Association of Caffeine Intake and CYP1A2 Genotype With Ovarian Cancer

• Published in: Nutrition and cancer Vol. 46; no. 1; pp. 23 - 29
• Main Authors: Goodman, Marc T, Tung, Ko-Hui, McDuffie, Katharine, Wilkens, Lynne R, Donlon, Timothy A
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Franklin Institute Press 01.01.2003; Lawrence Erlbaum Associates, Inc; Taylor& Francis
• Subjects: administration & dosage; Adolescent; Adult; adverse effects; Aged; Aged, 80 and over; alleles; animal ovaries; aromatic compounds; Biological and medical sciences; blood; caffeine; Caffeine - administration & dosage; Caffeine - adverse effects; carcinogenicity; Case-Control Studies; confidence interval; Confidence Intervals; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 - genetics; epidemiological studies; epidemiology; Female; Female genital diseases; Genetic Predisposition to Disease; genetics; Genotype; Gynecology. Andrology. Obstetrics; Hawaii; Hawaii - epidemiology; histology; Humans; Medical sciences; metabolism; Middle Aged; Neoplasms, Glandular and Epithelial; Neoplasms, Glandular and Epithelial - epidemiology; Neoplasms, Glandular and Epithelial - genetics; Odds Ratio; ovarian neoplasms; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - genetics; risk; Risk Assessment; Risk Factors; tea; Tumors; vegetable consumption; women; Hawaii; Human; Questionnaire; Genotype; Supplemented diet; Case control study; Malignant tumor; Gene expression; Carcinogenesis; Genetic determinism; Female genital diseases; Ovarian diseases; Ovary; Enzymatic activity; Risk factor; Female; Aromatic compound; Caffeine
• ISSN: 0163-5581; 1532-7914
• DOI: 10.1207/S15327914NC4601_03

Coffee and caffeine consumption has been associated with ovarian cancer risk in several epidemiological studies. CYP1A2 is a key enzyme in the metabolism of coffee and in the activation of heterocyclic aromatic compounds that may be carcinogenic. Data from a preliminary investigation conducted in Hawaii of 164 epithelial ovarian cancer cases and 194 controls were used to examine the hypothesis that coffee and caffeine intake increases the risk of ovarian cancer and that these relations are modified by the CYP1A2 high-inducibility A/A genotype. A personal interview and blood specimen were collected in the subjects' homes. A significant positive trend (p = 0.02) in the odds ratios (ORs) was found with increasing intake of caffeine but not with tea or soda. Regular coffee drinkers were at significantly increased risk (OR = 1.8, 95% confidence interval, CI = 1.1-2.8) of ovarian cancer compared with women who did not drink regular coffee. Women with any CYP1A2 C allele were at similar risk of ovarian cancer (OR = 1.1, 95% CI = 0.7-1.7) compared with women with the A/A genotype. The associations of caffeine and coffee intake with risk were stronger among women with the A/A genotype than among women with any C allele. Somewhat stronger relations of coffee and caffeine intake to risk were found among women with cruciferous vegetable consumption above the median and among cases with mucinous histology. These preliminary data suggest a modest positive association of caffeine and coffee consumption with the OR for ovarian cancer that may be modified by CYP1A2 genotype and exposures, such as cruciferous vegetable consumption, that influence CYP1A2 expression.