Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection
Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for the detection of gastric cancer. Salivary prote...
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Published in | Scientific reports Vol. 6; no. 1; p. 22165 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
25.02.2016
Nature Publishing Group |
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Online Access | Get full text |
ISSN | 2045-2322 2045-2322 |
DOI | 10.1038/srep22165 |
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Abstract | Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for the detection of gastric cancer. Salivary proteins were analyzed and compared between gastric cancer patients and matched control subjects by using tandem mass tags (TMT) technology. More than 500 proteins were identified with quantification, and 48 of them showed significant difference expression (p < 0.05) between normal controls and gastric cancer patients, including 7 up-regulated proteins and 41 down-regulated proteins. Five proteins were selected for initial verification by ELISA and three were successfully verified, namely cystatin B (CSTB), triosephosphate isomerase (TPI1), and deleted in malignant brain tumors 1 protein (DMBT1). All three proteins could differentiate gastric cancer patients from normal control subjects, dramatically (p < 0.05). The combination of these three biomarkers could reach 85% sensitivity and 80% specificity for the detection of gastric cancer with accuracy of 0.93. This study provides the proof of concept of salivary biomarkers for the non-invasive detection of gastric cancer. It is highly encouraging to turn these biomarkers into an applicable clinical test after large scale validation. |
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AbstractList | Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for the detection of gastric cancer. Salivary proteins were analyzed and compared between gastric cancer patients and matched control subjects by using tandem mass tags (TMT) technology. More than 500 proteins were identified with quantification, and 48 of them showed significant difference expression (p < 0.05) between normal controls and gastric cancer patients, including 7 up-regulated proteins and 41 down-regulated proteins. Five proteins were selected for initial verification by ELISA and three were successfully verified, namely cystatin B (CSTB), triosephosphate isomerase (TPI1), and deleted in malignant brain tumors 1 protein (DMBT1). All three proteins could differentiate gastric cancer patients from normal control subjects, dramatically (p < 0.05). The combination of these three biomarkers could reach 85% sensitivity and 80% specificity for the detection of gastric cancer with accuracy of 0.93. This study provides the proof of concept of salivary biomarkers for the non-invasive detection of gastric cancer. It is highly encouraging to turn these biomarkers into an applicable clinical test after large scale validation. Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for the detection of gastric cancer. Salivary proteins were analyzed and compared between gastric cancer patients and matched control subjects by using tandem mass tags (TMT) technology. More than 500 proteins were identified with quantification, and 48 of them showed significant difference expression (p < 0.05) between normal controls and gastric cancer patients, including 7 up-regulated proteins and 41 down-regulated proteins. Five proteins were selected for initial verification by ELISA and three were successfully verified, namely cystatin B (CSTB), triosephosphate isomerase (TPI1), and deleted in malignant brain tumors 1 protein (DMBT1). All three proteins could differentiate gastric cancer patients from normal control subjects, dramatically (p < 0.05). The combination of these three biomarkers could reach 85% sensitivity and 80% specificity for the detection of gastric cancer with accuracy of 0.93. This study provides the proof of concept of salivary biomarkers for the non-invasive detection of gastric cancer. It is highly encouraging to turn these biomarkers into an applicable clinical test after large scale validation.Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for the detection of gastric cancer. Salivary proteins were analyzed and compared between gastric cancer patients and matched control subjects by using tandem mass tags (TMT) technology. More than 500 proteins were identified with quantification, and 48 of them showed significant difference expression (p < 0.05) between normal controls and gastric cancer patients, including 7 up-regulated proteins and 41 down-regulated proteins. Five proteins were selected for initial verification by ELISA and three were successfully verified, namely cystatin B (CSTB), triosephosphate isomerase (TPI1), and deleted in malignant brain tumors 1 protein (DMBT1). All three proteins could differentiate gastric cancer patients from normal control subjects, dramatically (p < 0.05). The combination of these three biomarkers could reach 85% sensitivity and 80% specificity for the detection of gastric cancer with accuracy of 0.93. This study provides the proof of concept of salivary biomarkers for the non-invasive detection of gastric cancer. It is highly encouraging to turn these biomarkers into an applicable clinical test after large scale validation. |
ArticleNumber | 22165 |
Author | Kim, Sung Xiao, Hua Kim, Yong Yoshizawa, Janice Cao, Cheng-Xi Kim, Jae Joon Zhang, Yan Wong, David T. W. Kim, Kyoung Mee Fan, Liu-Yin |
Author_xml | – sequence: 1 givenname: Hua surname: Xiao fullname: Xiao, Hua email: huaxiao@sjtu.edu.cn organization: State Key Laboratory of Microbial Metabolism, Laboratory of Bioseparation and Analytical Biochemistry, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – sequence: 2 givenname: Yan surname: Zhang fullname: Zhang, Yan organization: School of Pharmacy, Shanghai Jiao Tong University – sequence: 3 givenname: Yong surname: Kim fullname: Kim, Yong organization: Dental Research Institute, School of Dentistry, University of California-Los Angeles, Los Angeles – sequence: 4 givenname: Sung surname: Kim fullname: Kim, Sung organization: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine – sequence: 5 givenname: Jae Joon surname: Kim fullname: Kim, Jae Joon organization: Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine – sequence: 6 givenname: Kyoung Mee surname: Kim fullname: Kim, Kyoung Mee organization: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine – sequence: 7 givenname: Janice surname: Yoshizawa fullname: Yoshizawa, Janice organization: Dental Research Institute, School of Dentistry, University of California-Los Angeles, Los Angeles – sequence: 8 givenname: Liu-Yin surname: Fan fullname: Fan, Liu-Yin organization: State Key Laboratory of Microbial Metabolism, Laboratory of Bioseparation and Analytical Biochemistry, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – sequence: 9 givenname: Cheng-Xi surname: Cao fullname: Cao, Cheng-Xi organization: State Key Laboratory of Microbial Metabolism, Laboratory of Bioseparation and Analytical Biochemistry, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University – sequence: 10 givenname: David T. W. surname: Wong fullname: Wong, David T. W. email: dtww@ucla.edu organization: Dental Research Institute, School of Dentistry, University of California-Los Angeles, Los Angeles |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26911362$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1038/srep11516 10.1021/ac500140s 10.3322/caac.21254 10.1245/s10434-007-9660-9 10.1002/prca.200780015 10.1021/pr400098r 10.1053/j.gastro.2006.02.011 10.1038/sj.bjc.6604861 10.1093/nar/gkq960 10.1002/ijc.28807 10.1021/pr700764j 10.1002/ijc.28999 10.1007/s10620-009-0908-z 10.1200/JCO.2014.60.1799 10.1053/j.gastro.2006.03.029 10.1158/1078-0432.CCR-07-5037 10.1007/s00535-008-2208-3 10.1038/nrgastro.2014.143 10.1021/ac702422x 10.1074/jbc.M010056200 10.1021/pr9007927 10.1074/jbc.M113.452458 10.1038/nature15756 10.3748/wjg.14.1149 10.1016/j.bios.2014.09.006 10.1002/pmic.201200319 10.1111/j.1349-7006.2010.01666.x 10.1002/art.22954 10.1097/00042737-200608000-00004 10.3748/wjg.15.865 10.1021/pr700638k 10.1038/nrc2857 10.1158/1078-0432.CCR-06-1404 10.1158/1078-0432.CCR-08-1143 10.1016/S0895-4356(02)00534-6 10.1007/s00432-008-0367-5 10.1016/j.ejca.2010.10.025 10.1002/pmic.200401037 10.3748/wjg.14.5657 10.1002/elps.200800207 10.1159/000326857 10.1158/1078-0432.CCR-07-1615 10.1093/carcin/bgi045 10.1053/j.gastro.2009.02.085 10.3748/wjg.v12.i3.354 10.1371/journal.pone.0015573 10.1021/pr100192h 10.1002/pmic.200600284 10.1371/journal.pone.0033037 10.1074/mcp.M111.012112 |
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References | Kang (CR13) 2008; 43 Nilsson (CR32) 2010; 9 Pan, Brentnall, Kelly, Chen (CR12) 2013; 13 Hu (CR23) 2005; 5 Poon (CR26) 2006; 130 Hu (CR39) 2007; 56 Hao (CR17) 2008; 7 Hoshino (CR44) 2015; 527 Kawada (CR24) 2006; 130 Werner, Chen, Tao, Brenner (CR14) 2015; 136 Tsunemi (CR28) 2010; 23 Shah (CR21) 2015; 33 Maconi, Manes, Porro (CR3) 2008; 14 Zhou, Yin, Dang, Ye, Zhang (CR19) 2015; 5 Zhang (CR40) 2010; 5 Liu (CR18) 2011; 47 Feldman, Banyard, Wu, McDougal, Zetter (CR48) 2009; 15 Chong (CR29) 2010; 9 Cui (CR11) 2011; 39 Lee (CR43) 2011; 84 CR45 Kang (CR50) 2005; 26 CR41 Rogers, Strehler (CR52) 2001; 276 Polk, Peek (CR6) 2010; 10 Zilberman, Sonkusale (CR35) 2015; 67 Conde (CR51) 2007; 30 Crew, Neugut (CR1) 2006; 12 Cho, Lim, Jun, Kim, Kim (CR7) 2010; 55 Jung (CR10) 2010; 101 Tan, Fielding (CR8) 2006; 18 Siegel, Miller, Jemal (CR9) 2015; 65 Wang, Wu, Tsao, Sun (CR15) 2006; 36 Deutsch (CR53) 2008; 29 Lam, Lo (CR25) 2008; 2 Dayon (CR33) 2008; 80 Denny (CR37) 2008; 7 Kelley, Duggan (CR4) 2003; 56 Watanabe (CR20) 2009; 136 Savitski (CR31) 2013; 12 Hsu (CR16) 2007; 13 Lee (CR47) 2008; 14 Ha (CR34) 2008; 15 Hu (CR38) 2008; 14 McLean, El-Omar (CR2) 2014; 11 Han (CR22) 2009; 100 Plummer, Franceschi, Vignat, Forman, de Martel (CR5) 2015; 136 Li (CR27) 2008; 14 Wu, Wang, Zhang (CR42) 2009; 15 Werner (CR30) 2014; 86 Hu, Loo, Wong (CR36) 2006; 6 Lau (CR46) 2013; 288 Wang (CR49) 2008; 134 R Liu (BFsrep22165_CR18) 2011; 47 S Hu (BFsrep22165_CR36) 2006; 6 S Pan (BFsrep22165_CR12) 2013; 13 KWK Lam (BFsrep22165_CR25) 2008; 2 N Kawada (BFsrep22165_CR24) 2006; 130 P Denny (BFsrep22165_CR37) 2008; 7 R Siegel (BFsrep22165_CR9) 2015; 65 PI Hsu (BFsrep22165_CR16) 2007; 13 Y Watanabe (BFsrep22165_CR20) 2009; 136 A Hoshino (BFsrep22165_CR44) 2015; 527 MIH McLean (BFsrep22165_CR2) 2014; 11 KD Crew (BFsrep22165_CR1) 2006; 12 SW Han (BFsrep22165_CR22) 2009; 100 L Dayon (BFsrep22165_CR33) 2008; 80 DB Polk (BFsrep22165_CR6) 2010; 10 MJ Lee (BFsrep22165_CR47) 2008; 14 ZZ Wu (BFsrep22165_CR42) 2009; 15 G Maconi (BFsrep22165_CR3) 2008; 14 TK Ha (BFsrep22165_CR34) 2008; 15 XY Zhou (BFsrep22165_CR19) 2015; 5 Y Zilberman (BFsrep22165_CR35) 2015; 67 H Lee (BFsrep22165_CR43) 2011; 84 L Zhang (BFsrep22165_CR40) 2010; 5 MM Savitski (BFsrep22165_CR31) 2013; 12 S Hu (BFsrep22165_CR23) 2005; 5 BFsrep22165_CR45 JR Kelley (BFsrep22165_CR4) 2003; 56 SO Cho (BFsrep22165_CR7) 2010; 55 BFsrep22165_CR41 S Tsunemi (BFsrep22165_CR28) 2010; 23 C Lau (BFsrep22165_CR46) 2013; 288 MA Shah (BFsrep22165_CR21) 2015; 33 JJ Jung (BFsrep22165_CR10) 2010; 101 CL Nilsson (BFsrep22165_CR32) 2010; 9 WQ Kang (BFsrep22165_CR50) 2005; 26 YK Tan (BFsrep22165_CR8) 2006; 18 PK Chong (BFsrep22165_CR29) 2010; 9 S Hu (BFsrep22165_CR39) 2007; 56 Y Hao (BFsrep22165_CR17) 2008; 7 MS Rogers (BFsrep22165_CR52) 2001; 276 T Werner (BFsrep22165_CR30) 2014; 86 XD Kang (BFsrep22165_CR13) 2008; 43 S Werner (BFsrep22165_CR14) 2015; 136 AS Feldman (BFsrep22165_CR48) 2009; 15 JA Cui (BFsrep22165_CR11) 2011; 39 S Hu (BFsrep22165_CR38) 2008; 14 AR Conde (BFsrep22165_CR51) 2007; 30 CS Wang (BFsrep22165_CR15) 2006; 36 X Wang (BFsrep22165_CR49) 2008; 134 M Plummer (BFsrep22165_CR5) 2015; 136 W Li (BFsrep22165_CR27) 2008; 14 TCW Poon (BFsrep22165_CR26) 2006; 130 O Deutsch (BFsrep22165_CR53) 2008; 29 16501233 - Ann Clin Lab Sci. 2006 Winter;36(1):23-30 20495574 - Nat Rev Cancer. 2010 Jun;10(6):403-14 11278607 - J Biol Chem. 2001 Apr 13;276(15):12182-9 16489633 - World J Gastroenterol. 2006 Jan 21;12(3):354-62 20515073 - J Proteome Res. 2010 Jul 2;9(7):3671-9 18361515 - J Proteome Res. 2008 May;7(5):1994-2006 19127259 - Br J Cancer. 2009 Jan 27;100(2):298-304 22096114 - Mol Cell Proteomics. 2012 Feb;11(2):M111.012112 18680356 - J Proteome Res. 2008 Sep;7(9):3668-77 16697748 - Gastroenterology. 2006 May;130(6):1858-64 18312001 - Anal Chem. 2008 Apr 15;80(8):2921-31 17083142 - Proteomics. 2006 Dec;6(23):6326-53 18709484 - J Gastroenterol. 2008;43(8):618-25 21136826 - Proteomics Clin Appl. 2008 Feb;2(2):219-28 22448232 - PLoS One. 2012;7(3):e33037 16825897 - Eur J Gastroenterol Hepatol. 2006 Aug;18(8):821-9 21525769 - Digestion. 2011;84(2):142-8 20731665 - Cancer Sci. 2010 Oct;101(10):2200-6 18300338 - World J Gastroenterol. 2008 Feb 28;14(8):1149-55 15800970 - Proteomics. 2005 Apr;5(6):1714-28 21112772 - Eur J Cancer. 2011 Mar;47(5):784-91 18937257 - Electrophoresis. 2008 Nov;29(20):4150-7 20204278 - Oncol Rep. 2010 Apr;23(4):949-56 25223554 - Biosens Bioelectron. 2015 May 15;67:465-71 17487364 - Int J Oncol. 2007 Jun;30(6):1441-6 26524530 - Nature. 2015 Nov 19;527(7578):329-35 19375421 - Gastroenterology. 2009 Jun;136(7):2149-58 20965966 - Nucleic Acids Res. 2011 Mar;39(4):1197-207 24615018 - Int J Cancer. 2015 May 15;136(10):2243-52 18829504 - Clin Cancer Res. 2008 Oct 1;14(19):6246-52 19188175 - Clin Cancer Res. 2009 Feb 1;15(3):1024-31 17968930 - Arthritis Rheum. 2007 Nov;56(11):3588-600 25134511 - Nat Rev Gastroenterol Hepatol. 2014 Nov;11(11):664-74 17289880 - Clin Cancer Res. 2007 Feb 1;13(3):876-83 18837081 - World J Gastroenterol. 2008 Oct 7;14(37):5657-64 26096073 - Sci Rep. 2015;5:11516 19899826 - J Proteome Res. 2010 Jan;9(1):430-43 23768245 - J Proteome Res. 2013 Aug 2;12(8):3586-98 18071825 - Ann Surg Oncol. 2008 Feb;15(2):508-13 19230049 - World J Gastroenterol. 2009 Feb 21;15(7):865-70 23880764 - J Biol Chem. 2013 Sep 13;288(37):26888-97 18309519 - J Cancer Res Clin Oncol. 2008 Sep;134(9):995-1003 25918288 - J Clin Oncol. 2015 Jun 1;33(16):1760-9 24579773 - Anal Chem. 2014 Apr 1;86(7):3594-601 12589864 - J Clin Epidemiol. 2003 Jan;56(1):1-9 18281540 - Clin Cancer Res. 2008 Feb 15;14(4):1080-9 19672714 - Dig Dis Sci. 2010 Jun;55(6):1550-64 23125171 - Proteomics. 2013 Feb;13(3-4):710-21 15760920 - Carcinogenesis. 2005 Jun;26(6):1129-37 21217834 - PLoS One. 2010;5(12):e15573 24889903 - Int J Cancer. 2015 Jan 15;136(2):487-90 25559415 - CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29 16697755 - Gastroenterology. 2006 May;130(6):1917-9 |
References_xml | – volume: 5 start-page: 11516 year: 2015 ident: CR19 article-title: Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer publication-title: Sci Rep doi: 10.1038/srep11516 – ident: CR45 – volume: 86 start-page: 3594 year: 2014 end-page: 3601 ident: CR30 article-title: Ion Coalescence of Neutron Encoded TMT 10-Plex Reporter Ions publication-title: Anal. Chem. doi: 10.1021/ac500140s – volume: 65 start-page: 5 year: 2015 end-page: 29 ident: CR9 article-title: Cancer statistics, 2015 publication-title: CA-Cancer J Clin. doi: 10.3322/caac.21254 – volume: 15 start-page: 508 year: 2008 end-page: 513 ident: CR34 article-title: Indication for endoscopic mucosal resection in early signet ring cell gastric cancer publication-title: Ann. Surg. Oncol. doi: 10.1245/s10434-007-9660-9 – volume: 2 start-page: 219 year: 2008 end-page: 228 ident: CR25 article-title: Discovery of diagnostic serum biomarkers of gastric cancer using proteomics publication-title: Proteom. Clin. Appl. doi: 10.1002/prca.200780015 – volume: 12 start-page: 3586 year: 2013 end-page: 3598 ident: CR31 article-title: Measuring and Managing Ratio Compression for Accurate iTRAQ/TMT Quantification publication-title: J. Proteome Res. doi: 10.1021/pr400098r – volume: 130 start-page: 1858 year: 2006 end-page: 1864 ident: CR26 article-title: Diagnosis of gastric cancer by serum proteomic fingerprinting publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.02.011 – volume: 23 start-page: 949 year: 2010 end-page: 956 ident: CR28 article-title: Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer publication-title: Oncol. Rep. – volume: 100 start-page: 298 year: 2009 end-page: 304 ident: CR22 article-title: Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6604861 – volume: 39 start-page: 1197 year: 2011 end-page: 1207 ident: CR11 article-title: An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq960 – volume: 136 start-page: 2243 year: 2015 end-page: 2252 ident: CR14 article-title: Systematic review: Serum autoantibodies in the early detection of gastric cancer publication-title: Int. J. Cancer doi: 10.1002/ijc.28807 – volume: 7 start-page: 1994 year: 2008 end-page: 2006 ident: CR37 article-title: The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions publication-title: J. Proteome Res. doi: 10.1021/pr700764j – volume: 136 start-page: 487 year: 2015 end-page: 490 ident: CR5 article-title: Global burden of gastric cancer attributable to Helicobacter pylori publication-title: Int. J. Cancer doi: 10.1002/ijc.28999 – volume: 55 start-page: 1550 year: 2010 end-page: 1564 ident: CR7 article-title: Helicobacter pylori in a Korean Isolate Expressed Proteins Differentially in Human Gastric Epithelial Cells publication-title: Dig. Dis. Sci. doi: 10.1007/s10620-009-0908-z – volume: 33 start-page: 1760 year: 2015 end-page: 1769 ident: CR21 article-title: Update on Metastatic Gastric and Esophageal Cancers publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2014.60.1799 – volume: 130 start-page: 1917 year: 2006 end-page: 1919 ident: CR24 article-title: Cancer serum proteomics in gastroenterology publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.03.029 – volume: 14 start-page: 6246 year: 2008 end-page: 6252 ident: CR38 article-title: Salivary Proteomics for Oral Cancer Biomarker Discovery publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-07-5037 – volume: 43 start-page: 618 year: 2008 end-page: 625 ident: CR13 article-title: Prohibitin: a potential biomarker for tissue-based detection of gastric cancer publication-title: J. Gastroenterol. doi: 10.1007/s00535-008-2208-3 – volume: 11 start-page: 664 year: 2014 end-page: 674 ident: CR2 article-title: Genetics of gastric cancer publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2014.143 – volume: 80 start-page: 2921 year: 2008 end-page: 2931 ident: CR33 article-title: Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags publication-title: Anal. Chem. doi: 10.1021/ac702422x – volume: 276 start-page: 12182 year: 2001 end-page: 12189 ident: CR52 article-title: The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X publication-title: J. Biol. Chem. doi: 10.1074/jbc.M010056200 – volume: 9 start-page: 430 year: 2010 end-page: 443 ident: CR32 article-title: Quantitative Phosphoproteomic Analysis of the STAT3/IL-6/HIF1 alpha Signaling Network: An Initial Study in GSC11 Glioblastoma Stem Cells publication-title: J. Proteome Res. doi: 10.1021/pr9007927 – volume: 288 start-page: 26888 year: 2013 end-page: 26897 ident: CR46 article-title: Role of Pancreatic Cancer-derived Exosomes in Salivary Biomarker Development publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.452458 – volume: 527 start-page: 329 year: 2015 end-page: 335 ident: CR44 article-title: Tumour exosome integrins determine organotropic metastasis publication-title: Nature doi: 10.1038/nature15756 – volume: 14 start-page: 1149 year: 2008 end-page: 1155 ident: CR3 article-title: Role of symptoms in diagnosis and outcome of gastric cancer publication-title: World J. Gastroenterol. doi: 10.3748/wjg.14.1149 – volume: 67 start-page: 465 year: 2015 end-page: 471 ident: CR35 article-title: Microfluidic optoelectronic sensor for salivary diagnostics of stomach cancer publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2014.09.006 – volume: 13 start-page: 710 year: 2013 end-page: 721 ident: CR12 article-title: Tissue proteomics in pancreatic cancer study: Discovery, emerging technologies, and challenges publication-title: Proteomics doi: 10.1002/pmic.201200319 – volume: 101 start-page: 2200 year: 2010 end-page: 2206 ident: CR10 article-title: Chemokine growth-regulated oncogene 1 as a putative biomarker for gastric cancer progression publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2010.01666.x – volume: 56 start-page: 3588 year: 2007 end-page: 3600 ident: CR39 article-title: Salivary proteomic and genomic biomarkers for primary Sjogren’s syndrome publication-title: Arthritis Rheum. doi: 10.1002/art.22954 – volume: 18 start-page: 821 year: 2006 end-page: 829 ident: CR8 article-title: Early diagnosis of early gastric cancer publication-title: Eur. J. Gastroenterol. Hepatol. doi: 10.1097/00042737-200608000-00004 – volume: 15 start-page: 865 year: 2009 end-page: 870 ident: CR42 article-title: Diagnostic model of saliva protein finger print analysis of patients with gastric cancer publication-title: World J. Gastroenterol. doi: 10.3748/wjg.15.865 – volume: 7 start-page: 3668 year: 2008 end-page: 3677 ident: CR17 article-title: IPO-38 is identified as a novel serum biomarker of gastric cancer based on clinical proteomics technology publication-title: J. Proteome Res. doi: 10.1021/pr700638k – volume: 10 start-page: 403 year: 2010 end-page: 414 ident: CR6 article-title: Helicobacter pylori: gastric cancer and beyond publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2857 – volume: 13 start-page: 876 year: 2007 end-page: 883 ident: CR16 article-title: alpha 1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-06-1404 – volume: 15 start-page: 1024 year: 2009 end-page: 1031 ident: CR48 article-title: Cystatin B As a Tissue and Urinary Biomarker of Bladder Cancer Recurrence and Disease Progression publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-08-1143 – volume: 56 start-page: 1 year: 2003 end-page: 9 ident: CR4 article-title: Gastric cancer epidemiology and risk factors publication-title: J. Clin. Epidemiol. doi: 10.1016/S0895-4356(02)00534-6 – volume: 134 start-page: 995 year: 2008 end-page: 1003 ident: CR49 article-title: Identification of triosephosphate isomerase as an anti-drug resistance agent in human gastric cancer cells using functional proteomic analysis publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/s00432-008-0367-5 – volume: 47 start-page: 784 year: 2011 end-page: 791 ident: CR18 article-title: A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2010.10.025 – volume: 5 start-page: 1714 year: 2005 end-page: 1728 ident: CR23 article-title: Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry publication-title: Proteomics doi: 10.1002/pmic.200401037 – volume: 14 start-page: 5657 year: 2008 end-page: 5664 ident: CR27 article-title: Comparative proteomics analysis of human gastric cancer publication-title: World J. Gastroenterol. doi: 10.3748/wjg.14.5657 – volume: 29 start-page: 4150 year: 2008 end-page: 4157 ident: CR53 article-title: An approach to remove alpha amylase for proteomic analysis of low abundance biomarkers in human saliva publication-title: Electrophoresis doi: 10.1002/elps.200800207 – volume: 30 start-page: 1441 year: 2007 end-page: 1446 ident: CR51 article-title: DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types publication-title: Int. J. Oncol. – volume: 84 start-page: 142 year: 2011 end-page: 148 ident: CR43 article-title: Survival Outcome Associated with the Screening Interval for Gastric Cancer in Korea publication-title: Digestion doi: 10.1159/000326857 – volume: 14 start-page: 1080 year: 2008 end-page: 1089 ident: CR47 article-title: Identification of cystatin B as a potential serum marker in hepatocellular carcinoma publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-07-1615 – volume: 26 start-page: 1129 year: 2005 end-page: 1137 ident: CR50 article-title: Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer publication-title: Carcinogenesis doi: 10.1093/carcin/bgi045 – volume: 36 start-page: 23 year: 2006 end-page: 30 ident: CR15 article-title: Serum TIMP-1 in gastric cancer patients: A potential prognostic biomarker publication-title: Ann. Clin. Lab. Sci. – volume: 136 start-page: 2149 year: 2009 end-page: 2158 ident: CR20 article-title: Sensitive and Specific Detection of Early Gastric Cancer with DNA Methylation Analysis of Gastric Washes publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.02.085 – volume: 12 start-page: 354 year: 2006 end-page: 362 ident: CR1 article-title: Epidemiology of gastric cancer publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v12.i3.354 – volume: 5 start-page: e15573 year: 2010 ident: CR40 article-title: Discovery and Preclinical Validation of Salivary Transcriptomic and Proteomic Biomarkers for the Non-Invasive Detection of Breast Cancer publication-title: PLoS One doi: 10.1371/journal.pone.0015573 – ident: CR41 – volume: 9 start-page: 3671 year: 2010 end-page: 3679 ident: CR29 article-title: ITIH3 is a Potential Biomarker for Early Detection of Gastric Cancer publication-title: J. Proteome Res. doi: 10.1021/pr100192h – volume: 6 start-page: 6326 year: 2006 end-page: 6353 ident: CR36 article-title: Human body fluid proteome analysis publication-title: Proteomics doi: 10.1002/pmic.200600284 – volume: 14 start-page: 5657 year: 2008 ident: BFsrep22165_CR27 publication-title: World J. Gastroenterol. doi: 10.3748/wjg.14.5657 – volume: 18 start-page: 821 year: 2006 ident: BFsrep22165_CR8 publication-title: Eur. J. Gastroenterol. Hepatol. doi: 10.1097/00042737-200608000-00004 – volume: 12 start-page: 354 year: 2006 ident: BFsrep22165_CR1 publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v12.i3.354 – volume: 5 start-page: e15573 year: 2010 ident: BFsrep22165_CR40 publication-title: PLoS One doi: 10.1371/journal.pone.0015573 – ident: BFsrep22165_CR45 doi: 10.1371/journal.pone.0033037 – volume: 100 start-page: 298 year: 2009 ident: BFsrep22165_CR22 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6604861 – volume: 86 start-page: 3594 year: 2014 ident: BFsrep22165_CR30 publication-title: Anal. Chem. doi: 10.1021/ac500140s – volume: 15 start-page: 1024 year: 2009 ident: BFsrep22165_CR48 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-08-1143 – volume: 130 start-page: 1917 year: 2006 ident: BFsrep22165_CR24 publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.03.029 – volume: 7 start-page: 3668 year: 2008 ident: BFsrep22165_CR17 publication-title: J. Proteome Res. doi: 10.1021/pr700638k – volume: 2 start-page: 219 year: 2008 ident: BFsrep22165_CR25 publication-title: Proteom. Clin. Appl. doi: 10.1002/prca.200780015 – volume: 101 start-page: 2200 year: 2010 ident: BFsrep22165_CR10 publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2010.01666.x – volume: 80 start-page: 2921 year: 2008 ident: BFsrep22165_CR33 publication-title: Anal. Chem. doi: 10.1021/ac702422x – volume: 56 start-page: 3588 year: 2007 ident: BFsrep22165_CR39 publication-title: Arthritis Rheum. doi: 10.1002/art.22954 – volume: 26 start-page: 1129 year: 2005 ident: BFsrep22165_CR50 publication-title: Carcinogenesis doi: 10.1093/carcin/bgi045 – volume: 23 start-page: 949 year: 2010 ident: BFsrep22165_CR28 publication-title: Oncol. Rep. – volume: 13 start-page: 876 year: 2007 ident: BFsrep22165_CR16 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-06-1404 – volume: 136 start-page: 2149 year: 2009 ident: BFsrep22165_CR20 publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.02.085 – volume: 136 start-page: 487 year: 2015 ident: BFsrep22165_CR5 publication-title: Int. J. Cancer doi: 10.1002/ijc.28999 – volume: 15 start-page: 865 year: 2009 ident: BFsrep22165_CR42 publication-title: World J. Gastroenterol. doi: 10.3748/wjg.15.865 – volume: 10 start-page: 403 year: 2010 ident: BFsrep22165_CR6 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2857 – volume: 47 start-page: 784 year: 2011 ident: BFsrep22165_CR18 publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2010.10.025 – volume: 29 start-page: 4150 year: 2008 ident: BFsrep22165_CR53 publication-title: Electrophoresis doi: 10.1002/elps.200800207 – volume: 5 start-page: 1714 year: 2005 ident: BFsrep22165_CR23 publication-title: Proteomics doi: 10.1002/pmic.200401037 – volume: 13 start-page: 710 year: 2013 ident: BFsrep22165_CR12 publication-title: Proteomics doi: 10.1002/pmic.201200319 – volume: 14 start-page: 1149 year: 2008 ident: BFsrep22165_CR3 publication-title: World J. Gastroenterol. doi: 10.3748/wjg.14.1149 – volume: 5 start-page: 11516 year: 2015 ident: BFsrep22165_CR19 publication-title: Sci Rep doi: 10.1038/srep11516 – volume: 67 start-page: 465 year: 2015 ident: BFsrep22165_CR35 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2014.09.006 – volume: 33 start-page: 1760 year: 2015 ident: BFsrep22165_CR21 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2014.60.1799 – volume: 134 start-page: 995 year: 2008 ident: BFsrep22165_CR49 publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/s00432-008-0367-5 – volume: 14 start-page: 1080 year: 2008 ident: BFsrep22165_CR47 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-07-1615 – volume: 43 start-page: 618 year: 2008 ident: BFsrep22165_CR13 publication-title: J. Gastroenterol. doi: 10.1007/s00535-008-2208-3 – volume: 9 start-page: 3671 year: 2010 ident: BFsrep22165_CR29 publication-title: J. Proteome Res. doi: 10.1021/pr100192h – ident: BFsrep22165_CR41 doi: 10.1074/mcp.M111.012112 – volume: 6 start-page: 6326 year: 2006 ident: BFsrep22165_CR36 publication-title: Proteomics doi: 10.1002/pmic.200600284 – volume: 15 start-page: 508 year: 2008 ident: BFsrep22165_CR34 publication-title: Ann. Surg. Oncol. doi: 10.1245/s10434-007-9660-9 – volume: 36 start-page: 23 year: 2006 ident: BFsrep22165_CR15 publication-title: Ann. Clin. Lab. Sci. – volume: 9 start-page: 430 year: 2010 ident: BFsrep22165_CR32 publication-title: J. Proteome Res. doi: 10.1021/pr9007927 – volume: 84 start-page: 142 year: 2011 ident: BFsrep22165_CR43 publication-title: Digestion doi: 10.1159/000326857 – volume: 527 start-page: 329 year: 2015 ident: BFsrep22165_CR44 publication-title: Nature doi: 10.1038/nature15756 – volume: 30 start-page: 1441 year: 2007 ident: BFsrep22165_CR51 publication-title: Int. J. Oncol. – volume: 65 start-page: 5 year: 2015 ident: BFsrep22165_CR9 publication-title: CA-Cancer J Clin. doi: 10.3322/caac.21254 – volume: 56 start-page: 1 year: 2003 ident: BFsrep22165_CR4 publication-title: J. Clin. Epidemiol. doi: 10.1016/S0895-4356(02)00534-6 – volume: 7 start-page: 1994 year: 2008 ident: BFsrep22165_CR37 publication-title: J. Proteome Res. doi: 10.1021/pr700764j – volume: 12 start-page: 3586 year: 2013 ident: BFsrep22165_CR31 publication-title: J. Proteome Res. doi: 10.1021/pr400098r – volume: 288 start-page: 26888 year: 2013 ident: BFsrep22165_CR46 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.452458 – volume: 11 start-page: 664 year: 2014 ident: BFsrep22165_CR2 publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2014.143 – volume: 130 start-page: 1858 year: 2006 ident: BFsrep22165_CR26 publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.02.011 – volume: 276 start-page: 12182 year: 2001 ident: BFsrep22165_CR52 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M010056200 – volume: 39 start-page: 1197 year: 2011 ident: BFsrep22165_CR11 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq960 – volume: 14 start-page: 6246 year: 2008 ident: BFsrep22165_CR38 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-07-5037 – volume: 136 start-page: 2243 year: 2015 ident: BFsrep22165_CR14 publication-title: Int. J. Cancer doi: 10.1002/ijc.28807 – volume: 55 start-page: 1550 year: 2010 ident: BFsrep22165_CR7 publication-title: Dig. Dis. Sci. doi: 10.1007/s10620-009-0908-z – reference: 21217834 - PLoS One. 2010;5(12):e15573 – reference: 17289880 - Clin Cancer Res. 2007 Feb 1;13(3):876-83 – reference: 20495574 - Nat Rev Cancer. 2010 Jun;10(6):403-14 – reference: 16697755 - Gastroenterology. 2006 May;130(6):1917-9 – reference: 19672714 - Dig Dis Sci. 2010 Jun;55(6):1550-64 – reference: 17487364 - Int J Oncol. 2007 Jun;30(6):1441-6 – reference: 18829504 - Clin Cancer Res. 2008 Oct 1;14(19):6246-52 – reference: 18071825 - Ann Surg Oncol. 2008 Feb;15(2):508-13 – reference: 15760920 - Carcinogenesis. 2005 Jun;26(6):1129-37 – reference: 26524530 - Nature. 2015 Nov 19;527(7578):329-35 – reference: 18312001 - Anal Chem. 2008 Apr 15;80(8):2921-31 – reference: 16489633 - World J Gastroenterol. 2006 Jan 21;12(3):354-62 – reference: 19899826 - J Proteome Res. 2010 Jan;9(1):430-43 – reference: 24579773 - Anal Chem. 2014 Apr 1;86(7):3594-601 – reference: 18300338 - World J Gastroenterol. 2008 Feb 28;14(8):1149-55 – reference: 17083142 - Proteomics. 2006 Dec;6(23):6326-53 – reference: 20204278 - Oncol Rep. 2010 Apr;23(4):949-56 – reference: 21112772 - Eur J Cancer. 2011 Mar;47(5):784-91 – reference: 19375421 - Gastroenterology. 2009 Jun;136(7):2149-58 – reference: 22448232 - PLoS One. 2012;7(3):e33037 – reference: 19188175 - Clin Cancer Res. 2009 Feb 1;15(3):1024-31 – reference: 16697748 - Gastroenterology. 2006 May;130(6):1858-64 – reference: 21525769 - Digestion. 2011;84(2):142-8 – reference: 23125171 - Proteomics. 2013 Feb;13(3-4):710-21 – reference: 25134511 - Nat Rev Gastroenterol Hepatol. 2014 Nov;11(11):664-74 – reference: 25223554 - Biosens Bioelectron. 2015 May 15;67:465-71 – reference: 12589864 - J Clin Epidemiol. 2003 Jan;56(1):1-9 – reference: 18309519 - J Cancer Res Clin Oncol. 2008 Sep;134(9):995-1003 – reference: 24615018 - Int J Cancer. 2015 May 15;136(10):2243-52 – reference: 18680356 - J Proteome Res. 2008 Sep;7(9):3668-77 – reference: 25559415 - CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29 – reference: 23768245 - J Proteome Res. 2013 Aug 2;12(8):3586-98 – reference: 24889903 - Int J Cancer. 2015 Jan 15;136(2):487-90 – reference: 18937257 - Electrophoresis. 2008 Nov;29(20):4150-7 – reference: 19230049 - World J Gastroenterol. 2009 Feb 21;15(7):865-70 – reference: 22096114 - Mol Cell Proteomics. 2012 Feb;11(2):M111.012112 – reference: 20731665 - Cancer Sci. 2010 Oct;101(10):2200-6 – reference: 26096073 - Sci Rep. 2015;5:11516 – reference: 23880764 - J Biol Chem. 2013 Sep 13;288(37):26888-97 – reference: 18281540 - Clin Cancer Res. 2008 Feb 15;14(4):1080-9 – reference: 17968930 - Arthritis Rheum. 2007 Nov;56(11):3588-600 – reference: 15800970 - Proteomics. 2005 Apr;5(6):1714-28 – reference: 20965966 - Nucleic Acids Res. 2011 Mar;39(4):1197-207 – reference: 16825897 - Eur J Gastroenterol Hepatol. 2006 Aug;18(8):821-9 – reference: 18837081 - World J Gastroenterol. 2008 Oct 7;14(37):5657-64 – reference: 25918288 - J Clin Oncol. 2015 Jun 1;33(16):1760-9 – reference: 16501233 - Ann Clin Lab Sci. 2006 Winter;36(1):23-30 – reference: 18709484 - J Gastroenterol. 2008;43(8):618-25 – reference: 19127259 - Br J Cancer. 2009 Jan 27;100(2):298-304 – reference: 21136826 - Proteomics Clin Appl. 2008 Feb;2(2):219-28 – reference: 20515073 - J Proteome Res. 2010 Jul 2;9(7):3671-9 – reference: 11278607 - J Biol Chem. 2001 Apr 13;276(15):12182-9 – reference: 18361515 - J Proteome Res. 2008 May;7(5):1994-2006 |
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Snippet | Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed... |
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SubjectTerms | 631/67/1504/1829 692/53/2421 82/16 82/58 82/81 Adult Aged Biomarkers Biomarkers, Tumor - metabolism Brain cancer Brain tumors Case-Control Studies Cystatin B - genetics Cystatin B - metabolism Cystatins DMBT1 protein Enzyme-linked immunosorbent assay Female Gastric cancer Humanities and Social Sciences Humans Male Middle Aged multidisciplinary Proteins Proteome - chemistry Proteome - genetics Proteome - metabolism Proteomics Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Saliva Saliva - metabolism Science Science (multidisciplinary) Stomach Neoplasms - diagnosis Stomach Neoplasms - metabolism Triose-phosphate isomerase Triose-Phosphate Isomerase - genetics Triose-Phosphate Isomerase - metabolism |
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Title | Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection |
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