Single‐dose pharmacokinetics of co‐crystal of tramadol–celecoxib: Results of a four‐way randomized open‐label phase I clinical trial in healthy subjects - Videla, Sebastián; Lahjou, Mounia; Vaqué, Anna; Sust, Mariano; Encabo, Mercedes; Soler, Lluis; Sans, Artur; Sicard, Eric; Gascón, Neus; Encina, Gregorio; Plata‐Salamán, Carlos (British journal of clinical pharmacology, 2017)
Keywords: Administration, Oral; Adolescent; Adult; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - blood; Analgesics, Opioid - chemistry; Analgesics, Opioid - pharmacokinetics; Area Under Curve; celecoxib; Celecoxib - administration & dosage; Celecoxib - chemistry; Celecoxib - pharmacokinetics; co‐crystal; Cross-Over Studies; Crystallization; Cyclooxygenase 2 Inhibitors - administration & dosage; Cyclooxygenase 2 Inhibitors - blood; Cyclooxygenase 2 Inhibitors - chemistry; Cyclooxygenase 2 Inhibitors - pharmacokinetics; Drug Administration Schedule; Drug Combinations; Drug Compounding; Female; Half-Life; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; pain; Pharmacokinetics; Quebec; tramadol; Tramadol - administration & dosage; Tramadol - chemistry; Tramadol - pharmacokinetics; Young Adult; pharmacokinetics; tramadol; pain; celecoxib; co-crystal