Clinical and Molecular Epidemiology of Community-Onset Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Escherichia coli over a 6-Year Period

• Published in: Journal of Korean medical science Vol. 28; no. 7; pp. 998 - 1004
• Main Authors: Kang, Cheol-In, Cha, Min Kyeong, Kim, So Hyun, Ko, Kwan Soo, Wi, Yu Mi, Chung, Doo Ryeon, Peck, Kyong Ran, Lee, Nam Yong, Song, Jae-Hoon
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.07.2013; 대한의학회
• Subjects: Aging; Bacteremia - drug therapy; Bacteremia - epidemiology; beta-Lactamases - metabolism; Biliary Tract Diseases - epidemiology; Biliary Tract Diseases - microbiology; Cephalosporin Resistance - genetics; Cephalosporins - therapeutic use; Community-Acquired Infections - epidemiology; Community-Acquired Infections - microbiology; Escherichia coli - isolation & purification; Escherichia coli - metabolism; Escherichia coli Infections - drug therapy; Escherichia coli Infections - epidemiology; Female; Humans; Male; Microbial Sensitivity Tests; Molecular Epidemiology; Multilocus Sequence Typing; Original; Prevalence; Retrospective Studies; Urinary Tract Infections - epidemiology; Urinary Tract Infections - microbiology; 의학일반; Epidemiology; Cephalosporin Resistance; Escherichia coli; Bacteremia; Community-Acquired Infections
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2013.28.7.998

Although extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) has emerged as a significant community-acquired pathogen, there is little epidemiological information regarding community-onset bacteremia due to ESBL-EC. A retrospective observational study from 2006 through 2011 was performed to evaluate the epidemiology of community-onset bacteremia caused by ESBL-EC. In a six-year period, the proportion of ESBL-EC responsible for causing community-onset bacteremia had increased significantly, from 3.6% in 2006 to 14.3%, in 2011. Of the 97 clinically evaluable cases with ESBL-EC bacteremia, 32 (33.0%) were further classified as healthcare-associated infections. The most common site of infection was urinary tract infection (n=35, 36.1%), followed by biliary tract infections (n=29, 29.9%). Of the 103 ESBL-EC isolates, 43 (41.7%) produced CTX-M-14 and 36 (35.0%) produced CTX-M-15. In the multilocus sequence typing (MLST) analysis of 76 isolates with CTX-M-14 or -15 type ESBLs, the most prevalent sequence type (ST) was ST131 (n=15, 19.7%), followed by ST405 (n=12, 15.8%) and ST648 (n=8, 10.5%). No significant differences in clinical features were found in the ST131 group versus the other group. These findings suggest that epidemic ESBL-EC clones such as CTX-M-14 or -15 type ESBLs and ST131 have disseminated in community-onset infections, even in bloodstream infections, which are the most serious type of infection.