Cinegraphic versus Combined Static and Cinegraphic Imaging for Initial Cranial Ultrasound Screening in Premature Infants

• Published in: Pediatric radiology Vol. 45; no. 11; pp. 1706 - 1711
• Main Authors: O’Dell, M. Cody, Cassady, Christopher, Logsdon, Gregory, Varich, Laura
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2015; Springer Nature B.V
• Subjects: Brain Diseases - diagnostic imaging; Echoencephalography - methods; Female; Humans; Imaging; Infant, Newborn; Magnetic Resonance Imaging, Cine - methods; Male; Medicine; Medicine & Public Health; Neuroradiology; Nuclear Medicine; Observer Variation; Oncology; Original Article; Pediatrics; Pregnancy; Premature Birth - diagnostic imaging; Radiology; Reproducibility of Results; Sensitivity and Specificity; Ultrasound; Video Recording - methods; Brain; Neonates; Cranial ultrasound; Intraventricular hemorrhage; Neonatal head ultrasound; Cinegraphic ultrasound imaging
• ISSN: 0301-0449; 1432-1998
• DOI: 10.1007/s00247-015-3382-0

Background Cranial ultrasound is an essential screening and diagnostic tool in the care of neonates and is especially useful in the premature population for evaluation of potential germinal matrix/intraventricular hemorrhage (GM/IVH). There are typically two screening examinations, with the initial cranial sonography performed between 3 days and 14 days after birth, usually consisting of a series of static images plus several cinegraphic sweeps. Objective Our primary goal was to assess whether cinegraphic sweeps alone are as accurate for diagnosing neurological abnormalities as combined static and cinegraphic imaging in the initial cranial US evaluation of premature infants. Our secondary goal was to establish the difference in time required to perform these two examinations. Materials and methods We retrospectively obtained 140 consecutive initial cranial US screening studies of premature infants. Three pediatric radiologists blinded to patient data read cinegraphic images alone and also combined (dual) imaging sets for a subset of subjects, recording findings for seven disease processes: germinal matrix/intraventricular hemorrhage (GM/IVH), right or left side; periventricular leukomalacia (PVL); choroid plexus cyst; subependymal cyst; cerebral and cerebellar infarction or hemorrhage; posterior fossa hemorrhage or infarction, and extra-axial hemorrhage. Separately, we compared retrospective dual imaging acquisition time against prospectively collected cinegraphic imaging time for premature infants undergoing initial cranial US evaluation. Results Equivalence testing demonstrated no difference in equivalency between initial cranial US screening using cinegraphic evaluation alone and dual imaging for GM/IVH, cerebral and cerebellar infarct or hemorrhage, and subependymal cyst (all P  < 0.05). For PVL and choroid plexus cyst, cinegraphic imaging and dual imaging did not demonstrate equivalence ( P  > 0.05). Cinegraphic images were obtained in less than one-third of the time required for dual imaging. Conclusion For the diagnoses that are critical to establish at initial screening (GM/IVH, cerebral and cerebellar infarct or hemorrhage) initial cranial US screening using cinegraphic sweeps was equivalent to dual imaging. Cinegraphic imaging required significantly less time to perform than dual imaging. We suggest that performance of cranial US screening using cinegraphic imaging alone is a potentially advantageous option in the initial evaluation of the premature neonate.