Early life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination
Previously, we demonstrated that male Wistar rats submitted to neonatal status epilepticus showed abnormal social behavior characterized by deficit in social discrimination and enhanced emotionality. Taking into account that early insult can produce different biological manifestations in a gender-de...
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| Published in | Journal of Neural Transmission Vol. 122; no. 3; pp. 349 - 355 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Vienna
Springer Vienna
01.03.2015
Springer Nature B.V |
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| Online Access | Get full text |
| ISSN | 0300-9564 1435-1463 1435-1463 |
| DOI | 10.1007/s00702-014-1291-2 |
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| Abstract | Previously, we demonstrated that male Wistar rats submitted to neonatal
status epilepticus
showed abnormal social behavior characterized by deficit in social discrimination and enhanced emotionality. Taking into account that early insult can produce different biological manifestations in a gender-dependent manner, we aimed to investigate the social behavior and anxiety-like behavior in female Wistar rats following early life seizures. Neonate female Wistar rats at 9 days postnatal were subject to pilocarpine-induced
status epilepticus
and the control received saline. Behavioral tests started from 60 days postnatal and were carried out only during the diestrus phase of the reproductive cycle. In sociability test experimental animals exhibited reduced motivation for social encounter and deficit in social discrimination. In open field and the elevated plus maze, experimental animals showed enhanced emotionality with no changes in basal locomotor activity. The results showed that female rats submitted to neonatal
status epipepticus
showed impaired social behavior, characterized by reduced motivation to novelty and deficit in social discrimination in addition to enhanced emotionality. |
|---|---|
| AbstractList | Previously, we demonstrated that male Wistar rats submitted to neonatal status epilepticus showed abnormal social behavior characterized by deficit in social discrimination and enhanced emotionality. Taking into account that early insult can produce different biological manifestations in a gender-dependent manner, we aimed to investigate the social behavior and anxiety-like behavior in female Wistar rats following early life seizures. Neonate female Wistar rats at 9 days postnatal were subject to pilocarpine-induced status epilepticus and the control received saline. Behavioral tests started from 60 days postnatal and were carried out only during the diestrus phase of the reproductive cycle. In sociability test experimental animals exhibited reduced motivation for social encounter and deficit in social discrimination. In open field and the elevated plus maze, experimental animals showed enhanced emotionality with no changes in basal locomotor activity. The results showed that female rats submitted to neonatal status epipepticus showed impaired social behavior, characterized by reduced motivation to novelty and deficit in social discrimination in addition to enhanced emotionality. Previously, we demonstrated that male Wistar rats submitted to neonatal status epilepticus showed abnormal social behavior characterized by deficit in social discrimination and enhanced emotionality. Taking into account that early insult can produce different biological manifestations in a gender-dependent manner, we aimed to investigate the social behavior and anxiety-like behavior in female Wistar rats following early life seizures. Neonate female Wistar rats at 9 days postnatal were subject to pilocarpine-induced status epilepticus and the control received saline. Behavioral tests started from 60 days postnatal and were carried out only during the diestrus phase of the reproductive cycle. In sociability test experimental animals exhibited reduced motivation for social encounter and deficit in social discrimination. In open field and the elevated plus maze, experimental animals showed enhanced emotionality with no changes in basal locomotor activity. The results showed that female rats submitted to neonatal status epipepticus showed impaired social behavior, characterized by reduced motivation to novelty and deficit in social discrimination in addition to enhanced emotionality.Previously, we demonstrated that male Wistar rats submitted to neonatal status epilepticus showed abnormal social behavior characterized by deficit in social discrimination and enhanced emotionality. Taking into account that early insult can produce different biological manifestations in a gender-dependent manner, we aimed to investigate the social behavior and anxiety-like behavior in female Wistar rats following early life seizures. Neonate female Wistar rats at 9 days postnatal were subject to pilocarpine-induced status epilepticus and the control received saline. Behavioral tests started from 60 days postnatal and were carried out only during the diestrus phase of the reproductive cycle. In sociability test experimental animals exhibited reduced motivation for social encounter and deficit in social discrimination. In open field and the elevated plus maze, experimental animals showed enhanced emotionality with no changes in basal locomotor activity. The results showed that female rats submitted to neonatal status epipepticus showed impaired social behavior, characterized by reduced motivation to novelty and deficit in social discrimination in addition to enhanced emotionality. Previously, we demonstrated that male Wistar rats submitted to neonatal status epilepticus showed abnormal social behavior characterized by deficit in social discrimination and enhanced emotionality. Taking into account that early insult can produce different biological manifestations in a gender-dependent manner, we aimed to investigate the social behavior and anxiety-like behavior in female Wistar rats following early life seizures. Neonate female Wistar rats at 9 days postnatal were subject to pilocarpine-induced status epilepticus and the control received saline. Behavioral tests started from 60 days postnatal and were carried out only during the diestrus phase of the reproductive cycle. In sociability test experimental animals exhibited reduced motivation for social encounter and deficit in social discrimination. In open field and the elevated plus maze, experimental animals showed enhanced emotionality with no changes in basal locomotor activity. The results showed that female rats submitted to neonatal status epipepticus showed impaired social behavior, characterized by reduced motivation to novelty and deficit in social discrimination in addition to enhanced emotionality. |
| Author | Cysneiros, Roberta Monterazzo Castelhano, Adelisandra Silva Santos Ramos, Fabiane Ochai Scorza, Fulvio Alexandre |
| Author_xml | – sequence: 1 givenname: Adelisandra Silva Santos surname: Castelhano fullname: Castelhano, Adelisandra Silva Santos organization: Laboratory of Neurobiology, Presbyterian Mackenzie University – sequence: 2 givenname: Fabiane Ochai surname: Ramos fullname: Ramos, Fabiane Ochai organization: Laboratory of Neurobiology, Presbyterian Mackenzie University, Department of Neurology and Neurosurgery, Experimental Neurology, Escola Paulista de Medicina, Federal University of São Paulo – sequence: 3 givenname: Fulvio Alexandre surname: Scorza fullname: Scorza, Fulvio Alexandre organization: Department of Neurology and Neurosurgery, Experimental Neurology, Escola Paulista de Medicina, Federal University of São Paulo – sequence: 4 givenname: Roberta Monterazzo surname: Cysneiros fullname: Cysneiros, Roberta Monterazzo email: roberta.cysneiros@mackenzie.br, rcysneiros@yahoo.com organization: Laboratory of Neurobiology, Presbyterian Mackenzie University |
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| CitedBy_id | crossref_primary_10_3390_brainsci14090892 crossref_primary_10_3390_ijms22137121 crossref_primary_10_1002_epi4_12664 crossref_primary_10_1080_00207454_2018_1486827 crossref_primary_10_3389_fnbeh_2020_560423 crossref_primary_10_1016_j_dib_2020_105819 crossref_primary_10_1016_j_yebeh_2017_04_031 crossref_primary_10_3389_fnins_2022_869671 crossref_primary_10_1016_j_dib_2016_03_029 crossref_primary_10_1016_j_bbr_2018_12_021 crossref_primary_10_1016_j_yebeh_2016_05_031 crossref_primary_10_1016_j_yebeh_2025_110307 crossref_primary_10_3390_cells11203228 crossref_primary_10_3389_fnins_2019_00981 crossref_primary_10_2174_1567202616666190906125444 crossref_primary_10_1016_j_expneurol_2017_06_022 crossref_primary_10_3389_fnins_2018_00897 crossref_primary_10_1016_j_expneurol_2019_113005 crossref_primary_10_1016_j_eplepsyres_2018_05_009 |
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| Keywords | Female Neonatal Pilocarpine Social behavior General anxiety |
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| SubjectTerms | Age Factors Analysis of Variance Animals Animals, Newborn Anxiety Anxiety - etiology Exploratory Behavior - physiology Female Maze Learning Medicine Medicine & Public Health Motivation - physiology Neurology Neurosciences Psychiatry Rats Rats, Wistar Seizures - complications Social Behavior Disorders - etiology Social Discrimination - psychology Translational Neurosciences - Original Article |
| Title | Early life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination |
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