Subjective cognitive decline: The first clinical manifestation of Alzheimer's disease?
ABSTRACT Background: Mild cognitive impairment is considered as the first clinical manifestation of Alzheimer's disease (AD), when the individual exhibits below performance on standardized neuropsychological tests. However, some subjects before having a lower performance on cognitive assessment...
Saved in:
| Published in | Dementia & neuropsychologia Vol. 10; no. 3; pp. 170 - 177 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Brazil
Associação de Neurologia Cognitiva e do Comportamento
01.07.2016
Associação Neurologia Cognitiva e do Comportamento |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1980-5764 1980-5764 |
| DOI | 10.1590/S1980-5764-2016DN1003002 |
Cover
| Abstract | ABSTRACT Background: Mild cognitive impairment is considered as the first clinical manifestation of Alzheimer's disease (AD), when the individual exhibits below performance on standardized neuropsychological tests. However, some subjects before having a lower performance on cognitive assessments already have a subjective memory complaint. Objective: A review about subjective cognitive decline, the association with AD biomarkers and risk of conversion to dementia. Methods: We performed a comprehensive non-systematic review on PubMed. The keywords used in the search were terms related to subjective cognitive decline. Results: Subjective cognitive decline is characterized by self-experience of deterioration in cognitive performance not detected objectively through formal neuropsychological testing. However, various terms and definitions have been used in the literature and the lack of a widely accepted concept hampers comparison of studies. Epidemiological data have shown that individuals with subjective cognitive decline are at increased risk of progression to AD dementia. In addition, there is evidence that this group has a higher prevalence of positive biomarkers for amyloidosis and neurodegeneration. However, Alzheimer's disease is not the only cause of subjective cognitive decline and various other conditions can be associated with subjective memory complaints, such as psychiatric disorders or normal aging. The features suggestive of a neurodegenerative disorder are: onset of decline within the last five years, age at onset above 60 years, associated concerns about decline and confirmation by an informant. Conclusion: These findings support the idea that subjective cognitive complaints may be an early clinical marker that precedes mild cognitive impairment due to Alzheimer's disease.
RESUMO Introdução: O comprometimento cognitivo leve é considerado como a primeira manifestação clínica da doença de Alzheimer, quando o indivíduo exibe um desempenho abaixo para idade e escolaridade em testes neuropsicológicos padronizados. No entanto, alguns já apresentam uma queixa subjetiva de memória antes doprejuízo nas avaliações cognitivas. Objetivo: Fazer uma revisão sobre o declínio cognitivo subjetivo, a associação com biomarcadores da doença de Alzheimer e o risco de conversão para demência. Métodos: Realizou-se uma revisão não-sistemática no PubMed. As palavras-chave utilizadas na busca foram relacionadas ao declínio cognitivo subjetivo. Resultados: O declínio cognitivo subjetivo é caracterizada por uma autoexperiência da deterioração no desempenho cognitivo não detectado objetivamente por meio de testes neuropsicológicos formais. Todavia, vários termos e definições são utilizados na literatura e a falta de um conceito largamente aceito dificulta uma comparação. Os dados epidemiológicos mostram que indivíduos com declínio cognitivo subjetivo estão em maior risco de progressão para demência. Além disso, há evidências de que este grupo tem maior prevalência de biomarcadores positivos para amiloidose e neurodegeneração. Porém, a doença de Alzheimer não é a única causa e várias outras condições podem estar associadas, tais como distúrbios psiquiátricos ou o envelhecimento normal. As características sugestivas de uma doença neurodegenerativa são: início nos últimos cinco anos, início acima de 60 anos, estar preocupado com declínio e confirmação por um informante. Conclusão: Estes resultados suportam a ideia de que o declínio cognitivo subjetivo pode ser um marcador clínico precoce que precede comprometimento cognitivo leve devido à doença de Alzheimer. |
|---|---|
| AbstractList | ABSTRACT Background: Mild cognitive impairment is considered as the first clinical manifestation of Alzheimer's disease (AD), when the individual exhibits below performance on standardized neuropsychological tests. However, some subjects before having a lower performance on cognitive assessments already have a subjective memory complaint. Objective: A review about subjective cognitive decline, the association with AD biomarkers and risk of conversion to dementia. Methods: We performed a comprehensive non-systematic review on PubMed. The keywords used in the search were terms related to subjective cognitive decline. Results: Subjective cognitive decline is characterized by self-experience of deterioration in cognitive performance not detected objectively through formal neuropsychological testing. However, various terms and definitions have been used in the literature and the lack of a widely accepted concept hampers comparison of studies. Epidemiological data have shown that individuals with subjective cognitive decline are at increased risk of progression to AD dementia. In addition, there is evidence that this group has a higher prevalence of positive biomarkers for amyloidosis and neurodegeneration. However, Alzheimer's disease is not the only cause of subjective cognitive decline and various other conditions can be associated with subjective memory complaints, such as psychiatric disorders or normal aging. The features suggestive of a neurodegenerative disorder are: onset of decline within the last five years, age at onset above 60 years, associated concerns about decline and confirmation by an informant. Conclusion: These findings support the idea that subjective cognitive complaints may be an early clinical marker that precedes mild cognitive impairment due to Alzheimer's disease. ABSTRACT Background: Mild cognitive impairment is considered as the first clinical manifestation of Alzheimer's disease (AD), when the individual exhibits below performance on standardized neuropsychological tests. However, some subjects before having a lower performance on cognitive assessments already have a subjective memory complaint. Objective: A review about subjective cognitive decline, the association with AD biomarkers and risk of conversion to dementia. Methods: We performed a comprehensive non-systematic review on PubMed. The keywords used in the search were terms related to subjective cognitive decline. Results: Subjective cognitive decline is characterized by self-experience of deterioration in cognitive performance not detected objectively through formal neuropsychological testing. However, various terms and definitions have been used in the literature and the lack of a widely accepted concept hampers comparison of studies. Epidemiological data have shown that individuals with subjective cognitive decline are at increased risk of progression to AD dementia. In addition, there is evidence that this group has a higher prevalence of positive biomarkers for amyloidosis and neurodegeneration. However, Alzheimer's disease is not the only cause of subjective cognitive decline and various other conditions can be associated with subjective memory complaints, such as psychiatric disorders or normal aging. The features suggestive of a neurodegenerative disorder are: onset of decline within the last five years, age at onset above 60 years, associated concerns about decline and confirmation by an informant. Conclusion: These findings support the idea that subjective cognitive complaints may be an early clinical marker that precedes mild cognitive impairment due to Alzheimer's disease. RESUMO Introdução: O comprometimento cognitivo leve é considerado como a primeira manifestação clínica da doença de Alzheimer, quando o indivíduo exibe um desempenho abaixo para idade e escolaridade em testes neuropsicológicos padronizados. No entanto, alguns já apresentam uma queixa subjetiva de memória antes doprejuízo nas avaliações cognitivas. Objetivo: Fazer uma revisão sobre o declínio cognitivo subjetivo, a associação com biomarcadores da doença de Alzheimer e o risco de conversão para demência. Métodos: Realizou-se uma revisão não-sistemática no PubMed. As palavras-chave utilizadas na busca foram relacionadas ao declínio cognitivo subjetivo. Resultados: O declínio cognitivo subjetivo é caracterizada por uma autoexperiência da deterioração no desempenho cognitivo não detectado objetivamente por meio de testes neuropsicológicos formais. Todavia, vários termos e definições são utilizados na literatura e a falta de um conceito largamente aceito dificulta uma comparação. Os dados epidemiológicos mostram que indivíduos com declínio cognitivo subjetivo estão em maior risco de progressão para demência. Além disso, há evidências de que este grupo tem maior prevalência de biomarcadores positivos para amiloidose e neurodegeneração. Porém, a doença de Alzheimer não é a única causa e várias outras condições podem estar associadas, tais como distúrbios psiquiátricos ou o envelhecimento normal. As características sugestivas de uma doença neurodegenerativa são: início nos últimos cinco anos, início acima de 60 anos, estar preocupado com declínio e confirmação por um informante. Conclusão: Estes resultados suportam a ideia de que o declínio cognitivo subjetivo pode ser um marcador clínico precoce que precede comprometimento cognitivo leve devido à doença de Alzheimer. Mild cognitive impairment is considered as the first clinical manifestation of Alzheimer's disease (AD), when the individual exhibits below performance on standardized neuropsychological tests. However, some subjects before having a lower performance on cognitive assessments already have a subjective memory complaint. A review about subjective cognitive decline, the association with AD biomarkers and risk of conversion to dementia. We performed a comprehensive non-systematic review on PubMed. The keywords used in the search were terms related to subjective cognitive decline. Subjective cognitive decline is characterized by self-experience of deterioration in cognitive performance not detected objectively through formal neuropsychological testing. However, various terms and definitions have been used in the literature and the lack of a widely accepted concept hampers comparison of studies. Epidemiological data have shown that individuals with subjective cognitive decline are at increased risk of progression to AD dementia. In addition, there is evidence that this group has a higher prevalence of positive biomarkers for amyloidosis and neurodegeneration. However, Alzheimer's disease is not the only cause of subjective cognitive decline and various other conditions can be associated with subjective memory complaints, such as psychiatric disorders or normal aging. The features suggestive of a neurodegenerative disorder are: onset of decline within the last five years, age at onset above 60 years, associated concerns about decline and confirmation by an informant. These findings support the idea that subjective cognitive complaints may be an early clinical marker that precedes mild cognitive impairment due to Alzheimer's disease. Mild cognitive impairment is considered as the first clinical manifestation of Alzheimer's disease (AD), when the individual exhibits below performance on standardized neuropsychological tests. However, some subjects before having a lower performance on cognitive assessments already have a subjective memory complaint.BACKGROUNDMild cognitive impairment is considered as the first clinical manifestation of Alzheimer's disease (AD), when the individual exhibits below performance on standardized neuropsychological tests. However, some subjects before having a lower performance on cognitive assessments already have a subjective memory complaint.A review about subjective cognitive decline, the association with AD biomarkers and risk of conversion to dementia.OBJECTIVEA review about subjective cognitive decline, the association with AD biomarkers and risk of conversion to dementia.We performed a comprehensive non-systematic review on PubMed. The keywords used in the search were terms related to subjective cognitive decline.METHODSWe performed a comprehensive non-systematic review on PubMed. The keywords used in the search were terms related to subjective cognitive decline.Subjective cognitive decline is characterized by self-experience of deterioration in cognitive performance not detected objectively through formal neuropsychological testing. However, various terms and definitions have been used in the literature and the lack of a widely accepted concept hampers comparison of studies. Epidemiological data have shown that individuals with subjective cognitive decline are at increased risk of progression to AD dementia. In addition, there is evidence that this group has a higher prevalence of positive biomarkers for amyloidosis and neurodegeneration. However, Alzheimer's disease is not the only cause of subjective cognitive decline and various other conditions can be associated with subjective memory complaints, such as psychiatric disorders or normal aging. The features suggestive of a neurodegenerative disorder are: onset of decline within the last five years, age at onset above 60 years, associated concerns about decline and confirmation by an informant.RESULTSSubjective cognitive decline is characterized by self-experience of deterioration in cognitive performance not detected objectively through formal neuropsychological testing. However, various terms and definitions have been used in the literature and the lack of a widely accepted concept hampers comparison of studies. Epidemiological data have shown that individuals with subjective cognitive decline are at increased risk of progression to AD dementia. In addition, there is evidence that this group has a higher prevalence of positive biomarkers for amyloidosis and neurodegeneration. However, Alzheimer's disease is not the only cause of subjective cognitive decline and various other conditions can be associated with subjective memory complaints, such as psychiatric disorders or normal aging. The features suggestive of a neurodegenerative disorder are: onset of decline within the last five years, age at onset above 60 years, associated concerns about decline and confirmation by an informant.These findings support the idea that subjective cognitive complaints may be an early clinical marker that precedes mild cognitive impairment due to Alzheimer's disease.CONCLUSIONThese findings support the idea that subjective cognitive complaints may be an early clinical marker that precedes mild cognitive impairment due to Alzheimer's disease. |
| Author | Nitrini, Ricardo Studart Neto, Adalberto |
| AuthorAffiliation | Universidade de São Paulo |
| AuthorAffiliation_xml | – name: Universidade de São Paulo |
| Author_xml | – sequence: 1 givenname: Adalberto surname: Studart Neto fullname: Studart Neto, Adalberto organization: Universidade de São Paulo, Brazil – sequence: 2 givenname: Ricardo surname: Nitrini fullname: Nitrini, Ricardo organization: Universidade de São Paulo, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29213452$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUk1v1DAQjVARLaV_AeUGlxR_xjYHUFVoqVTBoYWr5TiTXa8cu9hJJfj1eHfbssuFk0fz8d7zm3lZHYQYoKpqjE4xV-jdDVYSNVy0rCEIt5--YoQoQuRZdfRUOdiJD6uTnFcIIcxbhDF9UR0SRTBlnBxVP27mbgV2cvdQ27gIbhP1YL0L8L6-XUI9uJSnep1w1vh6NMENkCczuRjqONRn_vcS3AjpTa57l8Fk-Piqej4Yn-Hk4T2uvl98vj3_0lx_u7w6P7tuLGOINAKxfpCKmr4FAQIBEC4GCxI6hHppi95WdVgaSyWjpRmIUIBbq5iElnJ6XF1tcftoVvouudGkXzoapzeJmBbapMlZD5pbyZlhQzcYwwTtle2IanEHnFlrhSxYp1usbB34qFdxTqGI1xvD9drKtd9o4zYWqAx82A7czd0IvYUwJeP3VOxXglvqRbzXvCAxTArA2weAFH_OxVM9umzBexMgzlljJagq3IqW1te7XE8kj5v8K8ammHOCQVu33VGhdl5jpNfXs_MZvXc9BUD-A_DI8d_RP-NtxnA |
| CitedBy_id | crossref_primary_10_1053_j_jvca_2023_04_035 crossref_primary_10_1080_17437199_2022_2132980 crossref_primary_10_3389_fpsyg_2022_921062 crossref_primary_10_3389_fimmu_2022_997240 crossref_primary_10_1016_j_clineuro_2024_108365 crossref_primary_10_1590_1980_5764_dn_2022_s101en crossref_primary_10_3233_JAD_190624 crossref_primary_10_3390_jcm11236964 crossref_primary_10_3390_jcm8111900 crossref_primary_10_1177_07334648211058718 crossref_primary_10_1097_HTR_0000000000001027 crossref_primary_10_14309_ajg_0000000000002980 crossref_primary_10_1017_S1355617720001137 crossref_primary_10_1080_13607863_2020_1861214 crossref_primary_10_3928_00989134_20220110_01 crossref_primary_10_1556_650_2021_32130 crossref_primary_10_3233_JAD_190495 crossref_primary_10_2196_64149 crossref_primary_10_1145_3511906 crossref_primary_10_1073_pnas_2204933120 crossref_primary_10_1016_j_neurobiolaging_2019_07_011 crossref_primary_10_1093_ndt_gfab338 crossref_primary_10_3390_ijms21072658 crossref_primary_10_3233_JAD_200880 crossref_primary_10_1016_j_jpsychores_2023_111489 crossref_primary_10_3928_00989134_20201106_04 crossref_primary_10_1016_j_aggp_2025_100133 crossref_primary_10_3233_JAD_220501 crossref_primary_10_3389_fnagi_2022_885787 crossref_primary_10_3390_jcm13226855 crossref_primary_10_1017_S1355617723000115 crossref_primary_10_1177_08901171231224517 crossref_primary_10_21876_rcshci_v11i4_1106 crossref_primary_10_1007_s12207_022_09456_y crossref_primary_10_1007_s10461_018_2297_9 crossref_primary_10_17116_jnevro2023123041125 crossref_primary_10_1017_S0714980823000521 crossref_primary_10_30629_2658_7947_2023_28_3_22_27 crossref_primary_10_1007_s12671_024_02500_9 crossref_primary_10_1111_ene_15476 crossref_primary_10_1590_1980_57642018dn12_040013 crossref_primary_10_1186_s13195_022_01068_7 crossref_primary_10_1590_1980_5764_dn_2022_0064 crossref_primary_10_1177_07334648221139479 crossref_primary_10_3233_JAD_201300 crossref_primary_10_3389_fphar_2021_579489 crossref_primary_10_1007_s13365_021_01044_1 crossref_primary_10_2174_1871527317666181105111157 crossref_primary_10_1177_08982643221080287 crossref_primary_10_1080_13697137_2021_1892627 crossref_primary_10_1111_jnc_16002 crossref_primary_10_1080_13607863_2021_1958144 crossref_primary_10_1093_nutrit_nuac104 crossref_primary_10_1080_23279095_2022_2106572 crossref_primary_10_1590_1980_5764_dn_2022_s101pt crossref_primary_10_3233_JAD_220659 crossref_primary_10_1080_07853890_2024_2421443 crossref_primary_10_1177_0971333620937511 crossref_primary_10_3389_fneur_2020_00247 crossref_primary_10_1016_j_cccb_2022_100126 crossref_primary_10_14412_2074_2711_2021_4_66_74 crossref_primary_10_1186_s12937_018_0387_1 crossref_primary_10_12677_TCM_2020_94047 crossref_primary_10_1016_j_ypmed_2020_106279 crossref_primary_10_14412_2074_2711_2020_2_92_97 crossref_primary_10_1007_s11682_021_00545_1 crossref_primary_10_1016_j_psyneuen_2020_104601 crossref_primary_10_3233_JAD_221187 crossref_primary_10_1080_09602011_2022_2058965 crossref_primary_10_1371_journal_pone_0254639 crossref_primary_10_1111_ejn_15665 crossref_primary_10_3233_JAD_201431 crossref_primary_10_3233_JAD_201399 crossref_primary_10_1177_14799731241268338 crossref_primary_10_1002_dad2_12089 crossref_primary_10_1055_s_0044_1791755 crossref_primary_10_3233_JAD_240365 crossref_primary_10_1093_gerona_glaa321 crossref_primary_10_1055_s_0044_1787138 crossref_primary_10_1007_s40520_021_02052_1 crossref_primary_10_3233_JAD_180248 crossref_primary_10_1093_arclin_acad031 crossref_primary_10_3233_JAD_210334 crossref_primary_10_1093_sleep_zsac176 crossref_primary_10_1590_1806_9282_63_07_651 crossref_primary_10_3233_ADR_230193 crossref_primary_10_1093_geronb_gbae089 crossref_primary_10_14283_jpad_2024_80 crossref_primary_10_1590_s1980_6574201900010019 |
| ContentType | Journal Article |
| Copyright | This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Copyright_xml | – notice: This work is licensed under a Creative Commons Attribution 4.0 International License. |
| DBID | AAYXX CITATION NPM 7X8 5PM GPN DOA |
| DOI | 10.1590/S1980-5764-2016DN1003002 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) SciELO DOAJ (Directory of Open Access Journals) |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | CrossRef PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Psychology Nursing |
| DocumentTitleAlternate | Declínio cognitivo subjetivo: a primeira manifestação clínica da doença de Alzheimer |
| EISSN | 1980-5764 |
| EndPage | 177 |
| ExternalDocumentID | oai_doaj_org_article_5c854a4fbfaa473d9cb2961be54ccc78 S1980_57642016000300170 PMC5642412 29213452 10_1590_S1980_5764_2016DN1003002 |
| Genre | Journal Article Review |
| GroupedDBID | 5VS AAFWJ AAYXX ABIVO ABXHO ADBBV AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS APOWU AZFZN BCNDV CITATION FRP GROUPED_DOAJ HYE IPNFZ KQ8 OK1 PGMZT RIG RPM RSC SCD NPM 7X8 5PM GPN |
| ID | FETCH-LOGICAL-c4402-704df893ad6e7e70ee257fce8eb00d8c60169b18ac384304de279e16c948e6353 |
| IEDL.DBID | DOA |
| ISSN | 1980-5764 |
| IngestDate | Wed Aug 27 01:11:52 EDT 2025 Tue Sep 16 20:22:01 EDT 2025 Thu Aug 21 14:03:56 EDT 2025 Fri Jul 11 03:07:10 EDT 2025 Thu Jan 02 22:55:01 EST 2025 Thu Apr 24 22:58:15 EDT 2025 Tue Jul 01 04:28:13 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | dementia subjective cognitive decline Alzheimer's disease biomarkers doença de Alzheimer declínio cognitivo subjetivo biomarcadores |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4402-704df893ad6e7e70ee257fce8eb00d8c60169b18ac384304de279e16c948e6353 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Disclosure: The authors report no conflicts of interest. Author contribution.: Adalberto Studart Neto contributed to study concept and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript and critical revision of the manuscript for important intellectual content. Ricardo Nitrini contributed drafting of the manuscript and critical revision of the manuscript for important intellectual content. |
| OpenAccessLink | https://doaj.org/article/5c854a4fbfaa473d9cb2961be54ccc78 |
| PMID | 29213452 |
| PQID | 1973998093 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_5c854a4fbfaa473d9cb2961be54ccc78 scielo_journals_S1980_57642016000300170 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5642412 proquest_miscellaneous_1973998093 pubmed_primary_29213452 crossref_citationtrail_10_1590_S1980_5764_2016DN1003002 crossref_primary_10_1590_S1980_5764_2016DN1003002 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2016-07-01 |
| PublicationDateYYYYMMDD | 2016-07-01 |
| PublicationDate_xml | – month: 07 year: 2016 text: 2016-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Brazil |
| PublicationPlace_xml | – name: Brazil |
| PublicationTitle | Dementia & neuropsychologia |
| PublicationTitleAlternate | Dement Neuropsychol |
| PublicationYear | 2016 |
| Publisher | Associação de Neurologia Cognitiva e do Comportamento Associação Neurologia Cognitiva e do Comportamento |
| Publisher_xml | – name: Associação de Neurologia Cognitiva e do Comportamento – name: Associação Neurologia Cognitiva e do Comportamento |
| References | 2015; 36 2016; 31 1994; 24 2013; 70 2016; 71 2008; 2 2012; 54 2007; 37 2013; 9 2012; 72 2015; 48 2012; 135 1997; 10 2015; 138 2015; 84 2006; 27 2015; 85 2015; 44 2015; 43 2008; 23 2014; 13 2011; 68 2008; 22 2012; 69 2010; 4 1998; 56 2010; 6 2010; 9 2014; 10 1992; 4 2015; 1 2015; 14 2009; 21 2015; 11 2015; 9 2014; 83 2016; 16 2011; 5 2015; 7 2011; 7 2016; 12 2015; 24 2012; 50 2015; 29 2009; 8 2013; 81 2016; 139 2014; 264 2012; 6 2016; 28 2003; 61 1990; 5 2001; 31 |
| References_xml | – volume: 11 start-page: 1417 issue: 12 year: 2015 end-page: 1429 article-title: APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern publication-title: Alzheimers Dement – volume: 4 start-page: 54 issue: 1 year: 2010 end-page: 57 article-title: Subjective memory complaints in the elderly may be related to factors other than cognitive déficit publication-title: Dement Neuropsychol – volume: 28 start-page: 1513 issue: 9 year: 2016 end-page: 1520 article-title: Differences in quantitative methods for measuring subjective cognitive decline - results from a prospective memory clinic study publication-title: Int Psychogeriatr – volume: 22 start-page: 531 year: 2008 end-page: 544 article-title: The measurement of everyday cognition (ECog) Scale development and psychometric properties publication-title: Neuropsychology – volume: 10 start-page: 161 year: 1997 end-page: 167 article-title: Development and validation of a Structured Telephone Interview for Dementia Assessment (STIDA) The NIMH Genetics Initiative publication-title: J Geriatr Psychiatry Neurol – volume: 56 start-page: 412 issue: 3A year: 1998 end-page: 418 article-title: Memory complaints and the diagnosis of dementia publication-title: Arq Neuropsiquiatr – volume: 1 start-page: 33 issue: 1 year: 2015 end-page: 40 article-title: Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle-aged adults at risk for AD publication-title: Alzheimers Dement (Amst) – volume: 84 start-page: 1261 issue: 12 year: 2015 end-page: 1268 article-title: Subjective cognitive decline is related to CSF biomarkers of AD in patients with MCI publication-title: Neurology – volume: 12 start-page: 796 issue: 7 year: 2016 end-page: 804 article-title: Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease publication-title: Alzheimers Dement – volume: 10 start-page: 319 issue: 3 year: 2014 end-page: 327 article-title: The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults publication-title: Alzheimers Dement – volume: 5 start-page: 5 issue: Suppl 1 year: 2011 end-page: 10 article-title: Critérios para o diagnóstico de doença de Alzheimer publication-title: Dement Neuropsychol – volume: 37 start-page: 1753 year: 2007 end-page: 1762 article-title: Patterns of subjective memory impairment in the elderly Association with memory performance publication-title: Psychol Med – volume: 264 start-page: S3 year: 2014 end-page: S7 article-title: Subjective and objective cognitive decline at the pre-dementia stage of Alzheimer's disease publication-title: Eur Arch Psychiatry Clin Neurosci – volume: 4 start-page: 165 year: 1992 end-page: 176 article-title: Assessment of memory complaint in age-associated memory impairment The MAC-Q publication-title: Int Psychogeriatr – volume: 24 start-page: 145 year: 1994 end-page: 153 article-title: A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) Development and cross-validation publication-title: Psychol Med – volume: 9 start-page: 119 issue: 1 year: 2010 end-page: 128 article-title: Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade publication-title: Lancet Neurol – volume: 16 start-page: 69 issue: 1-2 year: 2016 end-page: 76 article-title: Cerebrospinal Fluid Biomarkers Predict Clinical Evolution in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment publication-title: Neurodegener Dis – volume: 48 start-page: S161 year: 2015 end-page: S170 article-title: Feature Binding Deficits in Subjective Cognitive Decline and in Mild Cognitive Impairment publication-title: J Alzheimers Dis – volume: 24 start-page: S63 issue: 48 year: 2015 end-page: S86 article-title: Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies publication-title: J Alzheimers Dis – volume: 139 start-page: 1551 issue: 5 year: 2016 end-page: 1567 article-title: Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease publication-title: Brain – volume: 1 start-page: 194 issue: 2 year: 2015 end-page: 205 article-title: Cognitive performance before and after the onset of subjective cognitive decline in old age publication-title: Alzheimers Dement (Amst) – volume: 7 start-page: 280 issue: 3 year: 2011 end-page: 292 article-title: Toward defining the preclinical stages of Alzheimer's disease Recommendations from the National Institute on Aging Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement – volume: 48 start-page: 1109 issue: 4 year: 2015 end-page: 1117 article-title: Concordance between Subjective and Objective Memory Impairment in Volunteer Subjects publication-title: J Alzheimers Dis – volume: 48 start-page: S151 year: 2015 end-page: S159 article-title: Amyloid-b Imaging in Older Adults Presenting to a Memory Clinic with Subjective Cognitive Decline A Pilot Study publication-title: J Alzheimers Dis – volume: 10 start-page: 99 issue: 1 year: 2014 end-page: 108 article-title: Gray matter atrophy pattern in elderly with subjective memory impairment publication-title: Alzheimers Dement – volume: 27 start-page: 1751 issue: 12 year: 2006 end-page: 1756 article-title: Volume reduction of the entorhinal cortex in subjective memory impairment publication-title: Neurobiol Aging – volume: 6 start-page: 291 issue: 3 year: 2010 end-page: 296 article-title: Addressing population aging and Alzheimer's disease through the Australian imaging biomarkers and lifestyle study collaboration with the Alzheimer's Disease Neuroimaging Initiative publication-title: Alzheimers Dement – volume: 43 start-page: 677 issue: 2 year: 2015 end-page: 686 article-title: Amyloid-b related memory decline is not associated with subjective or informant rated cognitive impairment in healthy adults publication-title: J Alzheimers Dis – volume: 31 start-page: 105 issue: 2 year: 2016 end-page: 114 article-title: From Subjective Cognitive Complaints to Dementia Who is at Risk?: A Systematic Review publication-title: Am J Alzheimers Dis Other Demen – volume: 10 start-page: 93 issue: 1 year: 2014 end-page: 98 article-title: Subjective cognitive decline self and informant comparisons publication-title: Alzheimers Dement – volume: 11 start-page: 1385 issue: 11 year: 2015 end-page: 1392 article-title: Subjective memory impairment in older adults predicts future dementia independent of baseline memory performance Evidence from the Betula prospective cohort study publication-title: Alzheimers Dement – volume: 61 start-page: 920 issue: 4 year: 2003 end-page: 924 article-title: Memory complaints and test performance in healthy elderly persons publication-title: Arq Neuropsiquiatr – volume: 13 start-page: 997 issue: 10 year: 2014 end-page: 1005 article-title: Age-specific population frequencies of cerebral b-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years a cross-sectional study publication-title: Lancet Neurol – volume: 70 start-page: 903 issue: 7 year: 2013 end-page: 911 article-title: Cross-sectional and longitudinal analysis of the relationship between Ab deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease publication-title: JAMA Neurol – volume: 31 start-page: 441 year: 2001 end-page: 449 article-title: Memory complaints as a precursor of memory impairment in older people A longitudinal analysis over 7-8 years publication-title: Psychol Med – volume: 138 start-page: 2701 issue: 9 year: 2015 end-page: 2715 article-title: Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects publication-title: Brain – volume: 68 start-page: 845 issue: 8 year: 2011 end-page: 852 article-title: Evidence of neuronal compensation during episodic memory in subjective memory impairment publication-title: Arch Gen Psychiatry – volume: 5 start-page: 482 year: 1990 end-page: 490 article-title: The memory functioning questionnaire for assessment of memory complaints in adulthood and old age publication-title: Psychol Aging – volume: 44 start-page: 1012 issue: 6 year: 2015 end-page: 1019 article-title: Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment publication-title: Age Ageing – volume: 36 start-page: 2145 issue: 6 year: 2015 end-page: 2152 article-title: Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment publication-title: Neurobiol Aging – volume: 7 start-page: 56 issue: 85 year: 2015 end-page: 62 article-title: Subjective cognitive concerns, amyloid-b, and neurodegeneration in clinically normal elderly publication-title: Neurology – volume: 85 start-page: 1852 issue: 21 year: 2015 end-page: 1858 article-title: Memory complaints and risk of cognitive impairment after nearly 2 decades among older women publication-title: Neurology – volume: 14 start-page: 114 issue: 1 year: 2015 end-page: 124 article-title: Tau imaging early progress and future directions publication-title: Lancet Neurol – volume: 54 start-page: 137 year: 2012 end-page: 150 article-title: Validación de un cuestionario de quejas cognitivas para adultos jóvenes Relación entre las quejas subjetivas de memoria, la sintomatología prefrontal y el estrés percibido publication-title: Rev Neurol – volume: 135 start-page: 2126 issue: 7 year: 2012 end-page: 2139 article-title: Regional dynamics of amyloid-b deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease a voxelwise PiB-PET longitudinal study publication-title: Brain – volume: 71 start-page: 1210 issue: 9 year: 2016 end-page: 1215 article-title: Regional Hippocampal Atrophy and Higher Levels of Plasma Amyloid-Beta Are Associated With Subjective Memory Complaints in Nondemented Elderly Subjects publication-title: J Gerontol A Biol Sci Med Sci – volume: 8 start-page: 619 issue: 7 year: 2009 end-page: 627 article-title: Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study a prospective cohort study publication-title: Lancet Neurol – volume: 6 start-page: 11 issue: 1 year: 2010 end-page: 24 article-title: Outcome over seven years of healthy adults with and without subjective cognitive impairment publication-title: Alzheimers Dement – volume: 81 start-page: 1409 issue: 16 year: 2013 end-page: 1416 article-title: Preclinical AD predicts decline in memory and executive functions in subjective complaints publication-title: Neurology – volume: 2 start-page: 42 issue: 1 year: 2008 end-page: 45 article-title: Subjective memory complaints and cognitive performance in a sample of healthy elderly publication-title: Dement Neuropsychol – volume: 9 start-page: 481 issue: 5 year: 2013 end-page: 487 article-title: Cerebrospinal fluid Ab42 is the best predictor of clinical progression in patients with subjective complaints publication-title: Alzheimers Dement – volume: 9 start-page: 807 issue: 74 year: 2010 end-page: 815 article-title: Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB publication-title: Neurology – volume: 50 start-page: 2880 issue: 12 year: 2012 end-page: 2886 article-title: Subjective cognitive complaints and amyloid burden in cognitively normal older individuals publication-title: Neuropsychologia – volume: 83 start-page: 1359 issue: 15 year: 2014 end-page: 1365 article-title: Self-reported memory complaints implications from a longitudinal cohort with autopsies publication-title: Neurology – volume: 23 start-page: 49 issue: 1 year: 2008 end-page: 54 article-title: Subjective memory complaints in an elderly sample a cross-sectional study publication-title: Int J Geriatr Psychiatry – volume: 21 start-page: 164 issue: 1 year: 2009 end-page: 171 article-title: Subjective memory impairment in a rural population with low education in the Amazon rainforest an exploratory study publication-title: Int Psychogeriatr – volume: 10 start-page: 76 issue: 1 year: 2014 end-page: 83 article-title: AD dementia risk in late MCI, in early MCI, and in subjective memory impairment publication-title: Alzheimers Dement – volume: 9 start-page: 51 issue: 1 year: 2015 end-page: 57 article-title: Subjective memory complaints associated with depression and cognitive impairment in the elderly A systematic review publication-title: Dement Neuropsychol – volume: 10 start-page: 752 issue: 6 year: 2014 end-page: 759 article-title: Subjective cognitive concerns, episodic memory, and the APOE e4 allele publication-title: Alzheimers Dement – volume: 10 start-page: 844 issue: 6 year: 2014 end-page: 852 article-title: A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease publication-title: Alzheimers Dement – volume: 7 start-page: 263 year: 2011 end-page: 269 article-title: The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement – volume: 72 start-page: 578 issue: 4 year: 2012 end-page: 586 article-title: Amyloid deposition, hypometabolism, and longitudinal cognitive decline publication-title: Ann Neurol – volume: 9 start-page: 1378 issue: 80 year: 2013 end-page: 1384 article-title: Cognitive trajectories associated with b-amyloid deposition in the oldest-old without dementia publication-title: Neurology – volume: 69 start-page: 223 issue: 2 year: 2012 end-page: 229 article-title: Subjective cognition and amyloid deposition imaging a Pittsburgh Compound B positron emission tomography study in normal elderly individuals publication-title: Arch Neurol – volume: 29 start-page: 229 issue: 3 year: 2015 end-page: 235 article-title: Prospective memory in subjective cognitive decline a preliminary study on the role of early cognitive marker in dementia publication-title: Alzheimer Dis Assoc Disord – volume: 6 start-page: 212 issue: 4 year: 2012 end-page: 218 article-title: Memory complaint scale (MCS) Proposed tool for active systematic search publication-title: Dement Neuropsychol |
| SSID | ssj0001560113 |
| Score | 2.3658283 |
| SecondaryResourceType | review_article |
| Snippet | ABSTRACT Background: Mild cognitive impairment is considered as the first clinical manifestation of Alzheimer's disease (AD), when the individual exhibits... Mild cognitive impairment is considered as the first clinical manifestation of Alzheimer's disease (AD), when the individual exhibits below performance on... |
| SourceID | doaj scielo pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 170 |
| SubjectTerms | Alzheimer's disease biomarkers CLINICAL NEUROLOGY dementia GERIATRICS & GERONTOLOGY HEALTH CARE SCIENCES & SERVICES MEDICINE, GENERAL & INTERNAL NURSING PSYCHIATRY PSYCHOLOGY subjective cognitive decline Views & Reviews |
| Title | Subjective cognitive decline: The first clinical manifestation of Alzheimer's disease? |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29213452 https://www.proquest.com/docview/1973998093 https://pubmed.ncbi.nlm.nih.gov/PMC5642412 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000300170&lng=en&tlng=en https://doaj.org/article/5c854a4fbfaa473d9cb2961be54ccc78 |
| Volume | 10 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbxUhECem8eDFaPx6ag0mJj1tCgss4KWp1aYx0YvW9EaAHdJnnvtMX3vxr3eA3c17qYkevO4Cy3wAMzvDbwh504EOhpcga5ca2SfVBA-xASWjVIwFXsp0fvrcnZ3LjxfqYqvUV84Jq_DAlXGHKholvUwheS-16G0Mre14yIPFqMs1X2bZljM13Q_mpTYyOtWsQaNajmk8yrLDL_NDVBLevc9Ys2L6szKdTQXC_0925-30ybv5tFptH0ynD8j90aKkx5WSh-QODI_IN9wQvte9jM4ZQrSHfBES3lJUDpqWaPjR6WYkzTgYCTY1Mk_XiR6vfl3C8gdcHWzoGMY5ekzOTz98PTlrxhIKTZToGTaaIfvRJPE9CgU0A8AlmiKYXDKoN7GAsQRufBRGCmwMrbbAu2ilAbRFxBOyN6wHeEaoFyCsTNyLwKW3LPiu5UEH0YJqjZcLoifmuTjii-cyFyuX_Qxkuytsd5ntboftC8Lnnj8rxsY_9HmX5TO3zyjZ5QHqjht1x_1Ndxbk9SRdh6sqh0r8AOubjeNWo-VmmBUL8rRKe_5UazMKnsIp6B092JnL7ptheVmQuxV6e5Jjz4OqMW7cMDZbdGYyi6eakY2e_w8yX5B7edCaZPyS7F1f3cA-mlLX4VVZNb8BoJAVCw |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Subjective+cognitive+decline%3A+The+first+clinical+manifestation+of+Alzheimer%27s+disease%3F&rft.jtitle=Dementia+%26+neuropsychologia&rft.au=Studart+Neto%2C+Adalberto&rft.au=Nitrini%2C+Ricardo&rft.date=2016-07-01&rft.pub=Associa%C3%A7%C3%A3o+de+Neurologia+Cognitiva+e+do+Comportamento&rft.issn=1980-5764&rft.volume=10&rft.issue=3&rft.spage=170&rft.epage=177&rft_id=info:doi/10.1590%2FS1980-5764-2016DN1003002&rft.externalDocID=S1980_57642016000300170 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1980-5764&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1980-5764&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1980-5764&client=summon |