Enhanced polygenic risk score incorporating gene–environment interaction suggests the association of major depressive disorder with cardiac and lung function - Pan, Chuyu; Cheng, Bolun; Qin, Xiaoyue; Cheng, Shiqiang; Liu, Li; Yang, Xuena; Meng, Peilin; Zhang, Na; He, Dan; Cai, Qingqing; Wei, Wenming; Hui, Jingni; et al. (Briefings in bioinformatics, 2024)
Keywords: Cardiovascular diseases; Case Study; Depressive Disorder, Major - complications; Depressive Disorder, Major - genetics; Drinking behavior; Environmental factors; Gene-Environment Interaction; Genetic Risk Score; Genomes; Health risks; Humans; Lung; Lungs; Mental depression; Nucleotides; Regression analysis; Respiratory diseases; Respiratory function; Risk; Single-nucleotide polymorphism; Smoking; Smoking - adverse effects; cardiac function; polygenic and gene–environment interaction risk score (PGIRS); lung function; depression