Interleukin-2, interleukin-6 and T regulatory cells in peripheral blood of patients with Behçet's disease and recurrent aphthous ulcerations
J Oral Pathol Med (2012) 41: 73–79 Background: One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell‐mediated immune response in which several cytokines (interleukin‐2, interleukin‐6) and T regulatory cell (T reg cell) population s...
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Published in | Journal of oral pathology & medicine Vol. 41; no. 1; pp. 73 - 79 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2012
Wiley |
Subjects | |
Online Access | Get full text |
ISSN | 0904-2512 1600-0714 1600-0714 |
DOI | 10.1111/j.1600-0714.2011.01061.x |
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Abstract | J Oral Pathol Med (2012) 41: 73–79
Background: One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell‐mediated immune response in which several cytokines (interleukin‐2, interleukin‐6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin‐2 (IL‐2), interleukin‐6 (IL‐6) levels and analysis of CD4+ CD25+ Foxp‐3+ Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison.
Methods: Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4+ CD25+ Foxp‐3+ Treg cells, IL‐2 and IL‐6 levels have been measured in flow cytometry.
Results: No statistical differences were observed in the serum levels of IL‐2 and IL‐6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4+ CD25+ Foxp‐3+ cells between groups, there were statistically significant differences in the number of CD4+ CD25bright Treg cells. CD4+ CD25bright Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4+ CD25bright cells between BD and RAU patients.
Conclusions: These results indicate that CD4+ CD25bright T regulatory cells may be contributing factor in the pathogenesis of BD and RAU. |
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AbstractList | J Oral Pathol Med
(2012)
41
: 73–79
Background:
One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell‐mediated immune response in which several cytokines (interleukin‐2, interleukin‐6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin‐2 (IL‐2), interleukin‐6 (IL‐6) levels and analysis of CD4
+
CD25
+
Foxp‐3
+
Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison.
Methods:
Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4
+
CD25
+
Foxp‐3
+
Treg cells, IL‐2 and IL‐6 levels have been measured in flow cytometry.
Results:
No statistical differences were observed in the serum levels of IL‐2 and IL‐6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4
+
CD25
+
Foxp‐3
+
cells between groups, there were statistically significant differences in the number of CD4
+
CD25
bright
Treg cells. CD4
+
CD25
bright
Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4
+
CD25
bright
cells between BD and RAU patients.
Conclusions:
These results indicate that CD4
+
CD25
bright
T regulatory cells may be contributing factor in the pathogenesis of BD and RAU. One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which several cytokines (interleukin-2, interleukin-6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin-2 (IL-2), interleukin-6 (IL-6) levels and analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison. Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells, IL-2 and IL-6 levels have been measured in flow cytometry. No statistical differences were observed in the serum levels of IL-2 and IL-6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4(+) CD25(+) Foxp-3(+) cells between groups, there were statistically significant differences in the number of CD4(+) CD25(bright) Treg cells. CD4(+) CD25(bright) Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4(+) CD25(bright) cells between BD and RAU patients. These results indicate that CD4(+) CD25(bright) T regulatory cells may be contributing factor in the pathogenesis of BD and RAU. One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which several cytokines (interleukin-2, interleukin-6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin-2 (IL-2), interleukin-6 (IL-6) levels and analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison.BACKGROUNDOne of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which several cytokines (interleukin-2, interleukin-6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin-2 (IL-2), interleukin-6 (IL-6) levels and analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison.Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells, IL-2 and IL-6 levels have been measured in flow cytometry.METHODSThirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells, IL-2 and IL-6 levels have been measured in flow cytometry.No statistical differences were observed in the serum levels of IL-2 and IL-6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4(+) CD25(+) Foxp-3(+) cells between groups, there were statistically significant differences in the number of CD4(+) CD25(bright) Treg cells. CD4(+) CD25(bright) Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4(+) CD25(bright) cells between BD and RAU patients.RESULTSNo statistical differences were observed in the serum levels of IL-2 and IL-6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4(+) CD25(+) Foxp-3(+) cells between groups, there were statistically significant differences in the number of CD4(+) CD25(bright) Treg cells. CD4(+) CD25(bright) Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4(+) CD25(bright) cells between BD and RAU patients.These results indicate that CD4(+) CD25(bright) T regulatory cells may be contributing factor in the pathogenesis of BD and RAU.CONCLUSIONSThese results indicate that CD4(+) CD25(bright) T regulatory cells may be contributing factor in the pathogenesis of BD and RAU. J Oral Pathol Med (2012) 41: 73–79 Background: One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell‐mediated immune response in which several cytokines (interleukin‐2, interleukin‐6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin‐2 (IL‐2), interleukin‐6 (IL‐6) levels and analysis of CD4+ CD25+ Foxp‐3+ Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison. Methods: Thirty patients (15 men and 15 women) with BD, 30 patients (12 men and 18 women) with RAU and 15 healthy control subjects (nine men and six women) participated in the study. Analysis of CD4+ CD25+ Foxp‐3+ Treg cells, IL‐2 and IL‐6 levels have been measured in flow cytometry. Results: No statistical differences were observed in the serum levels of IL‐2 and IL‐6 between BD and RAU patients, and healthy subjects. Although there were no statistical differences in the number of CD4+ CD25+ Foxp‐3+ cells between groups, there were statistically significant differences in the number of CD4+ CD25bright Treg cells. CD4+ CD25bright Treg cells were significantly increased in BD and RAU patients compared to healthy subjects. Statistical analysis revealed no difference according to the number of CD4+ CD25bright cells between BD and RAU patients. Conclusions: These results indicate that CD4+ CD25bright T regulatory cells may be contributing factor in the pathogenesis of BD and RAU. |
Author | Aytugar, Emre Demirel, Gulderen Yanikkaya Borahan, Mehmet Oguz Pekiner, Filiz Namdar |
Author_xml | – sequence: 1 givenname: Filiz Namdar surname: Pekiner fullname: Pekiner, Filiz Namdar organization: Marmara University Faculty of Dentistry, Department of Oral Diagnosis and Radiology – sequence: 2 givenname: Emre surname: Aytugar fullname: Aytugar, Emre organization: Marmara University Faculty of Dentistry, Department of Oral Diagnosis and Radiology – sequence: 3 givenname: Gulderen Yanikkaya surname: Demirel fullname: Demirel, Gulderen Yanikkaya organization: Yeditepe University, Medical Microbiology, Department of Immunology section, Istanbul, Turkey – sequence: 4 givenname: Mehmet Oguz surname: Borahan fullname: Borahan, Mehmet Oguz organization: Marmara University Faculty of Dentistry, Department of Oral Diagnosis and Radiology |
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Cites_doi | 10.1093/intimm/dxm014 10.1034/j.1600-065X.2001.1820102.x 10.1016/j.bjoms.2007.07.201 10.1073/pnas.0509484103 10.1620/tjem.212.101 10.1111/j.1600-0714.1988.tb01539.x 10.4049/jimmunol.178.4.2579 10.1016/j.preteyeres.2007.09.002 10.1002/eji.200636435 10.1016/0030-4220(72)90211-3 10.1086/515313 10.3109/00016358509046497 10.1016/0167-5699(89)90085-6 10.1038/ni1178 10.1111/j.1600-0714.2008.00661.x 10.1111/j.1601-0825.2009.01608.x 10.1038/sj.gene.6363882 10.4049/jimmunol.167.3.1245 10.1111/j.1365-2249.2005.02754.x 10.1016/j.micinf.2004.12.023 10.1034/j.1600-0714.2003.00096.x 10.1080/09629350220131935 10.1111/j.1365-2249.1990.tb05447.x 10.47102/annals-acadmedsg.V33N5p596 10.1002/art.20334 10.1111/j.1365-2567.2005.02317.x 10.1016/S0923-1811(96)00588-9 10.3109/s10165-008-0064-x 10.1016/j.archoralbio.2006.08.008 10.1001/archderm.134.7.827 10.1084/jem.193.11.1303 10.1016/S0167-4889(02)00325-7 10.1084/jem.193.11.1285 10.1046/j.1365-2249.1999.01069.x 10.1016/j.imlet.2005.01.002 10.1016/S0896-8411(03)00085-4 10.3121/cmr.4.2.147 |
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Keywords | Skin disease Relapse Cardiovascular disease ENT Blood Genital diseases Vascular disease Interleukin 6 Vasculitis Interleukin 2 Immunological investigation Systemic disease T-Lymphocyte Ulceration Human T regulatory cell recurrent aphthous ulcerations Stomatology Cytokine IL-2 Behçet syndrome Aphta IL-6 Eye disease Behçet's disease Oral cavity disease |
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References | e_1_2_5_3_27_2 e_1_2_5_3_25_2 e_1_2_5_3_24_2 e_1_2_5_3_29_2 e_1_2_5_3_28_2 e_1_2_5_3_3_2 e_1_2_5_3_2_2 e_1_2_5_3_7_2 e_1_2_5_3_6_2 e_1_2_5_3_5_2 e_1_2_5_3_4_2 CLSI (e_1_2_5_3_23_2) 2007 International Study Group for Behçet’s disease (e_1_2_5_3_21_2) 1990; 335 Sun A (e_1_2_5_3_16_2) 2000; 24 e_1_2_5_3_31_2 e_1_2_5_3_32_2 e_1_2_5_3_33_2 e_1_2_5_3_34_2 Akdeniz N (e_1_2_5_3_11_2) 2004; 33 e_1_2_5_3_12_2 e_1_2_5_3_10_2 e_1_2_5_3_30_2 e_1_2_5_3_15_2 e_1_2_5_3_14_2 e_1_2_5_3_13_2 e_1_2_5_3_35_2 e_1_2_5_3_36_2 e_1_2_5_3_18_2 e_1_2_5_3_37_2 e_1_2_5_3_17_2 e_1_2_5_3_38_2 Sugi N (e_1_2_5_3_26_2) 1997; 101 e_1_2_5_3_9_2 e_1_2_5_3_8_2 Hamzaoui K (e_1_2_5_3_39_2) 2006; 24 e_1_2_5_3_42_2 Valesini G (e_1_2_5_3_19_2) 1985; 60 e_1_2_5_3_43_2 e_1_2_5_3_44_2 e_1_2_5_3_22_2 e_1_2_5_3_40_2 e_1_2_5_3_20_2 e_1_2_5_3_41_2 |
References_xml | – ident: e_1_2_5_3_44_2 doi: 10.1093/intimm/dxm014 – volume: 335 start-page: 1078 year: 1990 ident: e_1_2_5_3_21_2 article-title: Criteria for diagnosis of Behçet’s disease publication-title: Lancet – volume: 24 start-page: 71 year: 2006 ident: e_1_2_5_3_39_2 article-title: CD4+ CD25+ regulatory T cells in patients with Behçet’s disease publication-title: Clin Exp Rheumatol – volume: 101 start-page: 335 year: 1997 ident: e_1_2_5_3_26_2 article-title: Analysis of the profile of CD4+ cells in Behçet’s disease (Japanese) publication-title: Nippon Ganka Gakkai Zasshi – ident: e_1_2_5_3_7_2 doi: 10.1034/j.1600-065X.2001.1820102.x – ident: e_1_2_5_3_17_2 doi: 10.1016/j.bjoms.2007.07.201 – ident: e_1_2_5_3_41_2 doi: 10.1073/pnas.0509484103 – ident: e_1_2_5_3_10_2 doi: 10.1620/tjem.212.101 – volume-title: Procedures for collections of diagnostic blood specimens by venipuncture; approved standard year: 2007 ident: e_1_2_5_3_23_2 – ident: e_1_2_5_3_20_2 doi: 10.1111/j.1600-0714.1988.tb01539.x – ident: e_1_2_5_3_42_2 doi: 10.4049/jimmunol.178.4.2579 – ident: e_1_2_5_3_34_2 doi: 10.1016/j.preteyeres.2007.09.002 – ident: e_1_2_5_3_43_2 doi: 10.1002/eji.200636435 – ident: e_1_2_5_3_22_2 doi: 10.1016/0030-4220(72)90211-3 – ident: e_1_2_5_3_28_2 doi: 10.1086/515313 – ident: e_1_2_5_3_3_2 doi: 10.3109/00016358509046497 – ident: e_1_2_5_3_25_2 doi: 10.1016/0167-5699(89)90085-6 – ident: e_1_2_5_3_9_2 doi: 10.1038/ni1178 – ident: e_1_2_5_3_6_2 doi: 10.1111/j.1600-0714.2008.00661.x – ident: e_1_2_5_3_15_2 doi: 10.1111/j.1601-0825.2009.01608.x – ident: e_1_2_5_3_30_2 doi: 10.1038/sj.gene.6363882 – ident: e_1_2_5_3_14_2 doi: 10.4049/jimmunol.167.3.1245 – ident: e_1_2_5_3_37_2 doi: 10.1111/j.1365-2249.2005.02754.x – ident: e_1_2_5_3_29_2 doi: 10.1016/j.micinf.2004.12.023 – ident: e_1_2_5_3_33_2 doi: 10.1034/j.1600-0714.2003.00096.x – ident: e_1_2_5_3_24_2 doi: 10.1080/09629350220131935 – ident: e_1_2_5_3_4_2 doi: 10.1111/j.1365-2249.1990.tb05447.x – volume: 33 start-page: 596 year: 2004 ident: e_1_2_5_3_11_2 article-title: Serum interleukin‐2, interleukin‐6, tumour necrosis factor‐alpha and nitric oxide levels in patients with Behçet’s disease publication-title: Ann Acad Med Singapore doi: 10.47102/annals-acadmedsg.V33N5p596 – ident: e_1_2_5_3_18_2 doi: 10.1002/art.20334 – volume: 60 start-page: 55 year: 1985 ident: e_1_2_5_3_19_2 article-title: Evaluation of T cell subsets in Behçet’s syndrome using anti‐T cell monoclonal antibodies publication-title: Clin Exp Immunol – ident: e_1_2_5_3_35_2 doi: 10.1111/j.1365-2567.2005.02317.x – ident: e_1_2_5_3_38_2 doi: 10.1016/S0923-1811(96)00588-9 – ident: e_1_2_5_3_8_2 doi: 10.3109/s10165-008-0064-x – volume: 24 start-page: 116 year: 2000 ident: e_1_2_5_3_16_2 article-title: Expression of interleukin‐2 by activated peripheral blood lymphocytes upregulated by plasma level of interleukin‐2 in patients with recurrent aphthous ulcers publication-title: Proc Natl Sci Counc Repub China B – ident: e_1_2_5_3_31_2 doi: 10.1016/j.archoralbio.2006.08.008 – ident: e_1_2_5_3_32_2 doi: 10.1001/archderm.134.7.827 – ident: e_1_2_5_3_13_2 doi: 10.1084/jem.193.11.1303 – ident: e_1_2_5_3_27_2 doi: 10.1016/S0167-4889(02)00325-7 – ident: e_1_2_5_3_12_2 doi: 10.1084/jem.193.11.1285 – ident: e_1_2_5_3_2_2 doi: 10.1046/j.1365-2249.1999.01069.x – ident: e_1_2_5_3_5_2 doi: 10.1016/j.imlet.2005.01.002 – ident: e_1_2_5_3_36_2 doi: 10.1016/S0896-8411(03)00085-4 – ident: e_1_2_5_3_40_2 doi: 10.3121/cmr.4.2.147 |
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Snippet | J Oral Pathol Med (2012) 41: 73–79
Background: One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU)... J Oral Pathol Med (2012) 41 : 73–79 Background: One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations... One of the factors involved in the pathogenesis of Behçet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which... |
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SubjectTerms | Adolescent Adult Behcet Syndrome - blood Behcet Syndrome - immunology Behçet's disease Biological and medical sciences CD4-Positive T-Lymphocytes - immunology cytokine Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Flow Cytometry Forkhead Transcription Factors - analysis Humans IL-2 IL-6 Interleukin-2 - blood Interleukin-2 Receptor alpha Subunit - analysis Interleukin-6 - blood Lymphocyte Activation - immunology Male Medical sciences Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology recurrent aphthous ulcerations Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Stomatitis, Aphthous - blood Stomatitis, Aphthous - immunology T regulatory cell T-Lymphocytes - immunology T-Lymphocytes, Regulatory - immunology Young Adult |
Title | Interleukin-2, interleukin-6 and T regulatory cells in peripheral blood of patients with Behçet's disease and recurrent aphthous ulcerations |
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