Fibrosis Progression in Patients with Budd–Chiari Syndrome and Transjugular Intrahepatic Portosystemic Shunt (TIPS): A Long-Term Study Using Transient Elastography

• Published in: Diagnostics (Basel) Vol. 14; no. 3; p. 344
• Main Authors: Rössle, Martin, Bettinger, Dominik, Sturm, Lukas, Reincke, Marlene, Thimme, Robert, Schultheiss, Michael
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2024
• Subjects: Angioplasty; Ascites; Budd–Chiari syndrome; Care and treatment; Chronic illnesses; cirrhosis; Development and progression; FibroScan; Fibrosis; Flow velocity; Hepatitis; Hypertension; Liver; Liver cirrhosis; Liver diseases; Medical research; Medicine, Experimental; Observational studies; Patients; Stents; Thrombosis; TIPS; transient elastography; Transplantation of organs, tissues, etc; Ultrasonic imaging; Variables; Germany; United States > US; transient elastography; Budd–Chiari syndrome; FibroScan; fibrosis; cirrhosis; TIPS
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics14030344

Hepatic vein outflow obstruction causes congestion of the liver, leading to necrosis, fibrosis, and portal hypertension (PH). A transjugular intrahepatic portosystemic shunt (TIPS) reduces congestion and PH by providing artificial outflow. The aim of the study was to investigate fibrosis progression in patients with Budd–Chiari syndrome (BCS) and TIPS using transient elastography (TE). From 2010 to 2022, 25 patients received 80 TEs using FibroScan®, Echosens, Paris, France (3.2 ± 2.1 per patient). TIPS function was assessed via Doppler ultrasound or radiological intervention. At the time of TE examination, 21 patients had patent shunts. Four patients had occluded shunts but normal pressure gradients during the intervention. The first TE measurement performed 9.8 ± 6.8 years after the BCS diagnosis showed stiffness values of 24.6 ± 11.5 kPa. A second or last measurement performed 7.0 ± 2.9 years after the first measurement showed similar stiffness values of 24.1 ± 15.7 kPa (p = 0.943). Except for three patients, the liver stiffness was always >12 kPa, indicating advanced fibrosis. Stiffness values obtained <5 years (n = 8, 23.8 ± 9.2 kPa) or >5 years after the BCS diagnosis (24.9 ± 12.7 kPa) did not differ (p = 0.907). In addition, stiffness was not related to the interval between BCS and TIPS implantation (p = 0.999). One patient received liver transplantation, and two patients died from non-hepatic causes. Most patients developed mild to moderate cirrhosis, possibly during the early phase of the disease. Timing of TIPS did not influence fibrosis progression. This and the release of portal hypertension may argue in favor of a generous TIPS implantation practice in patients with BCS.