The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout

With the worldwide epidemics of hyperuricemia and associated gout, the diseases with purine metabolic disorders have become a serious threat to human public health. Accumulating evidence has shown that they have been linked to increased consumption of fructose in humans, we hereby made a timely revi...

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Published inFrontiers in nutrition (Lausanne) Vol. 9; p. 890730
Main Authors Fang, Xin-yu, Qi, Liang-wei, Chen, Hai-feng, Gao, Peng, Zhang, Qin, Leng, Rui-xue, Fan, Yin-guang, Li, Bao-zhu, Pan, Hai-feng, Ye, Dong-qing
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 22.06.2022
Subjects
fructose
gout
gut microbiota
hyperuricemia
interaction
Nutrition
Online AccessGet full text
ISSN2296-861X
2296-861X
DOI10.3389/fnut.2022.890730

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Abstract With the worldwide epidemics of hyperuricemia and associated gout, the diseases with purine metabolic disorders have become a serious threat to human public health. Accumulating evidence has shown that they have been linked to increased consumption of fructose in humans, we hereby made a timely review on the roles of fructose intake and the gut microbiota in regulating purine metabolism, together with the potential mechanisms by which excessive fructose intake contributes to hyperuricemia and gout. To this end, we focus on the understanding of the interaction between a fructose-rich diet and the gut microbiota in hyperuricemia and gout to seek for safe, cheap, and side-effect-free clinical interventions. Furthermore, fructose intake recommendations for hyperuricemia and gout patients, as well as the variety of probiotics and prebiotics with uric acid-lowering effects targeting the intestinal tract are also summarized to provide reference and guidance for the further research.
AbstractList With the worldwide epidemics of hyperuricemia and associated gout, the diseases with purine metabolic disorders have become a serious threat to human public health. Accumulating evidence has shown that they have been linked to increased consumption of fructose in humans, we hereby made a timely review on the roles of fructose intake and the gut microbiota in regulating purine metabolism, together with the potential mechanisms by which excessive fructose intake contributes to hyperuricemia and gout. To this end, we focus on the understanding of the interaction between a fructose-rich diet and the gut microbiota in hyperuricemia and gout to seek for safe, cheap, and side-effect-free clinical interventions. Furthermore, fructose intake recommendations for hyperuricemia and gout patients, as well as the variety of probiotics and prebiotics with uric acid-lowering effects targeting the intestinal tract are also summarized to provide reference and guidance for the further research.
With the worldwide epidemics of hyperuricemia and associated gout, the diseases with purine metabolic disorders have become a serious threat to human public health. Accumulating evidence has shown that they have been linked to increased consumption of fructose in humans, we hereby made a timely review on the roles of fructose intake and the gut microbiota in regulating purine metabolism, together with the potential mechanisms by which excessive fructose intake contributes to hyperuricemia and gout. To this end, we focus on the understanding of the interaction between a fructose-rich diet and the gut microbiota in hyperuricemia and gout to seek for safe, cheap, and side-effect-free clinical interventions. Furthermore, fructose intake recommendations for hyperuricemia and gout patients, as well as the variety of probiotics and prebiotics with uric acid-lowering effects targeting the intestinal tract are also summarized to provide reference and guidance for the further research.With the worldwide epidemics of hyperuricemia and associated gout, the diseases with purine metabolic disorders have become a serious threat to human public health. Accumulating evidence has shown that they have been linked to increased consumption of fructose in humans, we hereby made a timely review on the roles of fructose intake and the gut microbiota in regulating purine metabolism, together with the potential mechanisms by which excessive fructose intake contributes to hyperuricemia and gout. To this end, we focus on the understanding of the interaction between a fructose-rich diet and the gut microbiota in hyperuricemia and gout to seek for safe, cheap, and side-effect-free clinical interventions. Furthermore, fructose intake recommendations for hyperuricemia and gout patients, as well as the variety of probiotics and prebiotics with uric acid-lowering effects targeting the intestinal tract are also summarized to provide reference and guidance for the further research.
Author Qi, Liang-wei
Chen, Hai-feng
Leng, Rui-xue
Fang, Xin-yu
Gao, Peng
Li, Bao-zhu
Fan, Yin-guang
Ye, Dong-qing
Zhang, Qin
Pan, Hai-feng
AuthorAffiliation 1 Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University , Hefei , China
2 Inflammation and Immune Mediated Diseases Laboratory of Anhui , Hefei , China
AuthorAffiliation_xml – name: 2 Inflammation and Immune Mediated Diseases Laboratory of Anhui , Hefei , China
– name: 1 Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University , Hefei , China
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  fullname: Ye, Dong-qing
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Reviewed by: Rongrong Li, Peking Union Medical College Hospital (CAMS), China; Yongbo Kang, Shanxi Medical University, China
This article was submitted to Nutritional Epidemiology, a section of the journal Frontiers in Nutrition
Edited by: Ren-You Gan, Institute of Urban Agriculture (CAAS), China
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Snippet With the worldwide epidemics of hyperuricemia and associated gout, the diseases with purine metabolic disorders have become a serious threat to human public...
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SubjectTerms fructose
gout
gut microbiota
hyperuricemia
interaction
Nutrition
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Title The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout
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