Early Application of Citicoline in the Treatment of Acute Stroke：A Meta-analysis of Randomized Controlled Trials

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 36; no. 2; pp. 270 - 277
• Main Author: 石佩玉 周小翠 尹晓雪 许亮亮 张兴明 白宏英
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.04.2016; Department of Neurology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China%Department of Pathology, West China Medical Center of Sichuan University, Chengdu 610000, China%Department of General Surgery, West China Medical Center of Sichuan University, Chengdu 610000, China%Department of Urology, West China Medical Center of Sichuan University, Chengdu 610000, China
• Subjects: Aged; Cytidine Diphosphate Choline - administration & dosage; Cytidine Diphosphate Choline - adverse effects; Cytidine Diphosphate Choline - therapeutic use; Female; Humans; Male; Medicine; Medicine & Public Health; Meta分析; Middle Aged; Nootropic Agents - administration & dosage; Nootropic Agents - adverse effects; Nootropic Agents - therapeutic use; Randomized Controlled Trials as Topic; Stroke - drug therapy; 应用; 急性; 早期; 治疗; 胆碱; 脑卒中; 随机对照试验; meta-analysis; acute stroke; randomized controlled trials; cytidine diphosphate choline
• ISSN: 1672-0733; 1993-1352; 1993-1352
• DOI: 10.1007/s11596-016-1579-6

This study was to evaluate the efficacy and safety of early application of citicoline in the treatment of patients with acute stroke by meta-analysis. Randomized controlled trials published until May 2015 were electronically searched in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, WHO International Clinical Trial Registration Platform, Clinical Trial.gov, and China Biology Medicine disc. Two reviewers independently screened the articles and extracted the data based on the inclusion and exclusion criteria. The quality of included articles was evaluated by using Revman5.0, and meta-analysis was performed. The results showed that 1027 articles were obtained in initial retrieval, and finally 7 articles, involving a total of 4039 cases, were included for analysis. The meta-analysis showed that no significant differences were found in the long-term mortality（OR=0.91, 95% CI 0.07 to 1.09, P=0.30）, the rate of dependency（OR=1.02, 95% CI 0.87 to 1.24, P=0.85）, and the effective rate（OR=0.98, 95% CI 0.84 to 1.14, P=0.82） between citicoline group and control group. The overall rate of adverse events in citicoline group was not significantly different from that in control group（P=0.30）. The quality of included articles reached moderate-low level. In conclusion, citicolne cannot reduce long-term mortality and dependence rate in the treatment of acute stroke, and the effective rate of citivoline may be not better than that of controls but with reliable safety.