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Control (SCS): A separate arm of patients received conventional static cold storage. Participants Total Randomized Trial: 102 patients (26 allocated to dHOPE, 76 to standard cold storage), all receiving donor-after-brain-death (DBD) liver grafts. dHOPE Cohort Analyzed: 26 adult recipients meeting in...

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Bibliographic Details
Published inTransplant international Vol. 38; p. 14820
Main Authors O’Callaghan, John, Fallon, John, Knight, Simon
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media SA 15.05.2025
Frontiers Media S.A
Subjects
Biomarkers
Clinical trials
Cold storage
Conflicts of interest
Cryopreservation
Generative artificial intelligence
Haplotypes
Health Archive
hypothermic oxygenated machine perfusion
immunosupression
Informed consent
kidney transplantation (KT)
Liver
Liver transplantation
liver transplantation (LT)
Metabolism
Patients
randomised controlled trial
Transplants & implants
hypothermic oxygenated machine perfusion
randomised controlled trial
kidney transplantation (KT)
immunosupression
liver transplantation (LT)
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ISSN1432-2277
0934-0874
1432-2277
DOI10.3389/ti.2025.14820

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Summary:Control (SCS): A separate arm of patients received conventional static cold storage. Participants Total Randomized Trial: 102 patients (26 allocated to dHOPE, 76 to standard cold storage), all receiving donor-after-brain-death (DBD) liver grafts. dHOPE Cohort Analyzed: 26 adult recipients meeting inclusion criteria (≥18 years old, informed consent). [...]methodologically there was no formal blinding described, but objective biomarker endpoints reduce detection bias.
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ISSN:1432-2277
0934-0874
1432-2277
DOI:10.3389/ti.2025.14820