Transplant Trial Watch

Control (SCS): A separate arm of patients received conventional static cold storage. Participants Total Randomized Trial: 102 patients (26 allocated to dHOPE, 76 to standard cold storage), all receiving donor-after-brain-death (DBD) liver grafts. dHOPE Cohort Analyzed: 26 adult recipients meeting in...

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Published inTransplant international Vol. 38; p. 14820
Main Authors O’Callaghan, John, Fallon, John, Knight, Simon
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media SA 15.05.2025
Frontiers Media S.A
Subjects
Biomarkers
Clinical trials
Cold storage
Conflicts of interest
Cryopreservation
Generative artificial intelligence
Haplotypes
Health Archive
hypothermic oxygenated machine perfusion
immunosupression
Informed consent
kidney transplantation (KT)
Liver
Liver transplantation
liver transplantation (LT)
Metabolism
Patients
randomised controlled trial
Transplants & implants
hypothermic oxygenated machine perfusion
randomised controlled trial
kidney transplantation (KT)
immunosupression
liver transplantation (LT)
Online AccessGet full text
ISSN1432-2277
0934-0874
1432-2277
DOI10.3389/ti.2025.14820

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Abstract Control (SCS): A separate arm of patients received conventional static cold storage. Participants Total Randomized Trial: 102 patients (26 allocated to dHOPE, 76 to standard cold storage), all receiving donor-after-brain-death (DBD) liver grafts. dHOPE Cohort Analyzed: 26 adult recipients meeting inclusion criteria (≥18 years old, informed consent). [...]methodologically there was no formal blinding described, but objective biomarker endpoints reduce detection bias.
AbstractList Control (SCS): A separate arm of patients received conventional static cold storage. Participants Total Randomized Trial: 102 patients (26 allocated to dHOPE, 76 to standard cold storage), all receiving donor-after-brain-death (DBD) liver grafts. dHOPE Cohort Analyzed: 26 adult recipients meeting inclusion criteria (≥18 years old, informed consent). [...]methodologically there was no formal blinding described, but objective biomarker endpoints reduce detection bias.
Author Fallon, John
Knight, Simon
O’Callaghan, John
AuthorAffiliation 3 Oxford Transplant Centre , Churchill Hospital , Oxford , United Kingdom
1 Centre for Evidence in Transplantation , Nuffield Department of Surgical Sciences , University of Oxford , Oxford , United Kingdom
2 University Hospitals Coventry and Warwickshire , Coventry , United Kingdom
AuthorAffiliation_xml – name: 3 Oxford Transplant Centre , Churchill Hospital , Oxford , United Kingdom
– name: 1 Centre for Evidence in Transplantation , Nuffield Department of Surgical Sciences , University of Oxford , Oxford , United Kingdom
– name: 2 University Hospitals Coventry and Warwickshire , Coventry , United Kingdom
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/40444215$$D View this record in MEDLINE/PubMed
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Keywords hypothermic oxygenated machine perfusion
randomised controlled trial
kidney transplantation (KT)
immunosupression
liver transplantation (LT)
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Snippet Control (SCS): A separate arm of patients received conventional static cold storage. Participants Total Randomized Trial: 102 patients (26 allocated to dHOPE,...
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StartPage 14820
SubjectTerms Biomarkers
Clinical trials
Cold storage
Conflicts of interest
Cryopreservation
Generative artificial intelligence
Haplotypes
Health Archive
hypothermic oxygenated machine perfusion
immunosupression
Informed consent
kidney transplantation (KT)
Liver
Liver transplantation
liver transplantation (LT)
Metabolism
Patients
randomised controlled trial
Transplants & implants
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Title Transplant Trial Watch
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