Association between genetic variants of the leukotriene biosynthesis pathway and the risk of stroke： a case-control study in the Chinese Han population

• Published in: Chinese medical journal Vol. 126; no. 2; pp. 254 - 259
• Main Authors: SUN, Hao, ZHANG, Jing, WANG, Jun, SUN, Tao, XIAO, Hang, ZHANG, Jin-song
• Format: Journal Article
• Language: English
• Published: China Department of Emergency, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China%Department of Emergency, Wuxi People's Hospital, Wuxi, Jiangsu 214023, China%Laboratory of Neurotoxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China%Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, Jiangsu 210029, China 01.01.2013
• Subjects: Aged; Asian Continental Ancestry Group - genetics; Case-Control Studies; Female; Humans; Leukotrienes - biosynthesis; Logistic Models; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk; Stroke - etiology; Stroke - genetics; 中国汉族人群; 中风; 动脉粥样硬化; 协会; 生物合成途径; 白三烯; 遗传变异体; 风险; arachidonate 5-lipoxygenase; genetics; stroke; leukotrienes; leukotriene A4 hydrolase
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20121113

Background Leukotrienes are arachidonic acid derivatives long known for their inflammatory properties. Leukotriene- based inflammation has been demonstrated to play a crucial role in atherosclerosis, a major risk factor for several human diseases. Recently, human genetic studies from us and others suggest that single nucleotide polymorphisms （SNPs） in leukotriene pathway genes influence the risk of atherosclerotic diseases such as stroke. This study aimed to assess the role of additional leukotriene pathway genes as a stroke risk factor within the Chinese Hart population. Methods We sequenced the promoter, exonic, and intronic regions of leukotriene A4 hydrolase （LTA4H） and arachidonate 5-1ipoxygenase （ALOX5）, and then genotyped five SNPs in LTA#H and four SNPs in ALOX5 among 691 cases with stroke and 732 controls from the Chinese population. Results We detected a significant association between an intronic SNP in LTA4H （rs6538697） and stroke in our subjects （adjusted odds ratio, recessive model, 1.75; P=0.022）; and the SNP rs2029253 in ALOX5 was associated with a decreased risk of stroke （adjusted odds ratio, 0.76; 95% confidence interval, 0.59-0.97）. Conclusion Genetic variants in LTA4H and ALOX5 may modulate the risk of stroke in the Chinese Han population.