Association of functional gene polymorphism IL-1β in patients with external apical root resorption
External apical root resorption (EARR) is a frequent complication of orthodontic treatment. Interleukin 1ß (IL-1ß) is a potent stimulus for bone resorption and osteoclastic cell recruitment during orthodontic tooth movement. The purpose of this study was to assess the association between a polymorph...
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| Published in | American journal of orthodontics and dentofacial orthopedics Vol. 136; no. 4; pp. 542 - 546 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Mosby, Inc
01.10.2009
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0889-5406 1097-6752 |
| DOI | 10.1016/j.ajodo.2007.10.051 |
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| Abstract | External apical root resorption (EARR) is a frequent complication of orthodontic treatment. Interleukin 1ß (IL-1ß) is a potent stimulus for bone resorption and osteoclastic cell recruitment during orthodontic tooth movement. The purpose of this study was to assess the association between a polymorphism in the IL-1β genes and EARR during orthodontic treatment.
The sample included 61 Brazilian orthodontic patients, divided into 2 groups according to the presence (affected group, n = 23) or absence (control group, n = 38) of EARR in the central and lateral maxillary incisors in the posttreatment period. DNA was obtained from buccal swab cells. The polymorphism was analyzed by the polymerase chain reaction followed by digestion with restriction enzyme. The polymerase chain reaction products were analyzed in 10% polyacrylamide gel and stained with silver.
There were significant statistical differences (
P <0.05) among the frequencies of the alleles and genotypes of the IL-1β gene polymorphism between the affected and unaffected groups, suggesting that allele 1 predisposed the subjects to EARR (odds ratio = 4.0).
The polymorphism of the IL-1β gene is associated with root resorption in the studied population. |
|---|---|
| AbstractList | External apical root resorption (EARR) is a frequent complication of orthodontic treatment. Interleukin 1ß (IL-1ß) is a potent stimulus for bone resorption and osteoclastic cell recruitment during orthodontic tooth movement. The purpose of this study was to assess the association between a polymorphism in the IL-1β genes and EARR during orthodontic treatment.
The sample included 61 Brazilian orthodontic patients, divided into 2 groups according to the presence (affected group, n = 23) or absence (control group, n = 38) of EARR in the central and lateral maxillary incisors in the posttreatment period. DNA was obtained from buccal swab cells. The polymorphism was analyzed by the polymerase chain reaction followed by digestion with restriction enzyme. The polymerase chain reaction products were analyzed in 10% polyacrylamide gel and stained with silver.
There were significant statistical differences (
P <0.05) among the frequencies of the alleles and genotypes of the IL-1β gene polymorphism between the affected and unaffected groups, suggesting that allele 1 predisposed the subjects to EARR (odds ratio = 4.0).
The polymorphism of the IL-1β gene is associated with root resorption in the studied population. IntroductionExternal apical root resorption (EARR) is a frequent complication of orthodontic treatment. Interleukin 1ß (IL-1ß) is a potent stimulus for bone resorption and osteoclastic cell recruitment during orthodontic tooth movement. The purpose of this study was to assess the association between a polymorphism in the IL-1β genes and EARR during orthodontic treatment. MethodsThe sample included 61 Brazilian orthodontic patients, divided into 2 groups according to the presence (affected group, n = 23) or absence (control group, n = 38) of EARR in the central and lateral maxillary incisors in the posttreatment period. DNA was obtained from buccal swab cells. The polymorphism was analyzed by the polymerase chain reaction followed by digestion with restriction enzyme. The polymerase chain reaction products were analyzed in 10% polyacrylamide gel and stained with silver. ResultsThere were significant statistical differences ( P <0.05) among the frequencies of the alleles and genotypes of the IL-1β gene polymorphism between the affected and unaffected groups, suggesting that allele 1 predisposed the subjects to EARR (odds ratio = 4.0). ConclusionsThe polymorphism of the IL-1β gene is associated with root resorption in the studied population. |
| Author | Costa, Fernando Oliveira Miranda Cota, Luís Otávio Brito, Rui Barbosa Pretti, Henrique Lages, Eugênio José Pereira Gontijo, Amanda Ianotta Bastos Lages, Elizabeth Maria Drummond, Alexandre Fortes |
| Author_xml | – sequence: 1 givenname: Elizabeth Maria surname: Bastos Lages fullname: Bastos Lages, Elizabeth Maria email: bethlages@uai.com.br organization: Professor, Department of Orthodontics, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil – sequence: 2 givenname: Alexandre Fortes surname: Drummond fullname: Drummond, Alexandre Fortes organization: Professor, Department of Orthodontics, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil – sequence: 3 givenname: Henrique surname: Pretti fullname: Pretti, Henrique organization: Professor, Department of Orthodontics, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil – sequence: 4 givenname: Fernando Oliveira surname: Costa fullname: Costa, Fernando Oliveira organization: Professor, Department of Periodontology, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil – sequence: 5 givenname: Eugênio José Pereira surname: Lages fullname: Lages, Eugênio José Pereira organization: Postgraduate student, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil – sequence: 6 givenname: Amanda Ianotta surname: Gontijo fullname: Gontijo, Amanda Ianotta organization: Postgraduate student, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil – sequence: 7 givenname: Luís Otávio surname: Miranda Cota fullname: Miranda Cota, Luís Otávio organization: Postgraduate student, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil – sequence: 8 givenname: Rui Barbosa surname: Brito fullname: Brito, Rui Barbosa organization: Professor, Department of Molecular Biology, Dental School, São Leopoldo Mandic, Campinas, São Paulo, Brazil |
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| Keywords | Human Tooth root Orthodontic procedures Association Gene Resorption Interleukin 1β Dentistry Polymorphism |
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| Snippet | External apical root resorption (EARR) is a frequent complication of orthodontic treatment. Interleukin 1ß (IL-1ß) is a potent stimulus for bone resorption and... IntroductionExternal apical root resorption (EARR) is a frequent complication of orthodontic treatment. Interleukin 1ß (IL-1ß) is a potent stimulus for bone... |
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| SubjectTerms | Biological and medical sciences Dentistry Medical sciences Otorhinolaryngology. Stomatology |
| Title | Association of functional gene polymorphism IL-1β in patients with external apical root resorption |
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