Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5
Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM ) was shown to trigger exc...
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| Published in | Biomolecules & therapeutics Vol. 27; no. 4; pp. 395 - 403 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Society of Applied Pharmacology
01.07.2019
한국응용약물학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1976-9148 2005-4483 2005-4483 |
| DOI | 10.4062/biomolther.2018.151 |
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| Abstract | Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM
) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and PM
severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or PM
. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and PM
. |
|---|---|
| AbstractList | Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM2.5) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and PM2.5 severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or PM2.5. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and PM2.5.Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM2.5) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and PM2.5 severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or PM2.5. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and PM2.5. Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM ) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and PM severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or PM . Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and PM . Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM2.5) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and PM2.5 severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or PM2.5. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and PM2.5. Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM2.5) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and PM2.5 severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or PM2.5. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and PM2.5. KCI Citation Count: 10 |
| Author | Kang, Kyoung Ah Hyun, Jin Won Koh, Young Sang Ahn, Mee Jung Piao, Mei Jing Kang, Hee Kyoung Zhen, Ao Xuan Ryu, Yea Seong Hyun, Yu Jae Kim, Tae Hoon Cho, Suk Ju |
| AuthorAffiliation | 1 Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea 2 Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea 3 Department of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of Korea |
| AuthorAffiliation_xml | – name: 3 Department of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of Korea – name: 2 Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea – name: 1 Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea |
| Author_xml | – sequence: 1 givenname: Ao Xuan surname: Zhen fullname: Zhen, Ao Xuan organization: Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea – sequence: 2 givenname: Mei Jing surname: Piao fullname: Piao, Mei Jing organization: Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea – sequence: 3 givenname: Yu Jae surname: Hyun fullname: Hyun, Yu Jae organization: Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea – sequence: 4 givenname: Kyoung Ah surname: Kang fullname: Kang, Kyoung Ah organization: Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea – sequence: 5 givenname: Yea Seong surname: Ryu fullname: Ryu, Yea Seong organization: Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea – sequence: 6 givenname: Suk Ju surname: Cho fullname: Cho, Suk Ju organization: Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea – sequence: 7 givenname: Hee Kyoung surname: Kang fullname: Kang, Hee Kyoung organization: Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea – sequence: 8 givenname: Young Sang surname: Koh fullname: Koh, Young Sang organization: Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea – sequence: 9 givenname: Mee Jung surname: Ahn fullname: Ahn, Mee Jung organization: Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea – sequence: 10 givenname: Tae Hoon surname: Kim fullname: Kim, Tae Hoon organization: Department of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of Korea – sequence: 11 givenname: Jin Won surname: Hyun fullname: Hyun, Jin Won organization: Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea |
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| Cites_doi | 10.4062/biomolther.2014.006 10.1002/jat.3249 10.3892/mmr.2016.4953 10.4062/biomolther.2016.022 10.1074/jbc.M510644200 10.3892/ijmm.2013.1478 10.1080/08958378.2016.1260185 10.1074/jbc.M511052200 10.4062/biomolther.2015.069 10.3390/ijms19020601 10.1016/j.celrep.2018.05.060 10.1016/j.colsurfb.2016.03.036 10.1038/sj.onc.1209608 10.1007/s00204-018-2197-9 10.1038/s41598-018-21567-8 10.1002/jat.3451 10.1016/j.tox.2008.03.014 10.1038/sj.cdd.4401975 10.1155/2014/254270 10.1186/1471-2121-14-32 10.1038/sj.emboj.7601126 10.7555/JBR.31.20160071 10.1002/med.21442 10.1073/pnas.0401141101 10.1007/BF00926518 10.1016/j.yexcr.2012.02.013 10.1006/rtph.2001.1476 10.1016/j.ejphar.2017.04.009 10.1016/j.toxlet.2018.04.020 10.1139/o92-104 10.1016/0006-2952(96)00447-9 10.1042/BCJ20160471 10.5487/TR.2018.34.1.031 10.1016/j.molcel.2006.03.030 10.1016/j.bbrep.2018.03.004 10.1016/j.etap.2014.08.017 |
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| Keywords | Oxidative stress Human HaCaT keratinocytes Particulate matter 2.5 Purpurogallin Ultraviolet B radiation |
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| Title | Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5 |
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