Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis

The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its...

Full description

Saved in:
Bibliographic Details
Published inJournal of Korean medical science Vol. 26; no. 9; pp. 1132 - 1139
Main Authors Hong, Yeon-Sik, Moon, Su-Jin, Joo, Young-Bin, Jeon, Chan-Hong, Cho, Mi-La, Ju, Ji Hyeon, Oh, Hye-Jwa, Heo, Yu-Jung, Park, Sung-Hwan, Kim, Ho-Youn, Min, Jun-Ki
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Academy of Medical Sciences 01.09.2011
대한의학회
Subjects
Adult
Aged
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - pathology
C-Reactive Protein - analysis
Female
Humans
Interleukin-1 Receptor-Like 1 Protein
Interleukin-1beta - analysis
Interleukin-1beta - blood
Interleukin-33
Interleukin-6 - analysis
Interleukin-6 - blood
Interleukins - analysis
Interleukins - blood
Male
Middle Aged
Original
Osteoarthritis - blood
Osteoarthritis - pathology
Receptors, Cell Surface - analysis
Receptors, Cell Surface - blood
Synovial Fluid - metabolism
의학일반
Interleukin-33
sST2, ST2L
Arthritis, Rheumatoid
Online AccessGet full text
ISSN1011-8934
1598-6357
1598-6357
DOI10.3346/jkms.2011.26.9.1132

Cover

Abstract The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.
AbstractList The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen–allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL,P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional diseasemodifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA. KCI Citation Count: 32
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.
Author Moon, Su-Jin
Hong, Yeon-Sik
Park, Sung-Hwan
Kim, Ho-Youn
Min, Jun-Ki
Cho, Mi-La
Jeon, Chan-Hong
Ju, Ji Hyeon
Joo, Young-Bin
Oh, Hye-Jwa
Heo, Yu-Jung
AuthorAffiliation 2 Department of Internal medicine, Soonchunhyang University College of Medicine, Bucheon, Korea
3 The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea
1 Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea
AuthorAffiliation_xml – name: 1 Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea
– name: 2 Department of Internal medicine, Soonchunhyang University College of Medicine, Bucheon, Korea
– name: 3 The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea
Author_xml – sequence: 1
  givenname: Yeon-Sik
  surname: Hong
  fullname: Hong, Yeon-Sik
  organization: Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 2
  givenname: Su-Jin
  surname: Moon
  fullname: Moon, Su-Jin
  organization: Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 3
  givenname: Young-Bin
  surname: Joo
  fullname: Joo, Young-Bin
  organization: Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 4
  givenname: Chan-Hong
  surname: Jeon
  fullname: Jeon, Chan-Hong
  organization: Department of Internal medicine, Soonchunhyang University College of Medicine, Bucheon, Korea
– sequence: 5
  givenname: Mi-La
  surname: Cho
  fullname: Cho, Mi-La
  organization: The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea
– sequence: 6
  givenname: Ji Hyeon
  surname: Ju
  fullname: Ju, Ji Hyeon
  organization: Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 7
  givenname: Hye-Jwa
  surname: Oh
  fullname: Oh, Hye-Jwa
  organization: The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea
– sequence: 8
  givenname: Yu-Jung
  surname: Heo
  fullname: Heo, Yu-Jung
  organization: The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea
– sequence: 9
  givenname: Sung-Hwan
  surname: Park
  fullname: Park, Sung-Hwan
  organization: Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 10
  givenname: Ho-Youn
  surname: Kim
  fullname: Kim, Ho-Youn
  organization: Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 11
  givenname: Jun-Ki
  surname: Min
  fullname: Min, Jun-Ki
  organization: Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21935266$$D View this record in MEDLINE/PubMed
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001586190$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNp9kc2O0zAUhS00iPmBJ0BC3tFZpMS-SexskKoRA5WKQKWsrcSxqaeJXWwHNG-Pkw4jYMHqWLrnnHut7xKdWWcVQi9JvgQoqjd3hyEsaU7IklbLekkI0CfogpQ1zyoo2Vl6p2HGayjO0WUId3lOy5LCM3ROSQ0lraoL5D6qJoxeDcpG7DRe26h8r8aDsRkAXqw3Sa5xYzs8P_FWSXWMzge8CF92dJ4k3VxjY_HnJppUFPBPE_d4u1fj0ERnOrzyce9NNOE5eqqbPqgXD3qFvt6-2918yDaf3q9vVptMFsBiVlNo2w54AbrQFSs7raRuFZMArOCtajVn0EiWFxLyFnjX1WXHQVLQuuaUwBVanHqt1-IgjXCNmfWbEwcvVtvdWpQsLeDJ-vZkPY7toDqZPuCbXhy9GRp_Pwf_nlizTzU_BBBGq7ng9UOBd99HFaIYTJCq7xur3BhEIsAo5WS66tWfqx53_OaRDHAySO9C8Eo_WkguJupioi4m6oJWohYT9ZSq_0lJExMKN91r-v9mfwFdv7Io
CitedBy_id crossref_primary_10_1016_j_rhum_2012_12_017
crossref_primary_10_1111_eci_12022
crossref_primary_10_18632_oncotarget_18393
crossref_primary_10_4103_jisp_jisp_390_21
crossref_primary_10_1016_j_jid_2018_10_048
crossref_primary_10_1007_s10067_022_06367_w
crossref_primary_10_1016_j_jbspin_2012_10_014
crossref_primary_10_1155_2013_924363
crossref_primary_10_1097_ACI_0000000000000309
crossref_primary_10_1080_14397595_2016_1246118
crossref_primary_10_1016_j_rhum_2013_02_015
crossref_primary_10_1016_j_semarthrit_2015_02_001
crossref_primary_10_20996_1819_6446_2018_14_6_879_886
crossref_primary_10_1038_s41584_019_0277_8
crossref_primary_10_1080_03008207_2022_2157270
crossref_primary_10_3389_fimmu_2021_589639
crossref_primary_10_3390_ijms241512143
crossref_primary_10_1111_cea_12283
crossref_primary_10_20538_1682_0363_2020_2_120_131
crossref_primary_10_3346_jkms_2013_28_8_1145
crossref_primary_10_1016_j_ihj_2018_11_014
crossref_primary_10_1186_s12879_019_4261_3
crossref_primary_10_1093_mmy_myx050
crossref_primary_10_3389_fcvm_2021_710425
crossref_primary_10_3390_ijms222010922
crossref_primary_10_1111_cas_14709
crossref_primary_10_3390_gels8080461
crossref_primary_10_1016_j_cyto_2022_156015
crossref_primary_10_2174_1573397118666220818095927
crossref_primary_10_1016_j_cyto_2013_07_006
crossref_primary_10_1038_s12276_024_01351_7
crossref_primary_10_33393_jcb_2021_2327
crossref_primary_10_3389_fimmu_2018_02663
crossref_primary_10_1002_cti2_1187
crossref_primary_10_3389_fmed_2021_739489
crossref_primary_10_1016_j_amjcard_2015_01_035
crossref_primary_10_1016_j_jecm_2014_02_010
crossref_primary_10_1186_s13017_019_0256_z
crossref_primary_10_1186_s13075_016_1042_x
crossref_primary_10_1186_s41927_017_0001_8
crossref_primary_10_3346_jkms_2014_29_9_1199
crossref_primary_10_4103_0366_6999_223847
crossref_primary_10_1016_j_phrs_2016_01_027
crossref_primary_10_1586_erm_12_128
crossref_primary_10_1016_j_cyto_2014_05_007
crossref_primary_10_1111_bcp_14361
crossref_primary_10_47360_1995_4484_2022_554_559
crossref_primary_10_1016_j_cytogfr_2019_04_004
crossref_primary_10_1155_2020_4297354
crossref_primary_10_1016_j_humimm_2013_06_029
crossref_primary_10_1080_14397595_2016_1266071
crossref_primary_10_1093_intimm_dxab062
crossref_primary_10_1111_jre_12235
crossref_primary_10_2478_sjecr_2022_0037
crossref_primary_10_1016_j_ejphar_2020_173238
crossref_primary_10_3390_ijms21186565
crossref_primary_10_1016_j_jacc_2018_11_054
crossref_primary_10_1111_all_12004
crossref_primary_10_3899_jrheum_170020
crossref_primary_10_1155_2016_1028401
crossref_primary_10_1371_journal_pntd_0003514
crossref_primary_10_1097_JIM_0000000000000213
crossref_primary_10_3109_03009742_2012_735700
crossref_primary_10_1007_s10266_016_0259_0
crossref_primary_10_1016_j_intimp_2022_108887
crossref_primary_10_1016_j_cyto_2017_07_022
crossref_primary_10_1155_2014_342410
crossref_primary_10_4103_err_err_8_17
crossref_primary_10_1016_j_arr_2018_07_004
crossref_primary_10_1016_j_rbre_2016_03_009
crossref_primary_10_2174_1871530319666190226164309
crossref_primary_10_1016_j_rbr_2016_01_006
crossref_primary_10_1111_imm_12174
crossref_primary_10_1016_j_jbspin_2012_10_007
crossref_primary_10_1155_2015_603750
crossref_primary_10_3389_fimmu_2014_00141
crossref_primary_10_1007_s10753_013_9802_0
crossref_primary_10_1016_j_cyto_2013_03_007
crossref_primary_10_3109_03009742_2014_882408
crossref_primary_10_1089_jir_2017_0067
crossref_primary_10_17795_gct_31087
crossref_primary_10_1002_eji_201848056
crossref_primary_10_1159_000350424
crossref_primary_10_1007_s11914_012_0104_5
crossref_primary_10_3390_cimb46040228
crossref_primary_10_1186_ar4143
crossref_primary_10_1016_j_jneuroim_2012_05_001
crossref_primary_10_1186_s12967_015_0745_0
crossref_primary_10_1002_eji_201545501
crossref_primary_10_1186_1479_5876_10_120
crossref_primary_10_1111_cen3_12067
crossref_primary_10_1186_s42358_019_0060_1
crossref_primary_10_1111_iji_12240
Cites_doi 10.1016/j.immuni.2005.09.015
10.1038/labinvest.2008.82
10.1073/pnas.0606854104
10.1016/j.it.2009.03.003
10.1073/pnas.0801898105
10.1016/j.cytogfr.2004.02.004
10.1006/bbrc.2001.5090
10.3899/jrheum.090492
10.1016/j.cyto.2007.09.013
10.3899/jrheum.100184
10.1073/pnas.0812690106
10.4049/jimmunol.0802449
10.1016/j.bbrc.2009.04.081
10.1002/art.1780310302
10.1038/ni1050
10.1006/bbrc.2001.5306
10.1093/intimm/dxn060
10.1186/ar1467
10.1002/eji.200838575
10.1002/1521-4141(2001010)31:10<2979::AID-IMMU2979>3.0.CO;2-B
10.1073/pnas.0712116105
10.1038/nrrheum.2010.196
10.1186/ar86
10.1136/ard.2009.122655
10.4049/jimmunol.173.1.145
10.1186/ar1733
10.1002/art.24305
10.1038/nri2692
10.4049/jimmunol.0902685
ContentType Journal Article
Copyright 2011 The Korean Academy of Medical Sciences. 2011
Copyright_xml – notice: 2011 The Korean Academy of Medical Sciences. 2011
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
ACYCR
DOI 10.3346/jkms.2011.26.9.1132
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
Korean Citation Index
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1598-6357
EndPage 1139
ExternalDocumentID oai_kci_go_kr_ARTI_573848
PMC3172648
21935266
10_3346_jkms_2011_26_9_1132
Genre Journal Article
GroupedDBID ---
29K
2WC
3O-
5-W
53G
5GY
8JR
8XY
9ZL
AAYXX
ADBBV
ADRAZ
AENEX
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
CITATION
CS3
D-I
DIK
DU5
E3Z
EBS
EF.
EJD
F5P
FRP
GROUPED_DOAJ
GX1
HYE
KQ8
M48
O5R
O5S
OK1
OVT
PGMZT
RNS
RPM
TR2
W2D
XSB
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
08R
ACYCR
M~E
ID FETCH-LOGICAL-c437t-923bbd3843f4f675dfecfbe7c33748bebf873ac704c30b38dd95d83c23ff98213
IEDL.DBID M48
ISSN 1011-8934
1598-6357
IngestDate Tue Nov 21 21:47:43 EST 2023
Tue Sep 30 16:41:46 EDT 2025
Fri Jul 11 11:08:04 EDT 2025
Thu Apr 03 07:09:34 EDT 2025
Thu Apr 24 23:03:45 EDT 2025
Tue Jul 01 01:44:45 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 9
Keywords Interleukin-33
sST2, ST2L
Arthritis, Rheumatoid
Language English
License http://creativecommons.org/licenses/by-nc/3.0
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c437t-923bbd3843f4f675dfecfbe7c33748bebf873ac704c30b38dd95d83c23ff98213
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Yeon-Sik Hong and Su-Jin Moon contributed equally to this work.
G704-000345.2011.26.9.019
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3346/jkms.2011.26.9.1132
PMID 21935266
PQID 893722811
PQPubID 23479
PageCount 8
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_573848
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3172648
proquest_miscellaneous_893722811
pubmed_primary_21935266
crossref_primary_10_3346_jkms_2011_26_9_1132
crossref_citationtrail_10_3346_jkms_2011_26_9_1132
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2011-09-01
PublicationDateYYYYMMDD 2011-09-01
PublicationDate_xml – month: 09
  year: 2011
  text: 2011-09-01
  day: 01
PublicationDecade 2010
PublicationPlace Korea (South)
PublicationPlace_xml – name: Korea (South)
PublicationTitle Journal of Korean medical science
PublicationTitleAlternate J Korean Med Sci
PublicationYear 2011
Publisher The Korean Academy of Medical Sciences
대한의학회
Publisher_xml – name: The Korean Academy of Medical Sciences
– name: 대한의학회
References Raza (10.3346/jkms.2011.26.9.1132_ref23) 2005; 7
Xu (10.3346/jkms.2011.26.9.1132_ref15) 2008; 105
Cavanagh (10.3346/jkms.2011.26.9.1132_ref16) 2005; 7
Schmitz (10.3346/jkms.2011.26.9.1132_ref3) 2005; 23
Tago (10.3346/jkms.2011.26.9.1132_ref9) 2001; 285
Bourgeois (10.3346/jkms.2011.26.9.1132_ref7) 2009; 39
Kapoor (10.3346/jkms.2011.26.9.1132_ref19) 2011; 7
Palmer (10.3346/jkms.2011.26.9.1132_ref14) 2009; 60
Brint (10.3346/jkms.2011.26.9.1132_ref26) 2004; 5
Kuroiwa (10.3346/jkms.2011.26.9.1132_ref12) 2001; 284
Trajkovic (10.3346/jkms.2011.26.9.1132_ref8) 2004; 15
Verri (10.3346/jkms.2011.26.9.1132_ref11) 2008; 105
Verri (10.3346/jkms.2011.26.9.1132_ref25) 2010; 69
Mu (10.3346/jkms.2011.26.9.1132_ref18) 2010; 37
Haraldsen (10.3346/jkms.2011.26.9.1132_ref4) 2009; 30
Moulin (10.3346/jkms.2011.26.9.1132_ref6) 2007; 40
Suzukawa (10.3346/jkms.2011.26.9.1132_ref5) 2008; 88
Arnett (10.3346/jkms.2011.26.9.1132_ref13) 1988; 31
Smithgall (10.3346/jkms.2011.26.9.1132_ref21) 2008; 20
Carter (10.3346/jkms.2011.26.9.1132_ref22) 2001; 31
Matsuyama (10.3346/jkms.2011.26.9.1132_ref20) 2010; 37
Cayrol (10.3346/jkms.2011.26.9.1132_ref29) 2009; 106
Xu (10.3346/jkms.2011.26.9.1132_ref2) 2010; 184
Wood (10.3346/jkms.2011.26.9.1132_ref1) 2009; 384
Ohno (10.3346/jkms.2011.26.9.1132_ref28) 2009; 183
Leung (10.3346/jkms.2011.26.9.1132_ref10) 2004; 173
Carriere (10.3346/jkms.2011.26.9.1132_ref27) 2007; 104
Kinne (10.3346/jkms.2011.26.9.1132_ref17) 2000; 2
Liew (10.3346/jkms.2011.26.9.1132_ref24) 2010; 10
19439663 - Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9021-6
3358796 - Arthritis Rheum. 1988 Mar;31(3):315-24
18250323 - Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2723-8
19918048 - J Rheumatol. 2010 Jan;37(1):18-25
16286016 - Immunity. 2005 Nov;23(5):479-90
11592074 - Eur J Immunol. 2001 Oct;31(10):2979-85
15004556 - Nat Immunol. 2004 Apr;5(4):373-9
21119608 - Nat Rev Rheumatol. 2011 Jan;7(1):33-42
19933859 - J Immunol. 2009 Dec 15;183(12):7890-7
18550585 - Int Immunol. 2008 Aug;20(8):1019-30
11478810 - Biochem Biophys Res Commun. 2001 Aug 3;285(5):1377-83
18023358 - Cytokine. 2007 Dec;40(3):216-25
11094428 - Arthritis Res. 2000;2(3):189-202
15743469 - Arthritis Res Ther. 2005;7(2):R230-40
17185418 - Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):282-7
19393621 - Biochem Biophys Res Commun. 2009 Jun 19;384(1):105-9
11414697 - Biochem Biophys Res Commun. 2001 Jun 29;284(5):1104-8
18667700 - Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10913-8
20081870 - Nat Rev Immunol. 2010 Feb;10(2):103-10
19266498 - Eur J Immunol. 2009 Apr;39(4):1046-55
20682660 - J Rheumatol. 2010 Oct;37(10):2006-13
20139274 - J Immunol. 2010 Mar 1;184(5):2620-6
19359217 - Trends Immunol. 2009 May;30(5):227-33
18762778 - Lab Invest. 2008 Nov;88(11):1245-53
15110792 - Cytokine Growth Factor Rev. 2004 Apr-Jun;15(2-3):87-95
15210768 - J Immunol. 2004 Jul 1;173(1):145-50
19248109 - Arthritis Rheum. 2009 Mar;60(3):738-49
15987480 - Arthritis Res Ther. 2005;7(4):R784-95
20472598 - Ann Rheum Dis. 2010 Sep;69(9):1697-703
References_xml – volume: 23
  start-page: 479
  year: 2005
  ident: 10.3346/jkms.2011.26.9.1132_ref3
  publication-title: Immunity
  doi: 10.1016/j.immuni.2005.09.015
– volume: 88
  start-page: 1245
  year: 2008
  ident: 10.3346/jkms.2011.26.9.1132_ref5
  publication-title: Lab Invest
  doi: 10.1038/labinvest.2008.82
– volume: 104
  start-page: 282
  year: 2007
  ident: 10.3346/jkms.2011.26.9.1132_ref27
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0606854104
– volume: 30
  start-page: 227
  year: 2009
  ident: 10.3346/jkms.2011.26.9.1132_ref4
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2009.03.003
– volume: 105
  start-page: 10913
  year: 2008
  ident: 10.3346/jkms.2011.26.9.1132_ref15
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0801898105
– volume: 15
  start-page: 87
  year: 2004
  ident: 10.3346/jkms.2011.26.9.1132_ref8
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2004.02.004
– volume: 284
  start-page: 1104
  year: 2001
  ident: 10.3346/jkms.2011.26.9.1132_ref12
  publication-title: Biochem Biophys Res Commun
  doi: 10.1006/bbrc.2001.5090
– volume: 37
  start-page: 18
  year: 2010
  ident: 10.3346/jkms.2011.26.9.1132_ref20
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.090492
– volume: 40
  start-page: 216
  year: 2007
  ident: 10.3346/jkms.2011.26.9.1132_ref6
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2007.09.013
– volume: 37
  start-page: 2006
  year: 2010
  ident: 10.3346/jkms.2011.26.9.1132_ref18
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.100184
– volume: 106
  start-page: 9021
  year: 2009
  ident: 10.3346/jkms.2011.26.9.1132_ref29
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0812690106
– volume: 183
  start-page: 7890
  year: 2009
  ident: 10.3346/jkms.2011.26.9.1132_ref28
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0802449
– volume: 384
  start-page: 105
  year: 2009
  ident: 10.3346/jkms.2011.26.9.1132_ref1
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2009.04.081
– volume: 31
  start-page: 315
  year: 1988
  ident: 10.3346/jkms.2011.26.9.1132_ref13
  publication-title: Arthritis Rheum
  doi: 10.1002/art.1780310302
– volume: 5
  start-page: 373
  year: 2004
  ident: 10.3346/jkms.2011.26.9.1132_ref26
  publication-title: Nat Immunol
  doi: 10.1038/ni1050
– volume: 285
  start-page: 1377
  year: 2001
  ident: 10.3346/jkms.2011.26.9.1132_ref9
  publication-title: Biochem Biophys Res Commun
  doi: 10.1006/bbrc.2001.5306
– volume: 20
  start-page: 1019
  year: 2008
  ident: 10.3346/jkms.2011.26.9.1132_ref21
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxn060
– volume: 7
  start-page: R230
  year: 2005
  ident: 10.3346/jkms.2011.26.9.1132_ref16
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar1467
– volume: 39
  start-page: 1046
  year: 2009
  ident: 10.3346/jkms.2011.26.9.1132_ref7
  publication-title: Eur J Immunol
  doi: 10.1002/eji.200838575
– volume: 31
  start-page: 2979
  year: 2001
  ident: 10.3346/jkms.2011.26.9.1132_ref22
  publication-title: Eur J Immunol
  doi: 10.1002/1521-4141(2001010)31:10<2979::AID-IMMU2979>3.0.CO;2-B
– volume: 105
  start-page: 2723
  year: 2008
  ident: 10.3346/jkms.2011.26.9.1132_ref11
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0712116105
– volume: 7
  start-page: 33
  year: 2011
  ident: 10.3346/jkms.2011.26.9.1132_ref19
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2010.196
– volume: 2
  start-page: 189
  year: 2000
  ident: 10.3346/jkms.2011.26.9.1132_ref17
  publication-title: Arthritis Res
  doi: 10.1186/ar86
– volume: 69
  start-page: 1697
  year: 2010
  ident: 10.3346/jkms.2011.26.9.1132_ref25
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2009.122655
– volume: 173
  start-page: 145
  year: 2004
  ident: 10.3346/jkms.2011.26.9.1132_ref10
  publication-title: J Immunol
  doi: 10.4049/jimmunol.173.1.145
– volume: 7
  start-page: R784
  year: 2005
  ident: 10.3346/jkms.2011.26.9.1132_ref23
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar1733
– volume: 60
  start-page: 738
  year: 2009
  ident: 10.3346/jkms.2011.26.9.1132_ref14
  publication-title: Arthritis Rheum
  doi: 10.1002/art.24305
– volume: 10
  start-page: 103
  year: 2010
  ident: 10.3346/jkms.2011.26.9.1132_ref24
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2692
– volume: 184
  start-page: 2620
  year: 2010
  ident: 10.3346/jkms.2011.26.9.1132_ref2
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0902685
– reference: 19266498 - Eur J Immunol. 2009 Apr;39(4):1046-55
– reference: 20081870 - Nat Rev Immunol. 2010 Feb;10(2):103-10
– reference: 18550585 - Int Immunol. 2008 Aug;20(8):1019-30
– reference: 11094428 - Arthritis Res. 2000;2(3):189-202
– reference: 11478810 - Biochem Biophys Res Commun. 2001 Aug 3;285(5):1377-83
– reference: 21119608 - Nat Rev Rheumatol. 2011 Jan;7(1):33-42
– reference: 11414697 - Biochem Biophys Res Commun. 2001 Jun 29;284(5):1104-8
– reference: 19359217 - Trends Immunol. 2009 May;30(5):227-33
– reference: 20682660 - J Rheumatol. 2010 Oct;37(10):2006-13
– reference: 11592074 - Eur J Immunol. 2001 Oct;31(10):2979-85
– reference: 16286016 - Immunity. 2005 Nov;23(5):479-90
– reference: 19248109 - Arthritis Rheum. 2009 Mar;60(3):738-49
– reference: 20472598 - Ann Rheum Dis. 2010 Sep;69(9):1697-703
– reference: 17185418 - Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):282-7
– reference: 18762778 - Lab Invest. 2008 Nov;88(11):1245-53
– reference: 15004556 - Nat Immunol. 2004 Apr;5(4):373-9
– reference: 15743469 - Arthritis Res Ther. 2005;7(2):R230-40
– reference: 18023358 - Cytokine. 2007 Dec;40(3):216-25
– reference: 20139274 - J Immunol. 2010 Mar 1;184(5):2620-6
– reference: 15210768 - J Immunol. 2004 Jul 1;173(1):145-50
– reference: 19439663 - Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9021-6
– reference: 18667700 - Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10913-8
– reference: 19918048 - J Rheumatol. 2010 Jan;37(1):18-25
– reference: 19393621 - Biochem Biophys Res Commun. 2009 Jun 19;384(1):105-9
– reference: 15110792 - Cytokine Growth Factor Rev. 2004 Apr-Jun;15(2-3):87-95
– reference: 15987480 - Arthritis Res Ther. 2005;7(4):R784-95
– reference: 18250323 - Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2723-8
– reference: 19933859 - J Immunol. 2009 Dec 15;183(12):7890-7
– reference: 3358796 - Arthritis Rheum. 1988 Mar;31(3):315-24
SSID ssj0025523
Score 2.2900243
Snippet The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and...
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen–allergen response, autoimmunity and...
SourceID nrf
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 1132
SubjectTerms Adult
Aged
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - pathology
C-Reactive Protein - analysis
Female
Humans
Interleukin-1 Receptor-Like 1 Protein
Interleukin-1beta - analysis
Interleukin-1beta - blood
Interleukin-33
Interleukin-6 - analysis
Interleukin-6 - blood
Interleukins - analysis
Interleukins - blood
Male
Middle Aged
Original
Osteoarthritis - blood
Osteoarthritis - pathology
Receptors, Cell Surface - analysis
Receptors, Cell Surface - blood
Synovial Fluid - metabolism
의학일반
Title Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis
URI https://www.ncbi.nlm.nih.gov/pubmed/21935266
https://www.proquest.com/docview/893722811
https://pubmed.ncbi.nlm.nih.gov/PMC3172648
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001586190
Volume 26
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Journal of Korean Medical Science, 2011, 26(9), 155, pp.1132-1139
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1598-6357
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0025523
  issn: 1011-8934
  databaseCode: KQ8
  dateStart: 19860101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1598-6357
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0025523
  issn: 1011-8934
  databaseCode: DOA
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 1598-6357
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0025523
  issn: 1011-8934
  databaseCode: DIK
  dateStart: 19860101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVFQY
  databaseName: GFMER Free Medical Journals
  customDbUrl:
  eissn: 1598-6357
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0025523
  issn: 1011-8934
  databaseCode: GX1
  dateStart: 0
  isFulltext: true
  titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php
  providerName: Geneva Foundation for Medical Education and Research
– providerCode: PRVERR
  databaseName: KoreaMed Open Access
  customDbUrl:
  eissn: 1598-6357
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0025523
  issn: 1011-8934
  databaseCode: 5-W
  dateStart: 19860101
  isFulltext: true
  titleUrlDefault: https://koreamed.org/journals
  providerName: Korean Association of Medical Journal Editors
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 1598-6357
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0025523
  issn: 1011-8934
  databaseCode: RPM
  dateStart: 19860101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 1598-6357
  dateEnd: 20250831
  omitProxy: true
  ssIdentifier: ssj0025523
  issn: 1011-8934
  databaseCode: M48
  dateStart: 19860901
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLXGkBAviG_KR2UkHjaJTI3txM4DQggxrbAiBKu0Nyt27DVqcUbTSvDvuddJC0WDB54cKXac-Njxufda5xLyQgDLLdJMJSLnPBGZdEnppQFAclUCwy5tlBSafMxPpuL9eXa-RzZZUfsBbK807TCf1HS5OPr-7cdrWPCv0OLkGKGcf207MU6WHxWYpQT-yddha2I4zSdiG1YA-sy6E_dpmsBGLToZor89JAoFFyggn-_sWtfC0l9FSP88V_nbRnV8m9zqGSZ9002JO2TPhbvkxqSPod8jzeSXW5A2nkaf4MKt53VIOKcH41MoDmkZKhovKTBLd4lJeehB--WMxTtQnh7SOtBPnS5rS9GhSz_P3BoocFNX2P8sCibdJ9Pjd2dvT5I-7UJiBZerBCifMRVXgnvhwZ6ovLPeOGk5StUYZ7ySHDAcCctHhquqKrJKccu494ViKX9A9kMT3CNCrZPcyBIVhUaiEqXKTcasdICEBeqYDgjbDKu2vSY5psZYaLBNEBaNsGiERbNcFxphGZCX20aXnSTHv6s_B7z03NYapbSxvGj0fKnBYBjrTMKHqgGhGzQ1LC-MmZTBNetWI51jTKXwqg87cLd9bubGgMgd2LcVsLvdO6GeRQVvIG14svDxf7d8Qm52zm087PaU7K-Wa_cM2NHKDMEuGH8YRt_CMM7-n9i8CzI
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Measurement+of+Interleukin-33+%28IL-33%29+and+IL-33+Receptors+%28sST2+and+ST2L%29+in+Patients+with+Rheumatoid+Arthritis&rft.jtitle=Journal+of+Korean+medical+science&rft.au=Hong%2C+Yeon-Sik&rft.au=Moon%2C+Su-Jin&rft.au=Joo%2C+Young-Bin&rft.au=Jeon%2C+Chan-Hong&rft.date=2011-09-01&rft.pub=The+Korean+Academy+of+Medical+Sciences&rft.issn=1011-8934&rft.eissn=1598-6357&rft.volume=26&rft.issue=9&rft.spage=1132&rft.epage=1139&rft_id=info:doi/10.3346%2Fjkms.2011.26.9.1132&rft_id=info%3Apmid%2F21935266&rft.externalDocID=PMC3172648
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1011-8934&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1011-8934&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1011-8934&client=summon