Effect of cyclosporine coadministration on the pharmacokinetics of eltrombopag in healthy volunteers - Aslanis, Vassilios; Zhang, Jianping; Lomeli, Barbara; Grosch, Kai; Ouatas, Taoufik (Cancer chemotherapy and pharmacology, 2018)
Keywords: Adolescent; Adult; Aplastic anemia; Area Under Curve; ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism; Benzoates - administration & dosage; Benzoates - adverse effects; Benzoates - blood; Breast cancer; Cancer Research; Cross-Over Studies; Cyclosporine - administration & dosage; Cyclosporine - pharmacology; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Female; Healthy Volunteers; Humans; Hydrazines - administration & dosage; Hydrazines - adverse effects; Hydrazines - blood; Immunosuppressive agents; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - pharmacology; Male; Medicine; Medicine & Public Health; Metabolic Clearance Rate; Middle Aged; Neoplasm Proteins - metabolism; Oncology; Original Article; Patients; Pharmacokinetics; Pharmacology/Toxicology; Pyrazoles - administration & dosage; Pyrazoles - adverse effects; Pyrazoles - blood; Receptors, Thrombopoietin - agonists; Substrate Specificity; Titration; Young Adult; BCRP; Severe aplastic anemia; Eltrombopag; Cyclosporine; Pharmacokinetics; Interaction