Cancer phase I clinical trials: efficient dose escalation with overdose control - Babb, James; Rogatko, André; Zacks, Shelemyahu (Statistics in medicine, 1998)
Keywords: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Bayes Theorem; Biological and medical sciences; Clinical trial. Drug monitoring; Clinical Trials, Phase I as Topic - statistics & numerical data; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose - prevention & control; General pharmacology; Humans; Medical sciences; Models, Statistical; Neoplasms - drug therapy; Pharmacology. Drug treatments; Probability; Stochastic Processes; Toxicity; Overdosing; Tolerance limit; Pharmacovigilance; Malignant tumor; Stochastic method; Adaptive method; Statistical method; Ethics; Simulation; Phase I trial; Control method; Effective dose