Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis
Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study i...
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| Published in | Journal of Korean medical science Vol. 29; no. 9; pp. 1199 - 1204 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Academy of Medical Sciences
01.09.2014
대한의학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1011-8934 1598-6357 1598-6357 |
| DOI | 10.3346/jkms.2014.29.9.1199 |
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| Abstract | Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8 ± 14.4 vs. 22.2 ± 6.1 ng/mL; P<0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (γ=0.671; γ=0.612; and γ=0.601, P<0.001, respectively), but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status (DAS28≥2.6) were significantly higher than those in remission (DAS28<2.6) (36.45 ± 14.36 vs. 24.63 ± 8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-α and it may be a novel biomarker for assessing inflammatory activity in patients with RA. |
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| AbstractList | Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8 ± 14.4 vs. 22.2 ± 6.1 ng/mL; P<0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (γ=0.671; γ=0.612; and γ=0.601, P<0.001, respectively), but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status (DAS28≥2.6) were significantly higher than those in remission (DAS28<2.6) (36.45 ± 14.36 vs. 24.63 ± 8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-α and it may be a novel biomarker for assessing inflammatory activity in patients with RA. Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG)levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed theircorrelation with disease activity parameters and pro-inflammatory cytokine, tumornecrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sexmatchedhealthy controls. Serum concentrations of TNF-α and LRG were determined byenzyme-linked immunosorbent assay. Serum LRG concentrations were significantlyelevated in patients with RA compared with those in healthy controls (30.8 ± 14.4 vs. 22.2 ± 6.1 ng/mL; P < 0.001). In patients with RA, serum LRG levels were found to becorrelated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, andC-reactive protein levels (γ = 0.671; γ = 0.612; and γ = 0.601, P < 0.001, respectively),but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status(DAS28 ≥ 2.6) were significantly higher than those in remission (DAS28 < 2.6) (36.45 ±14.36 vs. 24.63 ± 8.81 ng/mL; P < 0.001). Our findings suggest that serum LRG couldcontribute to the inflammatory process independent of TNF-α and it may be a novelbiomarker for assessing inflammatory activity in patients with RA. KCI Citation Count: 0 Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8 ± 14.4 vs. 22.2 ± 6.1 ng/mL; P<0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (γ=0.671; γ=0.612; and γ=0.601, P<0.001, respectively), but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status (DAS28≥2.6) were significantly higher than those in remission (DAS28<2.6) (36.45 ± 14.36 vs. 24.63 ± 8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-α and it may be a novel biomarker for assessing inflammatory activity in patients with RA.Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8 ± 14.4 vs. 22.2 ± 6.1 ng/mL; P<0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (γ=0.671; γ=0.612; and γ=0.601, P<0.001, respectively), but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status (DAS28≥2.6) were significantly higher than those in remission (DAS28<2.6) (36.45 ± 14.36 vs. 24.63 ± 8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-α and it may be a novel biomarker for assessing inflammatory activity in patients with RA. Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8±14.4 vs. 22.2±6.1 ng/mL; P<0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (γ=0.671; γ=0.612; and γ=0.601, P<0.001, respectively), but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status (DAS28≥2.6) were significantly higher than those in remission (DAS28<2.6) (36.45±14.36 vs. 24.63±8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-α and it may be a novel biomarker for assessing inflammatory activity in patients with RA. |
| Author | Choi, Sang Tae Park, Yong-Beom Ha, You Jung Song, Jung-Soo Kang, Eun-Jin Lee, Sang-Won Lee, Soo-Kon |
| AuthorAffiliation | 1 Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea 4 Division of Rheumatology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea 3 Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea 2 Division of Rheumatology, Department of Internal Medicine, Busan Medical Center, Busan, Korea |
| AuthorAffiliation_xml | – name: 2 Division of Rheumatology, Department of Internal Medicine, Busan Medical Center, Busan, Korea – name: 4 Division of Rheumatology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea – name: 1 Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea – name: 3 Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea |
| Author_xml | – sequence: 1 givenname: You Jung orcidid: 0000-0001-6107-9523 surname: Ha fullname: Ha, You Jung organization: Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 2 givenname: Eun-Jin surname: Kang fullname: Kang, Eun-Jin organization: Division of Rheumatology, Department of Internal Medicine, Busan Medical Center, Busan, Korea – sequence: 3 givenname: Sang-Won surname: Lee fullname: Lee, Sang-Won organization: Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea – sequence: 4 givenname: Soo-Kon surname: Lee fullname: Lee, Soo-Kon organization: Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea – sequence: 5 givenname: Yong-Beom orcidid: 0000-0003-4695-8620 surname: Park fullname: Park, Yong-Beom organization: Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea – sequence: 6 givenname: Jung-Soo orcidid: 0000-0001-8651-5125 surname: Song fullname: Song, Jung-Soo organization: Division of Rheumatology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea – sequence: 7 givenname: Sang Tae orcidid: 0000-0002-2074-1733 surname: Choi fullname: Choi, Sang Tae organization: Division of Rheumatology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea |
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| Cites_doi | 10.3899/jrheum.120757 10.1007/BF02207957 10.1002/ibd.22936 10.1038/nature12345 10.1016/j.bbrc.2009.03.104 10.1002/art.1780380107 10.1515/bchm2.1977.358.1.639 10.1371/journal.pone.0006242 10.3899/jrheum.090386 10.1186/1757-2215-3-21 10.1111/j.1365-2362.1994.tb02063.x 10.1371/journal.pone.0051748 10.1002/art.27584 10.1016/j.autrev.2011.04.020 10.1002/art.1780310302 10.1016/S0140-6736(10)60826-4 10.1016/S1471-4892(03)00037-7 10.1016/S0140-6736(09)60008-8 10.1038/bjc.2011.376 10.1136/ard.2009.123919 10.1136/ard.2009.118919 10.1073/pnas.82.7.1906 10.1136/ard.2009.126532 10.1007/s10495-006-8159-3 10.1002/pmic.201200550 10.3346/jkms.2011.26.9.1132 10.1007/978-3-7091-0923-6_20 10.1189/jlb.72.3.478 10.1016/j.annemergmed.2009.04.020 10.1172/JCI108159 |
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| Keywords | Disease Activity Leucine-Rich Alpha-2-Glycoprotein Tumor Necrosis Factor-alpha Arthritis, Rheumatoid |
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| References | Graf (10.3346/jkms.2014.29.9.1199_ref4) 2009; 4 Smolen (10.3346/jkms.2014.29.9.1199_ref3) 2010; 69 Arnett (10.3346/jkms.2014.29.9.1199_ref15) 1988; 31 Andersen (10.3346/jkms.2014.29.9.1199_ref30) 2010; 3 O'Donnell (10.3346/jkms.2014.29.9.1199_ref11) 2002; 72 Choi (10.3346/jkms.2014.29.9.1199_ref27) 2013; 13 Scott (10.3346/jkms.2014.29.9.1199_ref1) 2010; 376 Klareskog (10.3346/jkms.2014.29.9.1199_ref14) 2009; 373 Yen (10.3346/jkms.2014.29.9.1199_ref20) 1992; 25 Dale (10.3346/jkms.2014.29.9.1199_ref31) 1975; 56 Wascher (10.3346/jkms.2014.29.9.1199_ref21) 1994; 24 Kentsis (10.3346/jkms.2014.29.9.1199_ref26) 2010; 55 Wolfe (10.3346/jkms.2014.29.9.1199_ref5) 2009; 36 Nakajima (10.3346/jkms.2014.29.9.1199_ref9) 2012; 113 Takahashi (10.3346/jkms.2014.29.9.1199_ref6) 1985; 82 Serada (10.3346/jkms.2014.29.9.1199_ref8) 2012; 18 Marrelli (10.3346/jkms.2014.29.9.1199_ref24) 2011; 10 Wang (10.3346/jkms.2014.29.9.1199_ref23) 2013; 499 Liu (10.3346/jkms.2014.29.9.1199_ref28) 2012; 7 Serada (10.3346/jkms.2014.29.9.1199_ref12) 2010; 69 Hong (10.3346/jkms.2014.29.9.1199_ref18) 2011; 26 Liu (10.3346/jkms.2014.29.9.1199_ref25) 2003; 3 Cummings (10.3346/jkms.2014.29.9.1199_ref22) 2006; 11 Xie (10.3346/jkms.2014.29.9.1199_ref13) 2012; 39 Shirai (10.3346/jkms.2014.29.9.1199_ref10) 2009; 382 Smolen (10.3346/jkms.2014.29.9.1199_ref2) 2010; 69 Haupt (10.3346/jkms.2014.29.9.1199_ref7) 1977; 358 Sandanayake (10.3346/jkms.2014.29.9.1199_ref29) 2011; 105 Aletaha (10.3346/jkms.2014.29.9.1199_ref16) 2010; 62 Altomonte (10.3346/jkms.2014.29.9.1199_ref19) 1992; 11 Prevoo (10.3346/jkms.2014.29.9.1199_ref17) 1995; 38 12810199 - Curr Opin Pharmacol. 2003 Jun;3(3):317-22 3358796 - Arthritis Rheum. 1988 Mar;31(3):315-24 7818570 - Arthritis Rheum. 1995 Jan;38(1):44-8 23606366 - Proteomics. 2013 Aug;13(15):2361-74 1159089 - J Clin Invest. 1975 Oct;56(4):808-13 22116432 - Acta Neurochir Suppl. 2012;113:97-101 22374925 - Inflamm Bowel Dis. 2012 Nov;18(11):2169-79 8187811 - Eur J Clin Invest. 1994 Jan;24(1):73-5 19671807 - J Rheumatol. 2009 Aug;36(8):1568-9 19854709 - Ann Rheum Dis. 2010 Apr;69(4):770-4 23284758 - PLoS One. 2012;7(12):e51748 19157532 - Lancet. 2009 Feb 21;373(9664):659-72 21545851 - Autoimmun Rev. 2011 Aug;10(10):595-8 19556024 - Ann Emerg Med. 2010 Jan;55(1):62-70.e4 3856868 - Proc Natl Acad Sci U S A. 1985 Apr;82(7):1906-10 19606218 - PLoS One. 2009;4(7):e6242 16699948 - Apoptosis. 2006 Jul;11(7):1121-9 1617893 - Clin Rheumatol. 1992 Jun;11(2):202-5 20831812 - J Ovarian Res. 2010 Sep 10;3:21 12223515 - J Leukoc Biol. 2002 Sep;72(3):478-85 20444750 - Ann Rheum Dis. 2010 Jun;69(6):964-75 21970875 - Br J Cancer. 2011 Oct 25;105(9):1370-8 20872595 - Arthritis Rheum. 2010 Sep;62(9):2569-81 19324010 - Biochem Biophys Res Commun. 2009 May 15;382(4):776-9 1342640 - Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1992 Nov;25(4):232-43 23118293 - J Rheumatol. 2012 Nov;39(11):2220; author reply 2221 69600 - Hoppe Seylers Z Physiol Chem. 1977 Jun;358(6):639-46 20215140 - Ann Rheum Dis. 2010 Apr;69(4):631-7 20870100 - Lancet. 2010 Sep 25;376(9746):1094-108 23868260 - Nature. 2013 Jul 18;499(7458):306-11 21935266 - J Korean Med Sci. 2011 Sep;26(9):1132-9 |
| References_xml | – volume: 39 start-page: 2220 year: 2012 ident: 10.3346/jkms.2014.29.9.1199_ref13 publication-title: J Rheumatol doi: 10.3899/jrheum.120757 – volume: 11 start-page: 202 year: 1992 ident: 10.3346/jkms.2014.29.9.1199_ref19 publication-title: Clin Rheumatol doi: 10.1007/BF02207957 – volume: 18 start-page: 2169 year: 2012 ident: 10.3346/jkms.2014.29.9.1199_ref8 publication-title: Inflamm Bowel Dis doi: 10.1002/ibd.22936 – volume: 499 start-page: 306 year: 2013 ident: 10.3346/jkms.2014.29.9.1199_ref23 publication-title: Nature doi: 10.1038/nature12345 – volume: 382 start-page: 776 year: 2009 ident: 10.3346/jkms.2014.29.9.1199_ref10 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2009.03.104 – volume: 38 start-page: 44 year: 1995 ident: 10.3346/jkms.2014.29.9.1199_ref17 publication-title: Arthritis Rheum doi: 10.1002/art.1780380107 – volume: 358 start-page: 639 year: 1977 ident: 10.3346/jkms.2014.29.9.1199_ref7 publication-title: Hoppe Seylers Z Physiol Chem doi: 10.1515/bchm2.1977.358.1.639 – volume: 25 start-page: 232 year: 1992 ident: 10.3346/jkms.2014.29.9.1199_ref20 publication-title: Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi – volume: 4 start-page: e6242 year: 2009 ident: 10.3346/jkms.2014.29.9.1199_ref4 publication-title: PLoS One doi: 10.1371/journal.pone.0006242 – volume: 36 start-page: 1568 year: 2009 ident: 10.3346/jkms.2014.29.9.1199_ref5 publication-title: J Rheumatol doi: 10.3899/jrheum.090386 – volume: 3 start-page: 21 year: 2010 ident: 10.3346/jkms.2014.29.9.1199_ref30 publication-title: J Ovarian Res doi: 10.1186/1757-2215-3-21 – volume: 24 start-page: 73 year: 1994 ident: 10.3346/jkms.2014.29.9.1199_ref21 publication-title: Eur J Clin Invest doi: 10.1111/j.1365-2362.1994.tb02063.x – volume: 7 start-page: e51748 year: 2012 ident: 10.3346/jkms.2014.29.9.1199_ref28 publication-title: PLoS One doi: 10.1371/journal.pone.0051748 – volume: 62 start-page: 2569 year: 2010 ident: 10.3346/jkms.2014.29.9.1199_ref16 publication-title: Arthritis Rheum doi: 10.1002/art.27584 – volume: 10 start-page: 595 year: 2011 ident: 10.3346/jkms.2014.29.9.1199_ref24 publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2011.04.020 – volume: 31 start-page: 315 year: 1988 ident: 10.3346/jkms.2014.29.9.1199_ref15 publication-title: Arthritis Rheum doi: 10.1002/art.1780310302 – volume: 376 start-page: 1094 year: 2010 ident: 10.3346/jkms.2014.29.9.1199_ref1 publication-title: Lancet doi: 10.1016/S0140-6736(10)60826-4 – volume: 3 start-page: 317 year: 2003 ident: 10.3346/jkms.2014.29.9.1199_ref25 publication-title: Curr Opin Pharmacol doi: 10.1016/S1471-4892(03)00037-7 – volume: 373 start-page: 659 year: 2009 ident: 10.3346/jkms.2014.29.9.1199_ref14 publication-title: Lancet doi: 10.1016/S0140-6736(09)60008-8 – volume: 105 start-page: 1370 year: 2011 ident: 10.3346/jkms.2014.29.9.1199_ref29 publication-title: Br J Cancer doi: 10.1038/bjc.2011.376 – volume: 69 start-page: 631 year: 2010 ident: 10.3346/jkms.2014.29.9.1199_ref2 publication-title: Ann Rheum Dis doi: 10.1136/ard.2009.123919 – volume: 69 start-page: 770 year: 2010 ident: 10.3346/jkms.2014.29.9.1199_ref12 publication-title: Ann Rheum Dis doi: 10.1136/ard.2009.118919 – volume: 82 start-page: 1906 year: 1985 ident: 10.3346/jkms.2014.29.9.1199_ref6 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.82.7.1906 – volume: 69 start-page: 964 year: 2010 ident: 10.3346/jkms.2014.29.9.1199_ref3 publication-title: Ann Rheum Dis doi: 10.1136/ard.2009.126532 – volume: 11 start-page: 1121 year: 2006 ident: 10.3346/jkms.2014.29.9.1199_ref22 publication-title: Apoptosis doi: 10.1007/s10495-006-8159-3 – volume: 13 start-page: 2361 year: 2013 ident: 10.3346/jkms.2014.29.9.1199_ref27 publication-title: Proteomics doi: 10.1002/pmic.201200550 – volume: 26 start-page: 1132 year: 2011 ident: 10.3346/jkms.2014.29.9.1199_ref18 publication-title: J Korean Med Sci doi: 10.3346/jkms.2011.26.9.1132 – volume: 113 start-page: 97 year: 2012 ident: 10.3346/jkms.2014.29.9.1199_ref9 publication-title: Acta Neurochir Suppl doi: 10.1007/978-3-7091-0923-6_20 – volume: 72 start-page: 478 year: 2002 ident: 10.3346/jkms.2014.29.9.1199_ref11 publication-title: J Leukoc Biol doi: 10.1189/jlb.72.3.478 – volume: 55 start-page: 62 year: 2010 ident: 10.3346/jkms.2014.29.9.1199_ref26 publication-title: Ann Emerg Med doi: 10.1016/j.annemergmed.2009.04.020 – volume: 56 start-page: 808 year: 1975 ident: 10.3346/jkms.2014.29.9.1199_ref31 publication-title: J Clin Invest doi: 10.1172/JCI108159 – reference: 20872595 - Arthritis Rheum. 2010 Sep;62(9):2569-81 – reference: 7818570 - Arthritis Rheum. 1995 Jan;38(1):44-8 – reference: 20215140 - Ann Rheum Dis. 2010 Apr;69(4):631-7 – reference: 22116432 - Acta Neurochir Suppl. 2012;113:97-101 – reference: 21545851 - Autoimmun Rev. 2011 Aug;10(10):595-8 – reference: 19606218 - PLoS One. 2009;4(7):e6242 – reference: 23284758 - PLoS One. 2012;7(12):e51748 – reference: 19324010 - Biochem Biophys Res Commun. 2009 May 15;382(4):776-9 – reference: 20870100 - Lancet. 2010 Sep 25;376(9746):1094-108 – reference: 23868260 - Nature. 2013 Jul 18;499(7458):306-11 – reference: 3856868 - Proc Natl Acad Sci U S A. 1985 Apr;82(7):1906-10 – reference: 8187811 - Eur J Clin Invest. 1994 Jan;24(1):73-5 – reference: 19854709 - Ann Rheum Dis. 2010 Apr;69(4):770-4 – reference: 19556024 - Ann Emerg Med. 2010 Jan;55(1):62-70.e4 – reference: 23118293 - J Rheumatol. 2012 Nov;39(11):2220; author reply 2221 – reference: 12810199 - Curr Opin Pharmacol. 2003 Jun;3(3):317-22 – reference: 20444750 - Ann Rheum Dis. 2010 Jun;69(6):964-75 – reference: 12223515 - J Leukoc Biol. 2002 Sep;72(3):478-85 – reference: 1617893 - Clin Rheumatol. 1992 Jun;11(2):202-5 – reference: 21935266 - J Korean Med Sci. 2011 Sep;26(9):1132-9 – reference: 1159089 - J Clin Invest. 1975 Oct;56(4):808-13 – reference: 69600 - Hoppe Seylers Z Physiol Chem. 1977 Jun;358(6):639-46 – reference: 23606366 - Proteomics. 2013 Aug;13(15):2361-74 – reference: 22374925 - Inflamm Bowel Dis. 2012 Nov;18(11):2169-79 – reference: 19671807 - J Rheumatol. 2009 Aug;36(8):1568-9 – reference: 16699948 - Apoptosis. 2006 Jul;11(7):1121-9 – reference: 1342640 - Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1992 Nov;25(4):232-43 – reference: 20831812 - J Ovarian Res. 2010 Sep 10;3:21 – reference: 19157532 - Lancet. 2009 Feb 21;373(9664):659-72 – reference: 21970875 - Br J Cancer. 2011 Oct 25;105(9):1370-8 – reference: 3358796 - Arthritis Rheum. 1988 Mar;31(3):315-24 |
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| Title | Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis |
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