Cornelia B. (The AAPS journal, 2011)
Keywords: Algorithms; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Computer Simulation; Models, Biological; Monte Carlo Method; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - metabolism; Pharmacokinetics; Pharmacology/Toxicology; Pharmacy; Research Article; mechanistic population pharmacokinetic; Monte Carlo importance sampling; nonlinear mixed-effects modeling in S-ADAPT; pharmacodynamic modeling; parallel computing; Monte Carlo parametric expectation maximization (MC-PEM) algorithm