Diagnosis of Incomplete Kawasaki Disease in Infants Based on an Inflammation at the Bacille Calmette-Guérin Inoculation Site

• Published in: Korean circulation journal Vol. 42; no. 12; pp. 823 - 829
• Main Authors: Seo, Ji Hye, Yu, Jeong Jin, Ko, Hong Ki, Choi, Hyung Soon, Kim, Young-Hwue, Ko, Jae-Kon
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Cardiology 01.12.2012; 대한심장학회
• Subjects: Original; 내과학; Mucocutaneous Lymph Node Syndrome; Coronary vesseles
• ISSN: 1738-5520; 1738-5555
• DOI: 10.4070/kcj.2012.42.12.823

This study was intended to test how the inflammation at the Bacille Calmette-Guérin (BCG) inoculation site (BCGitis) can be a useful a diagnostic feature of Kawasaki disease (KD). All subjects were infants at the time of admission, and had received BCG vaccination during their neonatal period. There were 54 patients with complete KD (group 1) and 29 patients with incomplete KD (group 2). All 83 patients had BCGitis during the acute phase of illness. Data regarding the coronary artery diameters in 31 age-matched controls were used for comparison. The 2 patient groups did not differ in clinical and laboratory variables. During the acute phase, the median z scores of the left anterior descending coronary artery (LAD) diameter were 0.20, 0.42, and -0.48 in groups 1, 2, and control respectively, and that of right coronary artery (RCA) diameters were -0.15, -0.16, and -1.17 respectively. The z scores in both patient groups were greater than those in controls (p=0.0014 in LAD and p<0.0001 in RCA between group 1 and controls; p=0.0023 in LAD and p<0.0001 in RCA between group 2 and controls). A similar pattern was observed during the subacute and convalescent phases. BCGitis is a useful feature in the diagnosis of incomplete KD in infants who received BCG vaccine during neonatal period.