Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells - Li, Dong; Lu, Yu; Sun, Peng; Feng, Li-Xing; Liu, Miao; Hu, Li-Hong; Wu, Wan-Ying; Jiang, Bao-Hong; Yang, Min; Qu, Xiao-Bo; Guo, De-An; Liu, Xuan (PloS one, 2015)
Keywords: Animals; Anticancer properties; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis; Apoptosis - drug effects; Autophagy; BAX protein; bcl-2-Associated X Protein - metabolism; Benzylisoquinolines - pharmacology; Bisbenzylisoquinoline; Cancer; Cancer therapies; Caspase; Catalytic Domain; Cell cycle; Cell Cycle Checkpoints - drug effects; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Chinese medicine; Cyclin-Dependent Kinase Inhibitor p27 - metabolism; Cytokines; Cytotoxicity; Disease Models, Animal; Enzyme Activation; Enzymes; Erythrocytes; G1 phase; Gene Expression; Gene Knockdown Techniques; Humans; I-kappa B Proteins - metabolism; Inflammatory diseases; Inhibition; Male; Mice; Mouse devices; Overexpression; Penicillin; Prostate cancer; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Proteasome Endopeptidase Complex - chemistry; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; Proteasome inhibitors; Proteasome Inhibitors - pharmacology; Protein Binding; Protein Subunits - antagonists & inhibitors; Proteins; Recombinant Proteins; Substrates; Tetrandrine; Toxicity; Traditional Chinese medicine; Transfection; Tumors; Ubiquitination; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation; China