Raised interferon‐β, type 3 interferon and interferon‐stimulated genes – evidence of innate immune activation in neutrophilic asthma - da Silva, J.; Hilzendeger, C.; Moermans, C.; Schleich, F.; Henket, M.; Kebadze, T.; Mallia, P.; Edwards, M. R.; Johnston, S. L.; Louis, R. (Clinical and experimental allergy, 2017)
Keywords: Adrenal Cortex Hormones - therapeutic use; Adult; Aged; Anti-Asthmatic Agents - therapeutic use; Asthma - diagnosis; Asthma - drug therapy; Asthma - etiology; Asthma - metabolism; asthma phenotype; Cardiovascular & respiratory systems; Case-Control Studies; eosinophils; Female; Gene Expression Regulation; Human health sciences; Humans; Immunity, Innate; Immunoglobulin E - blood; Immunoglobulin E - immunology; interferon beta and lambda; Interferon Regulatory Factors - genetics; interferon stimulated genes; Interferon-beta - metabolism; Interferons - metabolism; interferon‐β and interferon‐λ; Male; Middle Aged; Neutrophil Activation - immunology; neutrophils; Neutrophils - immunology; Neutrophils - metabolism; Phenotype; Respiratory Function Tests; Risk Factors; Sciences de la santé humaine; Severity of Illness Index; Sputum - immunology; Sputum - metabolism; Sputum - virology; Systèmes cardiovasculaire & respiratoire; eosinophils; asthma phenotype; interferon-stimulated genes; interferon-β and interferon-λ; neutrophils