Bioinspired Hydrogels for 3D Organoid Culture

Organoids have stepped into the limelight as unique systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) t...

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Published inChimia Vol. 73; no. 1-2; p. 81
Main Authors Blondel, Delphine, Lutolf, Matthias P
Format Journal Article
LanguageEnglish
Published Switzerland Swiss Chemical Society 27.02.2019
Subjects
Cell Culture Techniques
Ecm
Extracellular Matrix
Hydrogel
Hydrogels
Matrigeltm
Organoid
Organoids
Photo-patterning
Stem Cells
Synthetic gel
Online AccessGet full text
ISSN0009-4293
2673-2424
DOI10.2533/chimia.2019.81

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Abstract Organoids have stepped into the limelight as unique systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) that are used for generating organoids in 3D stem cell culture. In particular, we propose the use of self-healing and light-responsive matrices that should afford control over the inherently stochastic self-organization process that currently underlies organoid morphogenesis. Such designer ECMs could accelerate the translation of organoid technology from the laboratory into various real-life applications.
AbstractList Organoids have stepped into the limelight as unique systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) that are used for generating organoids in 3D stem cell culture. In particular, we propose the use of self-healing and light-responsive matrices that should afford control over the inherently stochastic self-organization process that currently underlies organoid morphogenesis. Such designer ECMs could accelerate the translation of organoid technology from the laboratory into various real-life applications.
Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) that are used for generating organoids in 3D stem cell culture. In particular, we propose the use of self-healing and light-responsive matrices that should afford control over the inherently stochastic self-organization process that currently underlies organoid morphogenesis. Such designer ECMs could accelerate the translation of organoid technology from the laboratory into various real-life applications.
Author Lutolf, Matthias P
Blondel, Delphine
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Snippet Organoids have stepped into the limelight as unique systems for modeling organ development, function and disease. This review provides a perspective on how...
Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective...
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StartPage 81
SubjectTerms Cell Culture Techniques
Ecm
Extracellular Matrix
Hydrogel
Hydrogels
Matrigeltm
Organoid
Organoids
Photo-patterning
Stem Cells
Synthetic gel
Title Bioinspired Hydrogels for 3D Organoid Culture
URI https://www.ncbi.nlm.nih.gov/pubmed/30814005
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Volume 73
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