Interleukin-2, interleukin-6 and T regulatory cells in peripheral blood of patients with Behçet's disease and recurrent aphthous ulcerations

J Oral Pathol Med (2012) 41: 73–79 Background:  One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell‐mediated immune response in which several cytokines (interleukin‐2, interleukin‐6) and T regulatory cell (T reg cell) population s...

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Published inJournal of oral pathology & medicine Vol. 41; no. 1; pp. 73 - 79
Main Authors Pekiner, Filiz Namdar, Aytugar, Emre, Demirel, Gulderen Yanikkaya, Borahan, Mehmet Oguz
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.2012
Wiley
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Online AccessGet full text
ISSN0904-2512
1600-0714
1600-0714
DOI10.1111/j.1600-0714.2011.01061.x

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Abstract J Oral Pathol Med (2012) 41: 73–79 Background:  One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell‐mediated immune response in which several cytokines (interleukin‐2, interleukin‐6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin‐2 (IL‐2), interleukin‐6 (IL‐6) levels and analysis of CD4+ CD25+ Foxp‐3+ Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison. Methods:  Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4+ CD25+ Foxp‐3+ Treg cells, IL‐2 and IL‐6 levels have been measured in flow cytometry. Results:  No statistical differences were observed in the serum levels of IL‐2 and IL‐6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4+ CD25+ Foxp‐3+ cells between groups, there were statistically significant differences in the number of CD4+ CD25bright Treg cells. CD4+ CD25bright Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4+ CD25bright cells between BD and RAU patients. Conclusions:  These results indicate that CD4+ CD25bright T regulatory cells may be contributing factor in the pathogenesis of BD and RAU.
AbstractList J Oral Pathol Med (2012) 41 : 73–79 Background:  One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell‐mediated immune response in which several cytokines (interleukin‐2, interleukin‐6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin‐2 (IL‐2), interleukin‐6 (IL‐6) levels and analysis of CD4 +  CD25 +  Foxp‐3 + Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison. Methods:  Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4 +  CD25 +  Foxp‐3 + Treg cells, IL‐2 and IL‐6 levels have been measured in flow cytometry. Results:  No statistical differences were observed in the serum levels of IL‐2 and IL‐6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4 +  CD25 + Foxp‐3 + cells between groups, there were statistically significant differences in the number of CD4 +  CD25 bright Treg cells. CD4 +  CD25 bright Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4 +  CD25 bright cells between BD and RAU patients. Conclusions:  These results indicate that CD4 + CD25 bright T regulatory cells may be contributing factor in the pathogenesis of BD and RAU.
One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which several cytokines (interleukin-2, interleukin-6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin-2 (IL-2), interleukin-6 (IL-6) levels and analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison. Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells, IL-2 and IL-6 levels have been measured in flow cytometry. No statistical differences were observed in the serum levels of IL-2 and IL-6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4(+) CD25(+) Foxp-3(+) cells between groups, there were statistically significant differences in the number of CD4(+) CD25(bright) Treg cells. CD4(+) CD25(bright) Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4(+) CD25(bright) cells between BD and RAU patients. These results indicate that CD4(+) CD25(bright) T regulatory cells may be contributing factor in the pathogenesis of BD and RAU.
One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which several cytokines (interleukin-2, interleukin-6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin-2 (IL-2), interleukin-6 (IL-6) levels and analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison.BACKGROUNDOne of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which several cytokines (interleukin-2, interleukin-6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin-2 (IL-2), interleukin-6 (IL-6) levels and analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison.Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells, IL-2 and IL-6 levels have been measured in flow cytometry.METHODSThirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells, IL-2 and IL-6 levels have been measured in flow cytometry.No statistical differences were observed in the serum levels of IL-2 and IL-6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4(+) CD25(+) Foxp-3(+) cells between groups, there were statistically significant differences in the number of CD4(+) CD25(bright) Treg cells. CD4(+) CD25(bright) Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4(+) CD25(bright) cells between BD and RAU patients.RESULTSNo statistical differences were observed in the serum levels of IL-2 and IL-6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4(+) CD25(+) Foxp-3(+) cells between groups, there were statistically significant differences in the number of CD4(+) CD25(bright) Treg cells. CD4(+) CD25(bright) Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4(+) CD25(bright) cells between BD and RAU patients.These results indicate that CD4(+) CD25(bright) T regulatory cells may be contributing factor in the pathogenesis of BD and RAU.CONCLUSIONSThese results indicate that CD4(+) CD25(bright) T regulatory cells may be contributing factor in the pathogenesis of BD and RAU.
J Oral Pathol Med (2012) 41: 73–79 Background:  One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell‐mediated immune response in which several cytokines (interleukin‐2, interleukin‐6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin‐2 (IL‐2), interleukin‐6 (IL‐6) levels and analysis of CD4+ CD25+ Foxp‐3+ Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison. Methods:  Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4+ CD25+ Foxp‐3+ Treg cells, IL‐2 and IL‐6 levels have been measured in flow cytometry. Results:  No statistical differences were observed in the serum levels of IL‐2 and IL‐6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4+ CD25+ Foxp‐3+ cells between groups, there were statistically significant differences in the number of CD4+ CD25bright Treg cells. CD4+ CD25bright Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4+ CD25bright cells between BD and RAU patients. Conclusions:  These results indicate that CD4+ CD25bright T regulatory cells may be contributing factor in the pathogenesis of BD and RAU.
Author Aytugar, Emre
Demirel, Gulderen Yanikkaya
Borahan, Mehmet Oguz
Pekiner, Filiz Namdar
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  givenname: Gulderen Yanikkaya
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  surname: Borahan
  fullname: Borahan, Mehmet Oguz
  organization: Marmara University Faculty of Dentistry, Department of Oral Diagnosis and Radiology
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Cites_doi 10.1093/intimm/dxm014
10.1034/j.1600-065X.2001.1820102.x
10.1016/j.bjoms.2007.07.201
10.1073/pnas.0509484103
10.1620/tjem.212.101
10.1111/j.1600-0714.1988.tb01539.x
10.4049/jimmunol.178.4.2579
10.1016/j.preteyeres.2007.09.002
10.1002/eji.200636435
10.1016/0030-4220(72)90211-3
10.1086/515313
10.3109/00016358509046497
10.1016/0167-5699(89)90085-6
10.1038/ni1178
10.1111/j.1600-0714.2008.00661.x
10.1111/j.1601-0825.2009.01608.x
10.1038/sj.gene.6363882
10.4049/jimmunol.167.3.1245
10.1111/j.1365-2249.2005.02754.x
10.1016/j.micinf.2004.12.023
10.1034/j.1600-0714.2003.00096.x
10.1080/09629350220131935
10.1111/j.1365-2249.1990.tb05447.x
10.47102/annals-acadmedsg.V33N5p596
10.1002/art.20334
10.1111/j.1365-2567.2005.02317.x
10.1016/S0923-1811(96)00588-9
10.3109/s10165-008-0064-x
10.1016/j.archoralbio.2006.08.008
10.1001/archderm.134.7.827
10.1084/jem.193.11.1303
10.1016/S0167-4889(02)00325-7
10.1084/jem.193.11.1285
10.1046/j.1365-2249.1999.01069.x
10.1016/j.imlet.2005.01.002
10.1016/S0896-8411(03)00085-4
10.3121/cmr.4.2.147
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Issue 1
Keywords Skin disease
Relapse
Cardiovascular disease
ENT
Blood
Genital diseases
Vascular disease
Interleukin 6
Vasculitis
Interleukin 2
Immunological investigation
Systemic disease
T-Lymphocyte
Ulceration
Human
T regulatory cell
recurrent aphthous ulcerations
Stomatology
Cytokine
IL-2
Behçet syndrome
Aphta
IL-6
Eye disease
Behçet's disease
Oral cavity disease
Language English
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2011 John Wiley & Sons A/S.
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References e_1_2_5_3_27_2
e_1_2_5_3_25_2
e_1_2_5_3_24_2
e_1_2_5_3_29_2
e_1_2_5_3_28_2
e_1_2_5_3_3_2
e_1_2_5_3_2_2
e_1_2_5_3_7_2
e_1_2_5_3_6_2
e_1_2_5_3_5_2
e_1_2_5_3_4_2
CLSI (e_1_2_5_3_23_2) 2007
International Study Group for Behçet’s disease (e_1_2_5_3_21_2) 1990; 335
Sun A (e_1_2_5_3_16_2) 2000; 24
e_1_2_5_3_31_2
e_1_2_5_3_32_2
e_1_2_5_3_33_2
e_1_2_5_3_34_2
Akdeniz N (e_1_2_5_3_11_2) 2004; 33
e_1_2_5_3_12_2
e_1_2_5_3_10_2
e_1_2_5_3_30_2
e_1_2_5_3_15_2
e_1_2_5_3_14_2
e_1_2_5_3_13_2
e_1_2_5_3_35_2
e_1_2_5_3_36_2
e_1_2_5_3_18_2
e_1_2_5_3_37_2
e_1_2_5_3_17_2
e_1_2_5_3_38_2
Sugi N (e_1_2_5_3_26_2) 1997; 101
e_1_2_5_3_9_2
e_1_2_5_3_8_2
Hamzaoui K (e_1_2_5_3_39_2) 2006; 24
e_1_2_5_3_42_2
Valesini G (e_1_2_5_3_19_2) 1985; 60
e_1_2_5_3_43_2
e_1_2_5_3_44_2
e_1_2_5_3_22_2
e_1_2_5_3_40_2
e_1_2_5_3_20_2
e_1_2_5_3_41_2
References_xml – ident: e_1_2_5_3_44_2
  doi: 10.1093/intimm/dxm014
– volume: 335
  start-page: 1078
  year: 1990
  ident: e_1_2_5_3_21_2
  article-title: Criteria for diagnosis of Behçet’s disease
  publication-title: Lancet
– volume: 24
  start-page: 71
  year: 2006
  ident: e_1_2_5_3_39_2
  article-title: CD4+ CD25+ regulatory T cells in patients with Behçet’s disease
  publication-title: Clin Exp Rheumatol
– volume: 101
  start-page: 335
  year: 1997
  ident: e_1_2_5_3_26_2
  article-title: Analysis of the profile of CD4+ cells in Behçet’s disease (Japanese)
  publication-title: Nippon Ganka Gakkai Zasshi
– ident: e_1_2_5_3_7_2
  doi: 10.1034/j.1600-065X.2001.1820102.x
– ident: e_1_2_5_3_17_2
  doi: 10.1016/j.bjoms.2007.07.201
– ident: e_1_2_5_3_41_2
  doi: 10.1073/pnas.0509484103
– ident: e_1_2_5_3_10_2
  doi: 10.1620/tjem.212.101
– volume-title: Procedures for collections of diagnostic blood specimens by venipuncture; approved standard
  year: 2007
  ident: e_1_2_5_3_23_2
– ident: e_1_2_5_3_20_2
  doi: 10.1111/j.1600-0714.1988.tb01539.x
– ident: e_1_2_5_3_42_2
  doi: 10.4049/jimmunol.178.4.2579
– ident: e_1_2_5_3_34_2
  doi: 10.1016/j.preteyeres.2007.09.002
– ident: e_1_2_5_3_43_2
  doi: 10.1002/eji.200636435
– ident: e_1_2_5_3_22_2
  doi: 10.1016/0030-4220(72)90211-3
– ident: e_1_2_5_3_28_2
  doi: 10.1086/515313
– ident: e_1_2_5_3_3_2
  doi: 10.3109/00016358509046497
– ident: e_1_2_5_3_25_2
  doi: 10.1016/0167-5699(89)90085-6
– ident: e_1_2_5_3_9_2
  doi: 10.1038/ni1178
– ident: e_1_2_5_3_6_2
  doi: 10.1111/j.1600-0714.2008.00661.x
– ident: e_1_2_5_3_15_2
  doi: 10.1111/j.1601-0825.2009.01608.x
– ident: e_1_2_5_3_30_2
  doi: 10.1038/sj.gene.6363882
– ident: e_1_2_5_3_14_2
  doi: 10.4049/jimmunol.167.3.1245
– ident: e_1_2_5_3_37_2
  doi: 10.1111/j.1365-2249.2005.02754.x
– ident: e_1_2_5_3_29_2
  doi: 10.1016/j.micinf.2004.12.023
– ident: e_1_2_5_3_33_2
  doi: 10.1034/j.1600-0714.2003.00096.x
– ident: e_1_2_5_3_24_2
  doi: 10.1080/09629350220131935
– ident: e_1_2_5_3_4_2
  doi: 10.1111/j.1365-2249.1990.tb05447.x
– volume: 33
  start-page: 596
  year: 2004
  ident: e_1_2_5_3_11_2
  article-title: Serum interleukin‐2, interleukin‐6, tumour necrosis factor‐alpha and nitric oxide levels in patients with Behçet’s disease
  publication-title: Ann Acad Med Singapore
  doi: 10.47102/annals-acadmedsg.V33N5p596
– ident: e_1_2_5_3_18_2
  doi: 10.1002/art.20334
– volume: 60
  start-page: 55
  year: 1985
  ident: e_1_2_5_3_19_2
  article-title: Evaluation of T cell subsets in Behçet’s syndrome using anti‐T cell monoclonal antibodies
  publication-title: Clin Exp Immunol
– ident: e_1_2_5_3_35_2
  doi: 10.1111/j.1365-2567.2005.02317.x
– ident: e_1_2_5_3_38_2
  doi: 10.1016/S0923-1811(96)00588-9
– ident: e_1_2_5_3_8_2
  doi: 10.3109/s10165-008-0064-x
– volume: 24
  start-page: 116
  year: 2000
  ident: e_1_2_5_3_16_2
  article-title: Expression of interleukin‐2 by activated peripheral blood lymphocytes upregulated by plasma level of interleukin‐2 in patients with recurrent aphthous ulcers
  publication-title: Proc Natl Sci Counc Repub China B
– ident: e_1_2_5_3_31_2
  doi: 10.1016/j.archoralbio.2006.08.008
– ident: e_1_2_5_3_32_2
  doi: 10.1001/archderm.134.7.827
– ident: e_1_2_5_3_13_2
  doi: 10.1084/jem.193.11.1303
– ident: e_1_2_5_3_27_2
  doi: 10.1016/S0167-4889(02)00325-7
– ident: e_1_2_5_3_12_2
  doi: 10.1084/jem.193.11.1285
– ident: e_1_2_5_3_2_2
  doi: 10.1046/j.1365-2249.1999.01069.x
– ident: e_1_2_5_3_5_2
  doi: 10.1016/j.imlet.2005.01.002
– ident: e_1_2_5_3_36_2
  doi: 10.1016/S0896-8411(03)00085-4
– ident: e_1_2_5_3_40_2
  doi: 10.3121/cmr.4.2.147
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Snippet J Oral Pathol Med (2012) 41: 73–79 Background:  One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU)...
J Oral Pathol Med (2012) 41 : 73–79 Background:  One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations...
One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which...
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StartPage 73
SubjectTerms Adolescent
Adult
Behcet Syndrome - blood
Behcet Syndrome - immunology
Behçet's disease
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
cytokine
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Flow Cytometry
Forkhead Transcription Factors - analysis
Humans
IL-2
IL-6
Interleukin-2 - blood
Interleukin-2 Receptor alpha Subunit - analysis
Interleukin-6 - blood
Lymphocyte Activation - immunology
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
recurrent aphthous ulcerations
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Stomatitis, Aphthous - blood
Stomatitis, Aphthous - immunology
T regulatory cell
T-Lymphocytes - immunology
T-Lymphocytes, Regulatory - immunology
Young Adult
Title Interleukin-2, interleukin-6 and T regulatory cells in peripheral blood of patients with Behçet's disease and recurrent aphthous ulcerations
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Volume 41
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