Measurement error correction for nutritional exposures with correlated measurement error: Use of the method of triads in a longitudinal setting

Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Qi for the ith subject). The error can be both systematic and random. The diet record (DR) denoted by Ri for the ith subject is considere...

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Published inStatistics in medicine Vol. 27; no. 18; pp. 3466 - 3489
Main Authors Rosner, Bernard, Michels, Karin B., Chen, Ya-Hua, Day, Nicholas E.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 15.08.2008
Wiley Subscription Services, Inc
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ISSN0277-6715
1097-0258
DOI10.1002/sim.3238

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Abstract Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Qi for the ith subject). The error can be both systematic and random. The diet record (DR) denoted by Ri for the ith subject is considered an alloyed gold standard. However, some authors have reported both systematic and random errors with this instrument as well. One goal in measurement error research is to estimate the regression coefficient of Ti (true intake for the ith subject) on Qi denoted by λTQ. If the systematic errors in Qi and Ri (denoted by qi and ri) are uncorrelated, then one can obtain an unbiased estimate of λTQ by λRQ obtained by regressing Ri on Qi. However, if Corr(qi, ri)>0, then λRQ>λTQ. In this paper, we propose a method for indirectly estimating λTQ even in the presence of correlated systematic error based on a longitudinal design where Qi (surrogate measure of dietary intake), Ri (a reference measure of dietary intake), and Mi (a biomarker) are available on the same subjects at 2 time points. In addition, between‐person variation in mean levels of Mi among people with the same dietary intake is also accounted for. The methodology is illustrated for dietary vitamin C intake based on longitudinal data from 323 subjects in the European Prospective Investigation of Cancer (EPIC)‐Norfolk study who provided two measures of dietary vitamin C intake from the FFQ (Qi) and a 7‐day DR (Ri) and plasma vitamin C (Mi) 4 years apart. Copyright © 2008 John Wiley & Sons, Ltd.
AbstractList Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Qi for the ith subject). The error can be both systematic and random. The diet record (DR) denoted by Ri for the ith subject is considered an alloyed gold standard. However, some authors have reported both systematic and random errors with this instrument as well. One goal in measurement error research is to estimate the regression coefficient of Ti (true intake for the ith subject) on Qi denoted by λTQ. If the systematic errors in Qi and Ri (denoted by qi and ri) are uncorrelated, then one can obtain an unbiased estimate of λTQ by λRQ obtained by regressing Ri on Qi. However, if Corr(qi, ri)>0, then λRQ>λTQ. In this paper, we propose a method for indirectly estimating λTQ even in the presence of correlated systematic error based on a longitudinal design where Qi (surrogate measure of dietary intake), Ri (a reference measure of dietary intake), and Mi (a biomarker) are available on the same subjects at 2 time points. In addition, between‐person variation in mean levels of Mi among people with the same dietary intake is also accounted for. The methodology is illustrated for dietary vitamin C intake based on longitudinal data from 323 subjects in the European Prospective Investigation of Cancer (EPIC)‐Norfolk study who provided two measures of dietary vitamin C intake from the FFQ (Qi) and a 7‐day DR (Ri) and plasma vitamin C (Mi) 4 years apart. Copyright © 2008 John Wiley & Sons, Ltd.
Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Q... for the ith subject). The I error can be both systematic and random. The diet record (DR) denoted by R... for the ith subject is considered an alloyed gold standard. However, some authors have reported both systematic and random errors with this instrument as well. One goal in measurement error research is to estimate the regression coefficient of T... (true intake for I the ith subject) on Q... denoted by ... If the systematic errors in Q... and R... (denoted by q... and r...) are uncorrelated, then one can obtain an unbiased estimate of by obtained by regressing R... on Q... However, if Corr(q..., r...)>0, then ... In this paper, we propose a method for indirectly estimating ... even in the presence of correlated systematic error based on a longitudinal design where Q... (surrogate measure of dietary intake), R... (a reference measure of dietary intake), and M... (a biomarker) are available on the same subjects at 2 time points. In addition, between-person variation in mean levels of M... among people with the same dietary intake is also accounted for. The methodology is illustrated for dietary vitamin C intake based on longitudinal data from 323 subjects in the European Prospective Investigation of Cancer (EPIC)-Norfolk study who provided two measures of dietary vitamin C intake from the FFQ (Q...) and a 7-day DR (R...) and plasma vitamin C (M...) 4 years apart. (ProQuest: ... denotes formulae/symbols omitted.)
Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Q(i) for the ith subject). The error can be both systematic and random. The diet record (DR) denoted by R(i) for the ith subject is considered an alloyed gold standard. However, some authors have reported both systematic and random errors with this instrument as well.One goal in measurement error research is to estimate the regression coefficient of T(i) (true intake for the ith subject) on Q(i) denoted by lambda(TQ). If the systematic errors in Q(i) and R(i) (denoted by q(i) and r(i)) are uncorrelated, then one can obtain an unbiased estimate of lambda(TQ) by lambda(RQ) obtained by regressing R(i) on Q(i). However, if Corr(q(i), r(i))>0, then lambda(RQ)>lambda(TQ).In this paper, we propose a method for indirectly estimating lambda(TQ) even in the presence of correlated systematic error based on a longitudinal design where Q(i) (surrogate measure of dietary intake), R(i) (a reference measure of dietary intake), and M(i) (a biomarker) are available on the same subjects at 2 time points. In addition, between-person variation in mean levels of M(i) among people with the same dietary intake is also accounted for. The methodology is illustrated for dietary vitamin C intake based on longitudinal data from 323 subjects in the European Prospective Investigation of Cancer (EPIC)-Norfolk study who provided two measures of dietary vitamin C intake from the FFQ (Q(i)) and a 7-day DR (R(i)) and plasma vitamin C (M(i)) 4 years apart.Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Q(i) for the ith subject). The error can be both systematic and random. The diet record (DR) denoted by R(i) for the ith subject is considered an alloyed gold standard. However, some authors have reported both systematic and random errors with this instrument as well.One goal in measurement error research is to estimate the regression coefficient of T(i) (true intake for the ith subject) on Q(i) denoted by lambda(TQ). If the systematic errors in Q(i) and R(i) (denoted by q(i) and r(i)) are uncorrelated, then one can obtain an unbiased estimate of lambda(TQ) by lambda(RQ) obtained by regressing R(i) on Q(i). However, if Corr(q(i), r(i))>0, then lambda(RQ)>lambda(TQ).In this paper, we propose a method for indirectly estimating lambda(TQ) even in the presence of correlated systematic error based on a longitudinal design where Q(i) (surrogate measure of dietary intake), R(i) (a reference measure of dietary intake), and M(i) (a biomarker) are available on the same subjects at 2 time points. In addition, between-person variation in mean levels of M(i) among people with the same dietary intake is also accounted for. The methodology is illustrated for dietary vitamin C intake based on longitudinal data from 323 subjects in the European Prospective Investigation of Cancer (EPIC)-Norfolk study who provided two measures of dietary vitamin C intake from the FFQ (Q(i)) and a 7-day DR (R(i)) and plasma vitamin C (M(i)) 4 years apart.
Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Q(i) for the ith subject). The error can be both systematic and random. The diet record (DR) denoted by R(i) for the ith subject is considered an alloyed gold standard. However, some authors have reported both systematic and random errors with this instrument as well.One goal in measurement error research is to estimate the regression coefficient of T(i) (true intake for the ith subject) on Q(i) denoted by lambda(TQ). If the systematic errors in Q(i) and R(i) (denoted by q(i) and r(i)) are uncorrelated, then one can obtain an unbiased estimate of lambda(TQ) by lambda(RQ) obtained by regressing R(i) on Q(i). However, if Corr(q(i), r(i))>0, then lambda(RQ)>lambda(TQ).In this paper, we propose a method for indirectly estimating lambda(TQ) even in the presence of correlated systematic error based on a longitudinal design where Q(i) (surrogate measure of dietary intake), R(i) (a reference measure of dietary intake), and M(i) (a biomarker) are available on the same subjects at 2 time points. In addition, between-person variation in mean levels of M(i) among people with the same dietary intake is also accounted for. The methodology is illustrated for dietary vitamin C intake based on longitudinal data from 323 subjects in the European Prospective Investigation of Cancer (EPIC)-Norfolk study who provided two measures of dietary vitamin C intake from the FFQ (Q(i)) and a 7-day DR (R(i)) and plasma vitamin C (M(i)) 4 years apart.
Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Qi for the ith subject). The error can be both systematic and random. The diet record (DR) denoted by Ri for the ith subject is considered an alloyed gold standard. However, some authors have reported both systematic and random errors with this instrument as well. One goal in measurement error research is to estimate the regression coefficient of Ti (true intake for the ith subject) on Qi denoted by λTQ. If the systematic errors in Qi and Ri (denoted by qi and ri) are uncorrelated, then one can obtain an unbiased estimate of λTQ by λRQ obtained by regressing Ri on Qi. Howfever, if Corr(qi, ri) > 0, then λRQ > λTQ. In this paper, we propose a method for indirectly estimating λTQ even in the presence of correlated systematic error based on a longitudinal design where Qi (surrogate measure of dietary intake), Ri (a reference measure of dietary intake), and Mi (a biomarker) are available on the same subjects at 2 time points. In addition, between-person variation in mean levels of Mi among people with the same dietary intake is also accounted for. The methodology is illustrated for dietary vitamin C intake based on longitudinal data from 323 subjects in the European Prospective Investigation of Cancer (EPIC)-Norfolk study who provided two measures of dietary vitamin C intake from the FFQ (Qi) and a 7-day DR (Ri) and plasma vitamin C (Mi) 4 years apart.
Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Q i for the i th subject). The error can be both systematic and random. The diet record (DR) denoted by R i for the i th subject is considered an alloyed gold standard. However, some authors have reported both systematic and random errors with this instrument as well. One goal in measurement error research is to estimate the regression coefficient of T i (true intake for the i th subject) on Q i denoted by λ TQ . If the systematic errors in Q i and R i (denoted by q i and r i ) are uncorrelated, then one can obtain an unbiased estimate of λ TQ by λ RQ obtained by regressing R i on Q i . However, if Corr( q i , r i )>0, then λ RQ >λ TQ . In this paper, we propose a method for indirectly estimating λ TQ even in the presence of correlated systematic error based on a longitudinal design where Q i (surrogate measure of dietary intake), R i (a reference measure of dietary intake), and M i (a biomarker) are available on the same subjects at 2 time points. In addition, between‐person variation in mean levels of M i among people with the same dietary intake is also accounted for. The methodology is illustrated for dietary vitamin C intake based on longitudinal data from 323 subjects in the European Prospective Investigation of Cancer (EPIC)‐Norfolk study who provided two measures of dietary vitamin C intake from the FFQ ( Q i ) and a 7‐day DR ( R i ) and plasma vitamin C ( M i ) 4 years apart. Copyright © 2008 John Wiley & Sons, Ltd.
Author Day, Nicholas E.
Michels, Karin B.
Rosner, Bernard
Chen, Ya-Hua
AuthorAffiliation 3 Department of Epidemiology, Harvard School of Public Health, Boston, MA, U.S.A
4 Strangeways Research Laboratories, Institute of Public Health, University of Cambridge, Cambridge, U.K
2 Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, U.S.A
1 Channing Laboratory, Harvard Medical School, Boston, MA, U.S.A
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Snippet Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted...
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SubjectTerms Aged
Bias
biomarkers
correlated error
Correlation analysis
Diet
Diet Records
Estimates
Feeding Behavior
Female
Humans
longitudinal data
Longitudinal Studies
Male
measurement error
Measurement errors
Models, Statistical
Nutrition
Nutrition Assessment
Nutritional Status
Regression analysis
Surveys and Questionnaires
Vitamin C
Title Measurement error correction for nutritional exposures with correlated measurement error: Use of the method of triads in a longitudinal setting
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