Determination of gas-trapping during high frequency oscillatory ventilation

• Published in: Acta Paediatrica Vol. 86; no. 3; pp. 268 - 273
• Main Authors: Alexander, J, Milner, AD
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.1997; Blackwell
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Gas-trapping; high frequency oscillatory ventilation; High-Frequency Ventilation - methods; Humans; Infant, Newborn; Inspiratory Reserve Volume; Intensive care medicine; Medical sciences; Plethysmography; Respiratory Distress Syndrome, Newborn - rehabilitation; tidal volume; Time Factors; Human; Inspiration; Respiratory disease; Characteristic; Tidal volume; Duration; Lung function; Newborn; Oscillation; Respiratory distress; Biological effect; Expiratory reserve volume; High frequency ventilation
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/j.1651-2227.1997.tb08887.x

Objective:To determine the effect of frequency and percent inspiratory time on tidal volume and gastrapping during high‐frequency oscillatory ventilation (HFOV). Subjects: Nine preterm infants with respiratory distress syndrome tested in the first 48 h of life. Methods: Tidal volumes and the presence of gas‐trapping were measured by respiratory jacket plethysmography at frequencies of 10,14, and 17.8 Hz and at inspiratory times of 30%, 50% and 70%, using a commercially available high frequency oscillator. Results: Mean (SD) tidal volumes were 2.40 (1.06) ml/kg at 10 Hz, 2.52 (1.07) ml/kg at 14 Hz and fell significantly to 1.96 (0.92) at 17.8 Hz (p < 0.05). Tidal volumes at 50% inspiratory time were significantly greater than at 30% inspiratory time [2.81 (1.42) ml/kg and 2.32 (1.18) ml/kg, respectively] but fell to baseline levels at 70% inspiratory time. There was no significant gas‐trapping with increases in either frequency or percent inspiratory time. Conclusions: Gas‐trapping is not a significant problem during HFOV in premature infants. Changes in tidal volume with increases in frequency and percent inspiratory time are similar to that seen in animal models.