Korean Patients with Superwarfarin Intoxication and Their Outcome
This observational study aimed at evaluating recent superwarfarin intoxication of Korean patients. Ten patients were diagnosed as or highly suspicious for superwarfarin intoxication. Case report forms described by attending hematologists of the patients were collected and analyzed. Bleeding symptoms...
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| Published in | Journal of Korean medical science Vol. 25; no. 12; pp. 1754 - 1758 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Academy of Medical Sciences
01.12.2010
대한의학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1011-8934 1598-6357 1598-6357 |
| DOI | 10.3346/jkms.2010.25.12.1754 |
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| Abstract | This observational study aimed at evaluating recent superwarfarin intoxication of Korean patients. Ten patients were diagnosed as or highly suspicious for superwarfarin intoxication. Case report forms described by attending hematologists of the patients were collected and analyzed. Bleeding symptoms were varied among the patients. Patients uniformly showed prolonged prothrombin time (PT) and activated thromboplastin time (aPTT) with decreased activity of vitamin K dependent coagulation factors. Positive serum brodifacoum test results in 4 of 5 requested patients contributed to confirmatory diagnosis. Psychiatric interview revealed an attempted ingestion in one patient. High dose vitamin K1 therapy promptly corrected prolonged PT and aPTT, but hasty discontinuation caused repeated bleeding diathesis in 6 patients. Route of intoxication was unknown or not definite among 8 of 10 patients. Three patients had a possibility of environmental exposure considering their occupations: there might be intoxication by transdermal absorption or inhalation. Therefore, high dose and prolonged use of vitamin K1 therapy is necessary for effective detoxification. Further detailed investigation on environmental exposure and efforts to improve availability of the blood level test in clinic are requested. |
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| AbstractList | This observational study aimed at evaluating recent superwarfarin intoxication of Korean patients. Ten patients were diagnosed as or highly suspicious for superwarfarin intoxication. Case report forms described by attending hematologists of the patients were collected and analyzed. Bleeding symptoms were varied among the patients. Patients uniformly showed prolonged prothrombin time (PT) and activated thromboplastin time (aPTT) with decreased activity of vitamin K dependent coagulation factors. Positive serum brodifacoum test results in 4 of 5 requested patients contributed to confirmatory diagnosis. Psychiatric interview revealed an attempted ingestion in one patient. High dose vitamin K1 therapy promptly corrected prolonged PT and aPTT, but hasty discontinuation caused repeated bleeding diathesis in 6 patients. Route of intoxication was unknown or not definite among 8 of 10 patients. Three patients had a possibility of environmental exposure considering their occupations: there might be intoxication by transdermal absorption or inhalation. Therefore, high dose and prolonged use of vitamin K1 therapy is necessary for effective detoxification. Further detailed investigation on environmental exposure and efforts to improve availability of the blood level test in clinic are requested.This observational study aimed at evaluating recent superwarfarin intoxication of Korean patients. Ten patients were diagnosed as or highly suspicious for superwarfarin intoxication. Case report forms described by attending hematologists of the patients were collected and analyzed. Bleeding symptoms were varied among the patients. Patients uniformly showed prolonged prothrombin time (PT) and activated thromboplastin time (aPTT) with decreased activity of vitamin K dependent coagulation factors. Positive serum brodifacoum test results in 4 of 5 requested patients contributed to confirmatory diagnosis. Psychiatric interview revealed an attempted ingestion in one patient. High dose vitamin K1 therapy promptly corrected prolonged PT and aPTT, but hasty discontinuation caused repeated bleeding diathesis in 6 patients. Route of intoxication was unknown or not definite among 8 of 10 patients. Three patients had a possibility of environmental exposure considering their occupations: there might be intoxication by transdermal absorption or inhalation. Therefore, high dose and prolonged use of vitamin K1 therapy is necessary for effective detoxification. Further detailed investigation on environmental exposure and efforts to improve availability of the blood level test in clinic are requested. This observational study aimed at evaluating recent superwarfarin intoxication of Korean patients. Ten patients were diagnosed as or highly suspicious for superwarfarin intoxication. Case report forms described by attending hematologists of the patients were collected and analyzed. Bleeding symptoms were varied among the patients. Patients uniformly showed prolonged prothrombin time (PT) and activated thromboplastin time (aPTT) with decreased activity of vitamin K dependent coagulation factors. Positive serum brodifacoum test results in 4 of 5 requested patients contributed to confirmatory diagnosis. Psychiatric interview revealed an attempted ingestion in one patient. High dose vitamin K1 therapy promptly corrected prolonged PT and aPTT, but hasty discontinuation caused repeated bleeding diathesis in 6 patients. Route of intoxication was unknown or not definite among 8 of 10 patients. Three patients had a possibility of environmental exposure considering their occupations: there might be intoxication by transdermal absorption or inhalation. Therefore, high dose and prolonged use of vitamin K1 therapy is necessary for effective detoxification. Further detailed investigation on environmental exposure and efforts to improve availability of the blood level test in clinic are requested. This observational study aimed at evaluating recent superwarfarin intoxication of Korean patients. Ten patients were diagnosed as or highly suspicious for superwarfarin intoxication. Case report forms described by attending hematologists of the patients were collected and analyzed. Bleeding symptoms were varied among the patients. Patients uniformly showed prolonged prothrombin time (PT) and activated thromboplastin time (aPTT) with decreased activity of vitamin K dependent coagulation factors. Positive serum brodifacoum test results in 4 of 5 requested patients contributed to confirmatory diagnosis. Psychiatric interview revealed an attempted ingestion in one patient. High dose vitamin K1 therapy promptly corrected prolonged PT and aPTT, but hasty discontinuation caused repeated bleeding diathesis in 6 patients. Route of intoxication was unknown or not definite among 8 of 10 patients. Three patients had a possibility of environmental exposure considering their occupations: there might be intoxication by transdermal absorption or inhalation. Therefore, high dose and prolonged use of vitamin K1 therapy is necessary for effective detoxification. Further detailed investigation on environmental exposure and efforts to improve availability of the blood level test in clinic are requested. KCI Citation Count: 2 |
| Author | Hong, Junshik Yhim, Ho-Young Bang, Soo-Mee Yoon, Hwi-Joong Kim, Seung Taik Yuh, Young Jin Bae, Sung Hwa Yoon, Sung-Soo Chi, Hyun-Sook |
| AuthorAffiliation | 5 Department of Internal Medicine, Sanggye-Paik Hospital, Inje University College of Medicine, Seoul, Korea 1 Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science Graduate School of Medicine, Incheon, Korea 7 Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Korea 8 Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University School of Medicine, Cheongju, Korea 2 Department of Internal Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea 3 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea 4 Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University College of Medicine, Daegu, Korea 9 Department of Laboratory Medicine, Seoul Asan Medical Center, University o |
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| Cites_doi | 10.1097/01.mbc.0000169215.70184.56 10.1182/blood.V76.12.2555.2555 10.1016/0006-2952(82)90587-1 10.5045/kjh.2009.44.1.53 10.1016/0379-0738(95)01835-2 10.1001/archinte.158.17.1929 10.3109/15563650903438566 10.1016/S0140-6736(05)17916-1 10.1067/mem.2000.108317 10.1016/0736-4679(89)90010-3 10.1002/jat.1179 10.1111/j.1365-2125.1984.tb02526.x 10.1002/ajh.20784 10.1017/S002217240006928X 10.1007/s12185-009-0374-6 |
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| References | Park (10.3346/jkms.2010.25.12.1754_ref7) 1982; 31 Chow (10.3346/jkms.2010.25.12.1754_ref10) 1992; 147 Chua (10.3346/jkms.2010.25.12.1754_ref1) 1998; 158 Wu (10.3346/jkms.2010.25.12.1754_ref16) 2009; 90 Laurence (10.3346/jkms.2010.25.12.1754_ref6) 1973 Katona (10.3346/jkms.2010.25.12.1754_ref12) 1989; 7 Park (10.3346/jkms.2010.25.12.1754_ref13) 1984; 18 Kim (10.3346/jkms.2010.25.12.1754_ref3) 1996; 31 Pavlu (10.3346/jkms.2010.25.12.1754_ref14) 2005; 365 Jin (10.3346/jkms.2010.25.12.1754_ref18) 2007; 27 Spahr (10.3346/jkms.2010.25.12.1754_ref15) 2007; 82 Lee (10.3346/jkms.2010.25.12.1754_ref4) 2009; 44 Bruno (10.3346/jkms.2010.25.12.1754_ref19) 2000; 36 Kim (10.3346/jkms.2010.25.12.1754_ref5) 2010; 40 Zupancić-Salek (10.3346/jkms.2010.25.12.1754_ref17) 2005; 16 Weitzel (10.3346/jkms.2010.25.12.1754_ref9) 1990; 76 Hui (10.3346/jkms.2010.25.12.1754_ref11) 1996; 78 Bronstein (10.3346/jkms.2010.25.12.1754_ref2) 2009; 47 Lund (10.3346/jkms.2010.25.12.1754_ref8) 1981; 87 15870542 - Blood Coagul Fibrinolysis. 2005 Jun;16(4):239-44 8855043 - Forensic Sci Int. 1996 Mar 5;78(1):13-8 20028214 - Clin Toxicol (Phila). 2009 Dec;47(10):911-1084 2265249 - Blood. 1990 Dec 15;76(12):2555-9 17177169 - J Appl Toxicol. 2007 Jan-Feb;27(1):18-24 15708110 - Lancet. 2005 Feb 12-18;365(9459):628 7181945 - Biochem Pharmacol. 1982 Nov 15;31(22):3635-9 7019316 - J Hyg (Lond). 1981 Aug;87(1):101-7 10969235 - Ann Emerg Med. 2000 Sep;36(3):262-7 1393889 - CMAJ. 1992 Jul 1;147(1):60-2 2696752 - J Emerg Med. 1989 Nov-Dec;7(6):627-31 17022046 - Am J Hematol. 2007 Jul;82(7):656-60 19588218 - Int J Hematol. 2009 Sep;90(2):170-3 20689146 - Ann Clin Lab Sci. 2010 Summer;40(3):300-3 6508974 - Br J Clin Pharmacol. 1984 Nov;18(5):655-62 9759690 - Arch Intern Med. 1998 Sep 28;158(17):1929-32 |
| References_xml | – volume: 16 start-page: 239 year: 2005 ident: 10.3346/jkms.2010.25.12.1754_ref17 publication-title: Blood Coagul Fibrinolysis doi: 10.1097/01.mbc.0000169215.70184.56 – volume: 76 start-page: 2555 year: 1990 ident: 10.3346/jkms.2010.25.12.1754_ref9 publication-title: Blood doi: 10.1182/blood.V76.12.2555.2555 – volume: 31 start-page: 3635 year: 1982 ident: 10.3346/jkms.2010.25.12.1754_ref7 publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(82)90587-1 – volume: 44 start-page: 53 year: 2009 ident: 10.3346/jkms.2010.25.12.1754_ref4 publication-title: Korean J Hematol doi: 10.5045/kjh.2009.44.1.53 – start-page: 234 volume-title: Clinical pharmacholgy year: 1973 ident: 10.3346/jkms.2010.25.12.1754_ref6 – volume: 78 start-page: 13 year: 1996 ident: 10.3346/jkms.2010.25.12.1754_ref11 publication-title: Forensic Sci Int doi: 10.1016/0379-0738(95)01835-2 – volume: 158 start-page: 1929 year: 1998 ident: 10.3346/jkms.2010.25.12.1754_ref1 publication-title: Arch Intern Med doi: 10.1001/archinte.158.17.1929 – volume: 47 start-page: 911 year: 2009 ident: 10.3346/jkms.2010.25.12.1754_ref2 publication-title: Clin Toxicol (Phila) doi: 10.3109/15563650903438566 – volume: 31 start-page: 473 year: 1996 ident: 10.3346/jkms.2010.25.12.1754_ref3 publication-title: Korean J Hematol – volume: 40 start-page: 300 year: 2010 ident: 10.3346/jkms.2010.25.12.1754_ref5 publication-title: Ann Clin Lab Sci – volume: 365 start-page: 628 year: 2005 ident: 10.3346/jkms.2010.25.12.1754_ref14 publication-title: Lancet doi: 10.1016/S0140-6736(05)17916-1 – volume: 36 start-page: 262 year: 2000 ident: 10.3346/jkms.2010.25.12.1754_ref19 publication-title: Ann Emerg Med doi: 10.1067/mem.2000.108317 – volume: 7 start-page: 627 year: 1989 ident: 10.3346/jkms.2010.25.12.1754_ref12 publication-title: J Emerg Med doi: 10.1016/0736-4679(89)90010-3 – volume: 147 start-page: 60 year: 1992 ident: 10.3346/jkms.2010.25.12.1754_ref10 publication-title: CMAJ – volume: 27 start-page: 18 year: 2007 ident: 10.3346/jkms.2010.25.12.1754_ref18 publication-title: J Appl Toxicol doi: 10.1002/jat.1179 – volume: 18 start-page: 655 year: 1984 ident: 10.3346/jkms.2010.25.12.1754_ref13 publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.1984.tb02526.x – volume: 82 start-page: 656 year: 2007 ident: 10.3346/jkms.2010.25.12.1754_ref15 publication-title: Am J Hematol doi: 10.1002/ajh.20784 – volume: 87 start-page: 101 year: 1981 ident: 10.3346/jkms.2010.25.12.1754_ref8 publication-title: J Hyg (Lond) doi: 10.1017/S002217240006928X – volume: 90 start-page: 170 year: 2009 ident: 10.3346/jkms.2010.25.12.1754_ref16 publication-title: Int J Hematol doi: 10.1007/s12185-009-0374-6 – reference: 7181945 - Biochem Pharmacol. 1982 Nov 15;31(22):3635-9 – reference: 8855043 - Forensic Sci Int. 1996 Mar 5;78(1):13-8 – reference: 17022046 - Am J Hematol. 2007 Jul;82(7):656-60 – reference: 19588218 - Int J Hematol. 2009 Sep;90(2):170-3 – reference: 7019316 - J Hyg (Lond). 1981 Aug;87(1):101-7 – reference: 10969235 - Ann Emerg Med. 2000 Sep;36(3):262-7 – reference: 15870542 - Blood Coagul Fibrinolysis. 2005 Jun;16(4):239-44 – reference: 2265249 - Blood. 1990 Dec 15;76(12):2555-9 – reference: 2696752 - J Emerg Med. 1989 Nov-Dec;7(6):627-31 – reference: 9759690 - Arch Intern Med. 1998 Sep 28;158(17):1929-32 – reference: 20689146 - Ann Clin Lab Sci. 2010 Summer;40(3):300-3 – reference: 1393889 - CMAJ. 1992 Jul 1;147(1):60-2 – reference: 15708110 - Lancet. 2005 Feb 12-18;365(9459):628 – reference: 6508974 - Br J Clin Pharmacol. 1984 Nov;18(5):655-62 – reference: 17177169 - J Appl Toxicol. 2007 Jan-Feb;27(1):18-24 – reference: 20028214 - Clin Toxicol (Phila). 2009 Dec;47(10):911-1084 |
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| SubjectTerms | 4-Hydroxycoumarins - poisoning Adult Aged Aged, 80 and over Anticoagulants - poisoning Antifibrinolytic Agents - therapeutic use Environmental Exposure Female Hemorrhage - chemically induced Hemorrhage - diagnosis Hemorrhage - drug therapy Humans Male Middle Aged Original Partial Thromboplastin Time Prothrombin Time Republic of Korea Treatment Outcome Vitamin K 1 - therapeutic use 의학일반 |
| Title | Korean Patients with Superwarfarin Intoxication and Their Outcome |
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