Adenoviral-mediated gene expression of hepatocyte growth factor prevents postoperative peritoneal adhesion in a rat model
Mesothelial cell proliferation and migration play important roles in reducing formation of postoperative peritoneal adhesions. Hepatocyte growth factor (HGF) is a multifunctional cytokine that stimulates proliferation and migration of various cell types, including mesothelial cells. We investigated...
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| Published in | Surgery Vol. 140; no. 3; pp. 441 - 447 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Mosby, Inc
01.09.2006
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0039-6060 1532-7361 |
| DOI | 10.1016/j.surg.2005.12.014 |
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| Abstract | Mesothelial cell proliferation and migration play important roles in reducing formation of postoperative peritoneal adhesions. Hepatocyte growth factor (HGF) is a multifunctional cytokine that stimulates proliferation and migration of various cell types, including mesothelial cells.
We investigated the effect of adenovirus-mediated HGF gene expression on the proliferation and migration of mesothelial cells and evaluated its preventive effects on postoperative formation of peritoneal adhesions. Rat mesothelial cells were isolated and characterized by expression of cytokeratin and vimentin.
Immunohistochemical staining showed that these cells expressed c-Met, the receptor for HGF. Adenoviral-mediated HGF gene transfer into mesothelial cells resulted in high expression of HGF and enhanced migration. To evaluate the preventive effects of adenoviral-mediated HGF gene transfer on the formation of postoperative peritoneal adhesion, we employed a rat model of cecum abrasion-induced adhesion formation in which 80% of the rats developed postoperative peritoneal adhesions. Local application of recombinant adenovirus carrying the HGF gene reduced adhesion formation in 16 of 20 control rats compared with 7 of 20 treated rats in this model.
These results suggest that adenoviral-mediated HGF gene transfer may be a novel strategy for preventing postoperative peritoneal adhesions. |
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| AbstractList | Mesothelial cell proliferation and migration play important roles in reducing formation of postoperative peritoneal adhesions. Hepatocyte growth factor (HGF) is a multifunctional cytokine that stimulates proliferation and migration of various cell types, including mesothelial cells.
We investigated the effect of adenovirus-mediated HGF gene expression on the proliferation and migration of mesothelial cells and evaluated its preventive effects on postoperative formation of peritoneal adhesions. Rat mesothelial cells were isolated and characterized by expression of cytokeratin and vimentin.
Immunohistochemical staining showed that these cells expressed c-Met, the receptor for HGF. Adenoviral-mediated HGF gene transfer into mesothelial cells resulted in high expression of HGF and enhanced migration. To evaluate the preventive effects of adenoviral-mediated HGF gene transfer on the formation of postoperative peritoneal adhesion, we employed a rat model of cecum abrasion-induced adhesion formation in which 80% of the rats developed postoperative peritoneal adhesions. Local application of recombinant adenovirus carrying the HGF gene reduced adhesion formation in 16 of 20 control rats compared with 7 of 20 treated rats in this model.
These results suggest that adenoviral-mediated HGF gene transfer may be a novel strategy for preventing postoperative peritoneal adhesions. Mesothelial cell proliferation and migration play important roles in reducing formation of postoperative peritoneal adhesions. Hepatocyte growth factor (HGF) is a multifunctional cytokine that stimulates proliferation and migration of various cell types, including mesothelial cells.BACKGROUNDMesothelial cell proliferation and migration play important roles in reducing formation of postoperative peritoneal adhesions. Hepatocyte growth factor (HGF) is a multifunctional cytokine that stimulates proliferation and migration of various cell types, including mesothelial cells.We investigated the effect of adenovirus-mediated HGF gene expression on the proliferation and migration of mesothelial cells and evaluated its preventive effects on postoperative formation of peritoneal adhesions. Rat mesothelial cells were isolated and characterized by expression of cytokeratin and vimentin.METHODSWe investigated the effect of adenovirus-mediated HGF gene expression on the proliferation and migration of mesothelial cells and evaluated its preventive effects on postoperative formation of peritoneal adhesions. Rat mesothelial cells were isolated and characterized by expression of cytokeratin and vimentin.Immunohistochemical staining showed that these cells expressed c-Met, the receptor for HGF. Adenoviral-mediated HGF gene transfer into mesothelial cells resulted in high expression of HGF and enhanced migration. To evaluate the preventive effects of adenoviral-mediated HGF gene transfer on the formation of postoperative peritoneal adhesion, we employed a rat model of cecum abrasion-induced adhesion formation in which 80% of the rats developed postoperative peritoneal adhesions. Local application of recombinant adenovirus carrying the HGF gene reduced adhesion formation in 16 of 20 control rats compared with 7 of 20 treated rats in this model.RESULTSImmunohistochemical staining showed that these cells expressed c-Met, the receptor for HGF. Adenoviral-mediated HGF gene transfer into mesothelial cells resulted in high expression of HGF and enhanced migration. To evaluate the preventive effects of adenoviral-mediated HGF gene transfer on the formation of postoperative peritoneal adhesion, we employed a rat model of cecum abrasion-induced adhesion formation in which 80% of the rats developed postoperative peritoneal adhesions. Local application of recombinant adenovirus carrying the HGF gene reduced adhesion formation in 16 of 20 control rats compared with 7 of 20 treated rats in this model.These results suggest that adenoviral-mediated HGF gene transfer may be a novel strategy for preventing postoperative peritoneal adhesions.CONCLUSIONSThese results suggest that adenoviral-mediated HGF gene transfer may be a novel strategy for preventing postoperative peritoneal adhesions. |
| Author | Duan, Hai-Feng Wang, Lisheng Wu, Chu-Tse Wu, Bin Liu, Hong-Jun Lu, Zhuo-Zhuang |
| Author_xml | – sequence: 1 givenname: Hong-Jun surname: Liu fullname: Liu, Hong-Jun – sequence: 2 givenname: Chu-Tse surname: Wu fullname: Wu, Chu-Tse – sequence: 3 givenname: Hai-Feng surname: Duan fullname: Duan, Hai-Feng – sequence: 4 givenname: Bin surname: Wu fullname: Wu, Bin – sequence: 5 givenname: Zhuo-Zhuang surname: Lu fullname: Lu, Zhuo-Zhuang – sequence: 6 givenname: Lisheng surname: Wang fullname: Wang, Lisheng email: wangls@nic.bmi.ac.cn |
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| Keywords | Postoperative Animal model Adenoviridae Rat Hepatocyte growth factor Rodentia Gene expression Adhesion Virus Medicine Prevention Vertebrata Mammalia Treatment Surgery Peritoneum |
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| SubjectTerms | Adenoviridae - genetics Animals Biological and medical sciences Cell Movement - genetics Cell Proliferation Disease Models, Animal Epithelial Cells - metabolism Gene Expression Regulation - genetics Gene Expression Regulation, Viral - genetics Gene Transfer Techniques General aspects Genetic Therapy - methods Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Medical sciences Peritoneal Diseases - metabolism Peritoneal Diseases - prevention & control Peritoneum - cytology Peritoneum - metabolism Postoperative Complications - metabolism Postoperative Complications - prevention & control Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Rats Rats, Wistar Tissue Adhesions - etiology Tissue Adhesions - metabolism Tissue Adhesions - prevention & control |
| Title | Adenoviral-mediated gene expression of hepatocyte growth factor prevents postoperative peritoneal adhesion in a rat model |
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